POLYHEDRON
·
2022
·
IF 2.975
Xian-Hao Feng,Zhi-Chao Yu,Wei Zhang,Carl Redshaw,Timothy J. Prior,Tie-Hong Meng,Chun-Rong Li,Zhu Tao,Xin Xiao
In the work, we have studied the interaction of cucurbit[7]uril (Q[7]) with 1-[4-(dimethylamino)phenyl]-ethanone (DAPE) using a variety of techiniques including 1 H NMR spectroscopy, UV–vis adsorption and fluorescence spectroscopies, Isothermal titration calorimetry and single crystal X-ray diffraction. Results revealed the formation of a 1:1 complex, whilst the molecular structure of the species [(Q[7]@DAPE)Ca(H 2 O) 3 ] 2 (CdCl 4 ) 2 ·31(H 2 O) is reported.
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高影响因子
POLYMER DEGRADATION AND STABILITY
·
2013
·
IF 2.77
Hua Yan,Chunxiang Lu,Deqi Jing,Xianglin Hou
Chemical decomposition of an epoxy system made of tetraglycidyl 4,4′-diaminodiphenylmethane (TGDDM) and 4,4′-diaminodiphenylsulfone (DDS) in supercritical 1-propanol was investigated under different reaction temperature and time. The GC–MS results suggested that the epoxy system was decomposed to the products including aniline, N-propylbenzenamine, and 4,4′-diaminodiphenylsulfone. The change of the products' yield with time was measured by GC . In addition, the formed chars were characterized by SEM, elemental analysis , Raman and XRD . The results implied the presence of some graphite microcrystals and disordered structure in the solid residue. Upon the addition of KOH, the Guerbet reaction of 1-propanol was promoted to generate more hydrogen. A possible free-radical reaction mechanism was proposed for the depolymerization of TGDDM/DDS epoxy resin . Hydrogenation of radicals had a promotion effect on thermolysis of TGDDM/DDS epoxy resin.
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高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Jinyi Wu,Shuyi Huang,Lei Tan,Yuling Li,Xiaotong Wu,Yong Liang
Dengue fever is caused by mosquito-transmitted dengue virus infection and continues to increase worldwide, threatening public health in tropical and subtropical regions. The primary difficulties in preventing a reduction of the medical burden of dengue fever lies in the lack of effective mosquito control, preventive dengue vaccines, and clinically effective antiviral drugs to treat dengue infections. Rapid and accurate diagnosis is crucial for proper patient care and effective control of epidemics. The present work proposes an alternative strategy for detecting the dengue virus nonstructural protein 1 (NS1) antigen in clinical serum samples by using ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) in combination with the molecularly imprinted polymers. Rather than the whole protein, the NS1 signature peptide is selected as a template for molecular imprinting and quantified as a stoichiometric readout of NS1. Three functional monomers with hydrophobic, positively charged, and negatively charged groups were synthesized by click reactions in terms of the signature peptide. These three functional monomers provide abundant recognition sites for the peptide, allowing the peptide template to be effectively imprinted during polymerization. The imprinting conditions were optimized, and the molecularly imprinted polymers were characterized and used for enriching the signature peptide from digested serum samples by solid-phase extraction and then detected by UHPLC–MS/MS. The proposed method is used to detect the dengue virus NS1 in clinical samples and holds significant promise for early confirmation of dengue virus infection.
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高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 6
·065501
·
IF 3.404
Xiang Ran,Zhenzhen Wang,Enguo Ju,Fang Pu,Yanqiu Song,Jinsong Ren,Xiaogang Qu
The logic device demultiplexer can convey a single input signal into one of multiple output channels. The choice of the output channel is controlled by a selector. Several molecules and biomolecules have been used to mimic the function of a demultiplexer. However, the practical application of logic devices still remains a big challenge. Herein, we design and construct an intelligent 1:2 demultiplexer as a theranostic device based on azobenzene (azo)-modified and DNA/Ag cluster-gated nanovehicles. The configuration of azo and the conformation of the DNA ensemble can be regulated by light irradiation and pH, respectively. The demultiplexer which uses light as the input and acid as the selector can emit red fluorescence or a release drug under different conditions. Depending on different cells, the intelligent logic device can select the mode of cellular imaging in healthy cells or tumor therapy in tumor cells. The study incorporates the logic gate with the theranostic device, paving the way for tangible applications of logic gates in the future.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Wen Li,Hexiang Wang,Yuan Zhang,Limin Zhao,Pengfeng Guo,Hua Cao,Xiang Liu
Pyridinium 1,4-zwitterionic thiolates were regarded as powerful and versatile building blocks to prepare nitrogen- and sulfur-containing heterocycles. Herein, we reported a copper-catalyzed formal [4 + 1] annulation of pyridinium 1,4-zwitterionic thiolates and diazo compounds without any additives to access a library of trifunctionalized indolizines in good yields. Besides, isoquinolinium 1,4-zwitterionic thiolates and imidazolium 1,4-zwitterionic thiolates were also applied to this formal [4 + 1] annulation reaction. Of particular note is that various functional groups such as −CO2R, −CO2NR2, −CF3, −CN, and −(O)P(OR)2 could be easily introduced into cycloaddition products indolizines by this strategy.
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PubMed
高影响因子
EUROPEAN JOURNAL OF IMMUNOLOGY
·
2024
·
IF 4.5
A. W. Peshala Amarajeewa,Aslihan Özcan,Alveena Mukhtiar,Xu Ren,Qianyu Wang,Pemra Ozbek,Malgorzata A. Garstka,Onur Serçinoğlu
HLA-B*39:06, HLA-B*39:01, and HLA-B*38:01 are closely related HLA allotypes differentially associated with type 1 diabetes (T1D) risk and progression. B*39:06 is highly predisposing, while B*39:01 and B*38:01 are weakly predisposing and protective allotypes, respectively. Here, we aimed to decipher molecular mechanisms underlying the differential association of these allotypes with T1D pathogenesis. We addressed peptide binding and conformational stability of HLA-B allotypes using computational and experimental approaches. Computationally, we found that B*39:06 and B*39:01 allotypes had more rigid peptide-binding grooves and were more promiscuous in binding peptides than B*38:01. Peptidomes of B*39:06 and B*39:01 contained fewer strong binders and were of lower affinity than that of B*38:01. Experimentally, we demonstrated that B*39:06 and B*39:01 had a higher capacity to bind peptides and exit to the cell surface but lower surface levels and were degraded faster than B*38:01. In summary, we propose that promiscuous B*39:06 and B*39:01 may bind suboptimal peptides and transport them the cell surface, where such unstable complexes may contribute to the pathogenesis of T1D.
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PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 8
·1-13
·
IF 2.184
Qin Jianbin,Zhang Guangcheng,Shi Xuetao,Tao Min
The dispersions was prepared by dispersing hydrophilic silica nanoparticles with an average diameter of 50 nm in 1-butyl-methylimidazolium tetrafluoroborate ([C 4 mim][BF 4 ]), and investigated under the steady shear and oscillatory shear, respectively. Experimental results indicate that all of the dispersions present shear thinning, notable shear thickening, and shear thinning successively with increasing shear rate; the shear thickening behavior is derived from silica nanoparticle clusters and strongly controlled by silica nanoparticle content and temperature. The shear thickening fluid (STF) exhibits reversible property and transient response ability, and the time of transient response is no more than 100 ms. The conductivity of the STF is increased with increasing silica nanoparticle content, and the conductivity of 27 wt% dispersions is even two times as big as that of pure [C 4 mim][BF 4 ]. The dispersions with high solid content dilate and present a phase transition changing from a liquid-like to a solid-like soft material in the shear thickening region. A theoretical model is developed to imitate the mechanism of shear thickening in the dispersions.
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高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yun Luo,Baoqin Zhang,Ningbo Geng,Shuai Sun,Xiaoyao Song,Jiping Chen,Haijun Zhang
The toxicity of pyrene (Pyr) and its chlorinated species have not be comprehensively and clearly elucidated. In this study, an integrated approach of metabolomics and transcriptomics were applied to evaluate the hepatotoxicity of Pyr and 1-chloropyrene (1-Cl-Pyr) at human exposure level, using human L02 hepatocytes. After 24 h exposure to Pyr and 1-Cl-Pyr at 5–500 nM, cell viability was not significantly changed. Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1 , CYP1B1, AHR, ARNT . Pyr and 1-Cl-Pyr both induced a notable metabolic perturbation to L02 cells. Glycerophospholipid metabolism was found to be the most significantly perturbed pathway after exposure to Pyr and 1-Cl-Pyr, indicating their potential damage to the cell membrane. The other significantly perturbed pathways were identified to be oxidative phosphorylation (OXPHOS), glycolysis, and fatty acid β oxidation, all of which are related to energy production. Exposure to Pyr at 5 and 50 nM induced the up-regulation of fatty acid β oxidation and OXPHOS. The similar result was observed after exposure to 5 nM 1-Cl-Pyr. In contrast, exposure to 50 nM 1-Cl-Pyr induced the down-regulation of OXPHOS by inhibiting the activity of complex I. The obtained results suggested that the modes of action of Pyr and 1-Cl-Pyr on energy production remarkably varied not only with molecular structure change but also with exposure concentration.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Chen-Yan Hu,Ye-Ye Zhu,Bin Xu,Tian-Yang Zhang,Yi-Li Lin,Cun Xiong,Qiang-Bing Wang,Dan-Dan Huang,Ling Xu
This study explored the degradation of an iodine X-ray contrast media , iohexol, under heterogeneous ozone-catalyzed oxidation by adding Fe 3 O 4 and 1-hydroxybenzotriazole (HBT). Results show that increasing the dosages of Fe 3 O 4 catalyst and ozone as well as solution pH were beneficial to the degradation of iohexol. The presence of low background humic acid (HA) concentration (≤10 mg/L) promoted iohexol degradation, but high HA concentration (≥20 mg/L) inhibited it. Adding HBT exhibited a similar effect on iohexol degradation as HA. The degradation rate constant of iohexol was calculated as 0.07108 min −1 in the Fe 3 O 4 /O 3 /HBT process ([HBT] = 5 μM) at pH 7.0, which was approximately 1.5 times higher than that in the Fe 3 O 4 /O 3 process (0.04533 min −1 ), and 4 times higher than that in the O 3 process (0.01742 min −1 ). Fe 3 O 4 /O 3 /HBT process was pH-dependent with high degradation efficiency of iohexol at pH 5 or 7. Singlet oxygen ( 1 O 2 ), hydroxyl radical ( OH ∙ ), and superoxide radical ( O 2 - ∙ ) have been identified in the Fe 3 O 4 /O 3 /HBT process, and the conversion of Fe 2+ to Fe 3+ was more obvious on the surface of Fe 3 O 4 compared to that in the Fe 3 O 4 /O 3 process. Transformation intermediates were identified, and the degradation pathways of iohexol were proposed. Overall, Fe 3 O 4 /O 3 could enhance iohexol degradation compared with ozone-only system, and adding trace HBT in Fe 3 O 4 /O 3 system can further enhance heterogeneous ozone-catalyzed process for rapid organic matter degradation.
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高影响因子
Polymers
·
2022
·Vol. 14
·期 9
·1680
·
IF 4.967
Qiuping He,Wei Chen,Pengfei Wang,Xiaoming Dou
Separation of dichlorobenzene (DCB) isomers with high purity by time− and energy−saving methods from their mixtures is still a great challenge in the fine chemical industry. Herein, silicalite-1 zeolites/polydimethylsiloxane (PDMS) hybrid membranes (silicalite-1/PDMS) have been successfully fabricated on the porous polyvinylidene fluoride (PVDF) supports to first investigate the pervaporation separation properties of DCB isomers. The morphology and structure of the silicalite-1 zeolites and the silicalite-1/PDMS/PVDF hybrid membranes were characterized by XRD, FTIR, SEM and BET. The results showed that the active silicalite-1/PDMS layers were dense and continuous without any longitudinal cracks and other defects with the silicalite-1 zeolites content no more than 10%. When the silicalite-1 zeolites content exceeded 10%, the surfaces of the active silicalite-1/PDMS layers became rougher, and silicalite-1 zeolites aggregated to form pile pores. The pervaporation experiments both in single-isomer and binary−isomer systems for the separation of DCB isomers was further carried out at 60 °C. The results showed that the silicalite-1/PDMS/PVDF hybrid membranes with 10% silicalite-1 zeolites content had better DCB selective separation performance than the silicalite-1/α−Al2O3membranes prepared by template method. The permeate fluxes of the DCB isomers increased in the order of m−DCB < o−DCB < p−DCB both in single-isomer and binary-isomers solutions for the silicalite-1/PDMS/PVDF hybrid membranes. The separation factor of the silicalite-1/PDMS/PVDF hybrid membranes for p/o−DCB was 2.9 and for p/m−DCB was 4.6 in binary system. The permeate fluxes of the silicalite-1/PDMS/PVDF hybrid membranes for p−DCB in p/o−DCB and p/m−DCB binary−isomers solutions were 126.2 g∙m−2∙h−1and 104.3 g∙m−2∙h−1, respectively. The thickness−normalized pervaporation separation index in p/o−DCB binary−isomers solutions was 4.20 μm∙kg∙m−2∙h−1and in p/m−DCB binary−isomers solutions was 6.57 μm∙kg∙m−2∙h−1. The results demonstrated that the silicalite-1/PDMS/PVDF hybrid membranes had great potential for pervaporation separation of DCB from their mixtures.
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高影响因子
ChemNanoMat
·
2022
·Vol. 8
·期 10
·e202200268
·
IF 3.82
Mengmeng Liu,Jingjing Li,Pengfei Wang,Shuai Chen,Zhengping Dong,Fengwei Zhang
Graphical The encapsulation of Pt/TiO 2 -450H catalyst with SMSI into zeolite silicalite-1 (S-1) is reported. The resulting Pt/TiO 2 @S-1 catalyst dispalyed superior catalytic performance especially for halogenated nitroaromatics and without degradation in selectivity after 7 cycles. It is attributed to the high surface area, SMSI effect in confined space and the pore structure of S-1 with selective adsorption of substrates. The encapsulation of metal nanoparticles (NPs)-based active sites and homogeneous catalysts in nanoporous materials has been of highly research focus for tuning their catalytic activity, selectivity and stability. Although the catalysts with strong metal-support interaction (SMSI) hold the reversible encapsulation feature in a certain atmosphere, there is still a lack of systematic research on them in a real confined environment. Herein, we present a highly selective and stable Pt/TiO 2 @S-1 catalyst, which is prepared by in-situ growth of classical silicalite-1 on the external surface of Pt/TiO 2 -450H pre-catalyst with SMSI effect. Encouragingly, the encapsulated 20Pt/TiO 2 @S-1 catalyst demonstrates unprecedented catalytic performance for various nitroaromatics and without any degradation in selectivity after 7 cycles (>99%) for the hydrogenation of 1-chloro-4-nitrobenzene. Such situation is attributed to the high surface area, SMSI effect in confined space as well as the pore structure of silicalite-1 with selective adsorption of substrates.
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高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Dewei Ma,Xiaoyang Qin,Ning Dai,Xiuhua Cao
In contrast with three-dimensional perovskites , their two-dimensional (2D) analogues have been demonstrated to effectively improve the moisture tolerance due to the hydrophobicity of the long-chain organic layers. However, the insulating property of the long-chain organic layers will deteriorate the charge transport properties of the materials, limiting their applications in photovoltaics and optoelectronics . Short-chain organic cation with less carbon atoms may be a good substitution for the preparation of 2D perovskites with superior environmental stability and optoelectronic properties. In this research, quasi-2D (C 3 H 7 NH 3 ) 2 (MA) n-1 Pb n Br 3n+1 perovskite nanocrystals with an average size smaller than 10 nm were synthesized by a one-pot method, showing tunable emissions in the range of 406–524 nm for n = 1∼∞, with corresponding band-gaps of 3.63–2.30 eV. Time-resolved photoluminescence (PL) decays show that (C 3 H 7 NH 3 ) 2 PbBr 4 has the shortest average PL lifetime of 4.4 ns with the fast decay process occupying weighting proportion of 87.3%. When the nominal perovskite layers increases up to 2–4, the average PL lifetime raises up to 10.1–41.7 ns, with the slow decay process taking up most weighting percentage of >70%. MAPbBr 3 possesses the longest PL lifetime of 151.2 ns. The perovskite nanocrystals were then attempted to modify with oleic acid or to embed in PMMA matrix in order to improve their environmental stability. Results show that the stability of oleic acid and PMMA encapsulated nanocrystals improves greatly in comparison with bare nanocrystals.
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高影响因子
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