CELL CYCLE
·
2022
·
IF 5.173
Feng Zhang,Peng Liu,Zhaopeng He,like Zhang,Xinqi He,Feng Liu,Jinsheng Qi
Crocin (CRO) is feasible in alleviating atherosclerosis (AS), the mechanism of which was therefore explored in the study. High-fat diet (HFD)-induced apolipoprotein E-deficient (ApoE−/−) mice and lysophosphatidic acid (LPA)-treated macrophages received CRO treatment. Treated macrophage viability was determined via MTT assay. In both murine and macrophage, the lipid level and total Cholesterol/Cholesteryl l Ester (TC/CE) levels were quantified by oil-red-O staining and ELISA, respectively. Lipid droplet, aortic plaque formation and collagen deposition were detected via Oil-red-O staining, hematoxylin–eosin staining and Masson staining, respectively. Liver X Receptor-α (LXR-α), Peroxisome Proliferator-Activated Receptor γ (PPARγ), CD68, PCSK9, CD36, ATP Binding Cassette Subfamily A Member 1 (ABCA1), phosphorylated (p)-AKT, and AKT expressions were detected via Western blot, the former three also being detected using Immunohistochemistry and the first being measured by qRT-PCR. CRO decreased HFD-induced weight gain, ameliorated the abnormal serum lipid levels of HFD-treated mice, and inhibited aortic plaque formation and lipid deposition, and increased collagen fibers, with upregulated high-density lipoprotein-cholesterol (HDL-C) and downregulated TC and low-density lipoprotein-cholesterol (LDL-C). CRO alleviated the HFD-induced upregulations of CD68, PCSK9 and CD36 as well as downregulations of PPARγ/LXR-α, ABCA1 and AKT phosphorylation. In LPA-treated macrophages, CRO alone exerted no effect on the viability yet inhibited the lipid droplets formation and downregulated TC/CE levels. Silent LXR-α reversed the effect of CRO on the lipid droplets formation and levels of lipid metabolism-related factors. CRO ameliorated AS by inhibiting foam cells formation and promoting reverse cholesterol transport via PPARγ/LXR-α.
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高影响因子
AAPS PHARMSCITECH
·
2021
·Vol. 23
·期 1
·1-11
·
IF 3.246
Liu Hongfei,Zou Yi,Zhu Jie,He Haibing,Feng Yingshu,Firempong Caleb Kesse,Yu Yang,Sun Changshan
Recombinant human interferon α-2b (rhINF-α-2b), like most proteins, has several shortcomings such as relatively short half-life, low therapeutic index, high circulating drug fluctuations, and rapid degradation which could hinder its effective delivery. Novel electrostatic spray and ion exchange drug-loading techniques were combined to formulate rhINF-α-2b sodium hyaluronate cross-linked porous sustained-release microspheres (rhINF-α-2b-SHCPM), a protein delivery system. The different properties of rhINF-α-2b-SHCPM including the physicochemical nature, in vitro release behavior, and antitumor activity were evaluated. The loading rate (10.31 ± 0.94%) and encapsulation efficiency (89.09 ± 2.37%) of rhINF-α-2b-SHCPM produced acceptable values. The in vitro cumulative release rate of rhINF-α-2b-SHCPM within 24 h was also 86.26 ± 2.11% with a much better sustained release effect. Thus, the half-life (10.763 h) and retention time (14.067 h) of rhIFNα-2b-SHCPM were significantly prolonged with enhanced bioavailability (43,198.387 ng/L*h) and decreased peak concentration (15,266.4 ngL -1 ) compared with the free rhIFNα-2b protein (0.912 h, 0.952 h, 34,749.048 ng/L*h, and 48,870.2 ngL -1 , respectively). The in vitro anti-proliferative activity and in vivo tumor inhibitory rate of rhIFNα-2b-SHCPM also increased by 90 and 55.86%, respectively, compared with the free rhIFNα-2b solution. The findings significantly supported a well-developed protein delivery system with improved sustained release, acceptable bioavailability, and increased antitumor activities.
Graphical Abstract
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高影响因子
Nanoscale
·
2021
·Vol. 13
·期 47
·20170-20185
·
IF 7.79
Yanqin Song,Muhammad Ismail,Qi Shan,Jianing Zhao,Yanping Zhu,Leiming Zhang,Yuan Du,Longbing Ling
Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide and its current management requires more successful therapeutic approaches. The combination of nanomedicines and pathophysiology into one system may provide an alternative strategy for precise RA treatment. In this work, a practical ROS-mediated liposome, abbreviated as Dex@FA-ROS-Lips that comprised synthetic dimeric thioether lipids (di-S-PC) and a surface functionalized with folic acid (FA), was proposed for dexamethasone (Dex) delivery. Incorporation with thioether lipids and a FA segment significantly improved the triggered release and improved the triggered release of cytotoxic Dex as well as the active targeting of RA, altering its overall pharmacokinetics and safety profiles in vivo. As proof, the designed Dex@FA-ROS-Lips demonstrated effective internalization by LPS-activated Raw264.7 macrophages with FA receptor overexpression and released Dex at the inflammatory site due to the ROS-triggered disassembly. Intravenous injection of this Dex@FA-ROS-Lips into adjuvant-induced arthritis (AIA) mice led to its incremental accumulation in inflamed joint tissues and significantly alleviated the cartilage destruction and joint swelling via suppression of proinflammatory cytokines (iRhom2, TNF-α and BAFF), as compared to the effect of commercial free Dex. Importantly, the Dex@FA-ROS-Lips nanoformulation showed better hemocompatibility with less adverse effects on the body weight and immune organ index of AIA mice. The anti-inflammatory mechanism of Dex@FA-ROS-Lips was further studied and it was found that it is possibly associated with the down-regulation of iRhom2 and the activation of the TNF-α/BAFF signaling pathway. Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-α/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.
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高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Enrou Mei,Xiaodong Liu,Ya Chen,Yanxia Yu,Zhaoping Chen,Keqin Yang,Xiaojuan Liang,Weidong Xiang
Recently, perovskite has received extensive attention due to their excellent photoelectric properties, while the instability of perovskite quantum dots (PQDs) has always troubled us. Herein, we proposed a simple coating mechanism to protect PQDs. Using oleic acid (OA) for etching α-Al 2 O 3 wafer to make the surface appear pore structure, and the PQDs was coated within the modified α-Al 2 O 3 wafer, thereby improving the stability of PQDs. The CsPbX 3 @α-Al 2 O 3 composite material can achieve the emission of blue-green–red (436 nm to 636 nm) through adjustable luminescence wavelength. The photoluminescence (PL) intensity of CsPbBr 3 @α-Al 2 O 3 composite material exposure to the air after 28 days can maintain over 50%. It is worth noticing that the photoluminescent quantum yield (PLQY) of CsPbBrI 2 @α-Al 2 O 3 composite material can reach 58%, the colour purity of CsPbBr 3 @α-Al 2 O 3 and CsPbBrI 2 @α-Al 2 O 3 achieve 97.1% and 99.8%, respectively. It was due to the high colour purity of the composite materials can the selected CIE colour coordinate monochromatic light encompassed 114% of NTSC colour gamut. Moreover, the warm white light-emitting diode (WLED) yielded bright natural white light and showed the luminous efficiency (LE) of 86.58 lm/W, colour rendering index (CRI) of 86.9, correlated colour temperature (CCT) of 4602 K. The LE and CRI reaches a relatively balanced value, which showed that this composite material has a certain development prospect in the WLED field.
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高影响因子
ENERGY & FUELS
·
2021
·
IF 3.605
Fangwen Cheng,Shaoqi Zhan,Xinfeng Dai,Xiaofeng Huang,Binghui Wu,Nanfeng Zheng
α-FAPbI3-based perovskite solar cells have recently attracted increasing attention as a result of an ideal bandgap and longer exciton lifetime of FAPbI3 compared to perovskites with other compositions. However, in a traditional fabrication method, the α-FAPbI3 films were usually obtained by a direct phase transition from δ to α phase at a high annealing temperature, leading to low quality with poor crystallinity and numerous defects. The formation and stabilization of phase-pure, material-pure, high-quality α-FAPbI3 films remain challenging. In this work, a FA vapor-assisted cation-exchange pathway from low-dimensional perovskites to three-dimensional α-FAPbI3 was built, through which phase-pure and material-pure α-FAPbI3 films were achieved at 100 °C below the temperature of thermodynamic δ-to-α phase transition (∼150 °C). Through an in-depth study, the cation-exchange pathway was found to have a low reaction barrier directly toward α-FAPbI3 and suppress the formation of δ-FAPbI3, leading to high-quality α-FAPbI3 with high orientation and few trap states at a low annealing temperature. Consequently, small-area devices and large-area modules with as-prepared α-FAPbI3 films were achieved with improved performance, showing great potential for further study and application.
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高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.262
Xiaojuan Wang,Hanqing Gu,Guolin Wu
A series of poly (amino acid) with zwitterionic character was prepared for surface coating to avoid protein adsorption, by modifying the poly (aspartic acid) side chain with tertiary amine groups. An interesting and facile procedure is described with starts with polysuccinic acid which is followed by ring-opening with amino functions and finally hydrolysis of the remaining succinic acid groups achieving the polyaspartic acid structure as backbone. The degree of cationic tertiary amino group was easily varied by the degree of ring-opening with amines. The materials show isoelectric point between pH 4 and 9, have a typical zwitterionic character, and can be used to coat negatively as well as positively charged surfaces, depending on composition. The protein adsorption behavior is thus pH dependent and was studied with various proteins mainly available in blood. The adsorption test proved that a significant reduction of protein adsorption could be found for fibrinogen and albumin, and this protein-repellent behavior is strongly dependent on the amount of the absorbed polymer (adsorbed at pH = 7.4). This is a nice additional contribution to polymers with zwitterionic character used as coating reducing nonspecific protein adsorption.
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高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 48
·18061-18068
·
IF 4.39
Jiahui Guo,Xueqing Feng,Songrui Wang,Qikang Wu,Shanshan Lv,Yan Zhou,Han Li,Zheng Chen,Yuzhong Zhang
Novel hexagonal α-cobalt hydroxide nanosheets are synthesized through a 2-methylimidazole-induced hydrolysis strategy with cetyltrimethylammonium bromide (CTAB) as a surfactant. The weak alkaline environment provides favorable conditions for the formation of metastable α-Co(OH)2, while the same raw material will produce β-Co(OH)2 when a strong alkali solution is used. CTAB plays a vital role not only in hexagonal oriented growth, but also in the formation of the hydrotalcite-like structure of α-Co(OH)2 with high crystallinity. The crystallinity of both α- and β-Co(OH)2 is very poor without CTAB as a surfactant. The Co in this Co(OH)2−x layer presents most of the CoII and a small part of the CoIII, and the interlayer nitrate anion balances the positive charge of the host layer. The redox function produced by the CoII and CoIII of α-Co(OH)2 together with the large layer spacing jointly promotes the electron and mass transfer. The use of hydrazine hydrate for transfer hydrogenation involves the transport of protons and electrons produced by decomposition, and the rapid transport is bound to be conducive to the reduction process. Nitro compounds with varieties of functional groups can be smoothly reduced to the corresponding amines with high selectivity, when α-Co(OH)2 was used as a catalyst under mild conditions.
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高影响因子
Food Bioscience
·
2021
·
IF 4.24
Jia-Bin Wang,Le-Yi Yu,Xu Zeng,Jun-Wei Zheng,Bin Wang,Li Pan
Inhibition of α-glucosidase activity is an important strategy in lowering the concentration of blood sugar . In this paper, using domestic and foreign characteristic food-derived substances as the sources of lactobacillus , the performance of them were evaluated by measuring the strains’ α-glucosidase inhibitory ability. Finally, the cell-free extracellular supernatants (CFS) of Lactobacillus rhamnosus LB1lac10 was determined to have the highest α-glucosidase inhibition ability. Based on the Nanopore third-generation sequencing technology platform, the genome of LB1lac10 was sequenced and functional gene annotation was performed. After that, the biological activity and structural composition of the exopolysaccharide produced by L. rhamnosus LB1lac10 were studied. The purified exopolysaccharide EPS1-1 also showed efficient α-glucosidase inhibitory ability. The structure and conformation characteristics of EPS1-1 were further analyzed. The EPS1-1 from L. rhamnosus LB1lac10 had a molecular weight of 88,650 Da, and it was mainly composed of mannose , glucuronic acid , glucose, xylose , galactose , and arabinose . From the FT-IR and NMR analyses, EPS1-1 had functional groups of a typical polysaccharide structure and contained two types of glycosidic bonds with α-configuration pyranose . The main glycosidic bond corresponded to → 4)-α- d -Glcp-(1→, which might be an important reason why EPS1-1 could inhibit α-glycosidase. Thermodynamic studies showed that EPS1-1 had high heat resistance to meet the needs of food processing. The results suggested that L. rhamnosus LB1lac10 could be used as a potential probiotic to lower blood sugar, and the EPS1-1 has the potential to serve as a natural α-glycosidase inhibitor to regulate the concentration of blood glucose.
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高影响因子
Journal of Energy Storage
·
2021
·
IF 6.583
Weizhi Gong,Mingjun Wang,Yi An,Junli Wang,Liexing Zhou,Yi Xia,Chunjian Wang,Kun Dong,Cheng Pan,Rongfeng Zhou
Cycling stability and specific capacitance are two of important performance parameters for pseudocapacitive electrodes under frequent charging and discharging. Herein, we present a facile solvothermal approach to rationally design and fabricate chiffon-like and hydrotalcite-like α-Co(OH) 2 nanoflakes for extrinsic pseudocapacitive electrode, which exhibits linear galvanostatic discharge behavior and superior charge-storage performance, including high capacitance of 475 F g −1 at 1 A g −1 , excellent rate capability and superb cycling stability with capacitance retention of 93.9% after 10000 cycles at 10 A g −1 . The superior performance is mostly attributed to the good electrical conductivity and stable microstructure of the hydrotalcite-like α-Co(OH) 2 nanoflakes and the abundant redox active sites on the chiffon-like nanoflakes with short and facile electron transport. In addition, other α-Co(OH) 2 samples with different morphologies and size as contrast are prepared and discussed, indicating that the morphology/size design and optimization of the α-Co(OH) 2 could greatly improve the electrochemical energy-storage performance. The findings demonstrate that the chiffon-like and hydrotalcite-like α-Co(OH) 2 nanoflakes have a great practical application potential in long-life and high-performance supercapacitors . This study also presents a facile way to design and prepare nanoflake-like materials with adjustable lateral size and thickness from spherical morphology consisting of nanoflakes.
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高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yan-Fei Mu,Chao Zhang,Meng-Ran Zhang,Wen Zhang,Min Zhang,Tong-Bu Lu
Up to now, the majority of the developed photocatalytic CO2 reduction systems need to use expensive sacrificial reductants as electron source. It is still a huge challenge to drive the photocatalytic CO2 reduction using water as an electron source. Herein, we report a facile strategy for the construction of direct Z-scheme heterojunction of LF-FAPbBr3/α-Fe2O3, which is manufactured by the in situ and two-step controlled growth of ligand-free formamidinium lead bromide (LF-FAPbBr3) nanocrystals on the surface of α-Fe2O3 nanorods. The matchable energy levels and direct contact between LF-FAPbBr3 and α-Fe2O3 significantly accelerate the interfacial charge transfer, with a charge separation efficiency (ηseparation) of 93%, much higher than that of 11% shown by the ligand-capped FAPbBr3/α-Fe2O3 heterojunction. The resulting efficient separation and raised redox ability of photogenerated carriers endow the LF-FAPbBr3/α-Fe2O3 heterojunction with an outstanding photocatalytic performance for CO2 reduction (to CO and CH4) coupled with water oxidation (to O2), achieving a highest electron consumption rate of 175.0 μmol g–1 h–1 among the reported metal halide perovskite-based photocatalysts, which are 5 and 11 times higher in comparison with those of sole LF-FAPbBr3 and ligand-capped FAPbBr3/α-Fe2O3, respectively.
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Weili Xu,Kangxing Lv,Wei Mu,Shaobo Zhou,Yang Yang
The aim of this study was to develop an oil-in-water (O/W) emulsion using whey protein isolate (WPI)-chitosan (CN) complex to encapsulate α-tocopherol and to characterize their stability and bioaccessibility in vitro . The O/W emulsions prepared under the optimal conditions (mass ratio of WPI:CN = 1: 1, corn oil containing 5 g/100 g of α-tocopherol) exhibited a monomodal distribution (d = 803.3 ± 6.9 nm) with encapsulation rate of 86.3 ± 2.3%. The emulsions were stable under NaCl (0–150 mmol/L), sugar (0–5 g/100 g), 55 °C for 30 min, pH 5–6.5, even storage for 20 d at 4 °C and 25 °C. During gastric digestion, WPI situated at the surface of emulsion particles can be digested into small molecular peptides by pepsin, but the structure of the core-shell particles remained due to the cross-linking with CN. During intestinal digestion, the structure of the particles disintegrated over the digestion time, and the inner-oil phase was released. Release profiles of the α-tocopherol and free fatty acids showed a burst effect followed by slow release. These results suggest that the WPI-CN complex could be used to achieve a controlled and sustainable release of liposoluble bioactive compounds from O/W emulsions.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jing Deng,Cheng Ye,Anhong Cai,Linyi Huai,Shiqing Zhou,Feilong Dong,Xueyan Li,Xiaoyan Ma
As a typical iron-based oxide semiconductor with abundant reserves, α-Fe 2 O 3 has been widely used in the domain of photocatalysis and environmental remediation. Here, sulfur doped α-Fe 2 O 3 (S-α-Fe 2 O 3 ) has been successfully fabricated through coprecipitation, hydrothermal and calcination processes and applied to activate persulfate (PS) for carbamazepine (CBZ) degradation under UV irradiation. Systematic characterizations were conducted to analyze the morphology, structure and chemical composite of S-α-Fe 2 O 3 . UV/PS/S-α-Fe 2 O 3 process showed remarkably enhanced photocatalytic performance for CBZ degradation. The degradation rate constant (7.78 × 10 −2 min −1 ) was about 2.2 and 14.1 times as high as that of UV/PS/α-Fe 2 O 3 (3.60 × 10 −2 min −1 ) and UV/PS (5.53 × 10 −3 min −1 ) processes, respectively. With increasing PS concentration and photocatalyst dosage, the removal efficiency of CBZ both increased. UV/PS/S-α-Fe 2 O 3 process can efficiently and steadily operate in a wide pH range of 3.0–8.0. The introduction of water matrix species (i.e. chloride, bicarbonate, nitrate and humic acid) exerted different effects on CBZ degradation. S-dopant was doped via forming ≡Fe III -SO 4 2- bond on S-α-Fe 2 O 3 surface, and doped sulfur functioned as surface electrons trapping centers derived from DFT study. The band gap value of S-α-Fe 2 O 3 was reduced and the separation efficiency of photogenerated electrons and holes was improved. Hydroxyl radicals, sulfate radicals, superoxide radicals and holes all contributed to CBZ destruction. Furthermore, two major routes of CBZ degradation were proposed as hydroxylation and deamination, then followed by decarbonxylation, ketonization and ring cleavage based on the results of HPLC-MS and DFT calculation.
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危险品化学品经营许可证（带存储）