MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 4
·1-12
·
IF 5.3
Han Hong,Ji Yuhan,Zhao Xin,Yin Ling,Liu Xiangyi,Sha Jingquan
A colorimetric sensing method for salicylic acid (SA) was developed by designing and fabricating bimetallic oxide nanozymes. Firstly, by calcinating MIL-100(Fe)@PMo 12 (MOFs@POMs) at different temperature, Fe 2 (MoO 4 ) 3 -Ts (T = 400℃, 500℃, 600℃, 700℃) nanoparticles (NPs) were successfully prepared. Secondly, by evaluating the peroxidase-like activities, Fe 2 (MoO 4 ) 3 –600 NPs shows the best peroxidase-like activity attributed to the Fenton-like effect and the synergistic coupling interaction between Mo and Fe. Finally, based on the specific complexation between SA and Fe 3+ , a sensitive colorimetric sensor for SA was established, which exhibits superior selectivity and interference with a detection limit of 0.11 μM and a linear range of 10 to 100 μM, the lowest LOD for SA to date, to the best of our knowledge. Graphical abstract
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Nano-Micro Letters
·
2013
·Vol. 5
·期 3
·182-190
·
IF 2.057
Zhu Wen,Wu Yuanyuan,Wang Chengyin,Zhang Ming,Dong Guanxiu
The highly ordered silver-coated colloidal crystals arrays and macroporous silver films were derived through an electrostatics-induced adsorption effect using polystyrene (PS) as templates. Carboxyl-modified PS microspheres were prepared by emulsifier-free emulsion polymerization using methacrylic acid (MAA) as the functional monomer. PS microspheres were self-assembled into close packing colloidal crystals of facecentered cubic arrays to the substrate with vertical deposition method. These colloidal crystals were modified using dopamine (DA) to form poly-dopamine (PDA) during its oxidative polymerization. Through electrostatic interaction, the silver nanoparticles were deposited and adsorbed onto the surfaces of colloidal crystals templates by exposing [Ag(NH 3 ) 2 ] + solution to infrared irradiation. Removal of the polymeric template by etching with methylbenzene solvent resulted in 3D ordered macroporous silver films. The structural and properties of the ordered silver-coated arrays and macroporous silver films were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), UV-vis spectroscopy and surface-enhanced Raman spectroscopy (SERS). The results indicate that the prepared silver-coated arrays and macroporous silver films possess the features of ordered multilayer arrangement, uniformity and repeatability as well as an ideal SERS effect.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 18
·7333-7342
·
IF 4.569
Hua Yu,Liuyan Zhou,Renguang Ye,Degang Deng,Shiqing Xu
Polychromatic emission can be achieved by controlling the distribution of the rare earth activator in multi-cation lattices, which can be used in the fields of white light LED and fluorescence temperature sensing. However, it is still a challenge to control their distribution and location of the target site in a given host material because the distribution of the rare earth activator is uncertain. In this paper, we have chosen Li4SrCa(SiO4)2 as the multi-cation site host and induced the distribution of Eu2+ ions between different cation sites through anion substitution, for the first time, to regulate the luminescence characteristics of a series of Li4SrCaSi2O8−yN2y/3:Eu2+ phosphors. In Li4SrCa(SiO4)2:Eu2+ phosphors, the substitution of O2− by N3− triggered a distinct ordered to disordered structure transition of the SiO4 tetrahedron and induced the remote distribution of the Eu2+ activator, which was verified through the analysis of the XRD, EPR, FT-IR and fluorescence spectra. Due to the location of Eu2+ ions in different cation sites (Eu2+Sr and Eu2+Ca), two distinguishable emission peaks with tunable color emissions and different responses to temperature were realized. The white LED that utilized blue-orange-emitting Li4SrCaSi2O4N8/3:Eu2+ and green-emitting BaSi2O2N2:Eu2+ (500 nm) displayed an outstanding color rendering index (Ra) of 85.1. Based on the fluorescence intensity ratio (FIR) technique, an optical temperature measurement mechanism was hypothesized and studied in the temperature range of 293–473 K. The highest Sa of the material was 0.086 K−1, and Sr was 1.76% K−1 based on the FIR detection technology, revealing obviously better than most inorganic optical temperature-measuring materials reported before. Our work indicates that Li4SrCaSi2O8−2yN4y/3:Eu2+ is a promising material for application in White LEDs and optical thermometers.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Yingmin Jin,Chaojun Liu,Zhenggang Jia,Xin Zong,Dong Li,Mengyu Fu,Junhua Wei,Yueping Xiong
Solid-state electrolytes have become a promising approach for rechargeable lithium batteries with enhanced safety and high energy density . However, the rigid nature of ceramic electrolytes would result in the poor interfacial contact, and polymer electrolytes suffer from inferior electrochemical performance and unsatisfied mechanical strength to suppress Li dendrites. In this work, we report a flexible Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP)-reinforced polyvinylidene fluoride (PVDF)-based solid composite electrolyte with superior performances in terms of high ionic conductivity (1.64 × 10 −3 S cm −1 at room temperature), high lithium transference number (0.45), wide electrochemical window (0–4.76 V) and enhanced tensile strength (14.2 MPa). The existence of LATP permits the utilization of high Li-salt content which increases the charge carrier concentration. Meanwhile, LATP facilitates the Li + conduction process and enhances the mechanical strength, leading to a long-term electrochemical stability of symmetric Li cell for 600 h at 0.2 mA cm −2 . Assembled with LiFePO 4 cathode, the all-solid-state Li battery delivers a high capacity of 153.7 mA h g −1 at 0.3 C with remarkable cycle stability. This work provides a bright future for composite polymer electrolytes in the application of all-solid-state lithium batteries .
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Yang Xia,Liyue Yu,Chengwei Lu,Jing Zhu,Zhen Xiao,Jun Zhang,Chu Liang,Hui Huang,Yongping Gan,Wenkui Zhang
Monoclinic Li 3 V 2 (PO 4 ) 3 (LVP) fulfills safety requirements including superior chemical and thermal stabilities since the oxygen atoms are firmly anchored in PO 4 3− units, however the low intrinsic electronic conductivity strictly limits its electrochemical performance . Herein, to overcome this problem, a rationally designed passion fruit-like LVP@C/CNT composite constructed with LVP grains as seeds, carbon matrix as pulp, and carbon nanotubes (CNTs) as filaments, has been prepared via a facile spray pyrolysis method. In such unique biomimetic structure, carbon matrix encases LVP to reduce its particle size, which is beneficial to shorten ion pathways; Porous structure scattered around carbon matrix facilitates the rapid penetration of electrolyte; 3D CNT networks afford high-speed electron conduction and remarkable structural stability by forming the bridges between LVP grains. Owing to the multiple merits of this biomimetic structure, the rationally designed LVP@C/CNT composite with 3 wt% CNT exhibits high reversible capacity, superior cyclic stability and remarkable rate capability.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Jianwei Dao,Liang Yang,Zhihao Jiang,Zihao Han,Tiqin Wei
Narrow-band red inorganic phosphors excited by near-ultraviolet (n-UV) light have significant application potential in the manufacture of white light-emitting diodes (LEDs) with high R9 index. Novel near-UV-excitable Eu 3+ doped K 3 Ca 2 (SO 4 ) 3 × (X = F, Cl, Br) halosulphate phosphors were synthesized via high-temperature solid-state reaction method. By modifying the non-activating ions in the host matrix, the luminescence properties of Eu 3+ were effectively enhanced across various matrices, thereby optimizing the performance of this series of phosphors. As-prepared phosphors can be activated under 397 nm excitation and emit red light at 619 nm, corresponding to 5 D 0 → 7 F 2 transitions of Eu 3+ . Optimization of the doping concentration revealed that the optimal Eu 3+ concentration for different host matrices is 0.13. Notably, the K 3 Ca 2 (SO 4 ) 3 F host matrix doped with Eu 3+ exhibits stronger emission intensity and better performance. The K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ phosphor exhibited long fluorescence lifetime of 0.42 ms and high color purity of 92.25 %. The emission intensity of K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ at 423 K can retain 89.5 % of its value at room temperature. A white LEDs device was fabricated by mixing and encapsulating K 3 Ca 2 (SO 4 ) 3 F:0.13Eu 3+ phosphor with commercial BaMgAl 10 O 17 :Eu 2+ blue and (Ba, Sr) 2 SiO 4 :Eu 2+ green phosphors onto 397 nm n-UV InGaN chip. The device emits bright white light and exhibits high color rendering index (Ra = 79.9, R9 = 86.5) and a suitable correlated color temperature (CCT = 5915 K) at 50 mA drive current. The results suggest that this work provides new assistance in achieving high color rendering white LEDs excited by n-UV light.
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ACS Applied Polymer Materials
·
2024
·
IF 4.4
Haifeng Yu,Yanting Du,Jiayu Li,Songhao Zhao,Cheng Wang,Shuhong Wang,Haiyang Chang
Donor–acceptor (D–A) conjugated polymers have exhibited their utility in the fabrication of memory devices with high information storage capacity. The device performance can be effectively regulated through the appropriate pairing of the acceptor and donor moieties. Six different D–A conjugated polymers, featuring varied structures, were synthesized by using the Suzuki coupling reaction. Donor molecules such as fluorene, carbazole, and 4′-methoxytriphenylamine, as well as the acceptor molecule dipyrido[3,2-a:2′,3′-c]phenazine (dppz), were employed in this process. Interestingly, it was observed that simply increasing the ratio of donor groups did not yield improvements in device performance. On the other hand, the memory devices fabricated using these polymers as the active layers exhibited favorable ternary resistance memory behavior. Specifically, the first and second threshold voltages were impressively low, at −0.40 and −0.75 V, respectively. The OFF: ON1: ON2 current ratio reached an outstanding ratio of 1:102.90:105.47. Moreover, these devices demonstrated excellent stability with a retention time of 104 s and an endurance of 103 cycles. In conclusion, this study successfully synthesized D–A conjugated polymer with dppz as an acceptor and proved the great potential of constructing ternary memory devices using the dppz structure.
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ELECTROPHORESIS
·
2012
·Vol. 34
·期 4
·510-517
·
IF 3.303
Huihui Yang,Yingzhuang Chen,Yixuan Liu,Lihua Nie,Shouzhuo Yao
A novel (3-sulfopropyl methacrylate potassium)-silica hybrid monolithic column for CEC has been prepared by a simple one-pot approach based on efficient thiol-ene click chemistry. In this process, the polycondensation of hydrolyzed alkoxysilanes and in situ click reaction of vinyl groups on 3-sulfopropyl methacrylate potassium and thiol groups on the precondensed siloxanes simultaneously occurred in a pretreated capillary. Homogeneous monolithic matrix with large through-pores tightly bonded to the inner wall of the capillary was shown by optical microscope and SEM. The minimum plate height of this hybrid monolithic column was determined as 3.9 μm for thiourea. Anilines, alkylbenzenes, and phenols were well separated on this hybrid monolithic column by CEC, which indicated typical reversed-phase and cation-exchange chromatographic retention mechanisms of the column.
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LIFE SCIENCES
·
2025
·
IF 5.1
Qing Li,Mei Zhou,Ying Yang,Yangming Jiang,Chao Chen,Enming Hu,Jialin Chen,Daoping Wang
Overexpression of EphB3 has been documented across various cancers and essential for cell proliferation, survive and metastasis, making it a valuable therapeutic target. In this study, a series of novel penta-1,4-dien-3-one and quinoxaline conjugates were designed and synthesized using pharmacophore fusion strategies to explore potential EphB3 inhibitors. CCK-8 experiments revealed significant anti-cancer activity of most newly synthesized compounds against hepatocellular carcinoma (HCC). Among them, compound W8 displaying the highest inhibitory activity against MHCC97H (IC 50 = 1.87 μM), which arrests MHCC97H cells in the G0/G1 phase and induces apoptosis. Furthermore, compound W8 suppresses tumor growth in an MHCC97H xenograft model in vivo by suppressing phosphorylation level of EphB3 and down-regulating the SRC-AKT signaling pathway, leading to a dose-dependent reduction in tumor volumes and weights, with a 40 mg/kg dose achieving decreases of 68.4 % and 65.3 %, respectively. Given its ability to modulate EphB3 signaling, W8 represents a promising lead compound for further drug development, particularly for cancers characterized by EphB3 overexpression, and may offer new opportunities for targeted therapy in precision oncology.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Huiren Zheng,Jize Wang,Junye Pan,Chunyang Zheng,Yuxin Zhang,Ankang Shu,Bin Li,Shaowen Cao,Yong Peng
Underwater photovoltaics plays a pivotal role in photovoltaic applications. However, the underwater solar spectrum differs significantly from that in air, and as water depth increases, solar spectra across various wavebands exhibit distinct attenuation rates. Specifically, the attenuation rate of the red component of sunlight is considerably higher than that of green and blue light (400–600 nm). Thus, under these unique spectral conditions, there is an urgent need to develop stable devices that minimize power conversion efficiency (PCE) loss with increasing water depth. The 4-terminal (4T) structure tandem cell, designed with 2.35 eV CsPbBr3 and 1.63 eV Cs0.05(FA0.83MA0.17)0.95Pb(I0.83Br0.17)3, is prioritized due to its suitable optical response range and low PCE loss with increasing water depth. As CsPbBr3 utilized blue and green light in tandem, which has the highest light intensity underneath water, this study employed doping of SrBr2 into the CsPbBr3 film. This approach reduced the defect density of the film, enhanced carrier transport efficiency, and improved the photoelectric responsivity of the device in the 425–500 nm band. The CsPbBr3 perovskite solar cells that were fabricated demonstrated a high open-circuit voltage of 1.46 V and an exceptional PCE of 7.62%. Additionally, these devices exhibited excellent stability. Consequently, the 4T tandem device achieved PCEs of 15.28, 11.79, and 10.33% at 0, 0.5, and 0.7 m underwater depths respectively, with a variation rate of only 32%. Furthermore, the device demonstrated remarkable stability under working conditions, with an efficiency decay of less than 13% after continuous irradiation for 30 days. These findings suggest that the 4T tandem solar cell holds considerable potential for application in underwater photovoltaics.
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JOURNAL OF PHARMACEUTICAL SCIENCES
·
2015
·
IF 2.59
Hua Sun,Zhiguo Ma,Danyi Lu,Baojian Wu
ABSTRACT In th is study, we aimed to determine the glucuronidation potential of psoralidin in humans and to perform validation on use of psoralidin-3- O -glucuronidation as afunctional marker for UGT1A9. Glucuronidation kinetics was determined using human liver microsomes (HLMs), human intestine microsomes (HIM), and expressed UDP-glucuronosyltransferase (UGT) enzymes. The chemical structures of metabolites were determined by liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy analyses. Validation of psoralidin-3- O -glucuronidation as a UGT1A9 marker was performed using combined approaches including reaction phenotyping, chemical inhibition, activity correlation analysis, and determination of relative activity factor (RAF). HLM and UGT1A9 generated two monoglucuronides (9- O -glucuronide and 3- O -glucuronide) from psoralidin, whereas HIM, UGT1A1, UGT1A7, and UGT1A8 generated one only (9- O -glucuronide). Formation of 3- O -glucuronide in HLM was markedly inhibited by the UGT1A9-selective inhibitors magnolol and niflumic acid . Further, psoralidin-3- O -glucuronidation was strongly correlated with propofol-glucuronidation in a group of nine individual HLMs ( r = 0.978, p < 0.001). Strong correlation was also observed between psoralidin-3- O -glucuronidation and the UGT1A9 protein levels measured by Western blotting ( r = 0.944, p < 0.001). Moreover, UGT1A9 was responsible for 99.6% of psoralidin-3- O -glucuronidation in HLM based on the RAF approach. In conclusion, psoralidin was subjected to efficient glucuronidation, generating one or two monoglucuronides depending on UGT isozymes . Also, psoralidin-3- O -glucuronidation was an excellent in vitro marker for UGT1A9.
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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
·
2021
·
IF 2.9
Yonglu Li,Yaxuan Wang,Xin Yu,Ting Yu,Xiaodong Zheng,Qiang Chu
Lung cancer with high mortality is regarded as a challenging global problem with unsatisfied curative effects. Clinically, the chemotherapy drugs are often faced with side-effects and tumor resistance. Radix Tetrastigma (RT) is a traditional Chinese herb and now regarded as a kind of functional food. In this study, A549-bearing nude mice control was adopted to evaluate the anti-tumor capacity of RT. Results demonstrated that RT showed excellent anti-tumor ability with no side-effect on mice compared to chemotherapy drug (5-Fu).Further studies proved that RT down-regulated the proliferation-related proteins (PCNA, Ki67) and vascular endothelial growth factor (VEGF). Additionally, RT up-regulated the ratio of Bax/Bcl-2, which caused the over-expression of Caspase-9, leading to the activation of downstream protein caspase-3, eventually resulting in apoptosis of A549 in solid tumor. These results together suggest that RT inhibits the non-small cell lung cancer (NSCLC) via Bax/Bcl2/Caspase-9/Caspase-3 pathway. Furthermore, the anti-A549 abilities of the main flavonoid components from RT were compared, and kaempferol-3-O-rutinoside would play a role in RT’s outstanding anti-NSCLC ability.
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