ACS Applied Nano Materials
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2025
·
IF 5.5
Tianmin Zhang,Ming Xiang,Xianfeng Yang,Cheng Fu,Zhaoxiong Yan,Zhihua Xu
Metal sulfides are regarded as promising candidates for electrocatalytic applications owing to their highly conductive metal sulfide frameworks serving as the core and high-valence metal active layers functioning as the shell during the electrooxidation process. However, the catalytic ability of a single metal sulfide still needs to be optimized. Herein, a straightforward hydrothermal sulfidation approach was employed to fabricate a uniquely structured electrode composed of Ni3S2–Co9S8 heterojunction embedded in interconnected cobalt layered double hydroxide nanosheets grown on nickel foam (NF) (Ni3S2–Co9S8/Co LDH/NF). The Ni3S2–Co9S8/Co LDH/NF electrode demonstrated a low overpotential (240 mV at 10 mA cm–2) and a small Tafel slope (35.1 mV/dec) in the oxygen evolution reaction (OER). Furthermore, it exhibited a small Tafel slope (15.5 mV/dec) in the 5-hydroxymethylfurfural (HMF) oxidation reaction, achieving nearly 100% conversion of HMF and an approximately 86% yield of 2,5-furandicarboxylic acid (FDCA). The synthesis of Co LDH nanostructure on nickel foam facilitated the dispersion of the Ni3S2–Co9S8 heterojunction, thereby exposing more active sites and enhancing the mass transfer. Additionally, experimental results revealed that the electronic interactions at interfaces enabled precise adjustment of the electronic structure while promoting the formation of high-valence nickel species. Electrochemical measurements verified that the multiphase composite structure fabricated by interface engineering effectively reduced the interfacial impedances and charge transfer resistances, which in turn improved electrocatalytic performances for the OER and HMF oxidation reaction. This research provides a method for constructing a structure-optimized metal sulfide-based electrocatalyst, which can efficiently drive both the OER and oxidative HMF valorization.
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FOOD AND AGRICULTURAL IMMUNOLOGY
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2018
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IF 2.568
Fengyin Liu,Zijian Chen,Yudong Shen,Yuanming Sun,Jinyi Yang,Hong Wang,Hongtao Lei,Zhenlin Xu
Immunoassay direct for 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ), the metabolite of furaltadone, based on a specific antibody was usually unavailable due to its small molecule weight. In this work, a hapten with a double bond and an active carboxyl group was designed and then conjugated to peptide dendrimer to obtain novel multiple haptens. The haptens and multiple haptens were coupled to bovine serum albumin as immunogens. Polyclonal antibodies showed binding to free AMOZ in a heterologous competitive indirect enzyme-linked immunosorbent assay were obtained. The assay showed IC50 (half maximal inhibitory concentration) of 4.1 μg/kg and limit of detection of 0.2 μg/kg for AMOZ. Recoveries of AMOZ from grass carp were tested from 83.1% to 117.0%, with the coefficient of variation below 12%. As no laborious derivatisation procedure was employed, the proposed assay should be useful for the screening of AMOZ for a large number of samples.
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BREAST CANCER RESEARCH AND TREATMENT
·
2018
·Vol. 50
·期 4
·1362-1377
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IF 3.605
Lai Nar Tung,Senchuan Song,Kin Tak Chan,Mei Yuk Choi,Ho Yu Lam,Chung Man Chan,Zhiyong Chen,Hector K. Wang,Hoi Ting Leung,Simon Law,Yanmin Huang,Huacan Song,Nikki P. Lee
Purpose Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesis in its native microenvironment. Materials and Methods In this study,we described two simple and reproducible methods to develop tumor xenograft at the cervical or the abdominal esophagus in nude mice by direct injection of ESCC cells in the esophageal wall. Results In comparing these two methods, the cervical one presented with more clinically relevant features, i.e., esophageal stricture, body weight loss and poor survival. In addition, the derived tumor xenografts accompanied a rapid growth rate and a high tendency to invade into the surrounding structures. This model was subsequently used to study the anti-tumor effect of curcumin, which is known for its potential therapeutic effects in various diseases including cancers, and its analogue SSC-5. SSC-5 was selected among the eight newly synthesized curcumin analogues based on its superior anti-tumor effect demonstrated in an MTT cell proliferation assay and its effects on apoptosis induction and cell cycle arrest in cultured ESCC cells. Treatment of orthotopic tumor-bearing mice with SSC-5 resulted in an inhibition in tumor growth and invasion. Conclusion Taken together, we have established a clinically relevant orthotopic tumor xenograft model that can serve as a preclinical tool for screening new anti-tumor compounds, e.g., SSC-5, in ESCC.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2024
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IF 5.8
Yingna Li,Muhammad Sajjad Ahmad,Mudassir Hussain Tahir,Maryam Bashir,Arif Muhammad Khan,Rana Muhammad Irfan,Imran Riaz Malik,Boxiong Shen
This study investigates the selective production of aromatics through the co-pyrolysis of cabbage waste and plastics followed by catalytic reforming with Ni-modified ZSM-5. Co-pyrolysis significantly improves the inflection point (a parameter for determining thermal stability) to 251.3 °C from 232.7 °C. This process also enhances the relative yield of olefins and phenols , which are precursors for aromatic production to 25.46 and 17.23 respectively, up from 13.87 to 12.05. Furthermore, catalytic pyrolysis elevates the relative yield of aromatics to 53.4, as confirmed by Thermogravimetric Analysis (TGA) and Thermogravimetric-Fourier Transform Infrared Spectroscopy (TG-FTIR) analyses. GC-MS confirms the enhanced formation of valuable chemical precursors via co-pyrolysis such as phenols and olefines to 18.67 % and 22.13 % leading to a 63.81 % selective yield of aromatics in the final oil with 10Ni/ZSM-5. Ni modification of ZSM-5 is influential in decreasing PAH formation (7.26 % from 20.37 %), indicating that this two-step process is an effective method for transforming waste into high-quality bio-oil with enriched aromatic content.
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Nanoscale
·
2024
·
IF 5.8
Yufeng Wu,Zhiyan Hou,Changlong Wang
Renewable electricity-powered electrooxidation of 5-hydroxymethylfurfural (HMFOR) to FDCA offers a green and sustainable approach to producing an essential monomer for bio-polymers, provided that a highly efficient electrocatalyst is present. Herein, we show that the doping of scandium (Sc) into an NiFe-LDH electrocatalyst (Sc-NiFe-LDH) considerably promotes HMFOR by enhancing the formation of high-valence NiIII–O active sites, facilitating electron transport and HMF adsorption and suppressing the oxygen evolution reaction. In the presence of the Sc-NiFe-LDH electrocatalyst, an FDCA faradaic efficiency and selectivity of 96.5% and 99.5%, respectively, were achieved at a current density of >600 mA cm−2. The high performance of the Sc-NiFe-LDH electrocatalyst is the best among those of other reported electrocatalysts for this reaction, showing great promise in upgrading biomass to valuable chemicals. This work would inspire further studies on the rational design of novel and efficient electrocatalysts for green and sustainable energy transformations.
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高影响因子
FUEL
·
2024
·
IF 6.7
Renjie Ji,Defu Yin,Yao Chen,Like Ma,Fanglin Lv,Yuhao Zhang,Zhen Jia,Jingyun Zhang,Mingya Liu,Shitao Yu,Yue Liu
A core–shell catalyst mZSM-5@SO 4 2- /mSiO 2 composed of mZSM-5 core and SO 4 2- /mSiO 2 shell was prepared by the soft template method. Core-shell structure could promote the building of Brønsted -Lewis (B-L) acids interface and significantly improve the synergistic effect of B-L. In this paper, the Brønsted/Lewis (B/L) of mZSM-5@SO 4 2- /mSiO 2 was targeted regulating by innovatively introducing Brønsted acid (BA) sites into the shell. The optimal mZSM-5@SO 4 2- /mSiO 2 catalyst (B/L = 0.142) could achieve 72.1 % furfural yield at 140 ℃ for 1 h. In addition, 70.2 % furfural yield could be obtained after the catalyst was recycled and regenerated for 5 times. Combining In-situ IR and 13 C NMR, the reaction path was revealed in detail: xylose was first isomerized to xylulose and then dehydrated to furfural. This paper provides a research idea for the directional regulation of dual active sites of cascade reaction catalysts.
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Nanomaterials
·
2025
·Vol. 15
·期 5
·321
·
IF 4.3
Boyang Xu,Jie Chen,Kai Wang,Pengfei Li,Le Kang,Huiling Du,Qianqian Liu,Xiaoqing Lian
The accumulation of organic pollutants and solid waste is one of the major environmental challenges faced globally. Establishing an efficient recycling system for solid waste and designing cost-effective, high-performance photocatalysts are urgent tasks for the removal of organic pollutants from water. This study utilizes coal gangue as the precursor to synthesize a coal gangue-based phosphorus–silicon–aluminum molecular sieve (SAPO-5) via hydrothermal synthesis. The resulting material was then composited with bismuth oxybromide (BiOBr) to form a novel BiOBr/coal gangue-based SAPO-5 nanocomposite. When the mass ratio of BiOBr to coal gangue-based SAPO-5 molecular sieve is 0.3, the synthesized nanocomposite exhibits excellent adsorption and photocatalytic performance for the removal of methylene blue, achieving a removal rate of 97.8% and the mineralization rate of 57.4% within 30 min. The superior performance can be attributed to the optimal pore size, rapid charge transfer rate, and high photogenerated charge density of the BiOBr/coal gangue-based SAPO-5 nanocomposite. The novel BiOBr/coal gangue-based SAPO-5 molecular sieve nanocomposite catalyst presents a new approach for the harmless treatment of organic dye wastewater and the high-value utilization of coal gangue.
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RSC Advances
·
2024
·Vol. 14
·期 25
·17480-17490
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IF 3.9
Vinh Thanh Chau Doan,Thong Minh Dao,Thu Anh Huynh,The Thai Nguyen,Phuong Hoang Tran
The catalytic application of 3-(4-sulfobutyl)-1H-imidazole-3-ium chloride immobilized on activated silica gel (SiO2-Imi-SO3H) for the production of 5-hydroxymethylfurfural is described here for the first time. This material was synthesized using a three-step method involving the grafting of chloropropyl groups onto activated silica gel, the substitution of zwitterions, and the acidification of zwitterions to form silica-supported ionic liquid. The successful immobilization of the IL on silica gel was confirmed through energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and elemental mapping. SiO2-Imi-SO3H-2 demonstrated good catalytic activity and recycling ability in fructose dehydration to 5-HMF. Several conditions for reaction were investigated, and an excellent 5-HMF yield (94.1%) was obtained after 4 h at 160 °C in dimethyl sulfoxide (DMSO) from fructose. Furthermore, a mechanism was proposed, the catalyst's reusability was investigated, and the catalyst was applied for the conversion of glucose to 5-HMF with other metal salts.
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高影响因子
TETRAHEDRON
·
2011
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IF 3.011
Ming-Yu Wu,Kun Li,Ting He,Xing-Wen Feng,Na Wang,Xiao-Yan Wang,Xiao-Qi Yu
A lipase-catalyzed protocol for the synthesis of 5-hydroxyimino-4,5-dihydrofurans via tandem coupling between β-nitrostyrenes and 1,3-dicarbonyl compounds was developed in a ‘one-pot’ strategy. A series of β-nitrostyrenes were employed to expand the scope of this new biocatalytic promiscuity with high stereoselectivity ( Z / E up to 99:1) and moderate to good yields. The reaction activity of 1,3-cyclohexanedione was found to be better than linear 2,4-pentanedione, while ethyl acetoacetate and diethylmalonate were not suitable for this reaction under the same conditions. Single-crystal X-ray diffraction analysis indicated that the reaction was stereoselective and Z -stereomer was found to be the major product. A reaction mechanism was supposed to elucidate the biocatalytic process.
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ACS Catalysis
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2025
·
IF 13.1
Yuyang Wang,Chun Cai
It is a promising endeavor to explore the photocatalytic oxidation for 5-hydroxymethylfurfural (HMF) to produce high-value-added derivatives. The absence of efficient photocatalytic systems has hindered the transformation of HMF to 2,5-diformylfuran (DFF), while DFF is susceptible to subsequent oxidation into 2,5-furandicarboxylic acid (FDCA). Herein, we design a Z-scheme heterojunction photocatalyst α-Fe2O3/Zn0.5Cd0.5S via hydrothermal methods, which exhibits superior activity toward the selective oxidation of HMF to DFF or FDCA in aqueous solution. Photocatalytic investigations demonstrated the highest activity for 15% Fe2O3/Zn0.5Cd0.5S, resulting in a DFF selectivity of 99% and conversion of 75%, affording FDCA selectivity of 85% and conversion of 99%. The high catalytic activity has been ascribed to the effective separation of photogenerated charge carriers and generation of reactive oxygen species (ROS) in different atmospheres with the Z-scheme mechanism. Research revealed that the oxidation to DFF is associated with •OH in an Ar environment, while the generation of FDCA is related to •O2– in the air. Moreover, selective oxidation may also exhibit significant potential for the utilization of sunlight and other benzene substrates. Overall, this study offers a unique demonstration of designing a noble metal-free Z-scheme heterojunction photocatalyst for the oxidation of HMF to selective products in water.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
·
IF 4
Qianqian Xing,Xiaoliang Jia,Shiyu Jia,Yongqin Qi,Yuqi Wang,Yingxiong Wang,Xianglin Hou
The traditional synthesis methods of cyclopropyl methyl ketone (CPMK) have some disadvantages such as low yield, slow reaction rate and unclear catalytic mechanism. To solve these problems, a new strategy is developed to synthesize CPMK from 5‑chloro-2-pentanone (CPE) using 1,8-diazabicyclo[5.4.0]undec‑7-ene (DBU). Experiment results show that the yield of CPMK reached a maximum of 96.5 % in DBU at 40 °C for 30min. The mechanism study shows that the hydrogen bond between DBU and CPE is the key to drive the deprotonation and cyclization of CPE. The hydrogen bond is formed between the N atom on C = N of DBU and the α-H on the methylene group associated with the carbonyl group on CPE. The catalyst DBU is converted into [DBUH] + Cl − , which can be reclaimed and recycled completely. The density functional theory (DFT) calculation confirmed the existence of molecular hydrogen bonds and proved that the hydrogen bond driving force is the key to the reaction. The hydrogen bond driven mechanism provides a new idea for the basic research of cyclization reaction.
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VIBRATIONAL SPECTROSCOPY
·
2024
·
IF 2.7
Fan Yang,Jing Zhao,Zhengang Wu,Yingna Wei,Hengyong Wei,Jingwu Li,Bo Li
Cocrystal is a new class of pharmaceutical crystal form, which could improve the physical and chemical properties of drug substance without affecting the internal structure of drug substance. Therefore, the cocrystals show a great deal of potential in the development and research of drugs. 5-Fluorouracil (5-FU) is one of the most widely used anti-pyrimidine drugs. However, its solubility is poor and its oral bioavailability is low. In this work, the cocrystal of 5-FU with nicotinamide was prepared by the solvent evaporation method. The cocrystal structure was confirmed by infrared spectroscopy (IR), X-ray diffraction (XRD) and Raman spectroscopy. The X-ray diffraction and infrared spectroscopy presented that there were significantly different peaks between the raw drug and the cocrystal. Raman spectral results also indicated the differences of such cocrystal compared with the raw drug. In addition, TiN-Ag composite SERS substrate was used to study the formation of 5-FU cocrystal drugs and the formation process was dynamically monitored, and the interaction between molecules during the cocrystal reaction was deeply understood. The cocrystal reaction process was tracked, it can be found that the peak intensity of the raw drug and cocrystal changes with the reaction, indicating that the TiN-Ag composite substrate can monitor the cocrystal transformation process.
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