MATERIALS RESEARCH BULLETIN
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2023
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IF 5.4
Meiqi Mu,Haishan He,Yunfei Gan,Jing Yu,Jirong Mou,Jujun Yuan,Fangkun Li,Xingquan Wang,Xiaokang Li,Xianke Zhang,Jun Liu
The three-dimensional (3D) porous C/CoS nanocomposites were successfully synthesized using a spontaneous template method followed by a subsequent vulcanization process. As potassium ion battery anode, the 3D porous C/CoS nanocomposites exhibited a reversible capacity of 165 mAh g −1 at 5 A g −1 after 2000 cycles and superior rate performance. The excellent electrochemical performance of 3D porous C/CoS nanocomposites is ascribed to its distinctive architecture, which can alleviate the volume variation of CoS in the cyclic processes, improve electronic/ionic conductivity, and provide more chances of contact between electrode material and electrolyte. It is promising that our fabricating method can be expanded for synthesizing other 3D porous C/metal sulfides composites as high-performance PIB anodes.
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FOOD CHEMISTRY
·
2024
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IF 8.5
Jia-ping Ke,Jia-Yi Li,Zi Yang,Hao-Yue Wu,Jing-Ya Yu,Yi Yang,Chen-Hui Chen,Peng Zhou,Fang Hua,Wei Wang,Fenglin Hu,Gang-Xiu Chu,Xiao-Chun Wan,Guan-Hu Bao
Tea drinking impacts aging and aging-related diseases. However, knowledge of anti-aging molecules other than the major catechins in complex tea extracts remains limited. Here we used Caenorhabditis elegans to analyze the longevity effects of tea extracts and constituents comprehensively. We found that the hot water extract of green tea prolonged lifespan and heathspan. Further, the MeOH fraction prolonged lifespan significantly longer than other fractions. Correlation analysis between mass spectroscopic data and anti-aging activity suggests that ester-type catechins (ETCs) are the major anti-aging components, including 4 common ETCs, 6 phenylpropanoid-substituted ester-type catechins (PSECs), 5 cinnamoylated catechins (CCs), 7 ester-type flavoalkaloids (ETFs), and 4 cinnamoylated flavoalkaloids (CFs). CFs (200 μM) are the strongest anti-aging ETCs (with the longest 73% lifespan extension). Green tea hot water extracts and ETCs improved healthspan by enhancing stress resistance and reducing ROS accumulation. The mechanistic study suggests that they work by multiple pathways. Moreover, ETCs modulated gut microbial homeostasis , increased the content of short-chain fatty acids, and reduced fat content. Altogether, our study provides new evidence for the anti-aging benefits of green tea and insights into a deep understanding of the chemical truth and multi-target mechanism.
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Materials Today Communications
·
2025
·
IF 4.5
W.H. Qiu,J.N. Ren,C.C. Yuan,Y.F. Li,X.Y. Fan,H.M. Li,M. Oleksandr,S.W. Lu,J.J. Wang,M.W. Zhu
The widespread deployment of 5 G technology has intensified the demand for electromagnetic wave absorption materials to mitigate escalating electromagnetic pollution. Herein, we reported a bioinspired ant-nest-like CoNi@C composite synthesized through a facile hydrothermal method followed by pyrolysis treatment. A lamellar CoNi-MOF precursor was first constructed, and the molar ratio of cobalt to nickel was systematically adjusted to enhance carbon graphitization, thereby tailoring the electromagnetic parameters of the composite. The synergistic interplay between the optimized composition and the unique hierarchical architecture endowed the nanocomposite with exceptional microwave absorption performance. Specifically, the ant-nest-like porous structure facilitated impedance matching, interfacial polarization, and multi-scale attenuation of incident microwaves. The Co 2 Ni 3 @C composite achieved an effective absorption bandwidth (EAB, RL ≤ -10 dB) of 6.47 GHz, with a minimum reflection loss of -50.92 dB at 13.05 GHz with a mere 30 wt% filler loading. This work establishes a versatile MOF-derived strategy for designing high-performance electromagnetic absorbers with ultrawide bandwidth and lightweight advantages.
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Reaction Kinetics Mechanisms and Catalysis
·
2024
·
IF 1.7
Gao Xinglong,Qiu Feifei,Xie Hongzhao,Chen Xiaopeng,Wu Chenghong,Chen Yutong,Liang Jiezhen,Wang Linlin
In the present work, efficient catalytic hydrogenation of acrylic rosin (AR) were extensively investigated. Qualitative and quantitative analysis of AR and hydrogenated acrylic rosin (HAR) were carried out by GC and GC–MS, and the reaction pathway network about catalytic hydrogenation of AR was constructed. In addition, a Pd/C catalyst with well-dispersed ultrafine nano-palladium was prepared by impregnation method using Pd(NO 3 ) 2 ·2H 2 O precursor and put into use for the catalytic hydrogenation of AR. The structural properties of the catalyst were measured via XRD, TEM, ICP-OES, XPS, and BET. The characterizations showed that the ultrafine Pd nanoparticles (NPs) with an average Pd NPs size of 2.29 nm and consisting of 3.1% Pd were equably loaded on the surface of activated carbon. Benefiting from well-dispersed ultrafine Pd NPs, the catalyst exhibits outstanding activity in the hydrogenation of AR at 180 °C and 5 MPa, which shows 1.9 times superior activity than a commercial 10% Pd/C. The quality of prepared HAR is similar to the commercial HAR (Gardner color < 1, acid value of 235 mg KOH/g, softening point of 129 °C, 35% conversion rate of acrylpimaric acids). Graphical abstract
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xingyang Qiu,Qingquan Zheng,Dongdong Luo,Yue Ming,Tingting Zhang,Wenchen Pu,Min Ai,Jianhua He,Yong Peng
Cellular-mesenchymal epithelial transition factor (c-Met) is an attractive target for treating multiple cancers. Despite plentiful c-Met inhibitors have been developed, some issues, including the acquired drug resistance to c-Met inhibitors, have emerged to hamper their application in clinical treatment. Degradation of c-Met offers an opportunity to solve these issues. In this study, we developed a series of c-Met degraders, and the optimal compound 22b can efficiently degrade c-Met with a DC50 value of 0.59 nM in EBC-1 cells. Mechanistic studies revealed that compound 22b induced c-Met degradation via proteasome-mediated pathway. In addition, compound 22b suppressed the proliferation and also induced apoptosis of EBC-1 cells, outperforming the corresponding inhibitor tepotinib. Importantly, compound 22b showed favorable pharmacokinetic properties and significantly induced tumor regression in a xenograft model without obvious toxicity. In brief, this study provided compound 22b as a novel c-Met degrader for lung cancer therapy.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoxiao Li,Yu Yan,Xiaonan Zheng,Yuan Yao,Yang Liu
Single atom catalysts (SACs) exhibit impressive catalytic activity for various reactions due to low coordination environment and tunable electronic structures, attracting increasing attention. However, it is big challenge to develop transition-metal-based SACs for oxygen reduction reaction (ORR) with high stability. Bioinspired by the structure and mechanism of vanadium-dependent haloperoxidase, we herein demonstrate that saturated coordination could boost ORR activity of atomically dispersed V-N-C catalyst combining DFT prediction and experimental verification. Spontaneous axial OH coordination to V-N-C catalyst in alkaline electrolyte not only optimizes the adsorption interaction for key intermediates to boost ORR activity, but also keeps vanadium atom at the highest valence against Fenton activity to improve the stability. The as-designed catalyst exhibits half-wave potential of 0.858 V vs . RHE for ORR, comparable to the commercial Pt/C benchmark. This work provides a proof-of-concept design of SACs and broadens the horizon of its potential applications.
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FUEL
·
2025
·
IF 7.5
Jie Liu,Lin Yang,Wenju Jiang,Zhongde Dai,Lu Yao,Junfeng Zheng,Xingjian Wang
In this study, the Cu/C@Zeolite catalysts with carbon-zeolite bifunctional support was developed by using the zeolite-induced one-pot homogeneous synthesis of CuBTC composite (CuBTC@Zeolite). Three different zeolites (ZSM-5, 13X, NaY) and the activation conditions were discussed. Originating from the defective structure of CuBTC in the composite and its interactivity with the zeolite, compared to Cu/C, the Cu/C@zeolite catalysts had the hierarchical pore system, a higher content of oxygen vacancies, stronger redox properties, and more active Cu sites with smaller particle sizes and more Cu + /Cu 2+ coexisting valence states, in synergy with acid sites, all of these contributing to the improved catalytic activity for VOCs oxidation removal. The activity of toluene catalytic oxidation indicated by T 90 was in the order of Cu/C@NaY (268.5 °C) > Cu/C@ZSM-5 (280.0 °C) > Cu/C@13X (287.0 °C) > Cu/C (320.0 °C). They also performed a better activity for acetone and ethyl acetate oxidation, obtaining the lowest T 90 at 217.0 and 231.5 °C respectively when the Cu/C@NaY used. Moreover, the Cu/C@NaY and Cu/C@ZSM-5 performed good water resistance and stability, suggesting the potential in practical application scenarios. These findings underscored the potential of Cu/C@Zeolite catalysts for addressing complex VOCs in simultaneous catalytic oxidation.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Hui Tao,Hanhan Liu,Hanchen Zhang,Hong Ren,Binyu Wen,Jing Zhang,Jiaqi Du,Ziyi Cai,Zhihong Deng
Uveal melanoma (UM), a malignant tumor originating within the ocular, characterizes high metastasis and lethality among patients. Cancer stem cells (CSCs) distinguished by the c-Met protein are believed to mediate tumor metastasis in UM. However, the low bioavailability of c-Met inhibitors like Crizotilib (Criz) limits their clinical application. Herein, a GSH-responsive nanoparticle named NP @Oxa/Criz to precisely deliver Criz and Oxaliplatin (Oxa) is synthesized in this study. The dual-action mechanism of NP @Oxa/Criz inhibits the HGF/c-Met axis to prevent the nuclear translocation of β-Catenin, thereby reducing the transcription of metastasis-associated genes and undermining the stemness and metastasis of UM cells. Simultaneously, NP @Oxa/Criz induces immunogenic cell death to boost anti-tumor immunity. In vivo studies demonstrate that NP @Oxa/Criz can accumulate in tumor sites, significantly eradicating the primary UM in the ocular and suppressing the metastasis UM in the liver and peritoneal. The outcomes from this work illuminate the therapeutic mechanisms of NP @Oxa/Criz and provide a precise and potent nanotherapeutic strategy for clinical treatment and research in highly metastatic UM.
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Current Research in Food Science
·
2025
·
IF 7
Le Cheng,Haoyue Bai,Mingfang Zhang,Fengping Yang,Difeng Ren,Yunpeng Du
The emerging technology of inhibiting polyphenol oxidase (PPO) is crucial for preventing enzymatic browning in food. This study aimed to investigate the effects of 4.5 kJ/m 2 ultraviolet (UV)-C radiation and 0.02 mg/mL L-cysteine (L-cys) treatment on the enzyme activity, physico-chemical properties, thermal properties, structure, and molecular microstructure of PPO. UV-C/L-cys decreased PPO activity and had the highest aggregation index and turbidity of PPO. UV-C/L-cys further reduced the denaturation temperature point and increased the denaturation enthalpy of PPO. UV-C/L-cys turned the α-helix to random coil of PPO and destroyed the tertiary structure. This combined treatment aggregated the microstructure of PPO, which led to covering the active center of the enzyme, leading to its inactivation. Molecular docking simulation confirmed that L-cys bound to PPO through hydrogen bonding and ionic contact. This study established a foundation for the application of UV-C radiation and L-cys treatment to control food browning.
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LANGMUIR
·
2025
·
IF 3.9
Shijiang Feng,Rong Qiang,Yulong Shao,Lei Rong,Fangjie Ren,Na Xiao,Siyuan Zhang,Zheng Guo,Caihong Chen,Qing Miao
The construction of hollow structures and the incorporation of metal nanoparticles have been shown to be two potential approaches to achieving high-performance microwave absorption. In this study, a hollow polyhedron material featuring an FeN/Fe-doped carbon matrix was synthesized by an acidification corrosion and pyrolysis strategy. The formation of heterojunctions, coupled with the design of hollow structures, significantly improved the dielectric loss capacity of the material. Furthermore, the incorporation of magnetic metal nanoparticles not only increased the magnetic loss but also enriched the loss mechanisms of the material, leading to an overall improvement in the magnetic loss. Under the synergistic effects of these factors, the material exhibited exceptional microwave absorption properties. In particular, at a material thickness of only 2.3 mm, the minimum reflection loss value of the FeN/Fe@HC nanocomposite reached −64.5 dB with an effective absorption bandwidth of 5.1 GHz. These results further highlight the importance of a hollow structure design and metal atom doping in improving microwave absorption performance.
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DEVELOPMENTAL CELL
·
2022
·
IF 13.417
Yangli Liu,Jun Zhou,Ning Zhang,Xueying Wu,Qian Zhang,Wenfeng Zhang,Xinyu Li,Ye Tian
Mitochondrial perturbations within neurons communicate stress signals to peripheral tissues, coordinating organismal-wide mitochondrial homeostasis for optimal fitness. However, the neuronal control of the systemic stress regulation remains poorly understood. Here, we identified a G-protein-coupled receptor (GPCR), SRZ-75, that couples with Gαq signaling in a pair of chemosensory ADL neurons to drive the mitochondrial unfolded protein response (UPR mt ) activation in the intestine via the release of neuropeptides in Caenorhabditis elegans. Constitutive activation of Gαq signaling in the ADL neurons is sufficient to induce the intestinal UPR mt , leading to increased stress resistance and metabolic adaptations. Ablation of ADL neurons attenuates the intestinal UPR mt activation in response to various forms of neuronal mitochondrial dysfunction. Thus, GPCR and its Gαq downstream signaling in two sensory neurons coordinate the systemic UPR mt activation, representing a previously uncharacterized, but potentially conserved, neuronal signaling for organismal-wide mitochondrial stress regulation.
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Catalysts
·
2022
·Vol. 12
·期 10
·1250
·
IF 4.501
Lei Zhao,Tingting Yu,Bing Yang,Huilin Guo,Lifen Liu,Jinlong Zhang,Changfei Gao,Tao Yang,Mingyan Wang,Yu Zhang
Unlike many studies on the preparation of Z-scheme heterojunctions by doping precious metals, in this paper we first prepared a core-shell material obtained by C doping in ZnO and then composite with MnO2to form a heterojunction; that is, a low-cost and highly catalytic ternary composite catalyst was prepared by a simple hydrothermal reaction. Meanwhile, a large amount of experimental data have enabled the heterostructure type as well as the mechanism of photocatalytic performance to be fully demonstrated. It is proven that C as an intermediate medium achieves electron transport while making up the deficiency of ZnO, and constitutes an all-solid state Z-scheme heterojunction, which enables the rapid transfer of photogenerated electron pairs and visible light irradiation to the stream to improve the photocatalytic performance of the composite photocatalyst. In terms of examination of degradation performance, this catalyst showed a high photodegradation rate of tetracycline hydrochloride (TC) of 92.6% within 60 min, and the surface ZnO-C/MnO2catalysts also showed good degradation effect on practical petrochemical wastewater in CODcr degradation experiments.Keywords:ZnO-C/MnO2;Z-scheme heterojunction;wastewater purification;mechanism exploring
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