DYES AND PIGMENTS
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2026
·
IF 3.9
Wenjing Zhang,Xinyan Yan,Xujuan Huang,Shanshan Wang,Zhaolan Zhai,Dan Wang,He Liu,Shibin Shang,Zhanqian Song
Stimuli-responsive aggregation-induced emission (AIE) materials that enable dynamic emission control and adaptive applications in dynamic information encryption and advanced anti-counterfeiting via external stimuli have attracted considerable attention. A bio-based AIE amphiphile ( CSMPANa ) was synthesized by integrating maleopimaric acid (MPA) with a α-cyanostilbene, which exhibited typical AIE characteristic and obvious solvatochromism. Importantly, the fluorescence emission of CSMPANa showed dual stimuli-responsiveness. Adding alkali caused the cyano group turned into an amide, red-shifting the fluorescence emission. Subsequent adding acid resulted in a blueshift. Furthermore, 365 nm UV light induced a [2+2] cycloaddition to form a dimer, leading to a redshift. The obvious solvatochromism and dual stimuli-responsiveness of CSMPANa were exploited for multi-level information encryption. AIE wormlike micelles were further prepared by mixing CSMPANa and cetyltrimethylammonium bromide (CTAB). The viscoelasticity and optical physical properties of CSMPANa /CTAB wormlike micelles could be modulated by varying its concentration, pH, or UV light irradiation. Additionally, the system exhibited selective recognition to 4-Nitrophenol in aqueous media with high anti-interference capability, enabling ultrasensitive visual detection (LOD = 17.29 μM). Density functional theory (DFT) calculations elucidated the sensing mechanism, revealing that the specific recognition originates from the synergistic effect of the strongest binding affinity and minimized steric hindrance of the 4-NP para-isomer. This work developed a system that is not solely dependent on organic solvents and possesses dual responsiveness.
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Insects
·
2022
·Vol. 13
·期 12
·1126
·
IF 3.139
Xing Huang,Linjie Du,Tiantian Liu,Rui Ma,Xing Liu,Haibin Yuan,Shuai Liu
Simple SummaryPlutella xylostella(L.) (Lepidoptera: Plutellidae) is the most destructive pest of cruciferous crops around the world. The inappropriate use of insecticides to manage it has brought the development of resistance to several pesticide active ingredients. Keeping in view the resistance problem and long-term application, essential oils of plants may provide an environment-friendly solution to manage pests. Although the essential oil ofArtemisia lavandulaefoliaDC. was proven to exhibit promising insecticidal activities againstP. xylostella, which components have insecticidal activities are unknown. In the present study, four bioactive components were identified fromA. lavandulaefoliaessential oil by GC/MS, and their insecticidal activities againstP. xylostellawere also evaluated. Among them, (-)-4-terpineol was proven to be mostly responsible for its insecticidal activity againstP. xylostella. This effect was associated with decreased activity of GST, CAT, AChE and Na+/K+-ATPase. Overall, our findings indicated that (-)-4-terpineol may offer an alternative source for the control ofP. xylostella.AbstractPlutella xylostella(L.) is one of the most serious pests of cruciferous vegetables. Our previous work demonstrated that the essential oil ofArtemisia lavandulaefoliaDC. exhibits promising insecticidal activities againstP. xylostella. This study further characterizes the key components that are responsible for the insecticidal effect. In total, 47 compounds (96.52% of the total compounds) were identified from the total oil using GC-MS, and the major compounds were eucalyptol (21.57%), D(+)-camphor (17.33%), (-)-4-terpineol (9.96%) and caryophyllene oxide (10.96%). Among them, (-)-4-terpineol showed significantly larvicidal and fumigant activities againstP. xylostella. The LD50of (-)-4-terpineol was 43.15 mg/mL at 12 h and 31.22 mg/mL at 24 h for 3rd instar larvae, and the LC50for adults was 8.34 mg/mL at 12 h and 7.35 mg/mL at 24 h. In addition, the adults treated with (-)-4-terpineol showed varying degrees of inhibitory activity toward glutathione S-transferase, catalase, acetylcholinesterase and Na+/K+-ATPase at different post-treatment intervals and concentrations. The results indicate that (-)-4-terpineol has promising insecticidal activities againstP. xylostella, and it has good inhibitory effects on the four enzymes ofP. xylostellaadults.Keywords:Plutella xylostella;bioactive compounds;(-)-4-terpineol;insecticidal activities
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TOXICOLOGY LETTERS
·
2022
·
IF 4.271
Jianjun Lin,Ke Lin,Lijiang Huang,Yongsheng Jiang,Xiaoxiao Ding,Wu Luo,Aleksandr V. Samorodov,Valentin N. Pavlov,Guang Liang,Jianchang Qian,Yi Wang
Heme, as an essential component of hemoproteins , is a prosthetic co-factor found in many cells, which is essential for physiologically vital oxygen transport. However, extracellular or circulatory heme is cytotoxic and triggers inflammation. Although the proinflammatory role of heme has been reported to be associated with Toll-like receptor 4 (TLR4) signaling, the exact mechanism remains unknown. Here, we show that heme promotes TLR4 signaling and inflammation via directly physically interacting with TLR4 and its adaptor protein myeloid differentiation protein 2 (MD2). Genetic loss of MD2 ameliorates heme-induced inflammation and inflammatory cytokine production in the spleen of MD2 knockout (MD2 -/- ) mice. Using mouse macrophage RAW 264.7 cell line, we show that heme induces TLR4 dimerization and MD2/TLR4/MyD88 activation by physically interacting with TLR4 and MD2 in vitro . Genetic loss of MD2 inhibits heme-induced inflammation and MAPK/NF-κB pathway in mouse primary macrophages extracted from MD2 -/- mice. Furthermore, pharmacological inhibition of MD2 by L6H9 ameliorates heme-induced inflammation in macrophages. These findings demonstrate that heme causes inflammation by directly binding to MD2/TLR4 complex, leading to activation of TLR4/MAPK/NF-κB signaling pathway and production of downstream effectors of inflammation.
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Surfaces and Interfaces
·
2022
·
IF 6.137
Jin-Yu Wang,Zhong-Zhu Hu,Xin-Ting Sun,Ya-Qin Gao,Jun-Lin Wang,Jie Xu,Gan Jin
Photocatalytic cleavage of lignin C β -O-4 bonds is a very effective method to promote the high-value utilization of lignin because lignin can provide a large number of aromatics. However, the higher carrier recombination rate severely inhibits the efficiency of photocatalytic cleavage of C β -O-4 bonds in lignin model compound. Here, heterojunction photocatalysts CdS-C 3 N 4 were successfully synthesized through the photodeposition of different masses of CdS on the surface of C 3 N 4 . The obtained photocatalyst CdS-C 3 N 4 can effectively break the lignin C β -O-4 bonds in 2-Phenoxy-1-phenylethanol (lignin model compound) and the products formed are mainly phenol (Phol) and acetophenone (Ap). More importantly, the yields of Phol and Ap were up to 86.5% and 74.3%, after only irradiation for 1.5 h, respectively, under optimum conditions. A mechanistic study showed that photocatalytic reaction follows a photogenerated electron-hole coupled mechanism. The high photocatalytic performance of CdS-C 3 N 4 is mainly ascribed to the fast photogenerated electron-hole separation capability and good dispersion of CdS on C 3 N 4 . This work offers an idea for selective cleavage of lignin C β -O-4 bonds by constructing a heterojunction photocatalyst.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 140
·期 8
·e53520
·
IF 3.057
Yimei Chen,Wei Yang,Juan Liu,Yuanliang Wang,Yanfeng Luo
2-Ureido-4[1 H ]-pyrimidone (UPy) can form strong quadruple hydrogen bonding (H-bonding) and is widely used to construct supramolecules. Though the H-bonding assembly of UPy-containing polymers has been widely reported, little attention is paid to the H-bonding characteristics and mechanism of UPy-containing polyurethanes. Here, by using UPy- p -PDLLA-SMPU, a linear polyurethane with multiple pendant UPy units as the model polymer, the H-bonding assembly characteristics in solution, solid film and melt are systematically investigated. It is found that the UPy units mainly exist as free monomers in DMSO, UPy dimers in CHCl 3 , and both free monomers and dimers in DMF. The dimerization of UPy can promote the H-bonding of urea and urethane groups and thus the formation of hard segment aggregates. Thereby, the thermal resistance and reversibility of the H-bonds are significantly enhanced in both UPy- p -PDLLA-SMPU film and melt. UPy- p -PDLLA-SMPU can transition from a rubber state (70°C–85°C) to a viscous flow state (≥120°C), presenting the characteristics of both chemically crosslinked and linear polyurethanes. This work provides a clear picture on the H-bonding assembly of UPy units together with urea and urethane groups in UPy- p -PDLLA-SMPU. The obtained assembly characteristics and mechanism are beneficial for the design and processing of UPy-based physically crosslinked polyurethanes.
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CRYSTAL GROWTH & DESIGN
·
2022
·
IF 4.01
Xirui Zhang,Yunfei Xu,Denghui Yang,Yue Gong,Wei Du,Na Tang,Jianwei Jiang
Dry grinding and solvent-drop grinding to prepare the cocrystals of 4-nitropyridine N-oxide (NPNO) and p-aminobenzoic acid (PABA) were investigated in this study. Seven solvents were used during the solvent-drop grinding to accelerate the formation of the cocrystal, and the corresponding implicit solvent models were applied to compute the binding energy between NPNO and PABA via Gaussian 09 to determine the effect of the solvent on solvent-drop grinding. With a combination of Raman spectroscopy and powder X-ray diffraction (PXRD), the ternary phase diagrams of the NPNO–PABA–acetonitrile system at different temperatures were experimentally determined. It was found that the formation of the cocrystal is mainly due to the involvement of an O···H–O hydrogen bond between the −NO group of NPNO and the −OH group of PABA, and the stronger the binding energy of O···H–O in solvents, the faster the formation of the cocrystal. The crystallization region of the cocrystal of NPNO and PABA becomes larger with an increase in temperature. From an analysis of Ksp and K11, the equation KSPK11≪ [B]T is satisfied when the experimental temperature is 308.15 K, and a 1:1 complex solution model was used to describe the NPNO–PABA–acetonitrile system at 308.15 K. While the equation was not satisfied at 298.15 K, a solution-free complexation model was applied to describe the system at 298.15 K. The solution crystallization of the cocrystal of NPNO and PABA was successfully monitored by in situ Raman, PXRD, and a polarizing microscope, which collaboratively indicate that the nucleation of the cocrystal occurred almost immediately as soon as the two components were mixed in acetonitrile, and the dissolution processes of NPNO and PABA are the rate-determining steps during the solution crystallization of the cocrystals of NPNO and PABA.
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Clinical and Molecular Hepatology
·
2022
·
IF 8.337
Yang Liu,Xin Zhang,Shuo Chen,Jiazhong Wang,Shuo Yu,Yiming Li,Meng Xu,Harouna Aboubacar,Junhui Li,Tao Shan,Jixin Wang,Gang Cao
Background/Aims Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infiltration and increases the risk of hepatocellular carcinoma (HCC). Molecular mechanisms may involve the migration of bacterial metabolites from the gut to the liver and the activation of neutrophil extracellular traps (NETs). Methods Serum samples from both binge drinking and alcohol-avoiding patients were analyzed. Mouse models of chronic plus binge alcohol-induced hepatosteatosis and HCC models were used. Results A marker of NETs formation, lipopolysaccharide (LPS), was significantly higher in alcoholic hepatosteatosis and HCC patients and mice than in controls. Intrahepatic inflammation markers and HCC-related cytokines were decreased in mice with reduced NET formation due to neutrophil elastase (NE) deletion, and liver-related symptoms of alcohol were also alleviated in NE knockout mice. Removal of intestinal bacteria with antibiotics led to decreases in markers of NETs formation and inflammatory cytokines upon chronic alcohol consumption, and development of alcoholic hepatosteatosis and HCC was also attenuated. These functions were restored upon supplementation with the bacterial product LPS. When mice lacking toll-like receptor 4 (TLR4) received chronic alcohol feeding, intrahepatic markers of NETs formation decreased, and hepatosteatosis and HCC were alleviated. Conclusions Formation of NETs following LPS stimulation of TLR4 upon chronic alcohol use leads to increased alcoholic steatosis and subsequent HCC.
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高影响因子
JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Yani Liu,Yu Wang,Haoqiang Wang,Shuming Dou,Junwei Wu,Wei Gan,Qunhui Yuan
Aiming to the repetitively large volume change and the inevitably loss of volumetric capacity of bismuth (Bi) based sodium-ion battery (SIB) during cycling, a binder-free Bi anode based on one-step electrochemical co-deposited three-dimensional Bi nanosheets and conductive carbon nanotube networks (Bi NS/CNTs) was developed. Compared with the sole Bi anode achieved via the same strategy, the co-deposition of 3D hierarchical Bi nanosheet/CNTs arrays manifests the strong interfacial adhesion and accommodates the volume change upon sodium alloying/dealloying. Such structural feature endows the Bi NS/CNTs anode a long-term cycling stability (383.72 mAh g −1 at 0.1 A g −1 after 200 cycles, 311.68 mAh g −1 at 1 A g −1 after 1000 cycles) and a good rate performance. A full SIB assembled with Bi NS/CNTs anode and Na 3 (VOPO 4 ) 2 F@rGO cathode shows a high operating voltage (above 4 V) and a high energy density of 221.99 Wh kg −1 , which outperforms many reported Bi-based analogues. This work may open a new opportunity for developing efficient SIB with high energy and good practicability.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 10
·e6833
·
IF 4.072
Jing Hu,Yun Luo,Min Hou,Jia Jia Qi,Li Li Liang,Wen Ge Li
Two dinuclear complexes [Cu 2 (LO) 2 ] and [Ni 2 L 2 Cl 2 (C 2 H 5 OH) 2 ] derived from (5-chlorosalicylaldehyde)-4-aminoantipyrine (HL) were synthesized and characterized by infrared (IR) spectroscopy，thermogravimetric analysis, and powder X-ray diffraction. Molecular structures of the Cu (II) and Ni (II) complexes were determined by single-crystal X-ray diffraction. Their cytotoxicity was evaluated by methyl thiazolyl tetrazolium assay against human tumor cells, such as lung carcinoma A549, lung adenocarcinoma H1975, breast carcinoma MDA-MB-231, and nasopharyngeal carcinoma CNE-2Z cell lines. The results showed that the Cu (II) complex had much better anticancer activity than the Ni (II) complex, especially for MDA-MB-231 and CNE-2Z cells. The reason may be that they have different structures. The methyl group on the (5-chlorosalicylaldehyde)-4-aminoantipyrine (HL) was oxidized to the hydroxymethyl group, herein, namely LO, which is difficult to achieve in the normal chemical synthesis process. However, we did it by a solvothermal method at low temperature. It provides a new way of thinking and synthesis. The anticancer activity of the copper complex was next only to cisplatin, and the copper complex was nontoxic for the human normal cell lines. The experiment results also showed that the copper complex could inhibit tumor cell proliferation through the cell cycle and cell apoptosis.
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Animal Nutrition
·
2022
·
IF 5.285
Yuan Luo,Wenhao Zhou,Ruixin Li,Samwel M. Limbu,Fang Qiao,Liqiao Chen,Meiling Zhang,Zhen-Yu Du
Pyruvate dehydrogenase kinases (PDKs)-pyruvate dehydrogenase E1α subunit (PDHE1α) axis plays an important role in regulating glucose metabolism in mammals. However, the regulatory function of PDKs-PDHE1α axis in the glucose metabolism of fish is not well known. This study determined whether PDKs inhibition could enhance PDHE1α activity, and improve glucose catabolism in fish. Nile tilapia fingerlings (1.90 ± 0.11 g) were randomly divided into 4 treatments in triplicate (30 fish each) and fed control diet without dichloroacetate (DCA) (38% protein, 7% lipid and 45% corn starch) and the control diet supplemented with DCA, which inhibits PDKs through binding the allosteric sites, at 3.75 (DCA3.75), 7.50 (DCA7.50) and 11.25 g/kg (DCA11.25), for 6 wk. The results showed that DCA3.75, DCA7.50 and DCA11.25 significantly increased weight gain, carcass ratio and protein efficiency ratio ( P < 0.05) and reduced feed efficiency ( P < 0.05) of Nile tilapia. To investigate the effects of DCA on growth performance of Nile tilapia, we selected the lowest dose DCA3.75 for subsequent analysis. Nile tilapia fed on DCA3.75 significantly reduced the mesenteric fat index, serum and liver triglyceride concentration and total lipid content in whole fish, and down-regulated the expressions of genes related to lipogenesis ( P < 0.05) compared to the control. The DCA3.75 treatment significantly improved glucose oxidative catabolism and glycogen synthesis in the liver, but significantly reduced the conversion of glucose to lipid ( P < 0.05). Furthermore, the DCA3.75 treatment significantly decreased the PDK2/4 gene and protein expressions ( P < 0.05), accordingly stimulated PDHE1α activity by decreasing the phosphorylated PDHE1α protein level. In addition, DCA3.75 treatment significantly increased the phosphorylated levels of key proteins involved in insulin signaling pathway and glycogen synthase kinase 3β ( P < 0.05). Taken together, the present study demonstrates that PDK2/4 inhibition by using DCA promotes glucose utilization in Nile tilapia by activating PDHE1α and improving insulin sensitivity. Our study helps to understand the regulatory mechanism of glucose metabolism for improving dietary carbohydrate utilization in farmed fish.
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COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Kailei Ding,Cheng Zheng,Xueyu Huang,Li Yang,Yang Lei,Yunbing Wang
Bioprosthetic heart valve thrombosis (BHVT) is no longer considered a rare clinical entity in recent years and could cause valve motion abnormalities, which requires reoperation. Currently reported modifications of bioprosthetic heart valves (BHVs) mainly focused on improving the anti-calcification property. However, it was hard to improve their anti-thrombogenicity and crosslinking efficiency at the same time. Here we reported a method that combines improved hemocompatibility , crosslinking efficiency, cytocompatibility, and anti-calcification property for BHVs. Porcine pericardia (PPs) and 2-amino-4-pentanoic acid (APA) were first co-crosslinked with glutaraldehyde to introduce allyl moieties to the PPs, then poly(N, N-dimethylacrylamide) (PDMAA) was covalently immobilized on PPs through radical polymerization . In vitro and in vivo studies demonstrated that the structural stability of PDMAA modified PPs was much superior than that of traditional glutaraldehyde crosslinked PPs (GA). The PDMAA modified PPs exhibited enhanced antithrombogenic performance with a 75% decrease of platelet adhesion compared with GA. Moreover, the calcium content accumulated on the modified PPs after 90-day rat subcutaneous implantation decreased 93.5% compared with that on GA. The PDMAA modified PPs may alleviate BHVT and calcification, offering a potential option for BHVs fabrication in the future.
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Particuology
·
2022
·
IF 3.251
Fang Wang,Zhuang Liu,Rui Xie,Xiao-Jie Ju,Wei Wang,Da-Wei Pan,Liang-Yin Chu
Lead(II) (Pb 2+ ) ions are toxic heavy metal ions that can accumulate in the human body through water and cause severe health problems, including neurotoxicity, nephrotoxicity, hematological toxicity and even genotoxicity effects. To remove Pb 2+ selectively and effectively from aqueous solutions, we develop a novel type of Pb 2+ -recognizable microgels with excellent adsorption capacity to Pb 2+ , which are fabricated from 4-acrylamidobenzo-18-crown-6 (B18C6Am) and N -isopropylmethacrylamide (NIPMAM) monomers by precipitation copolymerization method. The prepared poly( N -isopropylmethacrylamide- co -4-acrylamidobenzo-18-crown-6) (PNMB) microgels exhibit expanded structures, because the electron-donating methyl groups at α-carbon could descend the polarity of C O in the NIPMAM monomers and thus weaken the polymer segment···segment interactions. The expanded structures of PNMB microgels are beneficial for adsorption of Pb 2+ due to the low steric hindrance in the polymeric networks. The Pb 2+ adsorption isotherms of PNMB microgels are consistent with the Langmuir model for monolayer adsorption. The results indicate that the prepared Pb 2+ -recognizable PNMB microgels are highly promising for the selective removal of lead(II) ions from aqueous solutions.
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