Journal of Inorganic and Organometallic Polymers and Materials
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2024
·
IF 3.9
Pei Xiu,Bai Jinchuan,Li Yaming,Kong Xiangbo
In this paper, a luminescent metal-organic framework Tb 3+ @tartaric acid-functionalized Zr-MOF (Tb 3+ @UiO-67-bpy-TA, TA = tartaric acid) was prepared by post-synthetic modification (PSM) and used as a fluorescence sensor for the detection of the pesticide nitenpyram (NTP). The fluorescence sensing experiment verified that Tb 3+ @UiO-67-bpy-TA had exceptional sensitivity and selectivity for NTP detection, and the detection limit was calculated to be as low as 1.28 µM. The mechanism studies indicated that competitive UV absorption, photoinduced electron transfer (PET) and dynamic quenching contributed to the fluorescence quenching process. In addition, the detection of NTP in tap water and Yellow River water samples by the Tb 3+ @UiO-67-bpy-TA were also investigated using standard addition method, and satisfactory recoveries were achieved.
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Nature Communications
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2024
·Vol. 15
·期 1
·1-10
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IF 14.7
Hu Zishou,Tang Xueqing,Yi Yuan-Qiu-Qiang,Nie Shuhong,Chen Xiaolian,Xu Wenya,Huang Chenchao,Mu Xinju,Ma Zhongsheng,Tang Pengyu,Wu Xinzhou,Su Wenming,Luscombe Christine K.
Irrespective of the specific see-through device, obtaining optimal transparency remains the primary goal. In this work, we introduce a general strategy to enhance the transparency of various see-through devices. We achieve this by structuring the colored functional materials into imperceptible three-dimensional mesh lines, addressing a common challenge in multi-layer structures where each layer causes a reduction in transparency due to their color or opacity. To overcome this limitation, we selectively integrate functional materials into micron-wide groove structures transforming functional layers to functional meshes. Regardless of the initial color of the functional material, the resulting functional mesh can exhibit a high transmittance of 88% (vs. air) under any operating state while maintaining its intended function within the device. We apply this strategy to fabricate proof-of-concept of devices such as electrochromic devices, supercapacitors, and zinc batteries, all of which exhibit remarkable overall transparency when compared to the multi-layer device.
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高影响因子
RESPIRATORY RESEARCH
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2024
·Vol. 25
·期 1
·1-13
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IF 4.7
Zhu Li,Wu Zhuhua,Liu Yingli,Ming Yue,Xie Pei,Jiang Miao,Qi Yong
Background Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role in the development of lung diseases. Aconitate decarboxylase 1 (Acod1) mediates the production of itaconate, and Acod1/itaconate axis has been reported to play a protective role in multiple diseases. However, the roles of Acod1/itaconate axis in the PMVECs of obese mice are still unclear.Methods mRNA-seq was performed to identify the differentially expressed genes (DEGs) between high-fat diet (HFD)-induced PMVECs and chow-fed PMVECs in mice (|log2 fold change| ≥ 1, p ≤ 0.05). Free fatty acid (FFA) was used to induce cell injury, inflammation and mitochondrial oxidative stress in mouse PMVECs after transfection with the Acod1 overexpressed plasmid or 4-Octyl Itaconate (4-OI) administration. In addition, we investigated whether the nuclear factor erythroid 2-like 2 (Nrf2) pathway was involved in the effects of Acod1/itaconate in FFA-induced PMVECs.Results Down-regulated Acod1 was identified in HFD mouse PMVECs by mRNA-seq. Acod1 expression was also reduced in FFA-treated PMVECs. Acod1 overexpression inhibited cell injury, inflammation and mitochondrial oxidative stress induced by FFA in mouse PMVECs. 4-OI administration showed the consistent results in FFA-treated mouse PMVECs. Moreover, silencing Nrf2 reversed the effects of Acod1 overexpression and 4-OI administration in FFA-treated PMVECs, indicating that Nrf2 activation was required for the protective effects of Acod1/itaconate.Conclusion Our results demonstrated that Acod1/Itaconate axis might protect mouse PMVECs from FFA-induced injury, inflammation and mitochondrial oxidative stress via activating Nrf2 pathway. It was meaningful for the treatment of obesity-caused pulmonary microvascular endotheliopathy.
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JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Yan Zitao,Zhu Dachuan
A series of dual-lanthanide metal–organic frameworks (MOFs: Dy 1-x Ce x -BTC) have been successfully prepared by hydrothermal method using dysprosium (Dy 3+ ) and cerium (Ce 3+ ) ions as metal sources and 1,3,5-benzenetricarboxylic acid (H 3 BTC) as organic ligand, confirmed by XRD patterns and FT-IR spectra, and then the luminescence property, the application in detecting small organic molecules and structural stability have been discussed. Among the samples, Dy 0.8 Ce 0.2 -BTC exhibited two strongest emission peaks located at 485 nm and 578 nm under the excitation at 295 nm, which are attributed to the excited electronic transitions of Dy 3+ from 4 F 9/2 to 6 H 15/2 and 6 H 13/2 . However, Dy 0.8 Ce 0.2 -BTC immersed in the solution of acetaldehyde (AH) demonstrated an obvious luminescence quenching with the calculated quenching constant ( K sv ) and the limit of detection ( LOD ) as 7.08 × 10 3 M −1 , 5.36 × 10 –7 M and high selectivity among the other tested organic solvents. Meanwhile, it revealed that the MOF could maintain good microstructural and recycle stability in deionized water, indicating a great potential as a turn-off fluorescent sensor for AH detection. Besides, the luminescence quenching mechanism was deduced from competitive absorption.
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Advanced Fiber Materials
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2025
·
IF 21.3
Yang Yujie,Gao Xue,Zhang Yongfeng,Li Shengyou,Wu Haining,Xia Bing,Hao Yiming,Yu Beibei,Gao Xueli,Geng Dan,Guo Lingli,Qin Mingze,Wei Yitao,Xue Borui,Yang Shijie,Liu Qi,Nie Shihao,Qin Anhui,Liu Jinya,Lu Lei,Ma Teng,Luo Zhuojing,Huang Jinghui
Chronic hypoxia affects stem cell function during tissue repair. Thus far, the hypoxia-associated impact on periosteal stem cells (PSCs), the main contributor to bone repair, remains unknown, and a tailored oxygen modulation strategy for optimizing PSC function is lacking. Here, PSCs exhibit time-dependent proliferation and survival upon hypoxic exposure and a critical 48-h time-point is identified at which hypoxia transitions from beneficial to detrimental. Then, a photothermal-sensitive coaxial fiber-reinforced membrane containing oxygen and pravastatin is constructed to function as an intelligent oxygen supply system. Leveraging near-infrared light as an ON/OFF switch, the system noninvasively scales up oxygen release beginning 48 h post-implantation, counteracting prolonged hypoxia and mitigating its adverse effects on PSCs. The sustained release of pravastatin from the membrane accelerates early neovascularization both directly through its pro-angiogenic effect and indirectly by stimulating vascular endothelial growth factor secretion from PSCs, ensuring a continuous oxygen supply after exogenous oxygen exhaustion. Notably, pravastatin steers PSCs toward robust osteogenic differentiation and provides multifunctional bioactive cues for advanced bone regeneration in vivo. This time-scheduled approach to modulate oxygen supply noninvasively could be applicable beyond bone regeneration for hypoxia-related diseases and multi-tissue repair. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-15
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IF 10.6
Zhang Yue,Chen Shuyi,Ma Jie,Zhou Xiaobin,Sun Xinchen,Zhou Chenglin
An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is proposed for breast cancer diagnosis. This strategy utilizes a three-dimensional mesoporous covalent organic framework (COF), immobilized horseradish peroxidase (HRP), and a novel redox mediator, 4-acetamidophenol (APAP). The mesoporous structure, with encapsulation effect, and good biocompatibility of COF, makes the functionalized COF an efficient carrier for HRP immobilization (HRP-Ab-AuNPs@COF). It demonstrates superior catalytic activity, stability, and electrochemical performance compared to free HRP, thus making it an ideal probe for simultaneous target recognition and signal amplification. APAP is screened from four candidate phenolic compounds based on its high formal potential (0.32 V vs. Ag/AgCl), rapid electron transfer activity (k app = 2.80 × 10 5 M − 1 s − 1 ), excellent solubility and stability. These properties prove significantly better than the conventional mediator hydroquinone (HQ), achieving a higher signal-to-background ratio. By integrating decorated multi-walled carbon nanotubes as substrate materials, the electrochemical aptasensor achieves a low HER2 detection limit (0.418 pg mL − 1 ) with high specificity. This method’s selectivity surpasses that of the HQ-mediated method by 59–73%. Moreover, the aptasensor can effectively distinguish breast cancer patients and healthy individuals, as well as patients at different stages of the disease with high accuracy (AUC = 0.928). This performance exceeds traditional biomarkers CEA and CA15-3. This work paves novel avenues for innovative applications of COF-immobilized enzymes and the novel mediator APAP in electrochemical biosensing, thus holding significant promise for individualized breast cancer diagnosis and treatment.
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高影响因子
MOLECULAR MEDICINE
·
2024
·Vol. 30
·期 1
·1-16
·
IF 6
Zhang Yanbin,Bai Jing,Xiao Bin,Li Chunyan
Osteoporosis is characterized by reduced bone mass due to imbalanced bone metabolism. Exosomes derived from bone mesenchymal stem cells (BMSCs) have been shown to play roles in various diseases. This study aimed to clarify the regulatory function and molecular mechanism of BMSCs-derived exosomes in osteogenic differentiation and their potential therapeutic effects on osteoporosis. Exosomes were extracted from BMSCs. Bone marrow-derived macrophages (BMDMs) were cultured and internalized with BMSCs-derived exosomes. Real-time quantitative PCR was used to detect the expression of macrophage surface markers and tripartite motif (TRIM) family genes. BMDMs were co-cultured with human osteoblasts to assess osteogenic differentiation. Western blot was performed to analyze the ubiquitination of triggering receptor expressed on myeloid cell 1 (TREM1) mediated by TRIM25. An ovariectomized mice model was established to evaluate the role of TRIM25 and exosomes in osteoporosis. Exosomes were successfully isolated from BMSCs. BMSCs-derived exosomes upregulated TRIM25 expression, promoting M2 macrophage polarization and osteogenic differentiation. TRIM25 facilitated the ubiquitination and degradation of TREM1. Overexpression of TREM1 reversed the enhanced M2 macrophage polarization and osteogenic differentiation caused by TRIM25 overexpression. TRIM25 enhanced the protective effect of BMSCs-derived exosomes against bone loss in mice. These findings suggested that BMSCs-derived exosomes promoted osteogenic differentiation by regulating M2 macrophage polarization through TRIM25-mediated ubiquitination and degradation of TREM1. This mechanism might provide a novel approach for treating osteoporosis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2024
·Vol. 59
·期 10
·4225-4235
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IF 3.5
Yang Xingchen,Fan Zhitian,Ni Rui,Zheng Long,Lu Haiyan
The original MOFs exhibit poor electrochemical performance when used as electrode materials for supercapacitors. To improve their conductivity and stability, in situ growth of high specific capacitance and conductivity layered double hydroxide (LDH) on the MOFs surface is an ideal approach. In this study, we employed the MOF as a template and employed a secondary hydrothermal synthesis method to enable in situ growth of NiCo-LDH on the surface of the MOF. The utilization of the MOF template enhances the stability of NiCo-LDH, while the flower-like structure of LDH exposes more active sites. By optimizing the Ni:Co molar ratio to 1:2 and the urea:NH 4 F molar ratio to 2:1, the resulting material exhibits higher specific capacitance and improved cycle stability. Specifically, at a current density of 1 A g −1 , the specific capacitance reaches 1674 F g −1 . At a current density of 5 A g −1 , the capacity retention rate after 2000 cycles is 80%. When NiCo-LDH/HKUST-1 is assembled with activated carbon as a supercapacitor, it exhibits a significant energy density of 33.96 Wh kg −1 and a power density of 745.4 W kg −1 . This work provides a novel approach for utilizing MOF-based composite materials as positive electrode materials for supercapacitors. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Yin Shuhu,Chen Long,Yang Jian,Cheng Xiaoyang,Zeng Hongbin,Hong Yuhao,Huang Huan,Kuai Xiaoxiao,Lin Yangu,Huang Rui,Jiang Yanxia,Sun Shigang
Replacement of expensive and rare platinum with metal–nitrogen–carbon catalysts for oxygen reduction reactions in proton exchange membrane fuel cells is hindered by their inferior activity. Herein, we report a highly active iron-nitrogen-carbon catalyst by optimizing the carbon structure and coordination environments of Fe-N 4 sites. A critical high-temperature treatment with ammonium chloride and ammonium bromide not only enhances the intrinsic activity and density of Fe-N 4 sites, but also introduces numerous defects, trace Br ions and creates mesopores in the carbon framework. Notably, surface Br ions significantly improve the interaction between the ionomer and catalyst particles, promoting ionomer infiltration and optimizing the O 2 transport and charge transfer at triple-phase boundary. This catalyst delivers a high peak power density of 1.86 W cm −2 and 54 mA cm −2 at 0.9 V iR-free in a H 2 -O 2 fuel cells at 80 °C. Our findings highlight the critical role of interface microenvironment regulation.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2024
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IF 4.7
Zhang Yimiao,Meng Fuliang,Hu Zhenguo,Jia Yufei,Chen Zeyu,Fei Hongwei,Zhou Dapeng,Yuan Xinhua
In this study, resveratrol was substituted for phenol in different molar ratios (4%, 8%, 12%, 16% and 20%) with lignin, phenol and formaldehyde as raw materials, and a new resveratrol modified lignin-based phenolic resin (R-LPF) with high glass transition temperature ( T g ) and improved mechanical properties was synthesized. The curing behaviors of phenolic resin (PF), lignin phenolic resin (LPF) and R-LPF were investigated. The thermal mechanical properties, thermal stability, comprehensive mechanical properties, frictional properties and morphology were systematically tested and analyzed. The results show that the highest T g of the modified R-LPF reaches 346.2 °C. The T s reaches 231.5 °C, and the residual carbon rate reaches 66.2% at 800 °C. For 12% substitution ratio, the maximum tensile strength, bending strength and impact strength are respective 28.72 ± 1.10 MPa, 57.58 ± 1.95 MPa and 3.14 ± 0.19 KJ/m 2 . Compared with PF and LPF, the tensile strength of R-LPF is increased by 21.5% and 40.4%, and the bending strength is increased by 6.5% and 30.4%, while the impact strength is increased by 38.9% and 58.6%, respectively. The wear resistance is also significantly improved. The modified R-LPF structure has good rigidity, high crosslinking density, excellent mechanical and thermal properties, and it makes up for the defects of system performance decline caused by the introduction of lignin and provides a direction for the development of green high-performance phenolic resin.
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Journal of Inorganic and Organometallic Polymers and Materials
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2024
·
IF 3.9
Zhao Jingru,Wei Zifei,Sun Linan,Wang Ying,Wu Xiaodan,Wang Tao,Wang Zihan,Fu Yujie
Heavy metal ions contain highly toxic and non-biodegradable wastewater pollutants seriously contaminating the environment and affecting human health. Removal of heavy metal ions from the environment is a vital step towards the elimination of water pollution on a global scale. Therefore, in this study, cellulose was modified with L-cysteine, sodium alginate and polyethyleneimine to produce cellulose/sodium alginate /polyethyleneimine/L-cysteine composite hydrogel microspheres (WCMs/SA/PEI/L-Cys) in order to efficiently adsorb heavy metal ions. Co(II) and Ni(II) are successfully removed from water. After their production, the sorbents underwent examination using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and Scanning electron microscopy (SEM). In addition, the investigation of the mechanism and adsorption characteristics of cellulose-modified gel microspheres WCMs/SA/PEI/L-Cys has been completed. The majority of the adsorption of contaminants by cellulose-modified gel microspheres WCMs/SA/PEI/L-Cys adhered to the Langmuir isothermal adsorption model and quasi-secondary kinetic model. The intra-particle diffusion model was adopted for improving the fitting of the adsorption process in the materials. It was indicated that the internal and external diffusion acted together to eliminate the contaminants from the materials. When exploring the decontamination mechanism of the materials using XPS, it was shown that the functional groups containing nitrogen, oxygen and sulfur play a key role in removing contaminants. For Co(II) and Ni(II), the highest adsorption capacities of the sorbent were 358 and 373 mg/g, respectively. The material exhibited robust stability and recyclability based on the regeneration experiment results, remaining stable after six adsorption cycles and retaining over 80% of the initial adsorption amount.
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Journal of Food Measurement and Characterization
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2024
·
IF 2.9
Wang Xin,Hu Xuetao,Zhai Xiaodong,Huang Xiaowei,Li Zhihua,Zou Xiaobo,Shi Jiyong
The effective detection of trace lead ions in food is a challenging task due to its stability, difficulty in elimination, and high toxicity to the human health. Therefore, an electrochemical sensing based on an amine-functionalized Zr (IV) metal–organic framework (UiO-66-NH 2 ) and polypyrrole (PPy) composite nanomaterials were established for detected lead ions in meat. The UiO-66-NH 2 @PPy composite nanomaterials were prepared by in-situ polymerization of reaction pyrrole on the surface of UiO-66-NH 2 . The porous structure, high specific surface area of UiO-66-NH 2 and amino groups as metal ion binding sites are conducive to the adsorption and preconcentration of lead ions. The addition of PPy can enhance the conductivity of the composite and the active area of the electrode. Under optimal experiment conditions, the electrochemical sensing can be successfully used for the detection of trace lead ions, and the detection limit is as low as 0.05 μg/L. In addition, the sensing was applied to analyze lead ions in 30 pork samples, and the results showed that the lead contents in pork kidney samples were significantly higher than that in pork liver and pork tenderloin.
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