Silicon
·
2019
·Vol. 12
·期 3
·585-594
·
IF 1.21
Wang Qikun,Wang Yongqing,Chang Qibing,Liu Han,Yang Yulong,Zhang Xiaozhen
To obtain the ultrafine pigment for ink-jet printing, ultrafine spherical Pr-ZrSiO 4 pigment was prepared by sol-gel-microemulsion method (S-G-M). In the emulsion, ZrO 2 and SiO 2 sols are used as water phase, cyclohexane serves as oil phase, Triton X-100 and 1-hexanol are chosen as surfactant and co-surfactant, respectively. The results show that without the introduction of demulsifier, the sol/oil microemulsion system is demulsified automatically due to the transformation of liquid/liquid to solid/liquid interface following the transformation from sol to gel. The obtained Pr-ZrSiO 4 pigment owns uniform spherical particles with the average particle size of about 0.785 μm, which is suitable for the ink-jet printing. The CIE coordination of the pigment is L* = 87.63, a* = −3.82, b* = 65.68, which shows bright lemon yellow. Hence, the ultrafine pigment in this work has the good application prospects.
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高影响因子
AAPS PHARMSCITECH
·
2019
·Vol. 20
·期 5
·1-12
·
IF 2.608
Ruan Jiuheng,Wan Xiaocao,Quan Peng,Liu Chao,Fang Liang
Chemical penetration enhancers are widely used in transdermal drug delivery system. However, few studies have focused on changes of concentration in chemical penetration enhancers. In this study, the effect of concentrations of enhancers on drug release and its mechanism were investigated. Zolmitriptan (ZOL) was used as a model drug and isopropyl palmitate (IPP) was used as a model enhancer to investigate drug release behaviors in pressure-sensitive adhesives (PSAs). The IPP concentrations were 2, 5, 10, 12, and 15%. Drug release percents increased by 4.8, 11.5, 16, 15.1, and 14.8%, respectively. Interestingly, the linear relationship between concentrations of IPP and release percents was improved in the 0–10% and remained unchanged in the 10–15%. Moreover, thermal and rheology studies were performed to investigate changes of the fluidity of PSAs. FT-IR and molecular dynamics simulation were conducted to confirm the interaction strength among ZOL, IPP, and PSAs. The results elucidated that IPP increased fluidity of PSAs and vied for drug from PSAs. As a result, the interaction among three components played a major role in changing release behaviors of ZOL, but the increased fluidity only worked in the concentration of less than 10%.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 3
·2552-2565
·
IF 2.993
Yang Qingsong,Li Li,Zhao Fang,Han Haoya,Wang Weihua,Tian Yuchuan,Wang Yunwei,Ye Zhishuang,Guo Xuhong
The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO 2 –PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 11
·1-7
·
IF 5.705
Wang Yi-Han,Xia Huan,Huang Ke-Jing,Wu Xu,Ma Ying-Ying,Deng Rui,Lu Yun-Fei,Han Zi-Wei
A sensitive aptamer/protein binding-triggered sandwich assay for thrombin is described. It is based on electrochemical-chemical-chemical redox cycling using a glassy carbon electrode (GCE) that was modified with WSe 2 and gold nanoparticles (AuNPs). The AuNPs are linked to thrombin aptamer 1 via Au-S bonds. Thrombin is first captured by aptamer 1 and then sandwiched through the simultaneous interaction with AuNPs modified with thrombin-specific aptamer 2 and signalling probe. Subsequently, the DNA-linked AuNP hybrids result in the capture of streptavidin-conjugated alkaline phosphatase onto the modified GCE through the specific affinity reaction for further signal enhancement. As a result, a linear range of 0–1 ng mL −1 and a detection limit as low as 190 fg mL −1 are accomplished. The specificity for thrombin is excellent. Conceivably, this strategy can be easily expanded to other proteins by using the appropriate aptamer.
Schematic presentation of an electrochemical biosensor for thrombin based on WSe 2 and gold nanoparticles, aptamer-thrombin-aptamer sandwiching, redox cycling, and signal enhancement by alkaline phosphatase.
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高影响因子
IONICS
·
2018
·Vol. 25
·期 4
·1921-1927
·
IF 2.347
Shen Feng-xia,Shi Jin,Shi Feng,Chen Tian-you,Li Yun-fei,Li Qing-yuan,Dai Yong-nian,Yang Bin,Qu Tao
Electro-reduction of carbon dioxide (CO 2 ) to carbon monoxide (CO) has been extensively studied on metal and alloy electrodes for many decades. However, owing to their disadvantages of low current density and high over-potential, the practical application of these electrodes has been limited. Hence, it is highly desirable to explore new and high efficient electrode for CO 2 reduction to CO. Ag 2 S has been widely studied as electrode material in electrochemistry due to its unique properties, such as high conductivity, chemical stability, and easy to be prepared. In this work, we have fabricated an Ag 2 S electrode via electro-oxidation of Ag in aqueous solution. X-ray diffraction (XRD) and scanning electron microscope (SEM) confirm that Ag 2 S has been modified on Ag foil, which made the electrode surface roughness. And then, we have evaluated the performance of Ag 2 S electrode as the cathode for CO 2 reduction in propylene carbonate/tetrabutylammonium perchlorate. The cathodic current density reaches to 9.85 mA/cm 2 , with the faradic efficiency for CO formation remaining stable at 92% during 4 h long-term electrolysis.
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CELLULOSE
·
2018
·Vol. 25
·期 12
·6935-6945
·
IF 3.809
Chen Huaxin,Yang Fahui,Du Jiehao,Xie Haibo,Zhang Lihua,Guo Yuanlong,Xu Qinqin,Zheng Qiang,Li Nanwen,Liu Yu
Abstract The transesterification reaction between cellulose and vinyl esters is regarded as a clean and facile strategy for the tunable synthesis of cellulose esters. In this study, a series of cellulose esters with degrees of substitution from 0.58 to 3.0 have been prepared successfully under mild conditions without adding any external catalysts when cellulose was dissolved in the 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)/DMSO/CO 2 solvent system and then followed by adding equimolar amounts of long chain fatty, aromatic, branched and steric vinyl esters. The optimization study of different reaction parameters like reaction time, temperature and amounts of substrates demonstrates that the reaction can proceed smoothly even at room temperature. This is evidenced by a cellulose benzoate with a DS of 2.6 obtained when the reaction is performed at 25 °C in 4 h. The as-prepared cellulose esters structure has been confirmed by 1 H NMR, 13 C NMR and FTIR, and material thermal properties were evaluated by DSC and TGA for an in-depth understanding the relationship between the cellulose esters structure and properties. It is believed that the DBU not only acts as a reagent for the CO 2 -derivative dissolution of cellulose in DMSO, but also acts as an in situ organocatalyst for the subsequent transesterification reaction. Graphical abstract Cellulose esters have been prepared successfully at low temperature using long chain fatty acids, aromatic, branched and steric vinyl esters as acyl donors in the DMSO/DBU/CO 2 solvents system, and the DBU not only acts as reagents for the CO 2 -derivative dissolution of cellulose in DMSO, acts as an organocatalyst for the subsequent derivatisation.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 25
·6529-6538
·
IF 3.307
Han Zhizhong,Luo Min,Weng Qinghua,Chen Li,Chen Jinghua,Li Chunyan,Zhou Ying,Wang Long
A highly sensitive and selective photoelectrochemical (PEC) aptasensor was constructed for carcinoembryonic antigen (CEA) detection based on ZnO flower-rods (ZnO FRs) modified with g-C 3 N 4 -Au nanoparticle (AuNP) nanohybrids. The nanohybrids of g-C 3 N 4 -AuNPs can improve the visible light absorbance of ZnO FRs and enhance the PEC property. We designed a sandwichlike structure formed with DNA hybridization of NH 2 -probe1, CEA aptamer, and CuS-NH 2 -probe2 to detect CEA. The p -type semiconductor CuS nanocrystals (NCs) at the terminational part of sandwichlike structure work as electron traps to capture photogenerated electrons and consequently lead to a magnified photocurrent change. The results indicate that the photocurrent is increased when CEA antigen (Ag) is introduced. Since the sandwichlike structure is destroyed, CuS NCs are restricted to capture photogenerated electron. The PEC aptasensor for CEA determination is ranged from 0.01 ng·mL −1 to 2.5 ng·mL −1 with a detection of 1.9 pg·mL −1 . The proposed aptasensor exhibits satisfactory PEC performances with rapid detection, great sensitivity and specificity. Specially, this PEC aptasensor shows a reliable result for the determination of CEA in invalid human serum compared with the ELISA method. The designed aptasensor may provide a new idea for a versatile PEC platform to determine various molecules.
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高影响因子
INVESTIGATIONAL NEW DRUGS
·
2018
·Vol. 36
·期 6
·1147-1157
·
IF 3.502
Guo Shewei,Zhen Yingwei,Guo Mengguo,Zhang Longzhou,Zhou Guosheng
Microtubule as an important target in the cancer therapy was used to design novel tubulin polymerization inhibitors. Sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and their antiproliferative activity against three selected cancer cell lines (BGC-823, MGC-803 and SGC-7901) were evaluated. All sulfanilamide-1,2,3-triazole hybrids displayed potent inhibitory activity against all cell lines. In particular, compound 10b showed the most excellent inhibitory effect against MGC-803 cells, with an IC 50 value of 0.4 μM. Cellular mechanism studies elucidated that 10b induced apoptosis by decreasing the expression level of Bcl-2 and Parp and increasing the expression level of BAX. 10b inhibited the epithelial-mesenchymal transition process by up-regulating E-cadherin and down-regulating N-cadherin. Furthermore, the tubulin polymerization inhibitory activity in vitro of 10b was 2.4 μM. In vivo anticancer assay, 10b effectively inhibited MGC-803 xenograft tumor growth without causing significant loss of body weight. These sulfanilamide-1,2,3-triazole hybrids as potent tubulin polymerization inhibitors might be used as promising candidates for cancer therapy.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 21
·14907-14921
·
IF 2.993
Pang Jiafeng,Li Zhixian,Li Shaomin,Lin Shuying,Wang Hongdi,Xie Qiuling,Jiang Yanbin
Integrating various functional components into a single nano-platform is an ideal but challenging strategy for cancer therapy. Herein, a facile approach to fabricating multi-targeted nano-drug delivery systems which can be monitored is reported. Superparamagnetic iron oxide nanoparticles (SPIONs) and gefitinib (GEF) were encapsulated into folic acid-conjugated zein (Fa–zein) nanocomplexes (GEF-FSZs) with good dispersity, high GEF loading efficiency and pH-dependent release profile. The uptake of water-insoluble GEF was facilitated by encapsulating GEF into a zein-based nanocomplex, the magnetic responsive property endowed by SPIONs and the conjugation of Fa, which resulted in enhanced toxicity to A549 cells. The endocytosis study indicated that macropinocytosis and clathrin/caveolae-independent endocytosis exerted great influence on the internalization of GEF-FSZs. These results implied that GEF-FSZs could be a promising candidate for controlled and targeted drug delivery.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 9
·1-10
·
IF 5.705
Liu Chaoqiao,Huang Jianzhi,Wang Lishi
The authors describe a method for electrochemical synthesis of a nanocomposite consisting of carboxylated multi-walled carbon nanotubes, polythionine and platinum nanoparticles (denoted as cMWCNT@pTh@Pt). The composite was placed on a glassy carbon electrode (GCE) to obtain a sensor for simultaneous determination of myricetin and rutin by differential pulse voltammetry, with typical peak voltages of 0.16 and 0.34 V (vs. SCE). Under optimal conditions, the modified GCE has a linear response in the range of 0.01–15 μM myricetin concentration range, and a 3 nM lower detection limit. For rutin, the data are 0.01–15 μM and 1.7 nM, respectively. The sensor is selective, stable and reproducible. It was successfully applied to the simultaneous determination of myricetin and rutin in spiked juice samples, and satisfactory results were obtained.
A nanocomposite consists of carboxy multi-walled carbon nanotube (cMWCNT), polythionine (pTh) and platinum nanoparticles (Pt) was presented for the simultaneous determination of myricetin and rutin. The nanocomposite shows excellent electrochemical determination performances based on a synergistic effect among cMWCNT, pTh and Pt.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 317
·期 3
·1299-1309
·
IF 1.181
He Jiarui,Jin Jiali,Wang Zhenzhen,Yin Hongwei,Wei Congcong,Xu Xiaoping
Polyacrylic acid, Chitosan and nanosilica particles composite (PCNS) was prepared for enrichment of U (VI) from aqueous solutions. Adsorption tests controlled by different parameters including contact time, pH, initial concentration of UO 2 2+ and coexistence ions were examined. FTIR, SEM and EDX studies proved the formation of composite and confirmed efficient adsorption of UO 2 2+ by PCNS. The experimental datas fit the Langmuir and pseudo-second-order models, the R L (0.115–0.645) indicates the adsorption of UO 2 2+ onto PCNS are favorable. The value of q m (451.118 mg g −1 ) and adsorption–desorption experiments showed PCNS hydrogel can be reckoned as a high efficienct and sustainable material for removal of U (VI).
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2019
·Vol. 125
·期 8
·1-11
·
IF 1.784
Dong Rui,Wang Luming,Zhu Jichao,Liu Lili,Qian Yanling
The nanohybrids of silicon dioxide–graphene oxide (SiO 2 –GO) were prepared by surface modification of graphene oxide (GO) by the hydrolysis of the tetraethoxysilane (TEOS) and then the SiO 2 –GO was added into acrylic resin as reinforcement to prepare acrylic nanocomposites. The structure of SiO 2 –GO was characterized by XRD, FT-IR, Raman and the morphology and dispersion study of SiO 2 –GO were observed by SEM and TEM. The results showed that the SiO 2 –GO was dispersed well in the acrylic resin matrix. Furthermore, the corresponding thermal, mechanical, and chemical resistance properties of the SiO 2 –GO/acrylic resin nanocomposites with mass ratios of SiO 2 –GO to acrylic resin (0.04, 0.06, 0.08, 0.10, and 0.12 wt%) were studied and compared with those of pure acrylic resin and the GO/acrylic resin nanocomposites with the same mass ratios of GO to acrylic resin. The results revealed that the loading of SiO 2 –GO effectively enhanced various properties of acrylic resin, which provides a new method for preparation of graphene nanocomposites.
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