JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 7
·3117-3133
·
IF 4.5
Huang Qian,Zhou Yiming,Fu Zhiwei,Zhu Jingyang
An injectable hydrogel based on poly(N-isopropylacrylamide) and carboxymethyl cellulose, reinforced with GO was successfully prepared by in situ generation of hydrazone bonds, and was employed to treat cationic dye wastewater through adsorption. The incorporation of GO significantly improved the mechanical strength and shortened the gelation time of the hydrogel, as well as the cooperative effect with the hydrogel matrix for the absorption of methylene blue (MB) dyes. The hydrogel could achieve effective removal of MB dye from aqueous solution. Adsorption capacity was determined 601.7 mg/g and 1622.1 mg/g with removal efficiency of 90.4% and 60.4%, at high concentrated MB solution of 500 mg/L and 2000 mg/L, respectively. The factors that affect the dye adsorption performance including the adsorbent dosage, solution pH and initial dye concentration were studied. The kinetic and isotherm equilibrium data were well fitted by the Pseudo-second-order and Langmuir models, respectively, and the hydrogel adsorbent showed remarkable reusability. The mechanism analysis revealed that ion exchange, chemical adsorption, electrostatic interaction and π - π stacking may control the adsorption process. Overall, this work provided a rapid, viable route to fabricate injectable hydrogels for efficient application in wastewater treatment.
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高影响因子
Drug Delivery and Translational Research
·
2022
·Vol. 13
·期 4
·1012-1021
·
IF 5.671
Zhao Dongyang,Chen Ping,Hao Yuanbin,Dong Jing,Dai Yu,Lu Qingqing,Zhang Xin,Liu Chia-Wen
Rasagiline has a certain potential in neuroprotection and delaying the progression of Parkinson’s disease (PD). However, the poor pharmacokinetics (PK) characteristics of conventional oral tablets and poor medication compliance limit the optimal efficacy of rasagiline. Based on this, we designed and optimized a sustained-release rasagiline in situ gel based on in vitro release and in vivo PK results. Among them, we found for the first time that aluminum hydroxide can effectively shorten the lag phase and promote early and late release, making the daily release more uniform. After subcutaneous administration of the optimized gel formulation at a monthly dose, the C max (64 ng/ml) was lower than that of free rasagiline (494 ng/ml) administered subcutaneously at a daily dose and comparable to that of oral administration of Azilect ® (59.1 ng/ml) at a daily dose. In the meantime, the plasma concentration of rasagiline was mainly maintained at 5–10 ng/ml for about 1 month, and the active metabolite 1-aminoindane in plasma was also able to maintain a steady state. The rasagiline in situ gel has suitable viscosity and injectability, good repeatability of subcutaneous injection, and controllable impurities and can achieve sustained release in vivo with small burst release, which may have the clinical application advantages of maximizing the disease-modifying effect of rasagiline and improving medication compliance. Graphical abstract The rasagiline in situ gel was optimized through the feedback of in vitro release and in vivo pharmacokinetics (PK), in which the addition of aluminum hydroxide had a modulating effect on uniform release. The gel has low burst release and maintains steady-state blood drug concentration for about 1 month.
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PubMed
高影响因子
IONICS
·
2022
·Vol. 29
·期 3
·917-930
·
IF 2.961
Zhong Weixu,Hong Jiabin,Wang Chunxiang,Li Zhifeng,Chen Jun,Dmytro Sydorov
Nano-MoS 2 and MoS 2 /graphene nanocomposites are prepared by a simple xylitol auxiliary ball milling method. Xylitol can increase the shear force in the ball milling process and overcome the interlayer van der Waals force between MoS 2 and the graphite layer, thus improving the efficiency of preparing nanomaterials by ball milling method. As a result, the MoS 2 /graphene hybrid nanosheets exhibit higher discharge capacity and better cycle stability as lithium-ion anode materials. When the original addition amount of MoS 2 and graphite is 1:1, the materials have the best electrochemical behaviors. The initial discharge capacity is as high as 1014 mAh·g −1 at a current density of 50 mA·g −1 , after 300 cycles at a current density of 250 mA·g −1 , the capacity remains at 664 mAh·g −1 without decay. Therefore, the xylitol auxiliary ball milling method is suitable for the scalable preparation of new transition metal sulfide (TMDS)-based anodes for lithium-ion batteries.
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Bio-Design and Manufacturing
·
2022
·Vol. 6
·期 2
·136-149
·
IF 5.887
Qiu Zhennan,Zhu Hui,Wang Yutao,Kasimu Ayiguli,Li Dichen,He Jiankang
Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications. However, it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion- and inkjet-based printing. Recently, an electrohydrodynamic (EHD) bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size, whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell spreading. This study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation, which leads to high cell viability (>90%) and cell spreading. The printed filaments can be further refined to as small as 30 μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous environment. By utilizing the presented alginate-based bioinks, layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments, which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation. Graphic abstract
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2023
·Vol. 37
·期 6
·1262-1270
·
IF 1.6
Rao Li,Huang Kang,Fu Qiong,Wang Junwei,Dai Li,Zhao Na,Li Xiangjun,He Yong,Zhou Yi,Chen Yanlin
A lead-free base glaze suitable for pearlescent pigments was prepared by a low-temperature solid-phase reaction with alkali waste. Tests were performed to evaluate the effects of the sintering conditions and alkali waste composition on the prepared base glaze and pearlescent glaze. The experimental results show that partially replacing SiO 2 with B 2 O 3 effectively reduced the sintering temperature and time to form a glass network, but the network structure becomes disconnected as the B 2 O 3 content increases. An amorphous base glaze was obtained when soda ash was replaced with a small amount of alkali waste, but increasing the addition of NaCl further was adverse to base glaze formation by resulting in crystallization of the base glaze and a decrease in the bridging oxygen content. The pearlescent pigment was thermally stable in the glaze at 750 °C, while higher temperatures caused the crystalline phase of NaAlSiO 4 to appear and adhere to the surface of pigment granules, which degraded the pearlescent effect of the glaze.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 1
·1-12
·
IF 2.8
Liang Xuan,Xue Suting,Wu Wangchen,Feng Qin,Zheng Xudong,Zhang Yakang,Xu Song,Zhou Man,Li Zhongyu
Herein, a series of CuS particles anchored three-dimensional ordered macroporous TiO 2 (CuS/3DOM-TiO 2 ) composites were fabricated by a biocompatible and environmental-friendly biomolecule-assisted route. For the first time in the macroporous 3DOM-TiO 2 , L-cysteine acted as multiple roles including sulfur source and chelating agent for anchoring of CuS particles. During the regulation by Cu/Ti molar ratios from 0.3 to 2, the average size of CuS particle which anchored on inner surface of 3DOM-TiO 2 was well-controlled from about 50 to 20 nm. The photocatalytic activities were investigated by visible-light degradation of methylene blue (MB). The highest activity of CuS/3DOM-TiO 2 was emerged when Cu/Ti equaled to 1. This optimized CuS/3DOM-TiO 2 -1 reached 99% in 180 min, which was 60% higher than that of pure TiO 2 . After four cycles, the photocatalytic activity of CuS/3DOM-TiO 2 retains more than 80% of its original performance. L-cysteine highly promoted the adhesion between CuS and TiO 2 which provided good cycling ability.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-20
·
IF 17.694
Yu Jifeng,Zhou Bangguo,Zhang Shen,Yin Haohao,Sun Liping,Pu Yinying,Zhou Boyang,Sun Yikang,Li Xiaolong,Fang Yan,Wang Lifan,Zhao Chongke,Du Dou,Zhang Yan,Xu Huixiong
Reprogramming the tumor immunosuppressive microenvironment is a promising strategy for improving tumor immunotherapy efficacy. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 system can be used to knockdown tumor immunosuppression-related genes. Therefore, here, a self-driven multifunctional delivery vector is constructed to efficiently deliver the CRISPR-Cas9 nanosystem for indoleamine 2,3-dioxygenase-1 ( IDO1 ) knockdown in order to amplify immunogenic cell death (ICD) and then reverse tumor immunosuppression. Lactobacillus rhamnosus GG (LGG) is a self-driven safety probiotic that can penetrate the hypoxia tumor center, allowing efficient delivery of the CRISPR/Cas9 system to the tumor region. While LGG efficiently colonizes the tumor area, it also stimulates the organism to activate the immune system. The CRISPR/Cas9 nanosystem can generate abundant reactive oxygen species (ROS) under the ultrasound irradiation, resulting in ICD, while the produced ROS can induce endosomal/lysosomal rupture and then releasing Cas9/sgRNA to knock down the IDO1 gene to lift immunosuppression. The system generates immune responses that effectively attack tumor cells in mice, contributing to the inhibition of tumor re-challenge in vivo. In addition, this strategy provides an immunological memory effect which offers protection against lung metastasis.
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PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2022
·Vol. 49
·期 8
·3381-3393
·
IF 3.134
Yang Haoguo,Guo Yijun,Han Shitong,Xi Hailing,Lin Huaxiang,Yuan Rusheng,Ding Zhengxin,Long Jinlin,Lin Qun
Mustard gas is a kind of erosive poison with great harm and used as a chemical weapon since World War. It has suggested that the photocatalytic technology is an effective method to eliminate it. Because the small difference in molecular structure between 2-CEES and Mustard gas, and the less toxic of 2-CEES, 2-CEES is often used as a simulator to evaluate the photocatalytic activity of catalysts. In this work, symbiotic mixture of Bi 2 WO 6 and Bi 6 O 6 (OH) 3 (NO 3 ) 3 ·1.5H 2 O nanosheets doped with Mo (Mo-B-B) have been synthesized by a facile hydrothermal treatment. The samples were characterized by XRD, DRS, XPS, SEM, TEM, Raman, and PL. The photocatalytic activity of the samples was evaluated by measuring the degradation of 2-CEES under visible light irradiation. The results showed that the doped Mo reduce the Eg of bare symbiotic mixture and improve the separation efficiency of photo-generated carriers that is beneficial to photocatalytic activity. The optimum amount of doped Mo is 5% that exhibits the best activity for degradation for 2-CEES.
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高影响因子
Food and Bioprocess Technology
·
2022
·Vol. 16
·期 4
·897-908
·
IF 5.581
Zhong Yejun,Zhang Yaqi,Liu Xiaozhen,Liu Chengmei,Wu Jianyong,Huang Haixia,Zhang Pei,Zeng Zicong
Superheated steam (SS), far-infrared radiation (FIR), and microwave treatment (Mw) are emerging stabilization treatments to improve the shelf life of black rice. However, their effects on the digestibility of cooked black rice remain unclear. Therefore, the structural characteristics of cooked black rice influenced by the above treatments and their effects on in vitro digestibility were compared. Results indicated that cooked SS stabilized black rice (CBR-SS) had the highest crystallinity (9.17%), the lowest porosity, and the completest protein network. Besides, the lowest level of rapidly digestible starch (31.02%) and the highest level of resistant starch (32.75%) were observed in CBR-SS. Consequently, CBR-SS showed the lowest equilibrium hydrolysis rate, kinetic constant, and expected glycemic index during in vitro starch digestion among the cooked stabilized black rice samples. Furthermore, the level of total bioaccessible phenolic compounds and antioxidant activity was the highest in CBR-SS. Therefore, SS stabilization treatment is the most valued as it grants cooked black rice the slowest starch digestibility and the highest level of bioaccessible phenolic compounds.
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高影响因子
Food and Bioprocess Technology
·
2022
·Vol. 16
·期 4
·844-856
·
IF 5.581
Gao Yuan,Guo Siru,Zhao Ying,Ji Qianru,Yun Cholil,Wang Shengfang,Zhang Yaru,Wang Wenjie,Wang Huimei
Freeze-ultrasonic thawing extraction (FUTE) is a novel, green, and effective method for extracting bioactive compounds from plants, and the Gemini surfactant had the excellent properties especially for extracting hydrophobic and hydrophilic molecules. Therefore, the purpose of this study was to establish an effective method of synthetic Gemini surfactant aqueous system coupled with FUTE to extract the main individual polyphenols from the aerial parts of Empetrum nigrum. Based on identification of the polyphenols in the aerial parts of E. nigrum by ultra-high-performance liquid chromatography (UHPLC)–time of flight (TOF)–mass spectrometry (MS)/MS, the Gemini surfactant– N , N ʹ-bis(dodecyldimethyl)-1,4-butane dibromide (BBD)–FUTE technology was applied to extract the six main individual polyphenols. Under the optimum conditions, the extraction yields of neochlorogenic acid, catechin, rutin, hyperoside, quercetin, and guaijaverin were 8.48, 0.33, 4.23, 2.19, 1.12, and 0.32 mg/g, respectively, which were 1.01–1.96 and 1.15–2.39 times to those of ultrasonic-assisted extraction and freeze-thawing extraction methods, respectively. After cloud-point extraction, a preconcentration factor of 9.1 was obtained. All the results indicated that BBD-FUTE was a green and efficient method in the extraction of polyphenols from the aerial parts of E. nigrum . Therefore, it was suggested that the BBD-FUTE technology can be used as an alternative innovation method to effectively extract bioactive compounds from plant materials.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 41
·期 4
·547-555
·
IF 3.815
Shi Hui-Hui,Wu Shuang-Shuang,Wang Rui-Jia,Zhang Yi,An Shu-Hui,Lu Wei,Chen Tao
Mechanofluorochromic materials that render sensitive fluorescence color/pattern change upon mechanical stimuli have drawn extensive attention. However, traditional mechanofluorochromism relies on the chemical transformations of mechanophores, but their types are quite few. It remains challenging to develop mechanofluorochromic materials with customized fluorescence color changing response. Herein, a generally applicable strategy is proposed to present a class of double-layer mechanofluorochromic hydrogels based on the facile integration of two different-colored fluorescent hydrogels. Due to the UV transmittance change of top layer under Poisson’s effect, the emission intensity ratio of the upper and lower hydrogels exhibits a strain-dependent change, resulting in a force-triggered overlapping color variation. Both the UV transmittance of top layer and the fluorescence emission of bottom layer can be readily modulated to enrich the variety of mechanofluorochromism. Besides, the bottom layer is available to be printed by ion inks to fabricate patterned double-layer fluorescent hydrogel, holding great potential to design flexible mechanofluorochromic platforms for smart display and information encryption.
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高影响因子
China Foundry
·
2022
·Vol. 19
·期 6
·551-558
·
IF 1.045
Lu Tao,Zhang Yue,Ding Li,Zheng Hao-yue,Pan Ye
High-entropy metal spinel oxide (HEO) is proved to be a promising oxygen evolution reaction (OER) catalyst with high catalytic performance and stability. A short routine synthesis process based on solution combustion synthesis was proposed to prepare (Co 0.25 Ni 0.25 Mn 0.25 Zn 0.25 )Fe 2 O 4 spinel HEO in this work. During the process, the products were rapidly synthesized and melted due to the high-temperature reaction, and then quickly crystallized on the surface of nickel foam to form a nano-structure coating. With the aid of nano-scale spinel structure, the overpotential of non-activation HEO electrode reaches 276 mV at the current density of 10 mA·cm −2 , and after 100 h i-t test, it can be further reduced to 230 mV, which proves the high activity of OER catalysis. The promotion of OER catalytic performance can be attributed to the surface reconstruction caused by the selective element leaching and the boost of oxygen vacancy, leading to the formation of nano-scale flocculation around spinel core after the long-term OER process. This work indicates a special casting process for functional materials and explores the application of rapid crystallization.
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高影响因子
危险品化学品经营许可证（带存储）