Nature Communications
·
2025
·Vol. 16
·期 1
·1-21
·
IF 15.7
Ding Junfeng,Wang Tianran,Lin Zhiqiang,Li Zhenyu,Yang Jiaxuan,Li Fujiang,Rong Yan,Chen Xuesi,He Chaoliang
The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study of chiral synthetic polypeptide hydrogels as cancer vaccines as well as of the impact of biomaterials themselves for antitumor immunotherapy has rarely been reported. Here, we show the key role of residue chirality of polypeptide hydrogels in antitumor immunity and local immune microenvironment regulation. Compared to poly(γ-ethyl-L-glutamate)-based hydrogels (L-Gel), poly(γ-ethyl-D-glutamate)-based hydrogels (D-Gel) induces enhanced level of immune cell infiltration. However, D-Gel causes higher levels of suppressive markers on antigen-presenting cells and even induces stronger T cell exhaustion than L-Gel. Finally, D-Gel establishes a local chronic inflammatory and immunosuppressive microenvironment and shows insufficient anti-tumor effects. Conversely, the milder host immune responses induced by L-Gel leads to more effective tumor inhibition. This study provides insights on the role of residue chirality in the regulation of local immune microenvironment and affecting antitumor immune response.
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CELLULOSE
·
2024
·
IF 4.9
Yang Jingjing,Zhao Jiyang,Xie Rui,Wu Cheng,Huang Fang
To address the challenges of low fixation and poor resistance to staining on white ground of reactive dyes in the dyeing and printing industry, two new polyfunctional reactive dyes (MFA-1 and MFA-2) were developed. These dyes, which contained m-phenylenediamine derivatives with sulfonic and methyl groups as bridge groups, demonstrated high solubility (above 350 g/L) and low affinity to fibers. Detailed investigations were conducted to understand the factors affecting printing performance. The two dyes exhibited exceptionally high fixations of 94.35% and 95.75%, respectively, on cotton fabrics at a high dye concentration of 5.0%. This represented a 24% and 43% improvement over C.I. Reactive Red 111 and C.I. Reactive Red 120, respectively. Notably, MFA-2 achieved a fixation above 95% even at a higher dye concentration of 10.0%. Additionally, both MFA-1 and MFA-2 showed minimal staining on white ground, with fastness properties of grades 3 and 4, respectively, representing 2–3 grades higher than C.I. Reactive Red 111 and C.I. Reactive Red 120. The mechanism behind the exceptional fixation and low staining properties of these dyes was proposed, suggesting that the unique structure of the bridge group disrupted the co-planarity of the dye molecule and evenly distributed the negative charge in the dye molecule. Furthermore, the cotton fabrics printed with MFA-1 and MFA-2 demonstrated good color uniformity, with low ΔE values of 0.46 and 0.32, respectively. The printed fabrics also exhibited good dry and wet rubbing fastness (grades 4 and 3, respectively), wash fastness (grades 4–5), light fastness (grade 4), and perspiration fastness (grades 4 or 4–5).
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Discover Oncology
·
2024
·Vol. 15
·期 1
·1-15
·
IF 2.8
Li Weinan,Fu Yuhan,Sun Jialin,Gong Hexin,Yan Ru,Wang Yanhong
Breast cancer is a major threat to safety and health of women. The breast cancer stem cells (BCSCs) have multi-drug resistance to chemotherapy drugs, which leads to chemotherapy failure. We proposed a strategy of delivery of tumor-killing drugs and a resistance reversal agent, to enhance inhibition of BCSCs. Here, schisandrin B (SchB)/AP NPs are constructed using acid-grafted-poly (β-amino ester) (ATRA-g-PBAE, AP) grafted polymer nanoparticle encapsulated SchB, with pH-sensitive release function. This drug delivery system has good pharmacological properties and can increase the SchB release with the decrease of pH. The NPs showed cytotoxic effects in reversing ATRA resistance to BCSCs. Lysosomal escape was achieved when the nanoparticles were taken up by BCSCs. In addition, we found that NPs may reverse MDR by inhibiting the expression of P-glycoprotein (P-gp) and affecting the energy supply of drug efflux. This study provides a nanodelivery therapy strategy that reverses BCSCs multidrug resistance (MDR) and demonstrates that it did so by interfering with cancer cell energy metabolism. Therefore, the co-delivery strategy of ATRA and SchB provides a new option for the treatment of breast cancer.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Lu Shuo,Liu Yashuang,Dong Jinfeng,Li Xuefeng
Here are described the dilution-driven gel-sol-gel-sol transitions in aromatic hydrotrope/zwitterionic surfactant bi-component aqueous mixtures. Long and entangled wormlike micelles (WLMs) of concentrated erucyl dimethyl amidopropyl betaine (EAPB) solutions sequentially transform into hexagonal liquid crystal phase (H 1 ), highly concentrated spherical micelles (HCSMs), and finally hexagonal close packed micellar phase (HCP) upon gradual introducing an aromatic hydrotrope, sodium salicylate (NaSal). The HCP then successively converts into HCSMs, WLMs, and spherical micelles (SMs) upon further dilution with water, corresponding to a gel-sol-gel-sol transition. This dilution-induced HCSMs to WLMs transition results in an interesting thickening process, which is caused by a slow kinetic process, from the agglomeration and recombination of SMs to long and rigid WLMs via the intermediately formed rodlike micelles. In this work, the sustained adjustment of the competitive self-sorting and co-assembly between hydrotropes and surfactants by dilution was identified, benefitting the creation and application of WLMs fluids with switchable viscosity.
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Nature Sustainability
·
2024
·
IF 25.7
Chen Xulong,Hu Wenping
Rubidium (Rb) is a valuable rare alkali metal that plays a crucial role in various high-tech applications, but extracting Rb from conventional sources poses sustainability challenges. A considerable amount of Rb is found in potassium chloride (KCl) salts, which can serve as a sustainable source depending on the extraction methods. Current liquid-phase methods are problematic due to the low Rb/K separation factor and high consumption of energy, water and chemicals. Extracting Rb directly from solid KCl salts is a promising approach, but achieving efficient recovery remains a challenge. Here we propose a crystal ripening microextraction strategy that enables in situ extraction of Rb from solid KCl salts with high selectivity, simplicity and high efficiency. By applying this strategy, we recovered 92.37% of Rb from KCl salts with an initial Rb content of 113 ppm. Compared with liquid-phase extraction, our approach results in a 97.57% reduction in energy consumption, a 22.24% increase in recovery efficiency and a 13.46-fold higher Rb/K separation factor, which substantially enhance environmental and economic benefits. In addition, this approach is suitable for recovering other target metals needed for various industrial applications directly from different solid metallic salts, providing a pathway to improve the sustainability of critical metal supply.
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Nano-Micro Letters
·
2024
·Vol. 17
·期 1
·1-17
·
IF 31.6
Zhou Chengwang,Ding Zhezheng,Ying Shengzhe,Jiang Hao,Wang Yan,Fang Timing,Zhang You,Sun Bing,Tang Xiao,Liu Xiaomin
A double-layered protective film based on zinc-based coordination compound and ZnF 2 -rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization.
The double-layered architecture can effectively modulate Zn 2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc deposition.
The as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Sun Mengyao,Chen Yanjun,Fan Xiaoqiang,Li Dong,Song Jiaxin,Yu Ke,Zhao Zhen
Photocatalytic oxidative coupling of methane with oxygen is promising to obtain valuable muti-carbon products, yet suffering low reactivity. Here, we apply cerium modifications on zinc oxide-supported gold catalysts based on the electronic asymmetry design of lattice oxygen to improve the coupling activity. The methane conversion rate exceeds 16000 μmol g −1 h −1 with muti-carbon selectivity of 94.9% and catalytic durability of 3 days, and it can increase to 34000 μmol g −1 h −1 under more thermal assistance, with a turnover frequency of 507 h −1 for ethane and an apparent quantum efficiency of 33.7% at 350 nm. According to systematic characterizations and theoretical analysis, cerium dopants not only can boost the formation of reactive oxygen species but also intervene in the vivacity of lattice oxygen by manipulating metal-oxygen bond strength, thereby leading to favorable methyl desorption to form ethane and quick water release. This work provides insight into the rational design of efficient photocatalysts for aerobic methane-to-ethane conversion.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Luan Xiaoxi,Tian Yu,Wu Fengxia,Cheng Lu,Tang Minghua,Lv Xiali,Wei Haili,Wang Xiaodan,Li Fenghua,Xu Guobao,Niu Wenxin
Helicoid metal nanoparticles with intrinsic chirality have unveiled tailorable properties and unlocked many chirality-related applications across various fields. Nevertheless, the existing strategies for enantioselective synthesis of helicoid metal nanoparticles have been predominantly limited to gold. Here, we demonstrate a robust and versatile strategy for the enantioselective synthesis of helicoid nanoparticles beyond gold, leveraging chiral nanoconfinement provided by chiral SiO 2 or nanoshells. The chiral nanoconfinement strategy enables the decoupling of ligand-directed crystal growth from chiral induction, allowing for the independent tuning of these two critical aspects. As a result, this approach can not only facilitate the replication of chiral shapes from the chiral nanoshells but also allow the generation of alternative chiral shapes. By employing this approach, we demonstrate the enantioselective synthesis of helicoid Pt, Au@Pt, Au@Pd, Au@Ag, and Au@Cu nanoparticles. The chiroplasmonic properties of Pt- and Pd-based chiral nanoparticles have been discovered, and the inversion of chiroplasmonic properties of Ag-based chiral nanoparticles via facet control has been documented and theoretically explained. The chiral nanoconfinement strategy enriches the toolbox for creating chiral nanoparticles and supports their exploration in diverse applications.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Wei Lei,Hai Xinyue,Xu Tongtong,Wang Zidi,Jiang Wentao,Jiang Shan,Wang Qisheng,Zhang Yue-Biao,Zhao Yingbo
Installing different chemical entities onto crystalline frameworks with well-defined spatial distributions represents a viable approach to achieve ordered and complex synthetic materials. Herein, a covalent organic framework (COF-305) is constructed from tetrakis(4-aminophenyl)methane and 2,3-dimethoxyterephthalaldehyde, which has the largest unit cell and asymmetric unit among known COFs. The ordered complexity of COF-305 is embodied by nine different stereoisomers of its constituents showing specific sequences on topologically equivalent sites, which can be attributed to its building blocks deviating from their intrinsically preferred simple packing geometries in their molecular crystals to adapt to the framework formation. The insight provided by COF-305 supplements the principle of covalent reticular design from the perspective of non-covalent interactions and opens opportunities for pursuing complex chemical sequences in molecular frameworks.
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Nature Communications
·
2026
·
IF 18.1
Zhu Yue,Liu Haoyang,Zhang Yu,Wang Jingjing,Mao Yanjin,Zhao Ruoyu,Sun Yuzhi,Zhang Yanan,Bao Xueyang,Chen Jingyu,Zheng Mingzhu,Chen Jialin,Ouyang Hongwei,Zhang Wei
Rapid and functional skin wound healing remains a major clinical challenge, while current biomaterial-based therapies largely serve as passive scaffolds or delivery vehicles. Whether biomaterials possess intrinsic bioactivities that instruct endogenous regenerative programs remains unclear. Here, independent of bulk structural/mechanical cues or exogenous biomolecules, we show that silk fibroin (SF), a clinically approved biomaterial, intrinsically programs keratinocytes into a Ccl27⁺ migratory-paracrine pro-regenerative state that coordinates epidermal-dermal crosstalk to drive regenerative wound healing. Integrated scRNA-seq, proteomics, and genetic perturbation reveal that SF engages keratinocyte ITGA2 to activate PI3K-Akt signaling and relieve P53-mediated Ccl27 repression. Elevated Ccl27 enhances keratinocyte migration and re-epithelialization, while its secretion from SF-activated keratinocytes promotes fibroblast proliferation and dermal remodeling, collectively enabling wound closure and appendage reconstruction. Keratinocyte-specific Ccl27 knockdown largely abrogates SF-mediated regeneration in vivo. These findings uncover the intrinsic bioactivity of SF and establish biomaterials as instructive cues rather than passive scaffolds for functional tissue repair.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·
IF 0
Hammad Eman N.,Eltaweil Abdelazeem S.,Abouelenein Saeyda A.,El-Subruiti Gehan
Water contamination by heavy metals, especially chromium (VI), poses a critical environmental issue due to its carcinogenic nature and persistence in the environment. Addressing this, the current study develops an efficient adsorbent, CPBr-MIL-88A@AmGO, which utilizes the synergistic capabilities of Cetylpyridinium bromide–modified MIL-88A and amine-functionalized graphene oxide to enhance Cr(VI) removal from aqueous solutions. The obtained results indicate that CPBr-MIL-88A@AmGO achieves its highest removal efficacy at pH 2, where the interaction of CPBr and AmGO’s positively charged centers significantly contributes to the adsorption processes. According to the Langmuir isotherm model, the composite’s adsorption capacity reached a maximum of 306.75 mg/g. The adsorption kinetics adhered to a pseudo-second-order model along with the endothermic nature of the process. Although the presence of SO 4 2- ions significantly reduces adsorption capacity, other interfering ions including Na + , K + , Ca 2+ , Cl - , and NO 3 - only slightly affect it. Remarkably, the composite maintains high removal efficiency, over 82%, even after 7 recycling tests, underscoring its potential for practical applications in water treatment systems. The proposed mechanism involves the contribution of electrostatic attractions, ion exchange, complexation, and the reduction of Cr(VI) to Cr(III) in the removal process. This study not only offers a potent solution for Cr(VI) remediation but also contributes to sustainable water resource management.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-19
·
IF 36.3
Wang Peng,Wang Guoqing,Sun Guifen,Bao Chenchen,Li Yang,Meng Chuizhou,Yao Zhao
A flexible multimodal proximity–pressure–temperature sensing patch with a simple structure was developed.
Thanks to structural design and material synthesis, the sensor has an outstanding temperature sensitivity of 0.5 °C −1 with good linearity, a high pressure sensitivity of 30.6 kPa −1 and a non-contact sensing range is 2 m.
After the multimodal sensing patches are integrated at different locations of the pillow, the sleeping conditions can be monitored comfortably.
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