Chemical Biology & Drug Design
·
2023
·Vol. 103
·期 1
·e14363
·
IF 3
Chun Li,Yuxin Xie,Shaoyu Hu,Hong Yu,Yunke Xu,Hongping Shen,Yuan Yuan,Long Gu,Bangming Pu
Hepatocellular carcinoma (HCC) is a life-threatening disease for which there is no cure. Traditional Chinese medicine is a treasure trove of Medicinals that has been used for thousands of years. In China, the traditional herb pair, Curcumae Rhizoma and Sparganii Rhizoma (CR-SR) represent a classic herbal combination used for the treatment of HCC. However, the drug targets and pharmacological mechanism of action of CR-SR in the treatment of HCC are unclear. To address this, we screened the active components and drug targets of CR-SR from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and a high-throughput experiment- and reference-guided database of traditional Chinese medicines (HERB database). Combined with the weighted co-expression network analysis of dataset GSE76427, we constructed an active component-target-disease regulatory network. It was found that CR-SR's active components for HCC treatment included trans-gondoic acid, beta-sitosterol, stigmasterol, hederagenin, and formononetin. These compounds specifically targeted the genes Estrogen Receptor 1 ( ESR1 ), Cyclin A2 ( CCNA2 ), Checkpoint Kinase 1 ( CHEK1 ), and Nuclear Receptor Coactivator 2 ( NCOA2 ). ESR1 , CCNA2 , and CHEK1 genes showed significant differences in survival prognosis, expression levels, and statistical significance during the pathological stage. Moreover, their high affinity for formononetin was determined through molecular docking analysis. Cell assays and high-throughput sequencing were performed to reveal that the inhibitory effect of formononetin on HepG2 cell proliferation was related to hepatocyte metabolism and cell cycle regulation-related pathways. This study provides insights into potential HCC treatments.
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高影响因子
Materials
·
2023
·Vol. 16
·期 20
·6667
·
IF 3.4
Yukun Li,Svenja Hanson,Cheng Heng Pang,Peng Lyu,Jun Jiang
In order to attain phosphor ceramics with a high Color-Rendering Index (CRI), samples with the composition of Y0.997−xRexCe0.003)3(Al0.9748Mn2+0.024Cr3+0.0012)5O12(Rex= 0, Gd0.333, Gd0.666, Gd0.997, Tb0.333, Tb0.666, Tb0.997and Lu0.997were prepared by solid-state reaction and vacuum sintering, and exhibited potential for high-quality, solid-state lighting. Doping with Cr3+and Mn2+effectively enhanced the red component of Ce3+spectra through the intense energy transfer from Ce3+ions to Mn2+/Cr3+ions. The crystal field splitting of [GdO8] and [TbO8] was more extensive than that of [YO8], causing a massive redshift in the Ce3+emission peaks from 542 to 561 and 595 nm, while [LuO8] had an opposite effect and caused a blueshift with a peak position at 512 nm. White LED devices incorporating Ce/Mn/Cr: (Gd0.333Y0.664)3Al5O12phosphor ceramic exhibited a high CRI of 83.97, highlighting the potential for enhancing the red-light component of white LED lighting.Keywords:garnet phosphor;laser lighting;full spectrum;spectral modulation;Ce/Mn/Cr: (Re,Y)3Al5O12
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Muhammad Usman,Adeel Ahmed,Bing Yu,Muhammad Rafiq,Zhijian Ji,Youqing Shen,Hailin Cong
Herein, we develop a versatile strategy for developing a Fe 3 O 4 -NH-β-CD-BP ILs based sorbent by installing synergistic bonding sites for simultaneous removal of per- and polyfluoroalkyl substances (PFASs) and heavy metals from contaminated water. This sorbent with its quaternary ammonium cation achieved remarkable removal efficiency (∼99 %)for both short and long chain anionic PFASs in pure water as compared to previous β-CD based materials. Moreover, when subjected to a challenging metal salt matrix, the adsorbents revealed that long-chain PFASs primarily relied on electrostatic and hydrophobic interactions, while short-chain PFASs depended solely on electrostatic attractions. The results indicate that the sorbent exhibits outstanding adsorption capacities for PFCAs, PFSAs and Cr (VI) coupled with fast adsorption kinetics featuring equilibrium times 5, 4 and 2 h, respectively. The simultaneous removal of PFOA, PFOS and Cr (VI) in multi-component systems (electroplating plant wastewater) was also determined due to their dual sites rendered by cationic and β-CD groups. The adsorption of PFCAs and Cr (VI) was significantly influenced by the initial pH compared to the sorption of PFSAs. Additionally, the viologen based sorbent also showed better photocatalytic hydrogen evolution activity. In summary, these results revealed the outstanding adsorption capacity and convenient regeneration process make the adsorbent as a promising candidate for efficient and rapid removal of PFASs from other pollutants.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2018
·
IF 11.698
Kexin Li,Ziai Huang,Suiyi Zhu,Shenglian Luo,Liushui Yan,Yuhua Dai,Yihang Guo,Yuxin Yang
A series of biochar-coupled graphitic carbon nitride nanosheets (BPCMSs/g-C 3 N 4 NSs) composites was successfully fabricated through a simple two-step calcination strategy by using waste Camellia oleifera shells (WCOSs) and melamine as raw materials. Hexavalent chromium [Cr(VI)] or total chromium (T-Cr) in water could be completely removed or mostly recovered through adsorption combined with photocatalytic reduction by using the as-prepared BPCMSs/g-C 3 N 4 NSs. The adsorbed Cr(VI) on BPCMSs/g-C 3 N 4 NSs could be reduced by photogenerated electrons into trivalent chromium ions (Cr 3+ ) and stably fixed on BPCMSs/g-C 3 N 4 NSs after strengthening. Interestingly, we found that the photocatalytic activity of the recycled Cr 3+ /BPCMSs/g-C 3 N 4 NSs was remarkably improved compared with that of the fresh BPCMSs/g-C 3 N 4 NSs for the degradation of aqueous organic pollutants . We tested the photocatalytic performance of the recycled Cr 3+ /BPCMSs/g-C 3 N 4 NSs in the combined pollution system containing Cr(VI) and 4-fluorophenol (4-FP) and observed that a synergistic photocatalytic effect occurred in the Cr(VI)/4-FP combined pollution system under acidic and neutral conditions.
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Petroleum Science
·
2023
·
IF 5.6
Bo-Long Jiang,Dong-Xu Zhang,Dan-Dan Yuan,Yan-Guang Chen,Tian-Zhen Hao,Hua Song
Oxidative desulfurization from fuel oil is one of the important methods for deep desulfurization. The development of efficient oxidative desulfurization catalysts is crucial for improving the desulfurization performance. Successful encapsulation of phosphotungstic acid (HPW) and ionic liquid (BMImBr) inside the mesoporous cages of MIL-101(Cr) was accomplished through a combination of “bottle around ship” and “ship in bottle” methods. The obtained BMImPW@MIL-101(Cr) composite was characterized by XRD, FTIR, BET, SEM, XPS and ICP methods. Results indicated that the BMImPW@MIL-101(Cr) composites with PW 3− loading of 23.1–50.7 wt% were obtained, demonstrating that the “bottle around ship” method is beneficial to make full use of nanocages of MIL-101(Cr) to obtain expected high loading of active PW 3 − . The BMImPW@MIL-101(Cr) exhibits excellent reusability with no evidence of leaching of active PW 3 − and BMIm + , and well-preserved structure after successive cycles of regeneration and reuse. The significantly improved stability of BMImPW@MIL-101(Cr) as compared to HPW@MIL-101(Cr) is possibly because the leaching of the active PW 3 − − sites can be greatly suppressed by forming large size of BMImPW owing to introduction of BMIm + cation. The BMImPW@MIL-101(Cr) exhibited excellent catalytic activity for solvent free oxidative desulfurization of refractory sulfides. The enhanced oxidative desulfurization activity as compared to HPW@MIL-101(Cr) can be explained by the intimate contact of sulfides with active PW 3 − sites owing the strong attraction of BMIm + cation with the sulfides.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yanfang Sun,Peng Sun,Shixin Niu,Boxiong Shen,Honghong Lyu
Obstacles such as aggregation and low activity of micron zero-valent iron in pollutant treatment could be overcome by sulfidation and biochar support. Ball milling is a promising method for the preparation of iron-based composites but the milling atmosphere is critical. To maximize the reactivity and identify the effects of ball mill atmosphere, ball milling technology under wet and dry atmosphere was applied to prepare composites from mZVI, Na 2 S 2 O 4 , and pine wood biochar (BC) for Cr(VI) removal. The results showed that S-mZVI/BC-wet was highly dispersible with more FeS 2 coverage and thus more efficient on Cr (VI) removal than S-mZVI/BC-dry (99.9 % removal in 80 min vs. 87.9 % removal in 24 h) at the optimum Fe: C mass ratio (1:1), S: Fe molar ratio (1:10), and reaction conditions. Cr(VI) was adsorbed by a spontaneous, endothermic mechanism that combined physisorption and chemisorption. The reduction process was vulcanization efficiency and iron cycle dependent. Reduction outperformed adsorption on the Cr(VI) removal and high reduction rateswere electron-selectively related (59.15 % for S-mZVI/BC-wet and 46.72 % for S-mZVI/BC-dry), implying S-mZVI/BC-wet was more capable. S-mZVI/BC-wet presented excellent anti-ageing property and slightly inferior regeneration performance. In conclusion, the composite prepared by wet ball milling have excellent performance in rapid and complete removal of Cr(VI), and S-mZVI/BC-wet has superior potential in acidic wastewater treatment.
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JOURNAL OF CHROMATOGRAPHY A
·
2017
·
IF 3.981
Qingxiang Zhou,Man Lei,Yalin Wu,Yongyong Yuan
Metal-organic framework material has been paid more attention because of its good physical and chemical properties. Nanoscale zero valent iron is also in the center of concern recently. Combination of their merits will give impressive results. Present study firstly synthesized a new magnetic nanomaterial nano-scale zero valent iron-functionalized metal-organic framworks MIL-101 (Fe@MIL-101) by co-precipitation method. The morphology and structure of the as-prepared Fe@MIL-101 were characterized by transmission electron microscopy and X-ray diffraction, etc. The experimental results showed that Fe@MIL-101 earned good adsorption ability to polycyclic aromatic hydrocarbons. The limits of detection of developed magnetic solid phase extraction were all below 0.064 μg L −1 and precision can be expressed as relative standard deviation (RSD, %) and which was better than 4.4% (n = 6). The real water analysis indicated that the spiked recoveries were satisfied, and Fe@MIL-101 earned excellent reusability. All these demonstrated that Fe@MIL-101 exhibited excellent adsorption capability to polycyclic aromatic hydrocarbons and would be a good adsorbent for development of new monitoring methods for environmental pollutants.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Zuoyu Jia,Fengkai Liang,Xinze Xu,Haifeng Zhou,Yaqing Zhang,Peng Liang
The removal of multiple heavy metal pollutants remains a challenge. Amination and carboxylation modified lignins (NCLs) prepared by one-pot hydrothermal method were used as adsorbents for Cr(VI) and Cd(II) removal. The oxygenous groups content in adsorbents was quantitatively analyzed by Boehm titration in which NCL10 (the mass ratio of citric acid: triethylene diamine = 10) possessed a maximum carboxyl group content of 1.22 mmol/g. The Langmuir adsorption isotherm model was the most suitable, with the highest theoretical adsorption capacity of Cr(VI) and Cd(II) of 1298.6 and 103.1 mg/g, respectively. Meanwhile, FT-IR and XPS exhibited that NCL5 surface contained many functional groups beneficial to the removal of Cr(VI) and Cd(II). The contribution of carboxyl and hydroxyl groups to the removal of Cr(VI) and Cd(II) was quantitatively analyzed. After the blocking of carboxyl and hydroxyl groups, the adsorption rate of Cr(VI) and Cd(II) decreased by 26.4 %, 67.7 % and 7.2 %, 43.3 %, respectively. This study provides effective strategies to overcome the limitations of lignin adsorbents for wastewaters containing a wide range of heavy metal pollutants.
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Journal of Environmental Sciences
·
2020
·
IF 4.302
Qian Guo,Guangbei Tang,Wenjie Zhu,Yongming Luo,Xiaoya Gao
Pyrite is the most abundant sulfide semiconductor mineral with excellent optical properties . However, few reports have investigated its photocatalytic activity because of the low photogenerated carrier separation efficiency. In this work, a Z-scheme FeS 2 /Fe 2 O 3 composite photocatalyst was fabricated in situ via structural transformation of pyrite through heat treatment. A remarkably enhanced photocatalytic performance was observed over the FeS 2 /Fe 2 O 3 composite photocatalyst. Compared with the pristine pyrite, the degradation efficiency of carbamazepine (CBZ) reached 65% at the added hexavalent chromium (Cr(Ⅵ)) concentration of 20 mg/L and the Cr(Ⅵ) was nearly completely reduced in the mixed system using FeS 2 /Fe 2 O 3 within 30 min under simulated solar light irradiation. The enhanced photocatalytic activity can be attributed to the efficient separation and transfer of photogenerated carriers in the FeS 2 /Fe 2 O 3 composite photocatalyst. This facilitated the generation of •OH, hole (h + ) and •O 2 − species, which participated in the photocatalytic reaction with CBZ. Based on the measurement of the active species and electric properties, a Z-scheme electron transfer pathway was proposed for the FeS 2 /Fe 2 O 3 composite photocatalyst. This work broadens the application potential of pyrite in environmental remediation.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yong Zhang,Jing Wang,Ying Liu,Xuemeng Wu,Lina Gao,Guihua Gao
In this study, a tip foam named as MIL-101(Cr)-NH₂/chitosan (MIL-101(Cr)-NH₂/CS) was prepared by cross-linking chitosan (CS) with MIL-101(Cr)-NH₂ using glutaraldehyde as the cross-linking agent. After freeze-drying, the internal structure of the MIL-101(Cr)-NH₂/CS foam became porous, thereby exposing more MIL-101(Cr)-NH₂, enriching binding sites, ensuring efficient adsorption, and allowing smooth passage of the sample solution. This also facilitates the inhalation and extrusion of the sample solution. Based on the unique advantages of the MIL-101(Cr)-NH₂/CS foam, a method combining pipette tip solid-phase extraction (PT-SPE) with high-performance liquid chromatography equipped with a fluorescence detector (HPLC-FLD) was established for the detection of puerarin and its metabolites (e.g., daidzein and equol) in rat serum. The method exhibited good linearity in the range of 0.5 to 5000 ng/mL, with limits of detection (LOD), lower limits of quantification (LLOQ), and limits of quantification (LOQ) ranging from 0.2 to 15 ng/mL, 0.5 to 50 ng/mL, and 1 to 100 ng/mL, respectively. The relative standard deviations (RSDs) of intra-day and inter-day precision for puerarin, daidzein, and equol were less than 19.8 %, meeting relevant regulatory requirements. The extraction recoveries of puerarin, daidzein, and equol ranged from 80.17 % to 91.70 %, 80.02 % to 87.41 %, and 80.29 % to 85.39 %, with corresponding RSDs of 3.2 % to 10.4 %, 11.2 % to 13.8 %, and 7.9 % to 11.1 %. These results indicate that the developed method meets the methodological requirements for the quantitative analysis of biological samples. The application of MIL-101(Cr)-NH₂/CS foam in PT-SPE further expands the application scope of metal-organic frameworks (MOFs) in solid-phase extraction (SPE) and provides a reference for PT-SPE technology in handling small-volume samples in complex matrices.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2013
·
IF 5.825
Yanhui Zhang,Zhang Chen,Siqi Liu,Yi-Jun Xu
The composites of reduced graphene oxide/ZnO (RGO/ZnO) with different particles size of ZnO have been prepared via a facile solvothermal reaction of graphene oxide (GO) and ZnO in an ethanol-water solvent. It is found that the RGO/ZnO-S1 composite with ZnO particle size of 20–100 nm exhibits the enhanced photoactivity toward degradation of organic dyes and reduction of heavy metal ions Cr(VI) in water as compared to the bare ZnO-S1 sample under UV light irradiation. However, the RGO/ZnO-S2 composite with ZnO particle size of 50–500 nm shows decreased photoactivity as compared to bare ZnO-S2. The recycled photoactivity testing shows that, for RGO/ZnO-S1, the photocorrosion of ZnO-S1 is efficiently inhibited by the hybridization with RGO whereas the case is not for RGO/ZnO-S2. A collection of characterization techniques disclose that the smaller particles size for RGO/ZnO-S1 than that for RGO/ZnO-S2 leads to a more interfacial contact and a chemical bonding between RGO and ZnO-S1, thereby resulting in enhanced photoactivity and efficient anti-photocorrosion as observed for RGO/ZnO-S1. Furthermore, the possible reaction mechanism for degradation of dyes and reduction of Cr(VI) over RGO/ZnO-S1 has also been studied. Our results suggest that the semiconductor particles size has an important effect on the photocatalytic performance of RGO/semiconductor composites photocatalysts. The hybridization of RGO with ZnO in an appropriate manner is able to significantly inhibit the well-known photocorrosion of semiconductor ZnO. It is anticipated that this work would enrich the applications of RGO/semiconductor photocatalysts in environment purification.
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JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Lei Li,Hengji Liu,Yuanyuan Wang,Gang Wang,Yongde Guo,Weimin Kang
Reasonable construction of low migration energy barrier and continuous proton transfer channel is the key to improving the performance of composite proton exchange membranes. In this paper, we prepared a novel bimetallic MOFs (MIL-(Cr Al)–NH 2 ) nanofibers (MCANs) consisting of Cr and Al elements by electro-blown spinning method (EBS) and hydrothermal synthesis, and subsequently introduced them into non-fluorinated sulfonic acid polymer sulfonated polysulfone (SPSF) matrix to obtain composite proton exchange membranes (MCANs@SPSF). Importantly, MCANs successfully constructed relatively long-range continuous unsaturated metal site proton transfer channels provided by the Cr-based MOFs, thereby reducing the proton migration energy barrier in the MCANs@SPSF, which confirmed by the density functional theory (DFT) calculation. In detail, DFT studies indicated that the migration energy barrier between H + and MCANs was 1.677 eV, while that of single Al-based MOF (MAN) and single Cr-based MOF (MCN) were 1.879 eV and 1.762 eV respectively. The existence of efficient low migration energy barrier and continuous proton transfer channels made the proton conduction efficiency of MCANs@SPSF greatly improved, that was under the condition of 80 °C and 100 % RH, the proton conductivity of MCANs@SPSF reached the maximum value of 0.358 S cm −1 and the power density reached 104 mW cm −2 . Moreover, MCANs@SPSF-5 displayed best DMFC durability performance with only 14.65 % voltage loss under 24h test. In addition, due to the acid-base pair interaction between MCANs and SPSF enhanced the interface binding force between the two phases, meanwhile, the pore structure of MOFs also had a certain adsorption effect on methanol, thus reducing the methanol permeability, and the addition of 5 wt% MCANs in SPSF was tested to reduce the methanol permeability to 5.53 × 10 -7 cm 2 s −1 . Overall, this work provided a new strategy for construction of low migration energy barrier and continuous proton transfer channels, which was beneficial for the development of high performance proton exchange membranes.
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