CERAMICS INTERNATIONAL
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2024
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IF 5.1
Lei Han,Ruiling Du,Yu Chen,Ling Zhang,Huifang Wang,Haijun Zhang,Shaowei Zhang
Porous high-entropy transition metal compounds, an important type of ultra-high temperature material, have attracted increasing attention in the applications of extreme environments due to their low density, good thermal insulation and stable chemical properties. A robust, flame-retardant and high-temperature resistant high-entropy carbonitride (Ti 1/5 V 1/5 Mo 1/5 Nb 1/5 Ta 1/5 )(C 0.55 N 0.45 ) (HECN) porous ceramic was synthesized and thoroughly characterized. It exhibited a porosity of 93.5 %, a compressive strength of 1.3 MPa and a good high-temperature stability up to 1673 K, which, along with its outstanding fire-retardancy, and low thermal conductivity (as low as 0.150 W m −1 K −1 at 298 K), made it a good candidate material for thermal insulation applications in ultra-high temperature environments. Moreover, the Density functional theory (DFT) calculations predict that the [N]/([C]+[N]) ratio in HECN foam affects its lattice thermal conductivity which is decreased by 67 % upon increasing the ratio from 0 to 1/2.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
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IF 19.503
Tianci Xiao,Xiaohao Liu,Guangyue Xu,Ying Zhang
Crystal structure of catalyst support has great influence on its surface and electronic properties. Thus, tuning the crystal phase may adjust the catalytic activity. Herein, we prepared a series of monoclinic, tetragonal and mixed phase of Co/ZrO 2 catalysts, denoted as Co/m-ZrO 2 , Co/t-ZrO 2 and Co/Mix-ZrO 2 . They showed different hydrogenation and hydrogenolysis activities in conversion of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF). The characterization and catalytic performance indicated that the interaction between cobalt and t-ZrO 2 resulted in cobalt electron-deficiency and higher concentration of Zr(III) species, which contributed to the higher hydrogenation activity of carbonyl on Co/t-ZrO 2 than Co/m-ZrO 2 . While the hydrogenolysis of C OH group showed higher efficiency on Co/m-ZrO 2 , which was determined by the acid concentration on the surface of catalysts. The combination of both high hydrogenation and hydrogenolysis activities in Co/Mix-ZrO 2 achieved the highest yield of DMF (90.7 %) under mild conditions of 130 °C and 1 MPa H 2 .
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JOURNAL OF THE ENERGY INSTITUTE
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2024
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IF 5.6
Shunnian Xu,Zhiguo Sun,Kaijun Hou,Gang Wang,Meijia Liu,Yahong Zhang,Chenwei Zhang,Zhongdong Zhang
Undesirable side reactions often occur during the catalytic pyrolysis of olefins in FCC gasoline to produce light olefins. We proposed a method to maximize light olefin selectivity by suppressing these side reactions. In this study, P-ZSM-5 and Ce–P-ZSM-5 were prepared by the pore volume impregnation method to investigate the regulatory relationship between their acidity/alkalinity and catalytic pyrolysis. The study found that acid sites could promote the olefin conversion and adjust the cracking pathway. Furthermore, the densities of strong B acid sites and base sites could regulate olefin adsorption, affecting hydrogen transfer activity. Acid strength was crucial in controlling the aromatization reaction. It showed that thermal cracking played a minor role in catalytic pyrolysis, with methane generation mainly resulting from acid sites promoting the cracking of terminal C–C bonds. Loading phosphorus strengthens the acidity of ZSM-5, while loading cerium weakens its acidity and enhances its alkalinity. By optimizing the acidity and alkalinity of ZSM-5, side reactions were suppressed, maximizing the selectivity of light olefins. The results showed that the light olefin selectivity of Ce–P-ZSM-5 increased from 33.2% to over 80%, while the side reaction selectivity decreased from over 60% to below 10%. This work will lay a good foundation for developing catalysts for catalytic pyrolysis of olefins to produce light olefins.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
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2025
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IF 6.8
Zhaoxiang Song,Huaduan Liang,Chu Xue,Shuxian Wang,Younan Ren,Zhuang Zhang,Tifei Xu,Bo Niu,Mengmeng Song,Mengru Liu,Xu Qin,Jie Li,Xianya Zhao,Fang Zhao,Jianhua Shen,Zhengyu Cao,Kai Wang
Transient receptor potential canonical channels 4 and 5 (TRPC4/5) are nonselective cation channels involved in emotional regulation, positioning them to be promising targets for treating mental disorders such as anxiety and depression. HC-070, a potent TRPC4/5 inhibitor, exhibits significant anxiolytic and antidepressant effects in animal models, though its drug-like properties require optimization. In this study, we applied a property-based drug design (PBDD) approach to optimize HC-070, leading to the discovery of compound 32, which shows improved LipE and Fsp3 values, reduced hERG blocking activity, enhanced metabolic stability, increased aqueous solubility, and superior oral bioavailability. Oral administration of compound 32 in mouse models demonstrates anxiolytic and antidepressant efficacy comparable to fluoxetine. This study supports the therapeutic potential of TRPC4/5 inhibitors for mental disorders and identifies compound 32 as a promising candidate for further investigation. Furthermore, our work underscores the value of PBDD in optimizing lead compounds during drug discovery process.
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PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
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IF 4.3
Dongyang Liu,Yuen Bai,Dongdong Chen,Nan Zhang,Liang Zhao,Jinsen Gao,Chunming Xu
This study investigates the co-cracking of n-hexane and 1-hexene, utilizing 1-hexene as an olefinic initiator to improve light olefin yields. Experimental investigations, kinetic analyses, and density functional theory calculations (DFT) were used to systematically explore cracking performance, interactions, and mechanisms for co-feeding. Comparied with single feeding of n-hexane, leading to higher light olefin yields (increased from 35.77 wt% to 58.61 wt%) when the olefin content is 20 wt%. Kinetic analysis revealed a shift from protolytic to hydrogen transfer cracking pathway when 1-hexene content exceeded 13.6 wt%, with the maximum cracking rate (13.12 h −1 ) constant at 20 wt% olefin content. DFT calculations showed a lower energy barrier for hydrogen transfer cracking between n-hexane and 1-hexene, compared to n-hexane cracking alone. Therefore, a co-cracking mechanism was proposed, involving paraffin activation through carbocation intermediates generated by olefin, followed by β-cracking to generated light olefins and carbenium ion regeneration, establishing a framework for paraffin-olefin co-conversion.
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高影响因子
Joule
·
2025
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IF 35.4
Huaimin Jin,Xingyu Wang,Simeng Zhang,Xiangzhen Zhu,Chong Liu,Junyi Yue,Jie Qu,Bei Wu,Xu Han,Yueyue Wang,Yang Xu,Han Wu,Liyu Zhou,Mingying Zhang,Hao Lai,Shuo Wang,Jiangwen Liang,Xueliang Sun,Xiaona Li
Fluoride solid-state electrolytes (SSEs) offer superior electrochemical stability, making them theoretically ideal for high-voltage all-solid-state batteries (ASSBs), but their low Li + conductivity hinders practical application. Here, we exploit the polyanion coordination strategy to develop a class of fluoride SSEs, Li x Ti(PO 4 ) x /3 F 4 , which exhibits high ionic conductivity and ultrahigh-voltage stability. Especially, Li 1.3 Ti(PO 4 ) 1.3/3 F 4 (1.16 × 10 −5 S cm −1 ) demonstrates a two-order-of-magnitude enhancement in Li + conductivity compared to analogous Li 2 TiF 6 . Combined experimental and theoretical analyses reveal that the high ionic conductivity of Li x Ti(PO 4 ) x /3 F 4 arises from weakened Li + -surrounding interactions and flexible network structures. Attractively, the exceptional ionic conductivity and ultrahigh-voltage stability of Li 1.3 Ti(PO 4 ) 1.3/3 F 4 enable a low-resistance and highly stable electrolyte-electrode interface, contributing to 91.6% capacity retention after 200 cycles for 5 V-class LiNi 0.5 Mn 1.5 O 4 -based ASSBs at 1 C and 30°C. The discoveries in this work open a new avenue for designing high-conductivity fluoride SSEs, paving the way for the application of high-voltage cathodes in high-energy-density ASSBs.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Junzhe Fu,Weijiang Yu,Yixian Mu,Xuedan Qian,Xinyi Li,Ke Sun,Youxiang Wang,Jian Ji
Hypertrophic scars (HS) result from aberrant wound healing, often leading to disfigurement and functional impairment. Hypoxia is a prominent feature of HS; however, its impact on therapeutic efficacy remains unexplored, presenting a potential pathway for advancing HS treatments. Here, hypoxia is identified as a limiting factor in the efficacy of 5-fluorouracil (5-Fu), a widely used clinical drug for HS. At the gene expression level, 5-Fu response genes associated with the mitotic cell cycle, such as BUB1 and SPAG5, fail to be downregulated under hypoxia in human HS fibroblasts, contributing to the altered cytotoxic response. To address this limitation, an oxygen-popping microneedle (MN) system is developed to alleviate hypoxia in HS and enhance 5-Fu-based therapy. Inspired by the gas-release mechanism of Pop Rocks candy, high-pressure oxygen-trapping particles (HOTP) are formulated and integrated into a core–shell MN platform, enabling localized co-delivery of oxygen and 5-Fu. The popping release of oxygen also facilitates 5-Fu penetration into dense HS tissue. In vivo studies provide strong evidence that the MN system effectively mitigates hypoxia, significantly enhancing the therapeutic efficacy of 5-Fu. This research presents an innovative strategy for optimizing HS therapy by alleviating hypoxia, with the potential to inform future advancements in HS treatment.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2019
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IF 3.414
Yuxuan Gan,Gaoxiang Ai,Jiazhen Wu,Huijuan Luo,Liping Chen,Qionghui Huang,Xue Wu,Nan Xu,Minyao Li,Ziren Su,Yuhong Liu,Xiaoqi Huang
Ethnopharmacological relevance Pogostemon cablin , commonly named “Guang-Huo-Xiang” in China, has long been renowned for its ability to dispel dampness and regulate gastrointestinal functions. Patchouli oil (P.oil), the major active fraction of Pogostemon cablin , has been traditionally used as the principal component of Chinese medicinal formulae to treat exterior syndrome and diarrhea. However, the effects of P.oil in treating 5-fluorouracil (5-FU)-induced intestinal mucositis have not yet been reported. Aim of the study To investigate the protective effects of P.oil against 5-FU-induced intestinal mucositis and the mechanisms underlying these effects. Materials and methods Sprague-Dawley rats were intraperitoneally injected with 5-FU (30 mg/kg) to establish an intestinal mucositis model. Meanwhile, rats with intestinal mucositis were orally administered with P.oil (25, 50, and 100 mg/kg). Histological analysis, ELISA (for detecting inflammatory cytokines and aquaporins), immunohistochemistry analysis (for examining caspases), qRT-PCR analysis (for assessment tight junctions), and western blotting analysis (for the assessment of TLR2/TLR4-MyD88 and VIP-cAMP-PKA signaling pathway-related proteins) were performed to estimate the protective effects of P.oil against intestinal mucositis and the mechanisms underlying these effects. Results The histopathological assessment preliminarily exhibited that P.oil alleviated the 5-FU-induced damage to the intestinal structure. After P.oil administration, the elevation of the expression of cytokines (TNF-α, IFN-γ, and IL-13) decreased markedly and the activation of NF-κB and MAPK signaling was significantly inhibited. P.oil also increased the mRNA expression of ZO-1 and Occludin , thereby stabilizing intestinal barrier. In addition, P.oil decreased the expressions of caspase-8, caspase-3, and Bax, and increased the expression of Bcl-2, thereby reducing the apoptosis of the intestinal mucosa. These results were closely related to the regulation of the TLR2/TLR4-MyD88 signaling pathway. It has been indicated that P.oil possibly protected the intestinal barrier by reducing inflammation and apoptosis. Furthermore, this study showed that P.oil inhibited the abnormal expression of AQP3, AQP7, and AQP11 by regulating the VIP-cAMP-PKA signaling pathway. Furthermore, it restored the intestinal water absorption, thereby alleviating diarrhea. Conclusions P.oil ameliorated 5-FU-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport.
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PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
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IF 5.876
En-Hui Yuan,Meng Li,Ming-Hui Yang,Xiaosheng Huang,Kun Zhang,Weiliang Han,Zhicheng Tang,Zhong-Wen Liu
A direct hydrothermal synthesis strategy is developed to prepare the Cu–Fe-ZSM-5 zeolites by using the ethylenediaminetetraacetic acid disodium dihydrate (EDTA-2Na·2H 2 O) chelated Cu 2+ and Fe 3+ precursors as metal sources. During the crystallization, the metal chelates were spontaneously embedded into the ZSM-5 crystals and subsequently transformed to the zeolites encapsulated copper and iron species after removing the chelating agent via the high-temperature calcination . Rigorous characterizations indicate that the resulted Cu 2+ /Cu + and Fe 3+ /Fe 2+ species are formed ultra-small nano-composites with an average diameter of ∼2.2 nm and highly dispersed in the ZSM-5 zeolite crystals. The acidity of the ZSM-5 zeolites is subtly modulated by the encapsulated Cu–Fe nano-composite. As expected, the as-prepared Cu–Fe-ZSM-5 exhibits outstanding catalytic performance for the selective catalytic reduction of NO x with ammonia (NH 3 -SCR) in the broad reaction temperature ranges of 220–480 °C, which is much better than the Cu–Fe/ZSM-5 prepared with the conventional wetness impregnation method. Furthermore, the resultant zeolites show high stability and good tolerance to H 2 O and SO 2 , and it is very competitive for practical application to eliminate NO x . The developed one-pot hydrothermal synthesis route by using EDTA-2Na·2H 2 O as chelating agent is very convenient and easily reproducible, providing a general guideline to design and fabricate the superior transition metal modified zeolite catalysts for NH 3 -SCR and the related reactions.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2019
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IF 4.191
Yazhen Chen,Hetong Lin,Yanjie Li,Mengshi Lin,Jicheng Chen
Non-enzymatic browning of vinegar soaked-soybean residual solution was investigated using a model solution. A glycine-fructose-gallic acid model system was proposed by analyzing reducing sugars, amino acids, total phenolics, and pH value of the vinegar soaked-soybean residual solution. Based on the proposed model, the kinetics of 5-hydroxymethylfurfural (5-HMF) formation was also studied. The results showed that Maillard reaction and sugar pyrolysis might be the accurate mechanisms of non-enzymatic browning in vinegar soaked-soybean residual solution. The formation of 5-HMF in the model solution exhibited characteristics of the first-order kinetic model at temperature from 60 to 140 °C. The frequency constant k f was 450.65 /h, and the apparent activation energy E a was 20.15 kJ/mol. Acetic acid, Fe 2+ , and Fe 3+ significantly enhanced the browning rate and 5-HMF formation; whereas Ca 2+ , Mg 2+ , Na + , glucose oxidase, and H 2 O 2 inhibited the browning rate.
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高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
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IF 5.89
Yang Bin,Sun Yiwen,Fu Shouying,Xia Miaomiao,Su Yuan,Liu Chuan,Zhang Chunzhi,Zhang Dawei
Ribulose 5-phosphate (Ru5P) and guanosine 5′-triphosphate (GTP) are two key precursors of riboflavin, whereby Ru5P is also a precursor of GTP. Ribulose 5-phosphate 3-epimerase (Rpe) catalyzes the conversion of ribulose 5-phosphate into xylulose 5-phosphate. Inactivation of Rpe can reduce the consumption of Ru5P, enhancing the carbon flux toward riboflavin biosynthesis. Here we investigated the effect of mutation of rpe and other related genes on riboflavin production, physiological and metabolic phenotypes in Bacillus subtilis LY (BSLY). Introducing single nucleotide deletion (generated BSR) or nonsense mutation (generated BSRN) on the genomic copy of rpe, resulting in more than fivefold increase of riboflavin production over the parental strain. BSR process 62% Rpe activity, while BSRN lost the entire Rpe activity and had a growth defect compared with the parent strain. BSR and BSRN exhibited increases of the inosine and guanine titers, in addition, BSRN exhibited an increase of inosine 5′-monophosphate titer in fermentation. The transcription levels of most oxidative pentose phosphate pathway and purine synthesis genes were unchanged in BSR, except for the levels of zwf and ndk, which were higher than in BSLY. The production of riboflavin was increased to 479.90 ± 33.21 mg/L when ribA was overexpressed in BSR. The overexpression of zwf, gntZ, prs, and purF also enhanced the riboflavin production. Finally, overexpression of the rib operon by the pMX45 plasmid and mutant gnd by pHP03 plasmid in BSR led to a 3.05-fold increase of the riboflavin production (977.29 ± 63.44 mg/L), showing the potential for further engineering of this strain.
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高影响因子
International Journal of Nanomedicine
·
2023
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IF 8
Chao Zhang,Mengnan Han,Fanghua Zhang,Xueli Yang,Jie Du,Honglei Zhang,Wei Li,Shengxi Chen
Background Chemotherapy, as an adjuvant treatment strategy for HER2-positive breast cancer, can effectively improve clinical symptoms and overcome the drug resistance of therapeutic monoclonal antibodies. Nucleoside analogues are a class of traditional chemotherapeutic drugs that are widely applied in adjuvant therapy. However, there are many critical issues that limit their clinical efficiency, including poor selectivity and stability, severe side effects and suboptimal therapeutic efficacy. Hence, this work aims to develop a new DNA nanocarrier for targeted drug delivery to solve the above problems.Methods Four 41-mer DNA strands were synthesized and 10 FUdR molecules were attached to 5ʹ end of each DNA strand by DNA solid-phase synthesis. An affibody molecule was connected to the end of polymeric FUdR through a linker in one of the four strands. The affibody-FUdR-tetrahedral DNA nanostructures (affi-F/TDNs) were self-assembled through four DNA strands, in which one vertex was connected to an affibody at the end of a polymeric FUdR tail and three vertices were only polymeric FUdR tails. In vitro cellular uptake of affi-F/TDNs was examined visually with confocal fluorescence microscopy and flow cytometry, and the cytotoxicity of affi-F/TDNs against cancer cells was investigated with MTT assay. Cell apoptosis was detected by Annexin V-FITC/PI double staining method. Using NOD/SCID (Mus Musculus) mice model, the targeted killing efficacy of affi-F/TDNs was also evaluated.Results The drug-loading of FUdR in affi-TDNs was 19.6% in mole ratio. The in vitro results showed that affi-F/TDNs had high selectivity and inhibition (81.2%) for breast cancer BT474 cells overexpressing HER2 and low toxicity in MCF-7 cells with low HER2 expression. During the in vivo application, affi-F/TDNs displayed good stability in the blood circulation, achieved specific accumulation in tumor region and the best antitumor efficacy (inhibition ratio of 58.1%), and showed excellent biocompatibility.Conclusions The affibody-DNA tetrahedrons, as a simple and effective active targeting delivery nanocarrier, provided a new avenue for the transport of nucleoside antitumor drugs.
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高影响因子
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