Journal of CO2 Utilization
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2022
·
IF 8.321
Zi-Dan Wang,Hu-Hong Peng,Yi-Xin Guan,Shan-Jing Yao
Bioavailability of oral administration is quite limited due to hydrophobicity of most of cancer drugs. Emphasis has been placed on the development of oral drug delivery systems to enhance solubility and stability of chemotherapeutics. In this work, a novel oral drug delivery system based on emulsion was implemented to encapsulate curcumin , in which ethylcellulose was employed as oil phase polymer while gum arabic was selected as emulsifier and wall material. After processed by ultrasonic emulsification , oil-in-water emulsion loaded with curcumin was transformed from liquid state to solid particles by an improved supercritical CO 2 assisted atomization technique (SAA-HCM) to achieve its long-term stability. Effects of SAA-HCM operating conditions on sizes and distributions of microparticles were investigated in detail and particle formation mechanism was discussed. The chemical stability and amorphous form of microparticles were identified by solid characterization. In vitro drug release behavior of curcumin-loaded microparticles exhibited controlled release and enzyme triggered properties, which implies the potential in the application of colon targeted delivery. This work expands the application of SAA-HCM technique to emulsion, which will be of great importance in the design of water-insoluble drug loaded microparticles with elaborate structures.
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Natural Product Communications
·
2024
·
IF 1.5
Zhang-lin Pu,Chi Zhang,Qian Yan,Zhou Liang,Zhi-Wei Xu,Ji-hu Wei,Hua Liu,Feng Chen
Objective: We explore the pharmacodynamic targets of kaempferol in treating osteoporosis using transcriptomics and animal experiment. Methods: Firstly, we constructed an ovariectomized rat model (OVX). The anti-osteoporosis effect of kaempferol was evaluated by bone mineral density (BMD) and hematoxylin-eosin staining comprehensively. Moreover, differential genes between groups were screened by RNA sequencing technology (RNA-seq) for transcriptomics and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways enrichment analysis were performed. Finally, partial results of transcriptomics were verified to detect the expression of the relevant gene expression by immunohistochemistry. Results: The pharmacodynamic findings indicated that the administration of kaempferol resulted in an elevation in BMD (P < .01) and a notable enhancement in tibia microstructural indices in the experimental rats (P < .01). The transcriptomic analysis revealed that NTN1, LTBP4, GSN, and EBF1 were identified as the principal targets for therapeutic intervention in osteoporosis. The results of animal experiments showed that kaempferol promoted osteogenesis and inhibited bone resorption by downregulating the protein expression of NTN1, LTBP4, GSN, and EBF1 (P < .01). Conclusion: Kaempferol enhances BMD levels, retards tibial bone loss with structural deterioration in OVX model rats, and promotes bone formation while curbing bone resorption through NTN1, LTBP4, GSN, and EBF1 protein down-regulation.
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DRUG DELIVERY
·
2019
·
IF 3.829
Ting Zhou,Xin Tang,Wei Zhang,Jianfang Feng,Wei Wu
10-Hydroxycamptothecin (HCPT) liposomes surface modified with stearyl glycyrrhetinate (SG) were prepared by the film dispersion method. Characterization of the liposomes, including drug release in vitro, pharmacokinetics and tissue distribution, was done. HCPT in plasma and tissues was determined by high-performance liquid chromatography (HPLC). Compared with the conventional HCPT-liposomes and commercially available hydroxycamptothecin injection (HCPT Inject), pharmacokinetic parameters indicated that SG-HCPT-liposomes had better bioavailability. Regarding tissue distribution, the concentration of HCPT loaded by SG modified liposomes in the liver was higher than other tissues and the risk to the kidney was lower than HCPT-liposomes and HCPT Inject. These results support the hypothesis that the HCPT-liposomes modified with SG show enhanced liver-targeting through the glycyrrhetinic acid (GA) receptor to be an efficient drug carrier, which may help to improve therapeutic methods for hepatic diseases in the future.
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POWDER TECHNOLOGY
·
2019
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IF 3.413
Chunli Han,Yunpeng Hu,Kai Wang,Guangsheng Luo
Nano-sized calcium carbonate , as a multifunctional material, is widely used in various industrial fields. The morphology, particle size, surface property of CaCO 3 particles have great impact on the application effect. This study presents an energy-saving and efficient approach to controllably prepare CaCO 3 nanoparticles and conduct surface modification simultaneously. Ca(OH) 2 /CO 2 carbonation method was adopted to prepare CaCO 3 nanoparticles using a membrane dispersion microreactor in the presence of calcium stearate (CaSt 2 ) surfactant . The effects of gas and liquid flow rates , temperature and the dosage of surfactant were systematically investigated. The effect of surface modification was evaluated by contact angle and active ratio. The as-prepared hydrophobic CaCO 3 nanoparticles were of good dispersity, with an average particle size of 34 nm, a specific surface area of above 30 m 2 /g and a contact angle of 107.8°. In this work, the effect of surfactant on the carbonation reaction was greatly diminished by adding CaSt 2 surfactant to a portion of Ca(OH) 2 slurry. Additionally, the modification process was carried out without organic solvents and high temperature. As compared to post-modification method, the in-situ modification process is of significant practical importance because of high production efficiency, excellent process stability, and high product quality.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
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IF 4.4
Hui Zhou,Yang Li,Ru Fang,Jinghua Li,Chen Hong,Wen Luo
In this research, an “off–on” long-wavelength fluorescent probe (DCMN-Cl) based on (E)-2-(3-(2-(6-hydroxynaphthalen-2-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene) malononitrile (DCMN) is designed and synthesized for cysteine (Cys) detection. DCMN-Cl exhibits a large Stokes shift (211 nm) and shows rapid response and high specificity to Cys. The fluorescence initensity at 635 nm reveals a good linear relationship with Cys concentration in the 0 to 50 μM range, and the detection limit is as low as 159 nM. The probe is also used for fluorescence imaging of Cys in cells and mice. Moreover, the probe provided visual evidence of Cu 2+ and curcumin-induced intracellular Cys fluctuations.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2024
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IF 4.8
Jiali Wen,Chuanqi Zhang,Yang Zhang,Zhifeng Zeng,Fei Ma,Jiuxing Jiang
The 24-membered ring - SYT type extra-large pore zeolite , denoted as DESO-SYSU-3, has been synthesized by employing N,N′-diethylsophoridine and trimethylsulfanium in a mixed-template system, where the N,N′-diethylsophoridine and trimethylsulfanium played different roles in the crystallization process . A single usage of N,N′-diethylsophoridine led to the formation of an unknown phase (donated as SYSU-5). These results reveal that the utilization of alkaloid-derived organic structure-directing agents (OSDAs) is an efficient synthetic strategy to produce specific extra-large pore zeolites and related structures. Compared to the prototype SYSU-3, the addition of TMSF into the system not only improved the silicon content in the framework of DESO-SYSU-3 but also facilitated the generation of carbon dots (CDs) confined in extra-large pore structure . The structure and the proposed formation mechanism of CDs were investigated based on HRTEM, XPS, FI-IR, UV–Vis, Raman and photoluminescence spectrum. The CDs@zeolite composite exhibited intriguing optical properties of both fluorescence and room temperature phosphorescence, respectively. This work extends extra-large pore zeolite as the matrix for the development of CDs@zeolite composites with tunable optical properties .
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AVIAN DISEASES
·
2025
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IF 1.3
Du Xiaowen,Zeng Mengting,Yang Wenzhuo,Jiang Yuting,Huang Guangyu,Ding Shiping,Jiang Danli,Yuan Zhaoxia
For decades, infectious bronchitis (IB), caused by the infectious bronchitis virus (IBV), has posed a significant threat to poultry health and is mainly controlled by vaccines. However, the currently available commercial vaccines do not provide adequate protection against new IBV strains that emerge due to ongoing evolution. Therefore, new antiviral strategies need to be explored. Cepharanthine (CEP), tetrandrine (TET), and berbamine hydrochloride (BBM) are natural plant-derived bis-benzylisoquinoline alkaloids (BBAs) with proven antiviral activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), porcine epidemic diarrhea virus (PEDV), and other viruses. Despite this, their potential antiviral activities against IBV remain unknown. As a proof-of-concept study, we aimed to investigate the inhibitory effects of CEP, TET, and BBM on the laboratory-adapted IBV Beaudette strain in Vero cells and of CEP in chicken embryos. Our research demonstrated that CEP, TET, and BBM effectively suppressed IBV infection in Vero cells, with CEP showing a particularly high selective index of 309.6. These compounds dose-dependently decreased IBV RNA levels and N protein expression and lowered intracellular and extracellular viral titers. Notably, CEP also exhibited antiviral activity against IBV infection in chicken embryos, resulting in reduced mortality and fewer lesions. While these findings highlight the potential of CEP, TET, and BBM as candidates for further development, further studies are required to evaluate their efficacy against field-prevalent IBV strains (e.g., Massachusetts, QX-like) and clarify the specific antiviral mechanisms.
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PubMed
高影响因子
WATER RESEARCH
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2021
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IF 11.236
Liang Luo,Qiang He,Zixin Ma,Duo Yi,Yi Chen,Jinxing Ma
Flow electrode capacitive deionization (FCDI) is a promising electrochemical technique for brackish water desalination; however, there are challenges in estimating the distribution of resistance and energy consumption inside a FCDI system, which hinders the optimization of the rate-limiting compartment. In this study, energy consumption of each FCDI component (e.g., flow electrodes, membranes and desalination chamber) was firstly described by using in situ potential measurement (ISPM). Results of this study showed that the energy consumption (EC) of the flow electrodes dominated under most conditions. While an increase in the carbon black content in the flow electrodes could improve the energy efficiency of the electrode component, consideration should be given to the contribution of ion exchange membranes (IEMs) and the desalination chamber to the EC. Based on the above analysis, system optimization was carried out by introducing IEMs with relatively low resistance and/or packing the desalination chamber with titanium meshes. Results showed that the voltage-driven desalination capability was increased by 39.3% with the EC reduced by 17.5% compared to the control, which overcame the tradeoff between the kinetic and energetic efficiencies. Overall, the present work facilitates our understanding of the potential drops across an FCDI system and provides insight to the optimization of system design and operation.
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NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 14
·6254-6262
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IF 3.591
Yao Cong,Qiaoran Jin,Qi Huang,Zijie Xu
Multilayer graphene (MLG) is in situ formed in a matrix of amorphous carbon prepared from carbonized waste paper at 750 °C. The resulting samples are systematically characterized by morphology, spectroscopy, diffractometry, nitrogen adsorption–desorption and electrochemistry. The carbon structure with six layered graphene can be formed in a matrix of amorphous carbon at such a low temperature. The resulting sample displays a specific surface area of 862 m2 g−1, a meso-pore volume of 0.55 cm3 g−1 and a capacitance of 214 F g−1, which are correspondingly 2.16, 2.29 and 2.14 times higher than those of the sample prepared directly from carbonized waste paper. Although the sample displays the basic characteristics of amorphous carbon, MLG is mostly found to be formed around the regular nickel crystal face in the amorphous carbon matrix. It is also found that the formation of MLG can be affected by the coexistence of nickel crystals and sodium metal. The optimized porous structural characteristics, including the specific surface area, and the micro- and meso-pore volumes, result from the rearrangement of graphite microcrystallites, giving an improved capacitive performance.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2021
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IF 7.963
Yin-Zhi Lv,Xiao-Jun Luo,Jian-Liang Zhao,Shan-Quan Wang,Bi-Xian Mai
Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for analysis. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), respectively, followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant positive correlations among some antibiotics in the same or different classes.
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FUEL
·
2022
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IF 8.035
Yining Wu,Qixin Liu,Dayu Liu,Xiao Peng Cao,Bin Yuan,Mingwei Zhao
Considerable research efforts have been devoted to finding and developing the oil locked within low-permeability reservoirs. The oil-rock interaction exacerbated in tiny pores and heterogeneities in formation epitomize the challenges accompanying the development of low-permeability reservoirs. CO 2 flooding has become a promising treatment to increase displacement efficiency and formation energy for enhanced oil recovery. Nevertheless, due to the mismatch in the viscosity of CO 2 with that of the crude oil and the intrinsic heterogeneity of the reservoir, gas channeling is inevitable, resulting in low oil recovery and low CO 2 storage efficiency. This paper is motivated to fabricate CO 2 intelligent responsive hydrogel that exhibits a delayed swelling: the hydrogel will uptake water and swell when encountering CO 2 or H + , to strengthen the plugging capacity for the gas channeling. A two-step method was used to prepare CO 2 responsive (CR) hydrogel which has good injection performance and can form gel in-situ to control the gas channeling in low-permeability reservoirs. To achieve the above functions, CR polymer with acrylamide (AM) and N-[3-(Dimethylamino) propyl] methacrylamide (DMAPMA) was synthesized by aqueous free-radical copolymerization. CR hydrogel was prepared by crosslinking CR polymer with polyethyleneimine (PEI). Then 1.2 wt% CR polymer and 0.2 ∼ 0.4 wt% PEI were determined as the optimal synthetic formulation of CR hydrogel which is capable of maintaining stability at 80 ℃ for more than 30 days without dehydration. The gelation time was more than 24 h indicating that the CR hydrogel has good injection and in-depth migration ability. Also, the swelling behaviors of CR hydrogel were studied, and the hydrogel can expand more than 10 times in acidic conditions (pH ∼ 4.5) with respect to about 2 times in neutral conditions (pH ∼ 7). The expansion mechanism is further revealed and proved to be feasible for CO 2 channeling control.
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CARBOHYDRATE POLYMERS
·
2018
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IF 5.158
Jie Chen,Meizhen Huang,Lili Kong,Mengshi Lin
This study aimed to develop a jellylike flexible substrate based on nanocellulose decorated with Ag nanoparticles (Ag/NC substrate) and explore its applications for rapid in-situ pesticide detections in fruits and vegetables by surface-enhanced Raman spectroscopy (SERS). The performances of Ag/NC substrate were characterized by rhodamine 6G (R6G). The limit of detection recorded by a portable Raman spectrometer is 10 −8 M. The substrate still exhibited satisfactory sensitivity after 60-day preservation. Jellylike and slightly sticky Ag/NC substrate demonstrated good adaptabilities in attaching to sample surfaces and is suitable for in-situ SERS detection. Two types of pesticides on apple peels and cabbages were detected by rapid in-situ and non-invasive SERS method coupled with Ag/NC substrate. The lowest detectable level was 0.5 ng/cm 2 for thiram and 5 ng/cm 2 for thiabendazole, which were well below the maximum residue levels. These results demonstrate that Ag/NC substrate is sensitive for rapid in-situ multi-pesticide detection in food.
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危险品化学品经营许可证（带存储）