JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-14
·
IF 10.435
Yang Yuming,Han Yu,Sun Qiuyang,Cheng Jin,Yue Caixia,Liu Yanlei,Song Jie,Jin Weilin,Ding Xianting,de la Fuente Jesús M.,Ni Jian,Wang Xiaoqiang,Cui Daxiang
Background Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, targeted, and safe delivery systems that can avoid siRNA degradation and reduce the toxicity and adverse effects of chemotherapy medicine.Results In this paper, a highly efficient AS1411 aptamer modified, dsDNA and MMP-2 cleavable peptide-fabricated gold nanocage vehicle, which could load doxorubicin hydrochloride (DOX) and siRNAs to achieve a combination of tumor responsive genetic therapy, chemotherapy, and photothermal treatment is presented. Our results show that this combined treatment achieved targeted gene silencing and tumor inhibition. After nearly one month of treatment with DOX-loaded Au-siRNA-PAA-AS1411 nanoparticles with one dose every three days in mice, a synergistic effect promoting the eradication of long-lived tumors was observed along with an increased survival rate of mice. The combined genetic, chemotherapeutic, and photothermal treatment group exhibited more than 90% tumor inhibition ratio (tumor signal) and a ~ 67% survival rate compared with a 30% tumor inhibition ratio and a 0% survival rate in the passive genetic treatment group.Conclusion sThe development of nanocarriers with double-stranded DNA and MMP-2 cleavable peptides provides a new strategy for the combined delivery of gene and chemotherapy medicine. Au-siRNA-PAA-AS1411 exerts high anticancer activities on lung cancer, indicating immense potentials for clinical application.
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ANALYST
·
2020
·Vol. 146
·期 3
·956-963
·
IF 3.978
Jun Ma,Gege Feng,Ying Ying,Yong Shao,Yongxin She,Lufei Zheng,A. M. Abd EI-Aty,Jing Wang
Herein, an indirect SERS sensing assay was developed for the determination of glyphosate (Gly) in tap water. The mechanism of detection was based on relieving the inhibitory effect of L-cysteine (L-cys) on a Au–Pt nanozyme by combining Gly with L-cys through divalent copper ions (Cu2+). In this method, a novel nano-chain-like Au–Ag composite with good repeatability was successfully fabricated to detect SERS signals of oxTMB without disturbing TMB Raman signals. Under optimal conditions, the SERS signal intensity of oxTMB (at 1605 cm−1) was proportional to the concentration of Gly. The results showed a good linear response over the concentration ranges of 10 μg L−1 to 1000 mg L−1. The limit of detection and limit of quantitation of Gly were found to be 5 μg L−1 and 10 μg L−1, respectively. In addition, good anti-interference ability against interfering cations and structural analogues deserves to be mentioned. This SERS assay can be used for detection of Gly in tap water that can meet the needs of practical detection.
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MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Ziyin Yang,Xiao Bai
This paper reports the synthesis of S-doped thin Co 3 O 4 shell with Au flower as core for nonenzymatic glucose sensing, where Au@Co 3 O 4 was obtained through assembly process triggered by redox reaction of Co 2+ and Au 3+ , and then S was doped into Co 3 O 4 shell via a hydrothermal process. The morphology, composition and structure of Au@Co 3 O 4 -S were characterized by transmission electron microscopy and X-ray diffraction, which showed that the core–shell structure was composed with Au core flower and S-doped thin Co 3 O 4 shell. Electrochemical property of Au@Co 3 O 4 -S toward glucose was explored, and an excellent electrocatalytic performance with a wide linear range of 0.2 μM–3.1 mM, a high sensitivity of 1127.3 μA mM −1 cm −2 and a low detection limit of 0.09 μM (S/N = 3) was obtained, which may be due to that the low conductivity of Co 3 O 4 was mitigated by conductive Au core flower and S doping, therefore making thin Co 3 O 4 shell provide more effective active sites for glucose reaction. Considering such excellent results, Au@Co 3 O 4 -S was proven as a promising material for electrochemical sensing of glucose.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 45
·期 3
·1231-1239
·
IF 3.288
Jiajia Li,Yun Zhao,Xiuxun Han,DingShu Xiao
The design of highly efficient and stable photoelectrocatalysts for the hydrogen evolution reaction (HER) is critical to the large-scale application of clean hydrogen energy. Here, Cu3BiS3 nanoflowers (NFs) with photoelectrochemical (PEC) activity were synthesized via a solvothermal method under mild and low-toxic reaction conditions, and the Au nanoparticles (Au NPs) were loaded onto Cu3BiS3 NFs to improve the photoelectrocatalytic performance. Compared with pure Cu3BiS3 NFs, Au-Cu3BiS3 composites (A@C) exhibit a much higher photocurrent density (2 × 10−4 A cm−2) and greatly enhanced photoelectrocatalytic activity (2.31 μmol h−1), which are attributed to the enhancement in electron capture abilities, active sites and visible light absorption from the localized surface plasmon resonance effect (LSPR) of Au NPs. Furthermore, the excellent conductivity of Au NPs can effectively accelerate the separation and collection of photogenerated carriers. This work highlights a feasible strategy to improve the PEC activity of the Cu3BiS3 photoelectrocatalyst, and confirms the great potential of Au-Cu3BiS3 composites for hydrogen evolution applications.
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JOURNAL OF NANOPARTICLE RESEARCH
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2021
·Vol. 23
·期 1
·1-12
·
IF 2.253
Zhang Gongguo,Liu Zhiang,Fu Xiaowei,Zhao Wenjun,Yin Xunxiao,Niu Xiankang,Kong Rongmei,Qu Fengli,Zheng Yiqun
Branched Au nanocrystals with sub-10-nm arms are synthesized via a one-pot reduction in aqueous phase. The success of current work relies on the use of octadecyltrimethylammonium chloride as the shape-directing capping agent to facilitate the formation of branched products in high purity. Their overall size could be controlled in the range of 16–60 nm by varying the Au precursor amount or concentration of capping agent, and the diameter of arms is limited to sub-10-nm size range. Interestingly, Au nanocrystals with a unique morphology, sheet-wrapped dendrites, could be obtained when the concentration of a reductant was varied. The current strategy is also validated effective in the fabrication of dendritic products composed of other noble metals or alloys in addition to Au by simply using the alternative metal precursor. As compared to spherical counterparts, the current branched Au nanocrystals exhibited noticeable red-shift in UV-Vis extinction spectrum and enhanced catalytic activities for electrooxidation of ethanol in alkaline media. Graphical abstract
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GOLD BULLETIN
·
2021
·Vol. 54
·期 1
·59-67
·
IF 1.61
Lin Shijun,Jiang Sirui,Zhang Yuchen,Dai Zhengwei,Dai Yu,Xia Fan,Zhang Xiaojin
Gold nanorod (AuNR) nanocomposite hydrogels have attracted increasing attention due to the photothermal effect of AuNRs. However, a facile strategy that avoids multi-step surface modification for synthesis of AuNR crosslinkers is still a critical challenge. Here, AuNRs crosslinking PNIPAM hydrogels were prepared by polymerization of NIPAM with N , N ′-bis(acryloyl)cystamine (BACA)-modified AuNRs as crosslinkers. BACA contains a disulfide bond in the structure. Dynamic and reversible Au-thiolate bonding was formed by directly mixing AuNRs and BACA to facilely prepare AuNR crosslinkers before hydrogel formation. The addition of AuNRs gives hydrogels their photothermal effect and remarkable mechanical behaviors. Hydrogels could repeatedly adhere to the surface of pigskin, metal, plastic, and glass with a relatively stable adhesion. The damaged hydrogels heal within 2 min with near-infrared (NIR) laser (808 nm, 300 mW∙cm −2 ) irradiation. This work provides a line of thinking for improvement of PNIPAM hydrogels, making them promising for further applications in biomedicine.
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JOURNAL OF ELECTRONIC MATERIALS
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2021
·Vol. 50
·期 3
·1189-1195
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IF 1.938
Li Ke,Chen Tingting,Mao Huibing,Chen Ye,Wang Jiqing
YVO 4 :Yb 3+ :Er 3+ nanoparticles and their mixture with Au nanoparticles have been fabricated by a simple chemical method. With the excitation of a 975-nm laser, both samples had strong upconversion emissions at 2.18, 2.25, and 2.36 eV, which correspond to the transitions 4 F 9/2 → 4 I 15/2 , 4 S 3/2 → 4 I 15/2 and 2 H 11/2 → 4 I 15/2 of Er 3+ ions, while the emission at 2.36 eV has a large overlap with the resonant absorption energy, 2.34 eV, of the Au nanoparticles. With the coupling of the Au nanoparticles, the upconversion emission at 2.36 eV presents a strong quenching effect which is due to the energy transfer from the Er 3+ ions to the Au nanoparticles. This depends on the energy difference between the emission of the Er 3+ ions and the absorption of the Au nanoparticles. The upconversion power dependence shows that the slope factor of the power dependence is about 3 for a high pump power, which means that the upconversion process is a three-photon process for both samples.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Jinling Li,Tao Shao,Bowen Meng,Shijie He,Qiankun Zhang,Dongxia Zhang,Xibin Zhou
At present, Pt-based catalysts with controllable compositions , architectures, and crystal facets are still the most prevalent materials for the electro-oxidation of methanol (MOR), which is a compelling reaction in proton exchange membrane fuel cells. Herein, based on graphene quantum dots (GQDs), we report a facial and environment-friendly approach to prepare the Au@GQDs@Pt x Pb core-shell nano-pompons for the MOR in alkaline solutions. It was noticed that among all the as-synthesized samples, Au@GQDs@Pt 3.5 Pb displays an admirable activity, which is as high as 15.14 A mg −1 Pt and almost 38-fold higher than that of commercial Pt/C catalyst. And its resistance to poisoning species and long-term stability are also greatly improved. The improved performance for MOR might be attributed to the channel-rich structure of catalysts with the aid of GQDs, Au, and the electronic effect between Pt and Pb. The results indicate that the reasonable composition and structure of Au@GQDs@Pt x Pb exhibits efficient MOR, it could be a promising candidate for direct methanol fuel cells.
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Catalysts
·
2020
·Vol. 10
·期 10
·1192
·
IF 3.52
Jun Yan,Longlong Shan,Xiaoli Gu,Xingguang Zhang,Junmeng Cai
Three series of catalysts consisting of gold (Au), platinum (Pt), or gold-platinum bimetallic nanoparticles (NPs) with controlled sizes (Au NPs 10 ± 2 nm, Pt NPs 6 ± 2 nm) anchored on hierarchical micro-/meso-/macroporous silica were successfully developed and systematically evaluated for the selective oxidation of aromatic alcohols to their corresponding aldehydes. The catalysts were prepared by the sol-immobilization method using as-made Au NPs and/or Pt NPs colloids; the silica supports were prepared with controlled pore structures and the hierarchical porous structures of catalysts were created by controllable desilication via the alkaline solution of the metal colloids. The catalysts were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), and Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), and these results showed no synergistic effect between Au and Pt on boosting the catalytic performance, whereas they demonstrated a clear dependence of catalytic conversions and reaction rates on the structural porosity of Au-Pt bimetallic catalysts. Our findings could potentially inspire peer researchers and scientists to develop designer porous catalysts and processes in the selective organic conversions.Keywords:steric effect;Au-Pt catalysts;alcohol oxidation;hierarchical porous silica
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
·
IF 5.316
Wenlong Liao,Kunpng Liu,Yangjie Chen,Jianping Hu,Ya Gan
Three-dimensional (3D) SERS substrates have being intensively investigated since they can afford substantial hot spots and trap targets exponentially, silicon nanowires (SiNWs) array is a promising candidate due to its facile preparation. Most often, the SiNWs based substrates were decorated with pure Ag or Au nanoparticles (NPs), Au–Ag bimetallic NPs (BMNPs) with superior plasmonic properties and stabilities are rarely studied for the fabrication of SiNWs based SERS substrates. In this work, we reported a facile method to fabricate Au-Ag BMNPs decorated SiNWs as 3D SERS substrates, the effects of Au-Ag BMNPs scale and composition ratios on SERS performance were well investigated through experiments and theoretical simulations. The vertically aligned SiNWs coated with dense Au-Ag BMNPs further improved the sensitivity by forming fixed and dynamic hot spots, and the detection limit of R6G on SiNWs-AuAg can be as low as 10 -12 M by using a portable Raman spectroscopy . Meanwhile, the prepared 3D SERS substrate showed a higher SERS enhancement factor (EF) and oxidation resistance ability due to the synergistic effect of Au and Ag atoms in Au–Ag BMNPs. Considering the facile fabrication process and excellent performances, the prepared 3D SERS substrate can be potentially applied for ultrasensitive detection of trace analytes.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
·
IF 4.098
Ya-Min Shen,Meng-Yue Gao,Xu Chen,Ai-Guo Shen,Ji-Ming Hu
Multiplex surface-enhanced Raman scattering (SERS) detection of markers without background in tumor biosystems has its superiority over other optical methods. Herein, we reported a strategy of quantitative discrimination of two breast cancer cell subtypes. Based on our previous studies, two kinds of Prussian blue analogue coated gold nanoparticles ( [email protected] NPs) were designed and synthesized by the replacement of Fe 2+ with Pb 2+ or Cu 2+ . Therefore, two distinct SERS emissions of C≡N bonds at 2122 cm −1 and 2176 cm −1 have been acquired. When modified with aptamers of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR), which are both expressed in MCF-7 and MDA-MB-231 cell lines but in different levels, the SERS nanoprobes simultaneously identified the relative expression of these biomarkers on the cell surface, providing a good example for ratiometric detection in biosystems without any interference. Each surface marker of tumor cells corresponds to a single SERS emission. Thus, each subtype could be described in a molecular profiling way through duplex C≡N bonds-based SERS emission, which is more advanced than traditional flow cytometry method.
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Nanoscale
·
2020
·Vol. 13
·期 6
·3528-3542
·
IF 6.895
Yaxing Liu,Weiyin Li,Guizhe Zhao,Gang Qin,Yuexia Li,Yaqing Liu
The lack of direct insight into the microstructural evolution of catalytic materials under electrochemical polarization has inhibited the development of heterogeneous catalysts. By investigating a typical Au@Pd core–shell nanostructure, the present study discloses the microstructural evolution of heterogeneous catalytic materials during the methanol electrooxidation reaction (MOR). The electrocatalytic activity of the as-prepared Au@Pd_core–shell nanoparticles continuously increased during the first 100 successive voltammetry cycles of the MOR. Microstructural characterization studies revealed that during the MOR, an Au/Pd mixed bimetallic shell was formed by the self-driven microstructural evolution of the Au@Pd_core–shell nanoparticles. Both the experimental and calculation results indicated that the Au/Pd mixed bimetallic shell reduced the binding strength of OH− and CO on the catalyst surface. The exposed Au atoms in the shell region also produced large-scale reactive ˙OH radicals that facilitated the oxidative removal of the adsorbed carbonaceous species from the adjacent Pd active sites.
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