JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2017
·
IF 3.454
Yi Ding,Hui Dan,Xirui Lu,Xiaoyan Shu,Zhihao Hong,Shuai Zhang
A series of Zr 1- x Nd x O 2- x /2 (0 ≤ x ≤ 1) ceramics was prepared by solid-state reaction method. The effects of Nd content on the phase evolution were investigated. The chemical durability of resulting waste forms was also examined. The results show that the ceramics with x < 0.1 show monoclinic and cubic zirconia phase, with 0.2 ≤ x < 0.4 exhibit a single cubic phase, with 0.4 ≤ x ≤ 0.6 exhibit a single pyrochlore phase, with 0.6 < x < 0.8 exhibit a single cubic phase and remain cubic phases and hexagonal Nd 2 O 3 when 0.8 ≤ x ≤ 1. The unit cell parameters of the Nd-doped zirconia samples increase as the Nd content increases. Moreover, the normalized element release rates of Nd element in Nd-doped zirconia ceramics firstly decrease with leaching time and almost no change after 21 days (∼0 −6 g m −2 d −1 ), demonstrating its good chemical durability.
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Tiantian Ping,Yu Dong,Shufeng Shen
Nonaqueous amine-based absorbents by replacing water with organic solvents have potential advantages of low energy penalty and reduced amine degradation for CO2 capture. An advanced nonaqueous system of 2-(butylamino)ethanol (BAE) with 2-butoxyethanol (EGBE) was proposed for low-energy consumption CO2 capture. EGBE was selected as a green cosolvent because of its superior properties over the reported organics and water. A comprehensive study on CO2 capture performance has been performed for secondary alkanolamine nonaqueous systems such as 2-(methylamino)ethanol (MAE), 2-(ethylamino)ethanol (EAE), and BAE and their aqueous counterparts. Product species in CO2-loaded solutions were identified by 13C nuclear magnetic resonance and Fourier transform infrared spectroscopy. Regeneration energy consumption was also evaluated using a modified method and compared with that of conventional aqueous monoethanolamine (MEA). Results demonstrated that the aqueous 5.0 M secondary amine absorbents had higher absorption capacity and larger cyclic capacity than their nonaqueous counterparts. The desorption efficiency for both systems was in a descending order: BAE > EAE > MAE. Surprisingly, the cyclic capacity of aqueous and nonaqueous BAE systems was about 180 and 100% higher than that of aqueous MEA, respectively. The underlying reasons were also discussed. CO2 can react with these amines, forming unstable carbamates and protonated amines in the EGBE solvent, whereas it forms bicarbonate species in addition to ionic couples in aqueous solutions. The regeneration heat duty of nonaqueous EGBE-based secondary amine absorbents was about 45–55% lower than that of aqueous MEA (3.82 MJ kg–1 CO2). In addition, the feasibility of low-temperature desorption makes the BAE/EGBE absorbent a compelling solution for energy-saving CO2 capture technology using low-grade industrial waste heat.
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JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Wubing Yao,Jiali Wang,Lili He,Dongdong Cao,Jianguo Yang
A ruthenium catalytic ortho-C–H diborylation of 2-arylpyridine derivatives, including challenging 2-phenoxypyridine functions, using a remarkably low catalyst loading and a low-cost and bench-stable boron source, has been developed. The novel strategy shows high activity with excellent selectivity and may offer a versatile and green alternative to currently employed high loadings of noble metals or extra additives for the selective borylations.
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CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
·
2022
·
IF 0.847
Jian-Chao SHI,Hao WANG,Rui-Juan ZHANG,Dan ZHAO
ABSTRACT Composite borate-phosphate compounds have always attracted much attention for their structure diversity and interesting properties. In this work, a new borate-phosphate CsNa 2 Lu 2 (BO 3 )(PO 4 ) 2 (CNLBP) was found for the first time and its structure was characterized by single-crystal X-ray diffraction method. It crystallizes in orthorhombic system , space group Cmcm with a = 6.8750(5), b = 14.6919(1), c = 10.5581(7) Å, V = 1066.44(1) Å 3 , Z = 4, M r = 777.58, D c = 4.843 g/cm 3 , F (000) = 1368, µ (Mo Kα ) = 22.20 mm −1 , R ( F 2 > 2σ( F 2 )) = 0.0173 and wR ( F 2 ) = 0.0367. The structure of CNLBP features a chain framework of [Lu 2 (BO 3 )(PO 4 ) 2 ] ∞ that delimits 1D tunnels filled by Na + and Cs + ions. Phosphors CNLBP: x Tb ( x = 0, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0) were prepared, and it can emit bright green light under near-UV excitation due to the 5 D 4 → 7 F j (j = 6, 5, 4, 3) transition of Tb 3+ . Due to the large separation of Lu 3+ ions in CNLBP structure lattice, the optimal concentration of Tb 3+ is 80%, and concentration quenching occurs only for the full Tb 3+ concentration.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2024
·
IF 5.6
Cong Wu,Qi Jiang,Hui Zhong,Xudong Zhou,Leping Liu,Tong Pan,Chao Liu,Wei Wang,Wenbing Sheng
An oxidising and substituting one-pot reaction strategy has been developed to synthesise dihydromyricetin derivatives with the aim of enhancing the inhibitory activity of dihydromyricetin against SARS-CoV-2. Different ω-methoxy-ω-oxeylkyl was introduced in C7-OH site and yielded eight analogs, all of them showed good inhibitory activity against SARS-CoV-2 3CLpro with IC50 values ranging from 0.72 to 2.36 μM. In the Vero E6-cell, compound 3 has a good activity of anti-SARS-CoV-2 virus (Omicron virus BA.5) in the prevention model, with an EC50 of 15.84 μM, and so do compound 10 in the therapeutic model, with an EC50 of 11.52 μM. The results suggest that the introduction of long chain ω-oxeylkyl at C7-OH facilitate the inhibition of viral replication in the therapeutic model, which is consistent with the binding energies predicted from molecular docking conclusions. It implies that dihydromyricetin derivatives have the potential to become effective inhibitors of SARS-CoV-2 Omicron and other viruses.
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PubMed
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Journal of Energy Chemistry
·
2024
·
IF 14
Xuejun Xu,Rutao Meng,Yue Liu,Han Xu,Jianpeng Li,Yi Zhang
Solution-processed chalcopyrite solar cells are widely regarded as a promising alternative method in reducing the cost compared with vacuum-based techniques. It is noted that the absorber layer usually needs to be prepared under a high insert pressure (∼1.6 atm) to suppress element loss or under a mild pressure but additional surface etching is needed for fabricating high efficient solar cell. Herein, a copper gradient structured precursor is proposed to prepare CuIn(S,Se) 2 (CISSe) film under a mild pressure (1.1 atm). The designed gradient Cu not only promotes crystal grain growth and tailors the defects, but also avoids the surface etching of the formed CISSe film for the fabrication of high efficient solar cells. Further, Cu gradient design decreases the conduction band offset of heterojunction, boosting the carriers transport across the p-n heterojunction. Accordingly, a 13.35% efficient CISSe solar cell, comparable to the high efficient CISSe solar cell prepared by this method under high pressure or with film surface etching, is fabricated. This work provides a facile pathway to fabricate high efficient solution-processed chalcopyrite solar cell, avoiding high selenization pressure and film etching, and shows huge potential for solution-processed copper-based solar cells.
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FirePhysChem
·
2024
·
IF 0
Qing-Xia Li,Er-Hai An,Qing-Feng Qin,Jing-Hao Guo,Zi-Jun Fan,Sheng-Nan Shi,Peng Deng,Xiong Cao
In this paper, we investigated the potential use of a new organic-inorganic hybrid crystal structure based on KNO 3 in ignition compositions. H 2 dabco[K(NO 3 ) 3 ] (DAN-2) with organic-inorganic hybrid crystal structure is synthesized through intermolecular assembly technology. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) were used to detect the crystal morphology, structure and molecular structure of DAN-2, which has a regular cubic structure. Experimental data were obtained using thermogravimetric/differential scanning calorimetry (TG-DSC), closed bomb test and high-speed photography, which were then used to study and analyze the thermal decomposition properties and combustion properties of DAN-2. The initial thermal decomposition temperature of DAN-2 was low (194 °C) and the activation energy of the thermal decomposition was 154 kJ/mol. Possible thermal decomposition mechanisms are further discussed and proposed. This research pushed forward the application of organic-inorganic hybrid crystal structure oxidant DAN-2 in ignition system.
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Nano Research
·
2024
·Vol. 17
·期 6
·4898-4907
·
IF 9.5
Geng Jing,Ji Sihan
Electrocatalytic nitrate ( \({\rm{N}}{{\rm{O}}_3}^ -\) ) reduction to ammonia (NH 3 ) offers a viable approach for sustainable NH 3 production and environmental denitrification. Copper (Cu) possesses a distinctive electronic structure, which can augment the reaction kinetics of \({\rm{N}}{{\rm{O}}_3}^ -\) and impede hydrogen evolution reaction (HER), rendering it a promising contender for the electrosynthesis of NH 3 from \({\rm{N}}{{\rm{O}}_3}^ -\) . Nevertheless, the role of Cu 2 O in copper-based catalysts still requires further investigation for a more comprehensive understanding. Herein, the Cu 2 O/Cu(OH) 2 heterostructures are successfully fabricated through liquid laser irradiation using CuO nanoparticles as a precursor. Experimental and theoretical researches reveal that Cu 2 O/Cu(OH) 2 heterostructure exhibits enhanced electrocatalytic performance for \({\rm{N}}{{\rm{O}}_3}^ -\) to NH 3 because Cu(OH) 2 promotes electron transfer and reduces the valence state of Cu active site in Cu 2 O. At −0.6 V (vs. reversible hydrogen electrode (RHE)), the NH 3 yield reaches its maximum at 1630.66 ± 29.72 \({\rm{\mu g}} \cdot {{\rm{h}}^{ - 1}} \cdot {\rm{m}}{{\rm{g}}_{{\rm{cat}}}}^{ - 1}\) , while the maximum of Faraday efficiency (FE) is 76.95% ± 5.51%. This study expands the technical scope of copper-based catalyst preparation and enhances the understanding of the electrocatalytic mechanism of \({\rm{N}}{{\rm{O}}_3}^ -\) to NH 3 .
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CHEMBIOCHEM
·
2024
·
IF 2.6
Yi Yang,Zhiyi Zhao,Xiaoying Li,Yian Chen,Lu Liu,Shao-Lin Zhang,Aimin Yang
Graphical Our study designs and synthesizes a series of peptides targeting the dimerization of SARS-CoV-2 M pro . Several peptides display potential inhibitory activities. Specifically, N8-A24 shows most efficient suppression of the M pro activity via inhibiting its dimerization. The severe acute respiratory syndrome virus 2 (SARS-CoV-2) seriously impacted public health. The evolutionarily conserved viral chymotrypsin-like main protease (M pro ) is an important target for anti-SARS-CoV-2 drug development. Previous studies have shown that the eight N-terminal amino acids (N8) of SARS-CoV M pro are essential for its dimerization, and are used to design inhibitors against SARS-CoV M pro dimerization. Here, we established a simple readout assay using SDS-PAGE and Coomassie blue staining to measure inhibitory activity of N8 peptide derived from SARS-CoV-2 M pro . To optimize its inhibitory effect, we then modified the side-chain length, charge, and hydrophilicity of the N8 peptide, and introduced a mutated M pro recognition sequence. As a result, we obtained a series of potent peptide inhibitors against SARS-CoV-2 M pro , with N8-A24 being the most efficient with an IC 50 value of 1.44 mM. We observed that N8-A24 reduced M pro dimerization with an IC 50 value of 0.86 mM. Molecular docking revealed that N8-A24 formed hydrogen bond interactions with critical dimeric interface residues, thus inhibiting its dimerization and activity. In conclusion, our study not only discovers a series of peptide inhibitors targeting the SARS-CoV-2 M pro dimerization, but also provides a promising strategy for the rational design of new inhibitors against COVID-19.
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IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
·
2021
·Vol. 28
·期 4
·1238-1246
·
IF 2.931
Z. L. Li,M. S. Fan,S. F. Zhou,B. X. Du
In this work, nano-titanium oxide (TiO
2
) is encapsulated into boron nitride nanosheets (BNNS) by the calcination process to fabricate core-shell structured TiO
2
@BNNS nanofillers. The effects of TiO
2
@BNNS fillers on the DC conductivity, space charge and breakdown strength of polypropylene (PP) composites are investigated. Experimental results show that PP/TiO2@BNNS composites have a lower temperature-dependent conductivity with an activation energy of 0.64 eV, which is much lower than that of PP, 0.95 eV. The DC breakdown strength of PP/TiO
2
@BNNS samples is 22.2% higher than that of PP at 90 °C. The average space charge density and electric field distortion rate of PP/TiO
2
@BNNS are reduced by 6.6 C/m
3
and 23.3%, respectively, compared with PP, under a polarization electric field of 40 kV/mm at 90 °C. It is proven that TiO
2
@BNNS nanofillers form numbers of electrical potential wells for charge carriers, thereby, inhibiting the hot electron transport and their damage to polymer molecules. This work provides an effective method to improve the dielectric performance of PP cable insulation.
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Research
·
2022
·
IF 11.036
Song Liu,Guanghui Li,Lei Ding,Jin Ding,Qian Zhang,Dan Li,Xingguo Hou,Xiangxing Kong,Jing Zou,Shiming Zhang,Hongbin Han,Yakun Wan,Zhi Yang,Hua Zhu
Due to the rapid spread of coronavirus disease 2019 (COVID-19), there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease. The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) with high affinity to neutralize the virus and block the angiotensin-converting enzyme 2- (ACE2-) RBD interaction. Here, we introduce a novel nanobody-based radiotracer named 68Ga-Nb1159. The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo. Preclinical positron emission tomography (PET) studies of 68Ga-Nb1159 in mice revealed its rapid clearance from circulation and robust uptake into the renal and urinary systems. Fortunately, 68Ga-Nb1159 could specifically reveal the distribution of the RBD in mice. This study also helped to evaluate the pharmacodynamic effects of the neutralizing nanobody. Moreover, 68Ga-Nb1159 may be a promising tool to explore the distribution of the RBD and improve the understanding of the virus. In particular, this study identified a novel molecular radioagent and established a reliable evaluation method for specifically investigating the RBD through noninvasive and visual PET technology.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2017
·Vol. 85
·期 2
·349-355
·
IF 1.575
Shi Min,Li Yanhong,Wang Li,Li Jing,Wang Meiri,Cui Hongtao
Abstract In this work, a facile material synthesis step-free strategy for the cost-effective assembly of Ni(OH) 2 -based electrodes was reported. The Ni(OH) 2 /MWCNTs composite electrodes for application in supercapacitors were assembled through the in-situ reaction of NiCl 2 ·6H 2 O in nickel foam as current collector with alkaline electrolyte. The characterization results indicated that NiCl 2 ·6H 2 O as raw material in electrode underwent the phase transformation from NiCl 2 ·6H 2 O to β-Ni(OH) 2 in electrolyte solution. The produced β-Ni(OH) 2 presented the same phase and same sheet morphology with thin thickness before and after electrochemical measurement. Based on the results of electrochemical measurement, 20 wt% was determined as the optimum content of MWCNTs for the assembly of electrodes. The as-assembled electrode with optimized content of MWCNTs exhibited high specific capacitance of 2001.4 F g −1 at current density of 3.2 A g −1 . This electrochemical performance of electrode could be attributed to the 2D flexible sheet morphology of Ni(OH) 2 and the improvement of electric conductivity by MWCNTs. Graphical abstract
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危险品化学品经营许可证（带存储）