JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Zhang Jie,Yin Yi-jing,Wang Xing-wang,Lu Wei-qi,Chen Zhao-yang,Yu Chao-hui,Ren Ke-feng,Xu Cheng-fu
Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for drug delivery system design. Here, we report an oral drug delivery system utilizing the tacrolimus-loaded poly (lactic-co-glycolic acid) (TAC/PLGA) particles with an adhesion coating by in situ UV-triggered polymerization of polyacrylic acid and N-hydroxysuccinimide (PAA-NHS). The negatively charged carboxyl groups effectively interact with the positively charged focal mucosa, and the NHS ester groups form the covalent bonds with the amino groups, thereby synergically enhancing the adhesion of the PLGA particles to the focal mucosa. Our findings reveal that, compared to the naked particles, the PAA-NHS coating increases the adhesion of particles to the inflammatory intestine. In a dextran sulfate sodium-induced acute colitis mouse model, the TAC/PLGA particles with PAA-NHS coating exhibits substantial retention of TAC within the inflammatory intestine, enhancing drug delivery efficiency and therapeutic effects. This approach holds promise for UC management, minimizing systemic side effects and optimizing therapeutic outcomes. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Agronomy-Basel
·
2024
·Vol. 14
·期 12
·2959
·
IF 3.3
Zhijia Cheng,Zhongbin Lu,Zhiwei Shao,Bowen Huang,Yang Xiong,Hongqiang Fei,Xian Wu,Yanwei Liu,Mei Li,Zhiguang Hou,Zongzhi Lu
The photolysis kinetics of propaquizafop in water under ultraviolet light was investigated in this study, and the effects of different influencing factors (pH,NO3−, metal ions) on the photolysis of propaquizafop were clarified. Propaquizafop residues in water were determined by a HPLC-UV detector. The results showed that the pH of the aqueous solution had no significant effect on the photolysis of propaquizafop (p< 0.05). The lowNO3−, concentration (0.5~2 mmol/L) had a weak inhibitory effect on the photolysis of the propaquizafop; when the concentration ofNO3−was 4 mmol/L, the degradation half-life of the propaquizafop was significantly higher than with other treatments (p< 0.05); Different concentrations of Fe3+had varying degrees of inhibitory effects on the photolysis of propaquizafop. The inhibitory effect was stronger at low concentrations (0.5 mmol/L and 1 mmol/L) and weaker at high concentrations (2 mmol/L and 4 mmol/L). As the concentrations of Cu2+, Cd2+, Mn2+, Zn2+, and Ni2+increased, their inhibitory effect on the photolysis of propaquizafop in an aqueous solution became stronger. In addition, LC–QTOF-MS was used to identify the photoproducts of propaquizafop in aqueous solution in this study. Five types of photoproducts were identified, and several propaquizafop degradation pathways and mechanisms were proposed, mainly including rearrangement, cracking reactions, dechlorination reactions, and light-induced redox reactions. The results of this study will help us to better understand the photodegradation law of propaquizafop in aqueous solution and provide data support for its safety evaluation in water.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Meiting Li,Bingxin Yuan,Xiangyang Zheng,Bo Chen,Chi Zhang,Xuejiao Wang,Ji-Guang Li
A series of LaNbO 4 :RE 3+ (RE = Tb and Eu) phosphors were successfully synthesized via a calcination-assisted hydrothermal reaction, where the vital roles of solution pH, calcination temperature and NbO 4 3− /La 3+ molar ratio in phase/morphology evolution of LaNbO 4 nanocrystals were elaborated. It was unambiguously demonstrated that monoclinic LaNbO 4 can be crystallized at solution pH = 8–13 after calcination at 900 °C. With pH = 10 precursor for example, higher calcination temperature led to phase transformation from orthorhombic to monoclinic structure. LaNbO 4 nanoparticles exhibit self-activated broad-band excitations ( 1 A 1 → 1 T 1,2 ) and emissions ( 3 T 2,1 → 1 A 1 ) within the NbO 4 3− ligand. Intriguingly, Tb 3+ /Eu 3+ incorporations allow for phase tailoring and full-visible-spectrum color-tunable luminescence, where the latter benefits from the effective NbO 4 3− → Tb 3+ → Eu 3+ energy transfer. LaNbO 4 :0.01 Tb 3+ ,0.01Eu 3+ phosphor exhibits stronger white-light emission, which gradually drifts to yellowish green at high heating temperature. This phosphor is an attractive candidate for optical thermometers and warm pc-WLED owning to excellent thermal stability, a low correlated color temperature of ∼5694 K and a high color rendering index of ∼90.
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Yuanna Zhang,Wenjun Sun,Wenxuan Yin
The widespread application of UV/H 2 O 2 is limited by the empirical operational practices, which can lead to excessive energy, chemical input and the generation of uncontrollable by-products. This study presents a precise regulation approach based on the characteristics of free radical generation/reaction and the chemical transformation of organics, assessed through a pilot experiment. The findings indicated that increasing H 2 O 2 dosage was more effective than increasing UV dose in enhancing •OH generation and pollutant removal. As the H 2 O 2 dosage and UV dose increased, the relative influence of water quality on pollutant removal gradually diminished. Dissolved organic matter (DOM) in the water quality background accounted for the largest proportion of •OH scavenging (76.4 %) and the most complex component. Moreover, changes in operating conditions were accompanied by the uncontrollable production of low-molecular-weight (LMW) DOM. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) revealed the chemical transformation of LMW DOM at the molecular level. Higher H₂O₂ dosages triggered more extensive oxidative degradation, resulting in more complex effluent compositions. Considering treatment efficiency, energy consumption, and effluent product composition, H₂O₂ dosages of 5–10 mg/L and UV doses of 350–450 mJ/cm² were identified as optimal. This research contributes to the efficient purification of organic micropollutants in water using UV/H 2 O 2 technology with low energy consumption, minimal chemical input, and relatively controllable by-products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Ziqi Wang,Yingyue Huang,Miao Yu,Wei Zhuang,Minghao Sui
Antimicrobial resistance (AMR) poses a global health threat to aquatic environments and its propagation is a hot topic. Therefore, deactivating antibiotic-resistant bacteria (ARB) and removing antibiotic resistance genes (ARGs) from water is crucial for controlling AMR transmission. Peracetic acid (PAA), which is known for its potent oxidizing properties and limited by-product formation, is emerging as a favorable disinfectant for water treatment. In this study, we aimed to assess the efficacy of pre-exposure to PAA followed by UV treatment (PAA-UV/PAA) compared with the simultaneous application of UV and PAA (UV/PAA). The focus was on deactivating vancomycin-resistant Enterococcus faecalis (VRE fs ), a typical ARB in water. Pre-exposure to PAA significantly enhanced the efficacy of subsequent UV/PAA treatment. At a UV fluence of 7.2 mJ cm −2 , the PAA-UV/PAA method achieved a 6.21 log reduction in VRE fs , surpassing the 1.29 log reduction observed with UV/PAA. Moreover, compared to UV/PAA, PAA-UV/PAA showed increased efficacy with longer pre-exposure times and higher PAA concentrations, maintaining superior performance across a broad pH range and in the presence of humic acid. Flow cytometry analysis indicated minimal cellular membrane damage using both methods. However, the assessments of superoxide dismutase (SOD) activity and adenosine triphosphate content revealed that PAA-UV/PAA induced greater oxidative stress under similar UV irradiation conditions, leading to slower bacterial regrowth. Specifically, SOD activity in PAA-UV/PAA surged to 3.06 times its baseline, exceeding the 1.73-fold increase under UV/PAA conditions. Additionally, pre-exposure to PAA amplified ARGs degradation and reduced resistance gene leakage, effectively mitigating the spread of AMR. Pre-exposure to 200 μM PAA for 10 and 20 min enhanced vanB gene removal efficiency by 0.14 log and 1.29 log, respectively. Our study provides a feasible approach for optimizing UV/PAA disinfection for efficient removal of ARB and ARGs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Zi-Bo Jing,Wen-Long Wang,Yu-Jia Nong,Lu Peng,Zi-Chen Yang,Bei Ye,Min-Yong Lee,Qian-Yuan Wu
Low-pressure mercury lamps emitting at 254 nm (UV254) are used widely for disinfection. However, subsequent exposure to visible light results in photoreactivation of treated bacteria. This study employed a krypton chloride excimer lamp emitting at 222 nm (UV222) to inactivate E. coli . UV222 and UV254 treatment had similar E. coli -inactivation kinetics. Upon subsequent irradiation with visible light, E. coli inactivated by UV254 was reactivated from 2.71-log to 4.75-log, whereas E. coli inactivated by UV222 showed negligible photoreactivation. UV222 treatment irreversibly broke DNA strands in the bacterium, whereas UV254 treatment primarily formed nucleobase dimers. Additionally, UV222 treatment caused cell membrane damage, resulting in wizened, pitted cells and permeability changes. The damage to the cell membrane was mainly due to the photolysis of proteins and lipids by UV222. Furthermore, the photolysis of proteins by UV222 destroyed enzymes, which blocked photoreactivation and dark repair. The multiple damages can be further evidenced by 4.0–61.1 times higher quantum yield in the photolysis of nucleobases and amino acids for UV222 than UV254. This study demonstrates that UV222 treatment damages multiple sites in bacteria, leading to their inactivation. Employing UV222 treatment as an alternative to UV254 could be viable for inhibiting microorganism photoreactivation in water and wastewater.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Chunchun Wang,Hongju Deng,Lulu Cui,Qun Liu,Zhiyu Liu,Wuyin Weng,Yucang Zhang
Collagen, extracted from Prionace glauca skin waste, exhibits exceptional anti-photoaging biological activity. Herein, a sustainable Pickering emulsion stabilized by Prionace glauca skin collagen/cellulose nanofibers (PGSC/CNFs) was developed to address UV-induced skin damage. PGSC extracted from fishery waste exhibited synergistic interactions with CNFs, demonstrating enhanced thermal stability and interfacial hydrophobicity. At an optimal ratio (0.2 wt% PGSC/0.08 wt% CNFs), the composite achieved ultra-fine emulsion droplets (0.713 ± 0.018 μm) and remained stable after 14 days. The emulsion exhibited exceptional UV-blocking performance (transmittance <0.07 % at 254 nm and 365 nm) and antioxidant activity (DPPH/ABTS scavenging >86 %/92 %). The PGSC/CNFs significantly suppressed UV-induced ROS generation by approximately 40 %, and the Pickering emulsions effectively inhibited pigmentation changes in a porcine skin model after 4 h of irradiation. Biocompatibility was confirmed by low hemolysis (<6 % at 4000 μg/mL). This work transformed marine waste into a bioactive emulsifier, offering a green strategy for multifunctional anti-UV skincare formulations.
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Shumin Jiang,Hangzhou Wang,Jun Shi,Xiaobin Li,Xiaoyan Xiong,Chenguang Kong,Cunzhi Li,Youcheng Huang,Kun Wu,Li Yang
In the semiconductor precision device processing and wafer cutting industry, products are typically etched or sliced to meet specific requirements. During this process, a novel type of adhesive is often utilized for bonding and securing purposes. After processing, some methods, such as light exposure and thermal application, can be used to make the adhesive lose its adhesiveness, so as to facilitate the peeling of the product without damaging the product. In this work, acrylate prepolymers containing photopolymerization groups were synthesized from 4-acryloyloxybenzophenone (4-ABP) and other acrylic monomers. UV-induced tack-loss of the acrylate pressure-sensitive adhesive (PSA) was achieved by blending the acrylic prepolymer with a small molecule isocyanate compound in an appropriate ratio and then coating for heat curing. It was observed that the incorporation of multifunctional isocyanate small molecule groups can enhance the overall performance of the tape. An addition amount of 0.6 wt% hexamethylene diisocyanate (HDI) was found to be more suitable than isophorone diisocyanate (IPDI), as it maintained good bonding performance and resulted in less residual glue. The increase in 4-ABP initially led to an improvement in bonding performance of the pressure sensitive adhesive tape, followed by a decrease, with an optimal addition amount of 1.2 wt%. After UV curing, the 180° peel strength of the adhesive tape measured below 1.0 N/25 mm, exhibiting the most significant decrease in peel strength and minimal residual adhesive content. This characteristic categorized it as a UV-induced tack-loss easy peeling pressure-sensitive adhesive tape. These results contribute to the further research and development of UV-induced tack-loss PSA.
✓ 已验证
产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Ziyang Zhou,Zhengquan Wang,Xueling Fan
Corrosion and UV degradation are among the primary threats to the long-term durability of epoxy coatings in outdoor applications. This study introduces a double-layer composite coating system comprising a silane sol-gel bottom layer to enhance the adhesion strength and an epoxy top layer loaded with functionalized graphene oxide@carbon nanotubes nanohybrids (F-GO@CNTs). This configuration imparts multifunctional properties including superior anti-corrosion, anti-UV, and mechanical performance. The Ep/F-GO@CNTs nanocomposite coating exhibits exceptional adhesion strength (8.8 MPa), high tensile strength (26.1 MPa), and outstanding corrosion resistance with an impedance of 5.49 × 10 8 Ω.cm 2 which is two orders of magnitude higher than that of the pristine epoxy coating after 40 days of immersion in the sodium chloride solution. After 240 h of UV irradiation, the Ep/F-GO@CNTs coating shows minimal photodegradation and retains excellent comprehensive performance even under combined UV and corrosive exposure. This study provides a promising strategy toward developing durable protective coatings for outdoor applications.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Chen Ming-Xuan,Tian Shu,Wang Shuai-Peng,Mahmud Sakil,Lu Guang-Ming,Dai Jin-Yue,Liu Xiao-Qing
Effective antifouling coatings are critical for protecting marine infrastructure from biofouling and environmental degradation; however, achieving long-term antifouling performance along with environmental stability remains a major challenge. In this study, a multifunctional bio-based epoxy coating is developed by integrating a dual-action antifouling system. Cinnamic acid (CA), which is known for its antibacterial and UV-shielding properties, was chemically grafted into ethylene glycol diglycidyl ether (EGDE) to provide intrinsic antifouling and anti-UV functions. Simultaneously, the KH560-modified silica aerogel was incorporated to create a dense hydrophobic surface that repels microorganism adhesion. The resulting coating exhibited a superhydrophobic contact angle of 154.3°, an ultralow surface energy, and exceptional resistance to protein and algal adhesion. Additionally, it achieves 99% bactericidal efficiency against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) while maintaining high transparency and ease of processing. These results highlight a promising strategy for designing durable and ecofriendly antifouling coatings suitable for demanding marine environments.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Jianwei Dao,Liang Yang,Zhihao Jiang,Zihao Han,Tiqin Wei
Narrow-band red inorganic phosphors excited by near-ultraviolet (n-UV) light have significant application potential in the manufacture of white light-emitting diodes (LEDs) with high R9 index. Novel near-UV-excitable Eu 3+ doped K 3 Ca 2 (SO 4 ) 3 × (X = F, Cl, Br) halosulphate phosphors were synthesized via high-temperature solid-state reaction method. By modifying the non-activating ions in the host matrix, the luminescence properties of Eu 3+ were effectively enhanced across various matrices, thereby optimizing the performance of this series of phosphors. As-prepared phosphors can be activated under 397 nm excitation and emit red light at 619 nm, corresponding to 5 D 0 → 7 F 2 transitions of Eu 3+ . Optimization of the doping concentration revealed that the optimal Eu 3+ concentration for different host matrices is 0.13. Notably, the K 3 Ca 2 (SO 4 ) 3 F host matrix doped with Eu 3+ exhibits stronger emission intensity and better performance. The K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ phosphor exhibited long fluorescence lifetime of 0.42 ms and high color purity of 92.25 %. The emission intensity of K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ at 423 K can retain 89.5 % of its value at room temperature. A white LEDs device was fabricated by mixing and encapsulating K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ phosphor with commercial BaMgAl 10 O 17 :Eu 2+ blue and (Ba, Sr) 2 SiO 4 :Eu 2+ green phosphors onto 397 nm n-UV InGaN chip. The device emits bright white light and exhibits high color rendering index (Ra = 79.9, R9 = 86.5) and a suitable correlated color temperature (CCT = 5915 K) at 50 mA drive current. The results suggest that this work provides new assistance in achieving high color rendering white LEDs excited by n-UV light.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2020
·Vol. 13
·期 6
·801-808
·
IF 2.596
Jing Zhao,Zhongqi Xu
A reliable and simple CE method with dual C4D and UV detection modes for simultaneous determination of major metal cations and whey proteins in milk samples was developed. Sample pretreatment comprised dilution, acidification to pH 4.55 with 10 mM AcOH and centrifugation. The complete separation of metal cations K+, Ca2+, Na+, and Mg2+ and whey proteins α-Lac, and β-Lg could be achieved respectively within 10 min and 20 min in a simple BGE composed of 1.0 M AcOH, 12 mM L-His and 2 mM 18-crown-6 with pH 2.74 at a voltage/current of +15 kV/12.5 μA. The samples were injected hydrodynamically by a pressure of 50 mbar for 5 s, the excitation voltage and excitation frequency of the C4D detector were 80 V and 1000 kHz, respectively and the detection wavelength of UV detection was set at 200 nm. In cation analysis, the range of the detection limit was 0.05–0.10 mg L−1 for C4D detection and 0.10–0.50 mg L−1 for UV detection, respectively, and the relative standard deviations (RSD%, n = 5) of intraday and interday analysis were 0.37–0.55% and 0.46–0.79% for the relative migration time, and 2.51–4.12% and 3.65–4.91% for the peak area, respectively. In whey protein analysis, the detection limits of β-Lg and α-Lac analysis were 5 mg L−1 and 3 mg L−1, respectively and the relative standard deviations (RSD%, n = 5) of intraday and interday analysis were 0.29–0.31% and 0.43–0.48% for the migration time and 2.89–3.25% and 3.29–4.18% for the peak area, respectively. The content of four major metal cations and two whey proteins in various types of milk samples was obtained. The results indicated that the content of metal cations varied little in milk samples of different brands and prices, while the content of whey proteins, as thermosensitive active proteins, varied greatly among different heat-treated milk samples.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）