CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Ruhe Zhang,Xinru You,Moucheng Luo,Xinyu Zhang,Yifen Fang,Hai Huang,Yang Kang,Jun Wu
The use of cisplatin is restricted by systemic toxicity and drug resistance. Supramolecular nano-drug delivery systems involving drugs as building blocks circumvent these limitations promisingly. Herein, we describe a novel supramolecular system [Pt(IV)-SSNPs] based on poly(β-cyclodextrin), which was synthesized for efficient loading of adamantly-functionalized platinum(IV) prodrug [Pt(IV)-ADA 2 ] via the host-guest interaction between β-cyclodextrin and adamantyl. Pt(IV)-ADA 2 can be converted to active cisplatin in reducing environment in cancer cells, which further reduces systemic toxicity. The introduction of the adamantane group-tethered mPEG 2k endowed the Pt(IV)-SSNPs with a longer blood circulation time. In vitro assays exhibited that the Pt(IV)-SSNPs could be uptaken by CT26 cells, resulting in cell cycle arrest in the G2/M and S phases, together with apoptosis. Furthermore, the Pt(IV)-SSNPs showed effective tumor accumulation, better antitumor effect , and negligible cytotoxicity to major organs. These results indicate that supramolecular nanoparticles are a promising platform for efficient cisplatin delivery and cancer treatment.
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RENEWABLE ENERGY
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2022
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IF 8.634
Wenjing Song,Mengxue Song,Wenqing Cai,Weichu Li,Xingmao Jiang,Weiping Fang,Weikun Lai
Development of highly active and stable catalyst for C–O bonds cracking is important in biomass conversion , in this work, we report a SiO 2 -encapsulated NiPt/HY core-shell catalyst for phenethoxybenzene (PEB) catalytic cracking . The as-grown silica shell with defined pores serves as a ‘storage’ to enhance local concentration of PEB and intermediate isomers and promotes catalytic cracking on NiPt/HY core. With the increase of silica shell thickness from 0 to 40 nm, PEB reaction rate has increased more than five times, and the major cracking product selectivity is raised to above 90%, which is attributed to the continuous conversion of PEB isomers within the shell. This designed structure endows the NiPt/HY@SiO 2 with a high activity and no obvious deactivation in PEB cracking to corresponding phenol and aromatics. The outstanding performance benefit from the enrichment effect on the unique core-shell structure, as well as the moderate acidity originated from silica regulation. This work can be extended to the modulation of microenvironment to promote the catalytic behavior of core-shell catalysts.
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BIOCHEMICAL ENGINEERING JOURNAL
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2022
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IF 4.446
Lihui Jiang,Yuheng Han,Juan Xu,Ting Wang
A cellulose-based hydrogel with synergistic therapeutic effect was prepared by a one-pot method. The hydrogel had hydroxyethyl cellulose (HEC) as a framework and epichlorohydrin (EPI) as a cross-linking agent. Cationic-β-cyclodextrin (C-β-CD) was homogeneously embedded in the grid of the cross-linked structure. Zinc oxide nanoparticles (ZnO NPs) and menthol were used to provide analgesic and bactericidal effects . Menthol was uniformly loaded onto the hydrogel matrix by the addition of C-β-CD and increased the solubility of menthol in water. ZnO NPs were synthesized by in situ hydrothermal treatment . The positively charged group of C-β-CD and the active hydroxyl group of HEC were used to distribute the ZnO NPs uniformly on the hydrogel matrix without significant agglomeration. The hydrogel had a smoothly ordered and compact morphology. It exhibited adequate mechanical, swelling, water retention and oxygen permeability properties in tests. In addition, the hydrogel had an efficient bactericidal effect. Release experiments showed that the encapsulation of menthol by C-β-CD allowed for a slow release of menthol. Biocompatibility tests had shown that the hydrogel was non-toxic to normal human cells.
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Frontiers in Materials
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2022
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IF 3.985
Pei Mengxi,Lv Shangchun,Liu Yishui,Si Zhichun,Wu Xiaodong,Ran Rui,Weng Duan,Kang Feiyu
Photocatalytic removal of organic pollutants under solar irradiation at room temperature is considered an energy-saving technique of environmental remediation. However, photocatalysis is impeded by the poor response to visible light and fast charge recombination. In this work, sub-nano Pt/β-FeOOH quantum dots (QDs) were designed to shorten the charge migration path and obtain wide light harvesting. Interestingly, the crystalline β-FeOOH QDs can be obtained by loading sub-nano Pt particles via a reconstruction mechanism of amorphous FeOOH induced by H2 spillover, which facilitates the fast kinetics of charge transition and benefits the oxygen-rich surface of the catalyst for photocatalytic oxidation reactions. Moreover, the Pt-VO-Fe interfaces were proved to be the most active sites for the activation of O2. As a result, the catalyst exhibits a predominant photocatalytic performance in toluene oxidation, achieving a TOFPt of 0.591 min−1 at room temperature under visible light irradiation. This work provides a new perspective on the design and preparation of nanocatalysts for high-efficient photocatalysis under visible light irradiation.
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2022
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IF 2.731
Huimin Li,Yapan Shi,Yudong Gao
A new voltammetric sensor, simultaneous electropolymerization of L-Citrulline (L-Cit) and β-cyclodextrin (β-CD) film modified glassy carbon electrode (GCE) was built for the first time. It was used to construct this sensor for quantification of these important pesticides and sensitive determination of metribuzin. The proposed metribuzin sensor displays excellent performance with wide linear range (3.0 × 10−8 ~ 1.0 × 10−6 mol L−1), ultralow detection limit of 10 nM (S/N = 3), and favourable specificity. Also, the sensor was applied for determination of metribuzin in the real samples, the satisfying results are achieved. The results imply that the proposed sensor can be potentially used for the environmental pollution science and environmental analytical chemistry.
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Frontiers in Chemistry
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2022
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IF 5.545
Hu Yanru,Zhang Gengrui,Liu Lele,Chi ZiXin,Wang Shuai,Lin Jingdong,Xiong Haifeng,Wan Shaolong
The thermocatalytic conversion of hexose into valuable chemicals such as methyl lactate under mild conditions is very appealing. Here, we report that Mo, Mg co-modified Sn-β catalyst can effectively catalyze the transformation of glucose and fructose into alkyl lactate at moderate temperatures. A maximum yield of around 35% of methyl lactate was achieved from the conversion of glucose in methanol at 100°C over Sn-β catalyst modified with 3 wt% Mo and 0.5 wt% Mg. However, up to 82.8% yield of ethyl lactate was obtained in the case of fructose in ethanol upon the same catalytic condition, suggesting a significant solvent effect. The Mo species plays a key role to enable the retro-aldol condensation of fructose, in which the competing side reactions are significantly suppressed with the assistance of neighboring Mg species probably through a synergetic effect of Lewis acid-base.
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ANALYTICAL CHEMISTRY
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2022
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IF 8.008
Yana Chen,Shuangling Wang,Jujie Ren,Haiyan Zhao,Min Cui,Na Li,Meng Li,Cong Zhang
Amyloid-β oligomer (AβO) is widely regarded as a reliable biomarker for the early diagnosis of Alzheimer’s disease (AD). In this study, a signal on–off ratiometric electrochemical immunosensor has been developed for ultrasensitive detection of AβO. To achieve the dual-signal ratiometric strategy, ultrasmall copper sulfide nanoparticle-engineered covalent organic framework hybrid nanocomposites (CuS@COFs) were utilized as excellent electrocatalysts toward hydroquinone (HQ) oxidation to produce detectable signals. Meanwhile, electroactive thionine (Thi) and Aβ antibody-modified gold nanoparticles (Thi-AuNPs-Ab bioconjugates) were designed as another electrochemical indicator. Based on these two signals, an ultrasensitive sandwich-like electrochemical immunosensor was established for AβO detection. The introduction of AβO resulted in a remarkable decline in the electrochemical signal of HQ but an increase in the signal of Thi. Under optimum conditions, the ratios between the double signals (IThi/IHQ) showed a proportional linear relationship with the AβO concentration (1 pM–1 μM) with a low detection limit of 0.4 pM (S/N = 3), and the biosensor was able to determine the content of AβO in real cerebrospinal fluid samples with satisfactory results. The ratiometric strategy proposed in our study offers a sensitive and efficient approach for early diagnosis of AD, and this work will promote the further applications of engineered COFs in electrochemical sensors.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Longfei Zhang,Na Yang,Yuhang Han,Xiang Wang,Luhong Zhang,Yongli Sun,Bin Jiang
Heterogeneous advanced oxidation process performs a promising perspective in the field of refractory pollutant degradation. However, the agglomeration and difficulty-to-recycle characters of the heterogeneous catalysts greatly impede its further development. In this study, membrane-confined pores were employed as the immobilization support to anchor highly dispersed β-FeOOH via an in situ mineralization method, which not only exposed highly active sites for refractory pollutants degradation but also endowed the membrane with hydrophilic/underwater superoleophobic properties. Accordingly, the Polyvinylidene fluoride/β-FeOOH (PVDF/β-FeOOH) catalytic membrane demonstrated favorable separation capacity and attractive catalytic oxidation performance via activating peroxymonosulfate. Instantaneous degradation (contact time about 1 s) of recalcitrant pollutants (over 98%) and high oil rejections (96.4% to 99.1%) can be achieved simultaneously under low operating pressure. Both the confined pore structure-induced enhanced mass transfer and enrichment of radicals and pollutants lead to favorable catalytic degradation performance. The mechanism of the catalytic membrane was analyzed by radical quenching test and electron paramagnetic resonance analysis, proving that sulfate radicals were predominant reactive oxygen species during catalytic oxidation. Besides, the PVDF/β-FeOOH catalytic membrane also possessed attractive stability without tedious catalyst separation/recovery processes. This work provides a meaningful tactic to further enhance the catalytic oxidation performance of catalytic membrane in water treatment.
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INDUSTRIAL CROPS AND PRODUCTS
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2021
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IF 5.645
Guangyu Wu,Qi Liu,Jingyi Wang,Siye Xia,Hualong Wu,Jiaxiang Zong,Jiangang Han,Weinan Xing
Wastewater containing pharmaceuticals can be bioaccumulated, posing a potential risk to drinking water, human health, and ecosystems. In order to make the adsorption process more suitable for actual application, rape straw biomass fiber (treated by an acidified sodium chlorite solution, 5%) and Fe 3 O 4 embedded β-CD to prepare a novel adsorbent (RSBCDF), which was used for the removal of ibuprofen (IBP) from aqueous solution. The RSBCDF was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) measurements, scanning electron microscopy (SEM), and zeta potential measurements. The synthesized adsorbent was studied with regard to IBP removal percent under different adsorption conditions such as varying initial pH levels (4–10), initial ibuprofen concentrations (20−160 mg/L), contact time (5−150 min), and the dosage of adsorbent (10−100 mg) via batch adsorption experiments. The adsorption kinetics, thermodynamics, and isotherms were also investigated. The IBP adsorption behaviour followed a pseudo-second-order kinetic model and the Freundlich isotherm model. The maximum adsorption capacity obtained for ibuprofen was 48.29 mg/g. The values of Gibbs free energy change were negative (-2.58∼-3.56KJ/mol), suggesting that the process of ibuprofen adsorption onto adsorbent was spontaneous. The positive value of standard enthalpy change (12.09 kJ/mol) indicated that the adsorption process was endothermic. The obtained results prove that RSBCDF is a proficient and economically suitable material for removing IBP from water environments.
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FOOD CHEMISTRY
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2021
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IF 7.514
Shuyun Bi,Di Shao,Yue Yuan,Rui Zhao,Xu Li
A novel surface-enhanced Raman spectroscopy (SERS) method for the determination of nitrofurazone was developed using AuNPs/ γ -Al 2 O 3 nanoparticles protected by β -cyclodextrin ( β -CD) as substrate prepared in our lab. The optimum experimental conditions were obtained from single factor procedure and response surface modeling. A linear relationship ( I SERS = 508.96 c + 31987.87, c : nmol L −1 , R 2 = 0.996) between SERS intensity and the concentration of nitrofurazone in the range of 3.3 – 667.0 nmol L −1 was established, the limit of detection (LOD) was found at nmol L −1 level (0.37 nmol L −1 by 3 S 0 / S ). The selectivity for the method was studied by the influences of foreign substances on the determination. The recoveries and RSD (n = 5) for the six meat samples were 95.1 % – 104.5% and 2.4 % – 4.8% respectively, which suggesting that the new SERS method was successfully to detecting nitrofurazone.
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FOOD HYDROCOLLOIDS
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2021
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IF 9.147
Jiabao Zheng,Qing Gao,Ge Ge,Jihong Wu,Chuan-he Tang,Mouming Zhao,Weizheng Sun
The associative phase separation of biomacromolecules can produce both liquid-like coacervates or solid-like precipitates. In this study, we found that sodium chloride (NaCl) can programme the phase transition of β-conglycinin/lysozyme (β-CG/LYS) complexes. NaCl reduced the ζ-potential of both β-CG and LYS. Their complex coacervate was formed at pHs 6 and 7 with 5–80 mM NaCl and at pH 8 with 40–80 mM NaCl. Unlike the high critical salt concentration and entropy gain driving force of polyelectrolyte-based complex coacervation, 100 mM NaCl almost completely inhibited β-CG/LYS complexation, and the exothermic enthalpy change was the main driving force for β-CG/LYS complex formation. Confocal laser scanning microscopy with fluorescein isothiocyanate-labeled proteins demonstrated dynamic protein exchange in coacervate droplets, similar to that in polyelectrolyte-based complex coacervates.
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Small Methods
·
2021
·Vol. 5
·期 11
·2100765
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IF 14.188
Ruizhe Li,Wujie Dong,Jun Pan,Fuqiang Huang
The transition metal oxides (TMOs) with high volumetric capacities are promising anodes for the future electronics, however, they usually suffer from severe capacity decay and poor rate capability. Carbon hybridization and nanosizing can resolve these challenges, yet these significantly compromise the volumetric capacity. Herein, both high capacity and long cycling stability are simultaneously achieved in the micrometer-sized Mo-based oxide particles by designing the dual conductive MoO 2 /β-MoO 3- x mosaics. The rational combination of the highly electronically conductive MoO 2 with the highly ionically conductive and open-structured β-MoO 3 achieves a promising volumetric capacity of 1742 mAh cm −3 , which is four times higher than the commercial graphite. Simultaneously, both stable cycling performance (87% retention after 500 cycles) and excellent rate capability (outperformed a majority of the MoO 2 -based anodes reported in literature) are obtained in the lithium-ion batteries. For the sodium-ion batteries, the composite exhibits three times higher Na + storage than pure MoO 2 . Moreover, the decisive role of the bond energy on the electrochemical performance of TMOs is also identified. This study may open up new perspectives for choosing and designing the TMO anodes with a high volumetric capacity for the practical applications.
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