MATERIALS & DESIGN
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2021
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IF 7.991
Youyou Huang,Jianan Zhang,Yue Zhang,Ling Shi,Xiru Qin,Bing Lu,Yue Ding,Yang Wang,Tingting Chen,Yong Yao
Multi-drug resistance (MDR) in tumor therapy often leads to relatively low efficiency of the current chemotherapeutics, attributing to the overexpression of P-glycoprotein (P-gp) increases the efflux of anticancer drugs out of the cells. To address this obstacle, herein, a photothermal-triggered nitric oxide (NO) gas releasing nanosystem was designed for reversing drug resistance in MDR cells based on mesoporous core–shell structured nanocomposites (MCSN) of Cu 2-x [email protected] 2 . The mesoporous shell provided the modification and encapsulation capacity for the NO donor— S -nitrosothiol (SNO) and doxorubicin (DOX) loading. Besides, the heat generated from the photothermal conversion of Cu 2-x Se could trigger NO gas generation and enhance DOX release in the acid microenvironment of cancer cells. The released NO gas in the cytoplasm could induce mitochondrial dysfunction to block adenosine triphosphate (ATP) synthesis and ATP-dependent drug efflux, thereby overcoming MDR. Therefore, this novel gas/chemo/photothermal triple-combination therapeutic nanoplatform is expected to be a potentially effective strategy against MDR and may reveal new insights for other NO gas-relevant medical applications.
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高影响因子
MICROCHEMICAL JOURNAL
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2021
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IF 4.821
Yeqing Xu,Ting Huang,Bo Hu,Minjia Meng,Yongsheng Yan
Molecular imprinted ratiometric fluorescent analysis method has been a popular method for the quantitative and qualitative tests of target analysis yet encounters low detection efficiency caused by the deep embedment and uneven distribution of fluorescent monomers, even the embedding rate of fluorescent monomer directly affects the visual detection effect. Herein, the ratiometric fluorescent molecularly imprinted polymers (F-PDA/CdTe QDs@SiO 2 @MIPs) based fluorescent polydopamine (F-PDA) and CdTe quantum dots (CdTe QDs) was successfully synthesized to detect p -nitrophenol ( p -NP) selectively and visually. F-PDA was firstly used in the synthesis of ratiometric fluorescent molecularly imprinted polymers to serve as both fluorescent monomer and functional monomer, which greatly shorten the detection time while reducing the fluorescence loss caused by polymer coating. The test results showed that the p -NP quenched the fluorescent of F-PDA via electron transfer. Meanwhile, F-PDA/CdTe QDs@SiO 2 @MIPs enabled to visually detect a low detection limit of p -NP (56.68 nM) within 2.0 min by naked eyes. The detection time was as fast as quantum dots detect targets directly and the detection limit was well below the standard concentration of p -NP in drinking water. Finally, the F-PDA/CdTe QDs@SiO 2 @MIPs realize the detection of p -NP in the drinking and wastewater respectively.
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Molecular Medicine Reports
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2021
·Vol. 25
·期 2
·1-9
·
IF 2.952
Fa-Xiu Chen,Qin Wan,Qing-Ling Li,Jing Fang,Le Peng,Jian Hu
The function of substance P (SP) in myocardial ischemia is well understood, but its effects on congestive heart failure are unclear. The present study aimed to use in vitro and in vivo approaches to investigate the effects of SP on doxorubicin‑induced cardiomyocyte injury. Pathological changes, apoptosis, cardiomyocyte ultrastructure and molecular mechanisms were evaluated in vitro and in vivo. The effects of SP on cell viability of H9c2 myocardial cells were evaluated using the Cell Counting Kit‑8 and flow cytometry. B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax), Beclin‑1 and microtubule‑associated protein 1A/1B‑light chain 3 (LC3) were detected by western blotting. Heart failure in rats was established by intraperitoneal injection of doxorubicin. The in vitro data demonstrated that SP at concentrations of 1 µg/ml inhibited doxorubicin‑induced apoptosis of H9c2 cells. Administration of doxorubicin reduced Bcl‑2, Beclin‑1 and LC3 expression levels in H9c2 cells, while having no effect on Bax levels. Administration of SP to these doxorubicin‑treated cells did not affect Bcl‑2 or Bax expression, but further reduced Beclin‑1 while inhibiting the reduction in LC3 expression. In vivo, food intake was significantly increased in rats in the SP group compared with the model group. Cardiomyocytes in the heart‑failure group underwent dysfunctional autophagy as ascertained by transmission electron microscopy. Compared with the heart‑failure group, these pathological changes, including loss of striations and vacuolation, were inhibited by SP treatment, which promoted Bax expression, reduced Beclin‑1 expression and inhibited the reduction in LC3 expression. Taken together, SP reduced cardiomyocyte apoptosis in doxorubicin‑induced cardiomyocyte injury, likely by promoting autophagy, which suggested that SP is a potential therapeutic target for doxorubicin‑induced heart failure.
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高影响因子
POLYMER DEGRADATION AND STABILITY
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2021
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IF 5.03
Weimiao Lu,Zhenfu Jin
Intumescent flame retardants (IFR) with phosphorus (P)/nitrogen (N)-containing diphenols (DH, DV and DS) were synthesized from p -hydroxybenzaldehyde (H), vanillin (V) and syringaldehyde (S) with different methoxyl groups on its aromatic ring. The FTIR, 1 H NMR, 13 C NMR, XPS methods were used to characterize the structures of IFR, and LOI, CCT, SEM, TG methods were used to investigate the flame retardancy and thermal stability of rigid polyurethane (RPU) foams when the three IFR were incorporated into RPU foams. Compared with H, V and S, the DH, DV and DS FTIR spectra showed absorption peaks at 3450 cm −1 , 1160 cm −1 , and 1222 cm −1 , 1050 cm −1 and 740 cm −1 , respectively, which attributed to N H, C N, and P = O , P-O, P-C groups. The 1 H NMR spectra of DH, DV and DS showed proton signals at 4.8 and 6.0 ppm, which were corresponding to H1 and H2 of C N groups, and corresponding C1 signal appeared around 62.3 ppm in the 13 C NMR spectra. The XPS spectra of DH, DV, DS showed peaks at 285, 398 eV and 133.5, 532 eV, which may be due to corresponding C1s, N1s of C N groups and P2p and O1s of P-O-C groups, respectively. These results indicated that the target compounds P/N-containing diphenols DH, DV and DS were synthesized successfully. Flame retardancy index (FRI) values of RPU-DH, RPU-DV, and RPU-DS were 2.33, 2.30 and 2.43, respectively, suggesting that DH, DV, and DS were good flame retardant additives. The THR and HRR values of RPU-DH, RPU-DV, RPU-DS foams were much lower than that of RPU foam. The fire growth rate (FIGRA) of RPU-DH, RPU-DV, and RPU-DS was 29.4%, 30.3%, and 24.4% lower comparing to RPU foam. The LOI value of RPU foam was 19%, while LOI values of RPU-DH, RPU-DV and RPU-DS foams increased to around 26%. These results suggested that the flame retardancy of RPU foams were improved by incorporating DH, DV, and DS. Compared with RPU foam, the CY 600 of RPU-DH, RPU-DV and RPU-DS foams increased by 215.2%, 152.2% and 195.6%, respectively, and the char residue after CCT were much compact and homogeneous, which could reduce heat and mass transfer, protecting underlying materials from further combustion in a fire. In conclusion, the P/N-containing diphenols DH, DV and DS were synthesized successfully, and they were good flame retardant additives. The char residue of RPU-DH, RPU-DV and RPU-DS foams increased remarkably, and formed compact and homogeneous char layer. The flame retardancy and thermal stability of RPU-DH, RPU-DV, RPU-DS foams were improved by incorporating DH, DV, and DS.
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CHEMOSPHERE
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2021
·
IF 7.086
Lin Zhou,Faqin Dong,Wei Zhang,Yuheng Chen,Lei Zhou,Fei Zheng,Zhenzhen Lv,Jingyuan Xue,Dengliang He
The biosorption and biomineralization behavior of U(VI) by Kocuria rosea with uranium resistance higher than other general microorganisms was investigated in this study. The results showed the obvious effects of initial U(VI) concentration, biomass, time, and especially pH, and presented that U(VI) was immobilized to K. rosea by physical and chemical action. The characterization results for the precipitation proved that U–P minerals with U(VI) (H 3 OUO 2 PO 4 ·3H 2 O, H 2 (UO 2 ) 2 (PO 4 ) 2 ·8H 2 O) or U(IV) (CaU(PO 4 ) 2 ) were dominant, and the crystallization level increased with time. In the process, the phosphorous containing groups, amino, hydroxyl and carboxyl groups played important roles in adsorption of U(VI), and the phosphate groups were crucial in immobilization of uranium, showing the importance of groups containing phosphorus in both biosorption and biomineralization processes. Our findings focus on the biosorption and biomineralization mechanism of U(VI) by K. rosea , emphasize the synergy of physical adsorption and chemical immobilization in the process and formation of U(VI)–P and U(IV)–P minerals, and highlight the significance of phosphorus involvement in the reaction.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
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IF 5.316
Xijun He,Xiaodong Wang,Ming Tang,Han Zhang,Yu Wang
Searching for high specific capacity anode materials with an optimized structure to achieve high energy density , long cycling life-span, and high rate performance for lithium-ion batteries (LIBs) is a pressing assignment. Metal phosphides have aroused much attention, however, enormous volume variations, poor electrical conductivity , and aggregation of nanoparticles hamper their practical applications. Herein, ZnP 2 nanoparticles grown on N, P co-doped carbon nanofibers (ZnP 2 @NPCNFs) composite synthesized by electrospinning and heat treatment is reported to directly act as binder-free anode in LIBs. The 3D self-standing ZnP 2 @NPCNFs featuring good flexibility can not only boost conductivity and alleviate the volumetric fluctuations in the cycling course, but also buffer the agglomeration and pulverization of nanoparticles. Lithium storage of ZnP 2 @NPCNFs electrode obey the conversion reaction mechanism. Besides, the additional lithium intercalation active sites created by the doped-nitrogen and the existence of P C bond along with the space-confined effect of NPCNFs are conjointly beneficial to endow the ZnP 2 @NPCNFs electrode with distinctive electrochemical properties . When assembled as the anode, the ZnP 2 @NPCNFs electrode reached a high reversible capacity of 746 mA h g −1 after 100 cycles at 0.2 A g −1 and 406.49 mA h g −1 after 1000 cycles at 2 A g −1 . Electrochemical tests manifest that most of the capacity contribution comes from capacitive process. Moreover, the similar superior electrochemical performances are obtained in the LiFePO 4 //ZnP 2 @NPCNFs full cell. Generally, this study widens researchers’ horizons to conceive rational structure of metal phosphides anodes in LIBs with high capacity conservation.
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高影响因子
ChemCatChem
·
2021
·Vol. 14
·期 1
·e202101311
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IF 5.686
Hang Yu,Ximeng Zhao,Feichao Wu,Yuhong Luo,Aizhong Jia,Yanji Wang,Jingde Li
Graphical Electrocatalysis : This work is about the development of the 3DOM Co/NPC@TiO 2-x ORR electrocatalyst. The unique TiO 2-x -based 3DOM structure and the synergistic between N, P co-doping and Co-decoration contribute to improve the ORR catalytic activity and stability. The proposed electrocatalyst exhibits an outstanding half-wave potential of 0.86 V in alkaline electrolyte. The resulting primary and flexible zinc-air batteries also deliver considerable performance. Developing efficient and durable electrocatalysts of oxygen reduction reaction (ORR) is critical for high-performance air cathodes. Herein, a novel three-dimensionally ordered macroporous oxygen-deficient TiO 2 framework embedded with N, P and Co-tridoped carbon (3DOM Co/NPC@TiO 2-x ) is elaborately designed for ORR. This unique structure offers a high surface area, good mass transfer, excellent electronic conductivity, and stability. Moreover, the experimental and theoretical studies reveal that the synergistic effect of N, P co-doping and Co-decoration is indispensable to promote the ORR performance, yielding high O 2 adsorption energy and lowering the reaction barriers simultaneously. Accordingly, the ORR catalytic activity and stability of the proposed electrocatalyst are better than Pt/C in alkaline media. The resulting primary zinc-air battery delivers a high open-circuit voltage (1.50 V) and specific capacity (820 Wh kg −1 ) at 20 mA cm −2 . This strategy, combining macroporous oxygen-deficient oxide support with binary heteroatom doping, provides a new perspective for exploiting efficacious ORR electrocatalysts.
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JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
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2021
·Vol. 98
·期 6
·673-682
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IF 1.849
Changqing Miao,Yanbo Wang,Zhiying Ma,Yang Luo,Yu Miao,Pingfang Yuan,Jiao Guo,Gairong Chen,Hongbo Liu
In this study, poly( p- phenylenediamine) (PPDA) was synthesized by an enzymatic polymerization method using p- phenylenediamine as the monomer in the water phase. The PPDA structure was characterized by infrared (IR), gel permeation chromatography, and elemental analysis. The antioxidation behavior of the as-synthesized PPDA in biodegradable castor oil was investigated using a rotary oxygen bomb test and pressurized differential scanning calorimetry. A theoretical calculation was conducted to investigate its antioxidation mechanism. PPDA was found to exhibit excellent oxidation resistance in castor oil at 150 °C, which effectively prolonged the oxidation induction time of the oil. The results obtained herein suggest that as with phenolic antioxidants, PPDA with a hindered structure effectively improves the antioxidation performance of the oil by enhancing the stability of nitrogen free radicals.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-20
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IF 10.435
Deng Xuanru,Liu Hongxing,Xu Yuan,Chan Leung,Xie Jun,Xiong Zushuang,Tang Zheng,Yang Fang,Chen Tianfeng
Background The design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is imminent.Results Herein, black phosphorus nanosheets (BPs) covalently with mono-dispersed and superparamagnetic ferrous selenide (FeSe2) to construct heteronanostructure nanoparticles modified with methoxy poly (Ethylene Glycol) (mPEG-NH2) to obtain good water solubility for MRI-guided photothermal tumor therapy is successfully designed. The mechanism reveals that the enhanced photothermal conversion achieved by BPs-FeSe2-PEG heteronanostructure is attributed to the effective separation of photoinduced carriers. Besides, through the formation of the P-Se bond, the oxidation degree of FeSe2 is weakened. The lone pair electrons on the surface of BPs are occupied, which reduces the exposure of lone pair electrons in air, leading to excellent stability of BPs-FeSe2-PEG. Furthermore, the BPs-FeSe2-PEG heteronanostructure could realize enhanced T2-weighted imaging due to the aggregation of FeSe2 on BPs and the formation of hydrogen bonds, thus providing accurate PTT guidance and generating hyperthermia to inhabit tumor growth under NIR laser with negligible toxicity in vivo.Conclusion sCollectively, this work offers an opportunity for fabricating BPs-based heteronanostructure nanomaterials that could simultaneously enhance photothermal conversion efficiency and photostability to realize MRI-guided cancer therapy.Graphic abstract
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高影响因子
MOLECULES
·
2021
·Vol. 26
·期 8
·2208
·
IF 4.412
Muhammad Sajid,Muhammad Rizwan Dilshad,Muhammad Saif Ur Rehman,Dehua Liu,Xuebing Zhao
Furfural is one of the most promising precursor chemicals with an extended range of downstream derivatives. In this work, conversion of xylose to produce furfural was performed by employingp-toluenesulfonic acid (pTSA) as a catalyst in DMSO medium at moderate temperature and atmospheric pressure. The production process was optimized based on kinetic modeling of xylose conversion to furfural alongwith simultaneous formation of humin from xylose and furfural. The synergetic effects of organic acids and Lewis acids were investigated. Results showed that the catalystpTSA-CrCl3·6H2O was a promising combined catalyst due to the high furfural yield (53.10%) at a moderate temperature of 120 °C. Observed kinetic modeling illustrated that the condensation of furfural in the DMSO solvent medium actually could be neglected. The established model was found to be satisfactory and could be well applied for process simulation and optimization with adequate accuracy. The estimated values of activation energies for xylose dehydration, condensation of xylose, and furfural to humin were 81.80, 66.50, and 93.02 kJ/mol, respectively.Keywords:catalysis;chlorides;furfural;kinetics;lewis acid;p-toluenesulfonic acid;xylose
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Nano Energy
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2021
·
IF 17.881
Liqin Yao,Zhao Zhang,Qi-long Zhang,Zheng Zhou,Hui Yang,Lu Chen
A lot of efforts have been devoted to enhance the outputs of triboelectric nanogenerators (TENGs) via optimizing the friction materials in recent years. Here, the modified organic polystyrene (PS) microspheres embedded Poly[(vinylidene fluoride)-co-trifluoroethylene] P(VDF-TrFE) composites are developed to construct lotus-leaf surface microstructure and enhance the permittivity of P(VDF-TrFE). Besides, owing to the rich positively charged -NH 3 groups of the hexadecyl-trimethyl-ammonium-bromide (CTAB) in the solvent, the surface potential of composites is significantly improved by CTAB modified PS microspheres. Coupling of designed surface microstructure, high permittivity, and enhanced surface potential, the TENG assembled by P(VDF-TrFE) (+) and Polytetrafluoroethylene (PTFE, -) exhibits considerable outputs (the short-circuit current density and peak power density are 47.45 mA/m 2 and 7.88 W/m 2 , respectively), much higher than those of pristine P(VDF-TrFE) and unretouched PS/P(VDF-TrFE). In the applications, 413 LEDs in series can be lighted up directly by the TENG without energy storage. A smart mouse pad is also proposed to work as the self-powered sensor to detect typical mouse motions. This research provides a comprehensive solution to optimize the positive friction material in simple and feasible methods of surface/interface design and surface potential regulation.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 7
·1-13
·
IF 3.097
Yao Qi,Lan Hai,Li Xin,Chen Youyi
Organic–inorganic interpenetrating network poly (acrylic acid- co -acrylamide) IPN-P(AA-co-AM) polymer sphere with core–shell structure has been synthesized by modified suspension polymerization, which the core is high cross-linked and shell is light cross-linked, respectively. The dispersed phase (water phase) and continuous phase (oil phase), as well as core and shell crosslinking agent are screened based on the water absorption capacity of the polymer spheres. In addition, SiO 2 is applied to endow polymer spheres with excellent thermal and water absorption properties. FTIR, TG, SEM, and XPS analyze the chemical structure, thermal properties, morphology and surface element of polymer spheres, respectively. Particularly, the forming mechanism of polymer spheres and water absorption dynamic model are discussed in detail. The results show that the Organic–inorganic IPN-P(AA-co-AM) polymer spheres are successfully synthesized. The polymer spheres could be wrapped effectively when the SiO 2 content up to 2%. Compared to polymer spheres without SiO 2 , the thermal stability is greatly improved. The optimum core and shell crosslinking agent are pentaerythritol triacrylate (PETA) and sodium alginate, respectively. The maximum absorption capacity of polymer spheres for distilled water and 0.9wt% sodium chloride can up to 922.22 g/g and 93.87 g/g, respectively. Finally, the water absorption of IPN-P(AA-co-AM) polymer spheres dynamic model is closed to second-order.
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