Science China-Chemistry
·
2023
·Vol. 66
·期 12
·3587-3593
·
IF 9.6
Zhang Mengmeng,Hou Zaiyan,Liu Simeng,Han Guoqiang,Tian Meirong,Zhu Jintao,Xu Jiangping
Development of block copolymer (BCP) microparticles with switchable morphology in response to external stimuli is important for exploiting new intelligent materials. In this work, thermo/pH dual-responsive nanoparticles (NPs) were employed as a co-surfactant to modulate the self-assembly morphology of polystyrene- b -poly(2-vinylpyridine) (PS- b -P2VP) microparticles within confined emulsion droplets. The co-surfactant was synthesized by grafting poly(acrylic acid)- b -poly( N -isopropylacrylamide) onto the surface of Fe 3 O 4 NP. The introduction of the dual-responsive co-surfactant enabled thermo/pH dual-responsive reversible morphology transition of the PS- b -P2VP microparticles by tailoring the hydrophobicity and interfacial affinity of the co-surfactant. By using this strategy, the thermo-inert PS- b -P2VP self-assembled into pupa-like microparticles at T = 10 °C and pH 7.5, which could transform into tulip-like microparticles when T was increased to 50 °C. When the pH value was increased to 11, the pupa-like particles turned into onion-like microparticles although the PS- b -P2VP was inert to alkali. However, the pupa-like microparticles remained unchanged when both T and pH were simultaneously increased. The PAA- b -PNIPAM-grafted Fe 3 O 4 NP surfactants showed obvious advantages over the linear PAA- b -PNIPAM surfactants in modulating the morphology transition, since the linear PAA- b -PNIPAM could not induce the reversible shape transition of microparticles. Our work provides an efficient strategy to achieve reversible shape transformation of BCP microparticles while the internal phase structure is preserved, which may be utilized to switch the structural color properties of BCP microparticles.
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Nano Today
·
2025
·
IF 10.9
Kecheng Quan,Yupu Lu,Ting Zhang,Shuren Wang,Hao Tang,Chunhao Yu,Yongsheng Zhou,Yunsong Liu,Dandan Xia,Yufeng Zheng
Antimicrobial coatings with the capabilities to prevent and treat biofilm infections on implant are promising surface treatment strategies, but it is difficult to eradicate an already-formed biofilm by the coating. Magnetically-drivable coatings can physically destruct the surface-attached biofilm to enhance antimicrobial killing. However, current magnetic coatings cannot inhibit the initial bacteria growth and the demand of coating stability restricts their magnetic controllability. Herein, a magnetically-drivable, pH-responsive coating is developed by simply mixing Fe 3 O 4 and ZIF-8 nanoparticles on titanium surface. In physiological pH, Fe 3 O 4 nanoparticles are stable and non-magnetically drivable on surface due to charge attractions and electrostatic interactions. While in acidic pH caused by bacterial growth, ZIF-8 degradation is significantly accelerated, releasing Zn 2 + and recovering the magnetic controllability of Fe 3 O 4 nanoparticles. The released Zn 2+ kills the initially-attached bacteria, inhibiting subsequent biofilm formation. Once a biofilm has formed, Fe 3 O 4 nanoparticles can be magnetically pulled-off to destruct the biofilm structure and then enhance antibiotic killing. The Fe 3 O 4 /ZIF-8 coating shows excellent biocompatibility and osteogenesis to compare with bare Ti disc. Animal experiments further proved the in-vivo antimicrobial and osteogenic performances of the coating. Therefore, this work put forward a new surface strategy to solve biofilm-related infections on implants.
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Small
·
2025
·
IF 12.1
Le Liu,Feng Chen,Haowei Yang,Xiaoli Yan,Jie Ren,Yanhui Song,Junjie Guo
Although Cu-N 4 -C single-atom catalysts (SACs) is proven to be a potential substitute for oxygen reduction reaction (ORR), the rigid coordination structure of Cu-N 4 active sites hampers mass transfer and electron transport during the ORR process, limiting their catalytic activity. In this study, an asymmetric coordination strategy (Cu-N-C/Cl) is implemented by doping chlorine, which subtly modulates the electronic structure of the Cu-N 4 coordination environment in two dimensions. The Cu-N-C/Cl electrocatalysts with the optimized electronic structure exhibit outstanding ORR activity across all pH ranges with the half-wave potentials of 0.915, 0.74, and 0.67 V ( vs . RHE) in alkaline, acidic, and neutral electrolytes, respectively. Experimental and theoretical findings demonstrate that the incorporation of Cl is crucial for enhancing ORR performance. This modification efficiently disrupts the electron symmetry of Cu-N 4 , resulting in a positive shift in the d-band center of Cu and optimizing the adsorption/desorption of ORR intermediates. Notably, the Cu-N-C/Cl electrocatalyst also shows promising performance in a Zn-air battery (ZAB), achieving a peak power density of 286 mW cm −2 and a specific capacity of 797.2 mAh g −1 . Moreover, this novel catalyst displays exceptional long-term stability, maintaining continuous operation for over 600 h, highlighting its significant potential for practical applications.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2025
·
IF 2
Shisheng Yuan,Tong He,Chengyuan Wang,Guoqing Huang,Zhuo GUO
The hydrogen evolution reaction (HER) is critical for sustainable hydrogen production via water electrolysis, but its practical application is hindered by high energy barriers and the cost of noble metal catalysts. This study presents a highly efficient NiCoP nanocrystal catalyst supported on nitrogen and sulfur co-doped reduced graphene oxide (NSrGO). The NiCoP/NSrGO catalyst combines optimized electronic structure via cationic alloying with the enhanced dispersion of active sites and superior conductivity provided by the NSrGO substrate. The resulting catalyst demonstrates excellent HER performance, achieving current densities of 10 mA cm-2 with overpotentials of 115 mV, 236 mV, and 283 mV in acidic, alkaline, and alkalized seawater electrolytes, respectively. The results of density functional theory (DFT) calculations show that alloying can effectively balance hydrogen adsorption desorption and improve water dissociation kinetics. Additionally, the catalyst maintains long-term stability in seawater electrolysis, making it a promising candidate for scalable hydrogen production.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Bing Zong,Feng Liu,Sibo Wang,Xuan Liu,Ruoting Cao,Zheng Gao,Libin Bai,Yuangong Zhang
Fluorine-19 magnetic resonance imaging (19F MRI) facilitates the imaging of deep tissues because of its excellent penetration capabilities and absence of background artifacts, which are very important in biology, medical diagnostics, and neuroscience. The functionality of 19F MRI is intrinsically linked to the structural composition of its contrast agents (CAs). Modifications with various structural or functional compounds can enhance the contrast, water solubility, biocompatibility, and targeting efficacy of 19F CAs. Notably, glucose-modified 19F CAs can cross the blood–brain barrier (BBB). Consequently, we synthesized pH-responsive linear and hyperbranched fluorinated polymers, which crossed the BBB in small-animal imaging experiments and generated weak 19F signals (OFF) under physiological conditions. However, because of the protonation of their tertiary amine groups, these glycopolymers exhibited the higher mobility of fluorine and generated obvious 19F signals (ON) under acidic conditions. Furthermore, their biocompatibility was excellent, as confirmed using cytotoxicity and hemolysis tests and hematoxylin and eosin staining. This research establishes a robust foundation for the application of 19F MRI technology in diagnosing brain diseases.
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Nano Today
·
2025
·
IF 10.9
Yating Qin,Yan Lin,Chao Tian,Yujie Qi,Shuling Wang,Xiaoyuan Chen,Wenxing Gu
Immune checkpoint blockade (ICB) therapy has emerged as a promising avenue for the treatment of malignant tumors. Nonetheless, the efficacy of this approach is constrained by low anti-tumor immunity and restricted intratumoral delivery of immune checkpoint inhibitors (ICIs) in solid tumors. In this study, a pH-responsive nanocomplex (BRM/PTX/aPD-1) was developed for the active transport of aPD-1 and PTX, thereby enhancing cancer chemoimmunotherapy. BRM/PTX/aPD-1 was prepared by using dynamic and reversible benzoic-imine bonds cross-linked bovine albumin (BSA), anti-PD-1 antibody (aPD-1) and PTX-loaded polylysine dendrimers. In the acidic tumor microenvironment, BRM/PTX/aPD-1 exhibited a charge reversal from negative to positive due to the hydrolysis of the β-carboxylic amide structure, which triggered cation-induced transcytosis. This process enabled active transport of adequate amounts of BRM/PTX/aPD-1 to the tumor parenchyma, where it was degraded by further hydrolysis of benzoic-imine bonds and effectively released aPD-1 and PTX. The nanocomplex demonstrated notable intratumoral permeability both in vitro and in vivo , particularly enhancing the delivery of aPD-1. Additionally, the nanocomplex showed robust anti-tumor activity in an orthotopic breast cancer model, significantly inhibiting tumor proliferation and preventing the progression of lung metastasis. This pH-responsive nanocomplex presents a promising platform for improved intratumoral delivery of ICIs and emerges as a practical solution for overcoming tumor immunosuppression.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Yifan Zhou,Fanjia Dai,Sifang Zhao,Zelong Li,Hongze Liang,Xiao Wang,Lingling Zhao,Hui Tan
The microenvironment of diabetic wounds is complicated and characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and ischemia, making wound restoration and healing extremely challenging. Therefore, functional hydrogel dressings with the ability to regulate the microenvironment of diabetic wounds are a promising strategy for the treatment of diabetic wounds. In this study, a pH/glucose dual-responsive hydrogel based on phenylboric acid-modified carboxymethyl chitosan (CMCSPBA), aldehyde-terminated polyethylene glycol (PEGCHO), and polyvinyl alcohol (PVA) has been developed for diabetic wound treatment via Schiff base and phenylboric ester interactions. Glucose oxidase (GOX), catalase (CAT), and deferoxamine mesylate (DFO) are incorporated into the hydrogel to endow it with multi-functionality. In the hyperglycemic environment of diabetic wounds, a benign feedback loop is formed through the synergistic action of each component of the hydrogel, which enables the reshaping of the microenvironment of diabetic wounds by adjusting the pH and glucose, alleviating oxidative stress and hypoxia, regulating the inflammatory response, inhibiting bacterial infection, and promoting angiogenesis, thus accelerating diabetic wound healing in streptozotocin (STZ)-induced diabetic mice.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Junying Xiang,Zhengyin Sun,Feng Chen,Haixia Zhang,Yujie Song,Hong Wei,Haojie Liang,Ying Hou,Yanhui Song,Peizhi Liu,Huifang Wang,Jianguo Liang,Junjie Guo
The hydrogen evolution reaction (HER) performance of Pt-based electrocatalyts in full pH range can be improved by employing Fe 3 O 4 support to generate the strong metal-support interaction (MSI) effect, which is still rarely reported. Herein, the rod- shaped Fe 3 O 4 supported Pt nanoparticles composite on carbon cloth (CC) (Pt-Fe 3 O 4 /CC) is obtained by hydrothermal method and the followed Atomic Layer Deposition method (ALD). The experimental and theoretical calculation results prove that the charges transfer from Pt to Fe 3 O 4 , and the strong MSI between Fe 3 O 4 and Pt nanoparticles is generated. Thus, the intrinsic activity and stability of Pt is greatly improved, optimizing the H adsorption on the catalyst surface and greatly promoting hydrogen (H 2 ) formation. The Pt-Fe 3 O 4 /CC catalyst exhibits excellent HER performance under alkaline, neutral and acidic conditions, with overpotentials of 22 mV, 59 mV and 29 mV, respectively, to drive a current density of 10 mA cm −2 . And its overpotentials are 79 mV and 288 mV under alkaline and neutral conditions at a current density of 100 mA cm −2 , respectively, which are significantly lower than those of Pt/C (112 mV and 389 mV). Meanwhile, the catalyst has excellent stability under alkaline and neutral conditions. This research proposes a novel approach for the strategic design of high-performance HER catalysts.
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Frontiers in Chemistry
·
2024
·
IF 3.8
Shang Xiujuan,Wang Hongdong,Yu Yongbo,Gu Jin,Zeng Jian,Hou Sinan
Antimicrobial photodynamic therapy (aPDT) has emerged as a highly promising strategy for non-antibiotic treatment of infections due to its unique advantages in efficient bactericidal action and reduction of drug resistance. The natural photosensitizing properties of curcumin (Cur) are widely acknowledged; however, its limited bioavailability has impeded its practical application. In this study, we developed a nanomaterial called Cur@ZIF-8@BA by encapsulating Cur within ZIF-8 and modifying the surface with boric acid (BA). The Cur@ZIF-8@BA exhibits pH-responsive properties and enhances bacterial binding, thereby effectively promoting photodynamic therapy. Moreover, its antibacterial activity against E. coli, Staphylococcus aureus and A. baumannii is significantly increased in the presence of light compared to a dark environment. The mechanism behind this may be that BA increases the affinity of Cur@ZIF-8@BA towards bacteria, and making released Zn2+ and BA from the nanomaterial increase bacterial cell membrane permeability. This facilitates efficient delivery of Cur into bacterial cells, resulting in generation of abundant reactive oxygen species (ROS) and subsequent bactericidal activity. In conclusion, our prepared Cur@ZIF-8@BA holds great promise as a photodynamically mediated antimicrobial strategy.
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Soft Matter
·
2018
·Vol. 14
·期 11
·2112-2117
·
IF 3.709
Shangyang Li,Aiyou Hao,Jian Shen,Ningzhao Shang,Chun Wang
In order to fabricate a novel supra-amphiphile with multiple stimulus properties, we developed the strategy of introducing a bi-functional linker to bridge the hydrophilic and hydrophobic building blocks together, by utilizing more than one kind of interaction. We characterized the assembled structure and morphology of the supra-amphiphile using transmission electron microscopy (TEM), dynamic light scattering (DLS) and X-ray diffraction (XRD). 1H NMR and UV-vis spectroscopy studies revealed that the amphiphile was constructed by the effect of host–guest recognition and a dynamic covalent bond, which could be switched ‘‘on’’ and ‘‘off’’ via UV irradiation and pH variation stimuli, respectively. This responsiveness realized finely controllable self-assembly behaviors of the supra-amphiphile, which was thus able to encapsulate and release the drug model rhodamine B.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiao Xie,Xiaoguang Zhu,Meng Wang,Cheng Liu,Guixia Ling,Peng Zhang
Arthritis exerts a major impact on people's physical health and quality of life. Flurbiprofen axetil (FA), an effective non-steroidal anti-inflammatory drug for arthritis, has been limited due to its poor solubility. To boost therapeutic impact and broaden its applicability, we created FA-loaded liposomes (FA@Lipo) with an EE% of 75% via thin-film hydration sonication. Since joint injections or transdermal patches are typically used to treat arthritis, the former has poor patient compliance and the latter has limited transdermal efficacy. Therefore, considering these two aspects, we concentrated FA@Lipo and mixed it with the microneedle matrix to form FA@Lipo loaded soluble microneedles (FA@Lipo-DMNs), which could break through the skin barrier and deliver drugs effectively while reducing patient pain. In vivo pharmacodynamic experiments indicated that FA@Lipo-DMNs had similar therapeutic efficacy and less pain compared with subcutaneous injection (SC), which improved patient compliance. FA@Lipo-DMNs reduced the swelling and inflammatory factors level (TNF-α, IL-1β) of plantar and ankle joints significantly. Histological evaluation showed that FA@Lipo-DMNs could relieved arthritis effectively. All of these results all demonstrated the bright prospects of FA@Lipo-DMNs in the treatment of arthritis.
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MATERIALS & DESIGN
·
2021
·
IF 7.991
Zuhao Li,Yue Zhao,He Liu,Ming Ren,Zhonghan Wang,Xianggang Wang,Hou Liu,Yubin Feng,Quan Lin,Chenyu Wang,Jincheng Wang
The healing of diabetic foot ulcers (DFUs) is a major challenge for clinical treatment because of the hyperglycemic and acidic microenvironment in the wound area. In this study, a self-healing, injectable, and pH-responsive hydrogel was synthesized by N-carboxyethyl chitosan (N-chitosan), hyaluronic acid–aldehyde (HA-ALD), adipic acid dihydrazide (ADH) through the formation of the reversible dynamic bonds, acylhydrazone and imine bonds. The presence of the acylhydrazone bond characterizes the hydrogel pH-responsive property. In this study, the insulin glargine was successfully incorporated into the hydrogel, allowing its sustained and pH-responsive releasing from the hydrogel for up to 14 days. The hydrogel presented good compatibility and pore structure, and the insulin released from the hydrogel maintained its original bioactivity. Full thickness wounds were established on the feet of diabetic rats to evaluate the therapeutic effect of the dressing. The results revealed that the bioactive insulin-loaded hydrogel dressing shortened the inflammatory phase, enhanced granulation tissue formation, promoted collagen deposition, accelerated re-epithelialization and neovascularization, and postponed or even improved peripheral neuropathy, thus, significantly accelerated DFUs healing. Our findings showed that the insulin-loaded hydrogels had promising potential as a multifunctional bioactive wound dressing for enhancing DFUs healing.
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