CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xuejian Zhang,Yongjie Wang,Shuanghong Zhao,Shuai Zhang,Xinhua Gao,Kangzhou Wang,Subing Fan,Qingxiang Ma,Tian-Sheng Zhao,Jianli Zhang
Although Fe-based Fischer-Tropsch synthesis catalysts exhibit advantages in linear α-olefins (LAOs) synthesis, how to promote C C coupling and inhibit the secondary hydrogenation of olefins remains a challenge. Herein, we report an N-doped carbon supported Fe-based catalyst fabricated via a self-templated combustion activation strategy and impregnation method, which enables the highly selective conversion of syngas to LAOs. Systematic characterizations revealed that sodium citrate-assisted activation optimized the pore structure of the supports, facilitated the transformation of N configurations and enhanced the relative content of pyrrolic N. Pyrrolic N regulated the surface electron density of the active sites, which enhanced the adsorption and activation of CO and facilitated the C C coupling reactions, leading to an increase in C 5 + selectivity from 25.64% to 40.71%. Meanwhile, the electronic effect of pyrrolic N effectively weakened the interaction between olefins and active sites, thereby suppressing the secondary hydrogenation of olefins. The Fe/CN(Act.)-550 catalyst exhibited LAOs selectivity increasing from 29.89% over Fe/CN550 catalyst to 70.15%. The catalyst outperforms most previously reported results and maintains stability during 120 h long-term operation without significant sintering or coking. This work provides new insights for the design of catalysts for the highly efficient conversion of syngas to LAOs.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Mengchao Feng,Yuchang Wang,Xuewei Lang,Feng Wei,Huayan Si,Jianbin Zhang
This work reports the synthesis of a novel ( α / β- CdS)/Ce(OH)CO 3 composite featuring both heterojunction and heterogeneous junction structures via a simple injection titration-stirring method. The as-prepared composite exhibited excellent visible-light-driven photocatalytic activity for the degradation of high-concentration oxytetracycline (OTC) solution. Under optimal conditions determined by single-factor and response surface analyses, 0.0300 g of the composite achieved a 75.26% degradation efficiency for 50 mL of 160 mg/L OTC solution within 120 min of visible light irradiation. Notably, the composite demonstrated remarkable stability, retaining 62.39% of its initial activity after five cycles, and showed enhanced performance under real sunlight for 120 min, with a degradation rate of 78.50%. The improved photocatalytic performance is attributed to the uniform dispersion of CdS nanoparticles with abundant sulfur vacancies, which increase light absorption and facilitate charge carrier separation. Furthermore, the formation of direct Z -scheme heterojunctions and heterogeneous junctions between CdS and Ce(OH)CO 3 promotes efficient separation and transport of photogenerated carriers, thereby enhancing both photocatalytic activity and material stability.
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TALANTA
·
2026
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IF 6.7
Linna Li,Yandi Hui,Zhen Li,Xingtong Liu,Rauf Ayesha,Lei Tian,Fujun Yao,Xiaofeng Kang,Yanli Guo
Adenosine phosphates (ATP, ADP, and AMP) play critical roles in cellular processes, yet their simultaneous detection remains challenging due to high structural similarity. To overcome this limitation, we developed a nanopore-aptamer sensing platform capable of tracking single-molecule binding dynamics in real time. This method leverages the specific interactions between aptamers and each adenosine phosphate, enabling discrimination among ATP, ADP, and AMP at the single-molecule level. We demonstrate the high sensitivity and selectivity of this approach, which supports high-throughput analysis even in complex matrices. The platform was successfully applied to quantify ATP, ADP, and AMP in human serum, with excellent recovery rates (85.33%-97.53%) and precision (RSD < 7.03%), demonstrating its practical utility for multiplexed detection in biologically relevant environments. This work provides a powerful strategy for precise metabolite analysis and facilitates new studies on nucleotide-dependent pathways.
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International Journal of Nanomedicine
·
2026
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IF 8.7
Qianghui Tang,Qiang Chao,Jianfeng Zhang,Bei Wang,Song Zhao,Kun Yang
Introduction Parasitic worms (helminths) express unique antigenic glycans such as LDN and LDNF, which are absent in mammalian hosts and represent promising vaccine targets. However, free glycans typically elicit weak immune responses and require multivalent delivery and adjuvants to enhance immunogenicity and promote antibody class-switching.Methods Two cetyl-modified glycan antigens (LDN-C16 and LDNF-C16) were chemo-enzymatically synthesized and incorporated into liposomes, either with or without the invariant natural killer T cell agonist α-GalCer as an adjuvant. C57BL/6 mice were immunized subcutaneously. Humoral immune responses were evaluated by ELISA using glycan-BSA conjugates. Cytokine levels were measured in sera from immunized mice. Additionally, the ability of immune sera to recognize native helminth proteins was assessed by Western blotting using protein extracts from adult Schistosoma japonicum worms.Results Liposomal delivery of LDNF, but not LDN, induced potent glycan-specific antibody responses. Adding α-GalCer slightly reduced total antibody titers but enhanced response quality by shifting IgM to IgG, increasing IgG1 and decreasing IgG2b. Liposomal LDNF with α-GalCer also boosted in vivo cytokine responses, increasing IL-4 and IL-10 while maintaining IFN-γ. The induced antibodies showed high specificity for LDNF and effective recognition of native schistosome worm proteins.Conclusion Liposomal presentation of the LDNF epitope strongly enhances immunogenicity. Co-delivery with α-GalCer effectively promotes class-switched IgG responses, modulates cytokine profiles, and improves recognition of native parasite antigens. This liposomal glycan-antigen delivery strategy represents a promising approach for the development of anti-helminth vaccines targeting glycan epitopes.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2026
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IF 6
Huan Zhou,Ning Zhang,Chaoyue Sun,Min Feng,Ting Yang,Yonghong Liang,Chang Peng,Zhao Fu,Haiyan Zhang
Ulcerative colitis (UC) demands lifelong therapy, yet current regimens require daily high-dose administration that drives poor adherence and cumulative toxicity. Although α-terpineol (αTL) shows therapeutic efficacy in colitis, its oral application is limited by poor oral bioavailability and a lack of colon specificity. Rather than relying on sophisticated surface engineering, we encapsulated αTL within zeolitic imidazolate framework-8 (ZIF-8) during co-nucleation. This unmodified design permitted partial gastric release (∼46%) in gastric fluid and minimal release in intestinal fluid, with the remaining cargo subsequently released in the acidic environment of the inflamed colon. Oral administration of αTL@ZIF-8 resulted in colonic retention exceeding 24 h in DSS-induced colitis mice. Leveraging this colonic accumulation, an every-other-day regimen at 10 mg kg −1 achieved efficacy comparable to daily free αTL at 100 mg kg −1 or cyclosporine A at 60 mg kg −1 . Mechanistically, αTL@ZIF-8 restored Claudin-1 and ZO-1 expression, enriched butyrate-producing genera and elevated butyrate levels, and uniquely modulated glutathione synthesis-related pathways. Safety evaluation in healthy mice showed no overt toxicity under this regimen. This formulation reduces premature drug exposure in the upper gastrointestinal tract and allows more αTL to reach the acidic environment of the inflamed colon. These features enable a low-dose, every-other-day oral regimen that decouples therapeutic efficacy from dosing frequency, positioning it as a promising candidate for long-term UC management. Scheme 1. Schematic diagram of the preparation of orally administered αTL@ZIF-8 and its alleviation effects on colitis mice. Download: Download high-res image (194KB) Download: Download full-size image
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Food Bioscience
·
2025
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IF 5.9
Wei Gao,Ru Yang,Mengli Li,Ming Miao,Tao Zhang
Non-food cellulose bioconversion to amylose offers a promising avenue for sustainable biomanufacturing while maximizing non-food biomass utilization. Nevertheless, current α -glucan phosphorylases ( α GPs) exhibit insufficient thermostability and suboptimal catalytic performance, thereby limiting their feasibility for industrial implementation. In this study, a novel thermostable α GP from Dictyoglomus sp. NZ13-RE01 ( Dspα GP) was identified and characterized through computational genome mining. The specific enzyme activity of Dspα GP was 36.3 ± 2.1 U/mg under the optimal conditions of temperature 70 °C and pH 5.0. The enzyme thermal melting temperature ( T m ) was 82.26 °C, and the residual activity retained 55.5 % after stored at 70 °C for 12 h. These results demonstrated the enzyme an exceptional catalytic efficiency and remarkable thermal stability. Kinetic analysis revealed superior substrate specificity toward maltotriose and maltotetraose with k ca t / K m values of 1.96 and 1.83 mM −1 s −1 , respectively. Integration of Dspα GP with Clostridium thermocellum cellobiose phosphorylase established a dual-enzyme cascade system capable of synthesizing amylose with tunable molecular weight (7392–16,632 g/mol) by adjusting the cellobiose/G4 ratio, a conversion efficiency of 35.67 % was achieved, significantly surpassing existing systems. Site-directed mutagenesis combined with molecular docking revealed that conserved residues Gly32, Arg364, Lys370, Tyr432, and Lys464 play critical roles in substrate binding and catalytic processes. This study provides enhanced process efficiency and operational stability for sustainable carbohydrate bioconversion applications and promoting valorization of non-edible cellulose resources.
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Qian Liu,Yawen Luo,Xinyi Tao,Qunlin Zhang,Haifeng Lu
As a membrane-bound enzyme, α-Glucosidase (α-Glu) was closely associated with the pathogenesis of type 2 diabetes mellitus, making accurate monitoring of its enzymatic activity and screening of potential inhibitory compounds crucial for both clinical diagnostics and therapeutic development. Herein, we developed a colorimetric platform that synergistically integrates enzymatic catalysis with the redox-responsive optical characteristics of 2,6-dichlorophenolindophenol (DCIP). In this strategy, α-Glu enabled the removal of glucose from 2-O-α-D-glucopyranosyl-L-ascorbic acid to yield ascorbic acid, followed by in situ reduction of DCIP to reduced DCIP (redDCIP). As a result, a dramatic color fading from blue to colorless and a substantial decrease of absorbance at 612 nm were both observed, which was used to both qualitative visual assessment and quantitative spectrophotometric analysis for α-Glu activity. The proposed mechanism was systematically validated through UV-vis spectroscopic characterization and electrospray ionization mass spectrometry analysis. Under optimized experimental conditions, the system demonstrated excellent analytical performance with a good linear response between the absorbance and α-Glu activity over a dynamic range of 2-70 U L⁻¹. The platform achieved a low detection limit of 0.68 U L⁻¹, fulfilling the sensitive monitoring of α-Glu activity. Notably, the proposed approach exhibited several advantages over conventional methods, including user-friendly operation, cost-effective instrumentation and rapid assay without the complex synthesis and modification of nanomaterials, and has been applied to the screening of α-Glu inhibitor obtained from natural plant extracts. Overall, the established sensing platform not only enables sensitive detection of α-Glu activity but also be feasible for its inhibitors screening.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Meng Wu,Ye Zhang,Bixin Jiang,Peng Huang,Nan Liang,Bailong Tao,Wangping Wu
Tricalcium silicate (TCS)-based bioactive cements have attracted great attention for various endodontic applications owing to their hydraulic property, sealing ability and biological properties. Nevertheless, poor handling property and anti-washout ability are the main challenges for traditional TCS-based cements and their osteoinductive capacity needs enhance for accelerated pulpal and periapical tissue repair/regeneration. Herein, we developed an injectable TCS/α-tricalcium phosphate (α-TCP)/hydroxypropyl methylcellulose (HPMC) biocomposite with improved physicochemical properties and osteoinductive ability via the incorporation of α-TCP/HPMC. HPMC endowed TCS/α-TCP cements excellent injectablity (above 93 %) and anti-washout property. The introduction of 10 wt% α-TCP shortened the setting time of cements and obtained high compressive strength while an excess quantity of α-TCP could compromise its setting property. TCS/α-TCP/HPMC cements had good apatite formation ability and dentin interface adhesion. Moreover, TCS/10α-TCP/HPMC could significantly enhance cell viability and osteogenic differentiation of osteoblasts by increasing alkaline phosphatase (ALP) activity, collagen secretion, and extracellular matrix (ECM) mineralization and up-regulating the osteogenesis-related proteins and gene expression. These results indicated that the injectable TCS/10α-TCP/HPMC biocomposite is a promising candidate for endodontic uses.
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JOURNAL OF FOOD SCIENCE
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2024
·Vol. 89
·期 12
·8398-8409
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IF 3.2
Junguo Wang,Hongyue Wang,Keshuang Guo,Xindi Zhang,Xiangrong Zhang
The purpose of this study was to prepare and evaluate the formulation of nanoemulsions (NEs) to encapsulate phloretin (PT) to improve its stability, antioxidant, and tyrosinase inhibitory competence. The aim of this study was to improve the stability, antioxidant, and tyrosinase inhibitory effects of PT via NEs. The formulations were prepared using low energy emulsification method for PT-VE-NEs, α -tocopherol (Vitamin E) and medium chain triglycerides (MCT) were used as the oil phase, and Tween 60 was used as the emulsifier and PEG-400 as the co-emulsifier. The droplet size and zeta potential of oil-in-water NEs were evaluated using dynamic light scattering. The PT-VE-NEs were also characterized by transmission electron microscopy and Fourier transform infrared spectroscopy. The mean droplet diameter was 14.85 ± 0.14 nm, with a zeta potential of −2.47 ± 0.51 mV. Fourier transform infrared spectroscopy revealed the formation of molecular interactions in the NEs formulations. PT-VE-NEs size was maintained the same during the in vitro digestion study. The particle size of PT-VE-NE remained stable during in vitro digestion. The addition of VE significantly improved the antioxidant, tyrosinase inhibitory effects, as well as thelion and physical stability of PT-VE-NE. The results revealed that NEs is a promising strategy to improve the functionality and stability of PT and VE. PT-VE-NEs will be applied for the preservation of fruits.
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Regenerative Biomaterials
·
2026
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IF 8.7
Du Yunzheng,Liu Zhuang,Chai Yamin,Wang Biao,Wang Lichun,Wang Zimeng,Guo Xiaofang,Zhou Guanlun,Yang Jingxuan,Zhu Chunling,Yang Leilei,Lv Xinyao,Ou Lailiang
Hemoperfusion has emerged as a crucial treatment for liver failure in clinics. However, the challenge remains in the incapacity to effectively and concurrently eliminate multiple harmful toxins, including inflammatory cytokines and bilirubin. This study employed molecular docking for directing the design of adsorbents. To develop a multi-target adsorbent material for liver failure, capable of absorbing both bilirubin and TNF-α, a functional platform was constructed. This platform employs a TiO2-modified polystyrene-based microsphere PSVT, which was designed for bilirubin adsorption, and coated with polydopamine and grafted with EGCG for TNF-α adsorption. The results confirm that EGCG possesses a high binding affinity for TNF-α, and the introduction of EGCG as a functional moiety markedly improves the clearance effectiveness of TNF-α. Meanwhile, PSVT served as the foundation to guarantee the effective removal of bilirubin. PSVT/P/EGCG exhibits outstanding clearance performance, with a maximum adsorption capacity of 263 ng/g for TNF-α and 23.91 mg/g for bilirubin, demonstrating its high efficiency in removing both inflammatory mediators and toxins. EGCG contributes exceptional antioxidant capabilities to PSVT/P/EGCG. The adsorbent exhibits remarkable biocompatibility and stability. The multi-target adsorbent material developed in this study has an extensive spectrum of potential applications in liver failure treatment employing an artificial liver.
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CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Zhichao Sun,Songyin Yu,Yuhang Gong,Changhai Liang,Chuang Li
Different from the dehydration of ethanol, the catalytic dehydration of long-chain fatty alcohols to linear α-olefins with the low selectivity arises from a complex reaction network, particularly the secondary isomerization to internal olefins. This study aimed to elucidate the fundamental mechanisms governing selectivity in the catalytic dehydration of n-octanol to 1-octene over conventional γ-Al 2 O 3 catalysts. The combination of kinetic analysis, in situ infrared spectroscopy, and density functional theory (DFT) calculations, we demonstrated that the reaction primarily proceeded via a dioctyl ether intermediate, which rapidly decomposed into olefin and alcohol. In contrast, the isomerization of 1-octene followed a water-assisted re-adsorption and hydration pathway: 1-octene re-adsorbed onto surface acid sites, hydrated to form 2-octanol, and subsequently underwent secondary dehydration, preferentially yielding internal olefins in accordance with Saytzeff's rule. Based on these mechanistic insights, an integrated reaction-separation process was designed using Aspen Plus simulation. Employing a dual-column distillation scheme with heat integration, the process achieved a 1-octene product purity exceeding 98% with ~5.9% lower overall energy consumption. This work provided systematic insights and a feasible strategy, that bridges molecular-scale mechanisms with process engineering, facilitating the highly selective production of α-olefins from biomass-derived long-chain alcohols.
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BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Xiaohui Tang,Yan Cai,Zonghui Li,Min Zhang,Bingqing Liang,Xinyu Liu,Xiang Chen,Nan Shi,Sijia Xie,Chang Chen
Despite the critical role of α-amylase assessment in diagnosing postoperative pancreatic fistula, conventional intermittent testing suffers from inherent delays, overburdened clinical laboratories, and color interference from pigmented drainage fluids. To address these limitations, we present an electrochemical biosensor enabling potential bedside continuous monitoring of α-amylase activity in abdominal drainage fluids from high-risk POPF patients. The system integrates chronoamperometry with a glucose oxidase-functionalized cellulose fiber membrane, a carbon screen-printed electrode, and a microfluidic channel, facilitating continuous, color-immune detection in flowing clinical samples. The sensor exhibited a bilinear range of 100-10000 U/L with a detection limit of 34.7 U/L. To ensure reproducibility, single-point calibration and on-site reconstruction methods were employed to minimize batch-to-batch variability. Finally, preliminary validation using complex, dynamic-flow clinical drainage samples demonstrated reasonable agreement with hospital-reported values, indicating potential clinical utility, though larger cohort studies are warranted to fully establish accuracy and reliability. Overall, this proof-of-concept study demonstrates quantitative α-amylase detection in raw drainage fluid under dynamic flow conditions, representing a step toward continuous monitoring and clinical translation, pending further optimization.
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