NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 10
·4700-4709
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IF 3.925
Hang Li,Qingsheng Zhao,Liwei Wang,Peidong Wang,Bing Zhao
Cannabidiol (CBD), a natural phenolic compound, has many promising biological activities, but its use in food or other fields is restricted owing to inferior water solubility. So hydroxypropyl-β-cyclodextrin (HP-β-CD) was selected to form the inclusion complex (IC) of CBD to improve its solubility. The results showed CBD/HP-β-CD IC was formed at a 1 : 1 molar ratio. The complexation was spontaneous, endothermic, and entropy-driven. The loading efficiency (LE) and complexation efficiency (CE) were 16.2% and 95.1%, respectively. NMR revealed CBD/HP-β-CD IC was formed through incorporating the benzene ring of CBD into the HP-β-CD cavity. The water solubility was greatly enhanced to 9.4 μg mL−1. About 80% of CBD molecules in the IC were released in simulated intestinal juice. The permeability, radical scavenging ability, and in vitro cytotoxicity of CBD were enhanced significantly after complexation. And the radical scavenging ability of digested IC was less potent compared with undigested IC but still stronger than that of CBD.
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高影响因子
Journal of Advanced Research
·
2022
·
IF 12.822
Weiwei Tao,Jie Ruan,Ruyan Wu,Min Zhao,Tong Zhao,Mingming Qi,Sonata S.Y. Yau,Guangda Yao,Hongru Zhang,Yue Hu,Gang Chen
Introduction Adult hippocampal neurogenesis (AHN) is acknowledged to play a critical role in depression. Emerging evidence suggests that the Wnt/β-catenin pathway can modulate hippocampal neurogenesis. Crocin, a natural carotenoid, possesses antidepressant property. Yet, how it affects neurogenesis and exerts antidepressant response remains unknown. Objective To explore the role of AHN and Wnt/β-catenin in the antidepressant action of crocin. Methods Depressive-related behaviors, including sucrose preference test (SPT), tail suspension test (TST), forced swimming test (FST), and sexual behaviors were performed following crocin treatment. Neurogenesis was characterized via immunohistochemistry, immunofluorescence, Golgi staining and electrophysiology approach. Wnt/β-catenin signaling was examined with western blot analysis. The role of AHN Wnt/β-catenin cascade in crocin’s antidepressant response was assessed by conditional removal of glial fibrillary acidic protein (GFAP)-expressing newborn neural cells, temozolomide administration, microinfusion of Dkk1 or viral-mediated shRNA of Wnt3a. Results Crocin decreased the immobility duration in TST and FST without impairing the performance in sexual behaviors. Crocin boosted the proliferation and differentiation of progenitors, and promoted dendritic maturation and functional integration of hippocampal newborn neurons. Conditional removal of GFAP-expressing neural cells or temozolomide administration impaired the antidepressant response of crocin. Additionally, Wnt/β-catenin signaling was promoted following crocin treatment. In chronic unpredictable mild stress (CUMS) murine model, crocin treatment displayed antidepressant response in SPT, FST and TST, and restored the neurogenesis levels and Wnt/β-catenin signaling impaired by CUMS. Infusion of Dickkopf-1 (DKK1) or knockdown of Wnt3a in the hippocampus impaired the antidepressant response of crocin. Conclusion Crocin exerted antidepressant response, which was dependent on enhancement of AHN and activation of the Wnt/β-catenin pathway.
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Journal of Advanced Research
·
2023
·
IF 10.7
Wenjuan Tang,Yu Hu,Kaihui Tu,Zhengyan Gong,Man Zhu,Tianfeng Yang,Ammar Sarwar,Bingling Dai,Dongdong Zhang,Yingzhuan Zhan,Yanmin Zhang
Introduction Tumor-associated calcium signal transducer 2 (Trop2) has been used as a transport gate for cytotoxic agents into cells in antibody–drug conjugate designs because of its expression in a wide range of solid tumors. However, the specific role of Trop2 itself in breast cancer progression remains unclear and small molecules targeting Trop2 have not yet been reported. Objectives To screen small molecules targeting Trop2, and to reveal its pharmacological effects and the molecular mechanisms of action. Methods Small molecule targeting Trop2 was identified by cell membrane chromatography, and validated by cellular thermal shift assay and point mutation analyses. We investigated the pharmacological effects of Trop2 inhibitor using RNA-seq, human foreskin fibroblast (HFF)-derived extracellular matrix (ECM), Matrigel drop invasion assays, colony-forming assay, xenograft tumor model, 4T1 orthotopic metastasis model and 4T1 experimental metastasis model. The molecular mechanism was determined using immunoprecipitation, mass spectrometry, immunofluorescence, immunohistochemistry and Western blotting. Results Here we identified Bruceine D (BD) as the inhibitor of Trop2, and demonstrated anti-metastasis effects of BD in breast cancer. Notably, Lys307 and Glu310 residues of Trop2 acted as critical sites for BD binding. Mechanistically, BD suppressed Trop2-induced cancer metastasis by blocking the formation of Trop2/β-catenin positive loop, in which the Trop2/β-catenin complex prevented β-catenin from being degraded via the ubiquitin-proteosome pathway. Destabilized β-catenin caused by BD reduced nucleus translocation, leading to the reduction of transcription of Trop2, the reversal of epithelial-mesenchymal transition (EMT) process, and the inhibition of ECM remodeling, further inhibiting cancer metastasis. Additionally, the inhibitory effects of BD on lung metastatic colonization and the beneficial effects of BD on prolongation of survival were validated in 4T1 experimental metastasis model. Conclusions These results support the tumor-promoting role of Trop2 in breast cancer by stabilizing β-catenin in Trop2/β-catenin positive loop, and suggest Bruceine D as a promising candidate for Trop2 inhibition.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Tongtong Hou,Xu Shao,Minling Ding,Kun Mei,Xin Wang,Ping Guan,Xiaoling Hu
Photoinduced modulation of A β 42 aggregation has emerged as a therapeutic option for treating Alzheimer's disease (AD) due to its high spatiotemporal controllability, noninvasive nature, and low systemic toxicity. However, existing photo-oxidants have the poor affinity for A β 42 , low depolymerization efficiency, and difficulty in crossing the blood-brain barrier (BBB), hindering their application in the treatment of AD. Here, through hydrophobic interactions and hydrogen bonding, we integrated the near-infrared (NIR) photosensitizer indocyanine green with transferrin (denoted as TF-ICG), a protein with a high affinity for A β 42 , and demonstrated its anti-amyloid activity in vitro. TF-ICG was shown to bind to A β 42 residues via hydrophobic interaction, impeding π-π stacking of A β 42 peptide monomers and disassembling mature A β 42 protofibrils in a concentration-dependent manner. More importantly, under NIR (808 nm, 0.6w/cm 2 ) irradiation, TF-ICG completely inhibited the fibrillation process of A β 42 to generate amorphous aggregates, with an inhibition rate of 96 % at only 65 nM. Meanwhile, TF-ICG could photo-oxidize rigid A β 42 aggregates and break them down into small amorphous structures. Tyrosine fluorescence assay further demonstrated the intrinsic affinity and targeting of TF-ICG to A β 42 fibrils. In vitro studies validated the anti-amyloid activity of TF-ICG, which provided a theoretical basis for further in vivo application as a BBB-penetrating nanotherapeutic platform.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2023
·Vol. 25
·期 19
·13474-13486
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IF 3.3
Xin Guan,Xiao-li Wang,Xue-wen Zhu,Hui Yu,Ming Yang,Xiang-ting Dong,Ying Yang,Long Xia
β-Bi2O3 demonstrates excellent photocatalytic activity under visible light, but it has a very high photogenerated e−–h+ recombination rate and quite low quantum efficiency. AgBr also shows excellent catalytic activity but Ag+ is easily reduced to Ag under light radiation, which limits its application in the photocatalysis field, and there are few reports about the application of AgBr in photocatalysis. In this study, the spherical flower-like porous β-Bi2O3 matrix was first obtained, and then the spherical-like AgBr was embedded between the petals of the flower-like structure to avoid direct light radiation. The only light through the pores on the β-Bi2O3 petals could be transmitted onto the surfaces of AgBr particles to form a nanometer point light source, which photo-reduced Ag+ on the surface of the AgBr nanospheres to construct the Ag-modified AgBr/β-Bi2O3 embedded composite and a typical Z-scheme heterojunction was constructed. Under this bifunctional photocatalyst and visible light, the RhB degradation rate reached 99.85% in 30 min, and the photolysis water hydrogen production rate reached 6.288 mmol g−1 h−1. This work is as an effective method for not only the preparation of the embedded structure, quantum dot modification and flower-like morphology but also for the construction of Z-scheme heterostructures.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Jiyan Li,Yanju Jing,Min Qiao,Wenzhe Yang,Hanxue Sun,Rui Jiao,Junping Zhang,An Li
Solar-driven interfacial evaporation (SDIE) stands out as a prospective technology for freshwater production, playing a significant role in mitigating global water scarcity. Herein, a cyclodextrin polymer/chitosan composite aerogel (PPy-La/Al@CDP-CS) with vertically aligned channels was prepared as a solar evaporator for efficient solar steam generation. The vertically aligned pore structure, achieved through directional freezing assisted by liquid nitrogen, not only improves water transport during evaporation but also enhances light absorption through multiple reflections of sunlight within the pores. The polypyrrole particles sprayed on the surface of the aerogel acted as a light-absorbing layer, resulting in an impressive absorbance of 98.15 % under wetting conditions. The aerogel has an evaporation rate of 1.85 kg m −2 h −1 under 1 kW m − 2 irradiation. Notably, the vertical pore structure of the aerogel allows it to exhibit excellent evaporation performance and salt resistance even in highly concentrated salt solutions. Furthermore, this aerogel is an excellent solar-driven interfacial evaporator for purifying seawater and fluoride-containing wastewater. This photothermal aerogel has the advantages of excellent performance, low cost, and environmental friendliness, and thus this work provides a new approach to the design and fabrication of solar photothermal materials for water treatment.
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Small
·
2023
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IF 13.3
Rui Gao,Wanqing Xu,Zhiqing Wang,Fen Li,Yueli Liu,Guogang Li,Keqiang Chen
Synthesis of upconversion nanoparticles (UCNPs)-metal halide perovskites (MHPs) heterostructure is garnered immense attentions due to their unparalleled photophysical properties. However, the obvious difference in their structural forms makes it a huge challenge. Herein, hexagonal β-NaYF 4 and hexagonal Cs 4 PbBr 6 are filtrated to construct the UCNP/MHP heterostructural luminescent material. The similarity in their crystal structures facilitate the heteroepitaxial growth of Cs 4 PbBr 6 on the surface of β-NaYF 4 NPs, leading to the formation of high-quality β-NaYF 4 :Yb,Tm/Cs 4 PbBr 6 core/shell nanocrystals (NCs). Interestingly, this heterostructure endows the core/shell NCs with typically narrow-band green emission centered at 524 nm under 980 nm excitation, which should be attributed to the Förster resonance energy transfer (FRET) from Tm 3+ to Cs 4 PbBr 6 . It is noteworthy that the FRET efficiency of β-NaYF 4 :Yb,Tm/Cs 4 PbBr 6 core/shell NCs (58.33%) is much higher than that of the physically mixed sample (1.84%). In addition, the reduced defect density, lattice anchoring effect, as well as diluted ionic bonding proportion induced by the core/shell structure further increase the excellent water-resistance and thermal cycling stability of Cs 4 PbBr 6 . These findings open up a new way to construct UCNP/MHP heterostructure with better multi-code luminescence performance and stability and promote its wide optoelectronic applications.
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Journal of Materials Research and Technology-JMR&T
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2023
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IF 6.4
Bo Dong,Chengji Deng,Jun Ding,Hongxi Zhu,Qian Wang,Yong Zhang,Chao Yu
In this investigation, we have employed a novel approach to fabricate β–Sialon/Ti(C, N) composites through the nitridation treatment of Ti 3 SiC 2 powder. At temperatures ranging from 1373 to 1773 K, the reaction process was subjected to a comprehensive analysis to explore the transformation of phase and microstructure. The findings unequivocally highlight the influence of α–Al 2 O 3 presence and the high specific surface area of Ti 3 SiC 2 powder, resulting in distinctive phase and structural evolutions post nitridation, distinctly different from those observed in bulk Ti 3 SiC 2 . The β–Sialon/Ti(C, N) composites produced via this innovative method exhibit uniform local chemical composition and meticulous regulation of grain morphology. Moreover, the synthesis mechanism of β–Sialon/Ti(C, N) composites under nitrogen ambiance was thoroughly discussed. This straightforward approach has the potential for extensive–scale synthesis of β–Sialon/Ti(C, N) composites, offering promising avenues for their application in developing high–performance refractories or structural ceramics tailored to withstand severe high–temperature environments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yufan Huang,Jiaofen Lin,Bihua Shen,Chenmin Zheng,Bingqing Huang,Jinmei Zou,Guoguang Zhang,Peng Fei
In this study, chlorogenic acid-chitosan (CA-CS) copolymers were prepared with varying Chitosan (CS): chlorogenic acid (CA)ratios and characterized for their water solubility, antioxidant capacity, and emulsions stability. Results showed that CA-CS samples exhibited up to 90.5 % increase in DPPH scavenging efficiency and 20 % increase in hydroxyl radical scavenging efficiency compared to CS alone. CA-CS copolymers used to stabilize oil in water (O/W) emulsions, which were evaluated for their potential in encapsulating and protecting β-carotene. Microscopic observations revealed homogeneous spherical droplets in stable emulsions, suggesting effective interfacial structures. The selected CA-CS-stabilized O/W emulsions demonstrated encapsulation efficiencies of 74.8 % and 75.26 % for β-carotene. The CA-CS stabilized O/W emulsions provided the most effective protection against β-carotene degradation under UV exposure, retaining over 80 % of β-carotene content after 12 h of testing. These findings indicate that CA-CS-based O/W emulsions show promise as carriers and protectors for bioactive compounds, due to their improved antioxidant capacity, emulsions stability, and protection against degradation.
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BIOORGANIC & MEDICINAL CHEMISTRY
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2016
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IF 2.923
Shenqi Wei,Wei Chen,Jingfang Qin,Yingzi Huangli,Li Wang,Yue Shen,Huang Tang
A series of 8- and 11-substituted oxoisoaporphine derivatives have been designed, synthesized, and tested for their ability to inhibit cholinesterase (ChE) in vitro and in vivo, and self-induced β-amyloid (Aβ) aggregation. Their autophagy activity and blood–brain barrier (BBB) permeability were also assessed. The new derivatives exhibited high AChE inhibitory activity in vivo and in intro. Over half the derivatives exhibited a significant in vitro inhibitory activity toward the self-induced Aβ aggregation. While, treatment of SH-SY5Y cells overexpressing the Swedish mutant form of human β-amyloid precursor protein (APPsw) with derivatives was associated with significant reduction of Aβ secretion levels. Moreover, one-third of the synthetic compounds were predicted to be able to cross the BBB to reach their targets in the central nervous system (CNS) according to a parallel artificial membrane permeation assay for BBB. Compounds 5b and 6b were chosen for assessing their autophagy activity. The fluorescence intensity of the BC12921 was decreased significantly after treatment with compounds. The result encourages us to study such compounds thoroughly and systematically.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Chao Wang,Baokang Dang,Hanwei Wang,Yipeng Chen,Yushan Yang,Yingying Li,Ye Xiong
The assembly of heterogeneous photocatalysts with unique structures by 2D heterojunctions is an advanced strategy for efficient solar energy conversion. However, heterogeneous photocatalysts constructed from 2D materials will suffer from high photogenerated charge recombination and low light absorption due to the arbitrary stacking and weak bonding of lamellae. Here, flower-like Bi 4 O 5 I 2 / β -Bi 2 O 3 (FL-Bi 4 O 5 I 2 / β -Bi 2 O 3 ) heterojunctions are developed in situ using FL-δ-Bi 2 O 3 as the starting material. It is noteworthy that the basic compositional form of the material was well maintained throughout the synthesis. Besides, due to the random reaction of iodide ions with the exposed surface of δ-Bi 2 O 3 , multiple heterogeneous regions are displayed on the basic lamellar units constituting the Bi 4 O 5 I 2 /β-Bi 2 O 3 nanoflowers. Theoretical and experimental results reveal that FL-Bi 4 O 5 I 2 /δ-Bi 2 O 3 possesses not only improved photogenerated carrier separation, enhanced light harvesting, but also considerable CO 2 adsorption. Importantly, FL-Bi 4 O 5 I 2 / β -Bi 2 O 3 achieves S-scheme CO 2 conversion due to its reasonable energy band structure, and with the CO generation rate of up to 31.74 μmol g −1 h −1 under simulated sunlight.
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JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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2023
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IF 5.6
Siyu Xia,Feifei Xi,Kunlin Ou,Ying Zhang,Huizhen Ni,Chonggang Wang,Qin Wang
Tea and tea products are widely used as the most popular beverage in the world. EGCG is the most abundant bioactive tea polyphenol in green tea, which has positive effects on the prevention and treatment of diabetes. However, the impact of EGCG exposure on glucose homeostasis and islets in adult mice have not been reported. In this study, we studied glucose homeostasis and the morphological and molecular changes of pancreatic islet α and β cells in adult male mice after 60 d of exposure to 1 and 10 mg/kg/day EGCG by drinking water. Glucose homeostasis was not affected in both EGCG groups. The expression of pancreatic duodenal homebox1 (Pdx1) in β cells was upregulated, which might be related to increased insulin level , β cell mass and β cell proliferation in 10 mg/kg/day EGCG group. The expression of aristaless-related homeobox (Arx) in α cells did not change significantly, which corresponded with the unchanged α-cell mass. The significant reduction of musculoaponeurotic fibrosarcoma oncogene homolog B (MafB) positive α-cells might be associated with decreased glucagon level in both EGCG groups. These results suggest that EGCG supplementation dose-dependent increases β cell mass of adult mice and affects the levels of serum insulin and glucagon. Our results show that regular tea drinking in healthy people may have the possibility of preventing diabetes.
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危险品化学品经营许可证（带存储）