AAPS PHARMSCITECH
·
2024
·Vol. 25
·期 7
·1-15
·
IF 3.4
Shi Feng,Gong Mingjie,Adu-Frimpong Michael,Jiang Xia,Wang Xiaowen,Hua Qinyang,Li Tingyuan,Li Jiaying,Yu Jiangnan,Toreniyazov Elmurat,Cao Xia,Wang Qilong,Xu Ximing
In this study, N, N '-bis {4- [(α-L- rhamnosyloxy) benzyl]} thiourea (PG-1), a phenolic glycoside compound was purified from Moringa seed. The PG-1 has attracted extensive attention due to its anti-cancer, antioxidant, anti-inflammatory and hypoglycemic properties. However, some of its physicochemical properties such as oral bioavailability has not been studied. Herein, a highly purified PG-1 was extracted and incorporated in multiple layered liposomes (PG-1-L) to avoid its burst release and enhance oral bioavailability. After appropriate characterization, it was discovered that the obtained PG-1-L was stable, homogeneous and well dispersed with the average particle size being 89.26 ± 0.23 nm. Importantly, the in vitro release and in vivo oral bioavailability of PG-1-L were significantly improved compared with PG-1. In addition, MTT results showed that compared with the free PG-1, PG-1-L displayed obvious inhibitory effect on the HepG2 cells, while the inhibitory effect on healthy non-malignant 3T6 and LO-2 cells was not significant, indicating that PG-1-L had high safety. In conclusion, PG-1-L can be used as a promising delivery system and an ideal novel approach to improve the oral bioavailability and anticancer activity of PG-1. Graphical Abstract
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高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 6
·065501
·
IF 3.404
Xiang Ran,Zhenzhen Wang,Enguo Ju,Fang Pu,Yanqiu Song,Jinsong Ren,Xiaogang Qu
The logic device demultiplexer can convey a single input signal into one of multiple output channels. The choice of the output channel is controlled by a selector. Several molecules and biomolecules have been used to mimic the function of a demultiplexer. However, the practical application of logic devices still remains a big challenge. Herein, we design and construct an intelligent 1:2 demultiplexer as a theranostic device based on azobenzene (azo)-modified and DNA/Ag cluster-gated nanovehicles. The configuration of azo and the conformation of the DNA ensemble can be regulated by light irradiation and pH, respectively. The demultiplexer which uses light as the input and acid as the selector can emit red fluorescence or a release drug under different conditions. Depending on different cells, the intelligent logic device can select the mode of cellular imaging in healthy cells or tumor therapy in tumor cells. The study incorporates the logic gate with the theranostic device, paving the way for tangible applications of logic gates in the future.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 8
·1-13
·
IF 2.184
Qin Jianbin,Zhang Guangcheng,Shi Xuetao,Tao Min
The dispersions was prepared by dispersing hydrophilic silica nanoparticles with an average diameter of 50 nm in 1-butyl-methylimidazolium tetrafluoroborate ([C 4 mim][BF 4 ]), and investigated under the steady shear and oscillatory shear, respectively. Experimental results indicate that all of the dispersions present shear thinning, notable shear thickening, and shear thinning successively with increasing shear rate; the shear thickening behavior is derived from silica nanoparticle clusters and strongly controlled by silica nanoparticle content and temperature. The shear thickening fluid (STF) exhibits reversible property and transient response ability, and the time of transient response is no more than 100 ms. The conductivity of the STF is increased with increasing silica nanoparticle content, and the conductivity of 27 wt% dispersions is even two times as big as that of pure [C 4 mim][BF 4 ]. The dispersions with high solid content dilate and present a phase transition changing from a liquid-like to a solid-like soft material in the shear thickening region. A theoretical model is developed to imitate the mechanism of shear thickening in the dispersions.
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高影响因子
JOURNAL OF POWER SOURCES
·
2016
·
IF 6.333
Lingchao Pan,Yonggao Xia,Bao Qiu,Hu Zhao,Haocheng Guo,Kai Jia,Qingwen Gu,Zhaoping Liu
Migration of transition metal (TM) ions to tetrahedral sites plays a crucial role on structural transformation and electrochemical behaviors for Li-rich layered oxides . Here, incorporating small B 3+ in the tetrahedral interstice is employed to block the migration channel of TM ions and stabilize the crystal structure. Benefiting from their good structural stability, Li-rich layered materials with B-doped Li 1.198 Ni 0.129 Co 0.129 Mn 0.535 B 0.01 O 2 and Li 1.196 Ni 0.127 Co 0.127 Mn 0.529 B 0.02 O 2 , exhibit excellent cycling performance and voltage stability. After 51 cycles at 0.2 C, 1 mol.% boron incorporated sample can deliver 211 mAh g −1 with capacity retention of 89.9%, which is much higher than that of the undoped sample of 177 mAh g −1 with the retention of 79.2%. Moreover, the declined voltage per cycle decreases from 3.6885 mV to 2.7530 mV after 2 mol.% boron doping. XRD patterns after extended cycling verified the suppression of the structural transformation by the incorporation of boron.
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高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zhen Sun,Yanqing Lai,Na lv,Yaqi Hu,Bingqin Li,Liangxing Jiang,Jiong Wang,Shuo Yin,Kui Li,Fangyang Liu
Argyrodite sulfide solid electrolytes, such as Li6PS5Cl (LPSC), have received much attention due to their high ionic conductivity (>1 mS cm–1) and success in all-solid-state batteries (long cycle performance, high energy density, etc.). Numerous efforts are spent on modifying the properties of the electrolyte itself. Here, we combine first-principles calculations with experiments to investigate O-doped argyrodite sulfide solid electrolytes (Li6PS5–xClOx,x = 0–1). It is found that Li6PS4.75ClO0.25 (LPSCO0.25) with x = 0.25 and cubic phase (F4̅3 m) shows the highest ion conductivity of 4.7 mS cm–1 (cold-pressed), higher than that of undoped Li6PS5Cl (4.2 mS cm–1). The bare LiCoO2/LPSCO0.25/Li–In all-solid-state battery exhibits an initial capacity of 131 mA h g–1 at 0.1 C and satisfactory cycling stability with 86% capacity retention after 250 cycles to the 4th cycle at 0.3 C under 25 °C. In addition, the NCM811/LPSCO0.25/Li–In cell is assembled using bare LiNi0.83Co0.06Mn0.11O2 cathode and shows an initial discharge capacity of 181 mA h g–1 at 0.1 C and 160 mA h g–1 at 0.3 C. The doping of oxygen-forming Li6PS5–xClOx also improves the stability to Li metal, proven by cyclic voltammetry and powder X-ray diffraction tests. The calculation results for the band structure reveals that LPSC has the lowest unoccupied molecular orbital than LPSCO0.25, further confirming the above conclusion.
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高影响因子
ACS Applied Energy Materials
·
2023
·
IF 6.4
Lixin Chen,Xiaorui Yu,Zhe Hua,Qing Liu,Vladimir An,Lizhi Feng,Jiaming Guo,Xinglai Zhang,Jing Li,Baodan Liu
Photoelectrochemical water splitting based on suitable catalysts has attracted wide attention as a promising strategy to utilize solar energy to produce clean and renewable hydrogen fuel. Herein, we reported cobalt phosphate-modified (GaN)1–x(ZnO)x/GaN nanowire arrays on a high-temperature conductive GaN substrate toward enhanced photoelectrochemical water splitting by a facile two-step Au-assisted chemical vapor deposition method. The highly conductive Si-doped GaN substrate is designed to serve as a current collector and epitaxial substrate to grow GaN nanowires at high temperature. Meanwhile, high density of branched (GaN)1–x(ZnO)x nanowires with a tunable band gap, strong visible-light absorption, and high catalytic activity is deposited on the surface of GaN nanowires to act as active components to harvest light toward the oxygen evolution reaction. Such multi-junction heterostructures effectively enhance wide spectral utilization and light absorption and simultaneously accelerate the separation of electrons and holes and the transfer of photogenerated electrons from (GaN)1–x(ZnO)x nanowires to the GaN substrate collector and Pt electrode. The photocurrent density of the (GaN)1–x(ZnO)x/GaN nanowire array photoanode can reach 37.5 μA cm–2 at 1.23 V vs reversible hydrogen electrode and could be further enhanced to 186 μA cm–2 by modifying the cobalt phosphate cocatalyst, showing promising potential in clean hydrogen production.
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高影响因子
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
·
2024
·Vol. 27
·期 13
·1919-1929
·
IF 1.6
Zhang Fei,Chu Mingliang,Liu Jiemin,Zhao Qi,Zhu Yanqiu,Wu Xuefang
Aim: The study aimed to study the potential roles and mechanisms of shikonin in gastric cancer by network pharmacology and biological experiments. Methods: The key genes and targets of shikonin in gastric cancer were predicted by network pharmacology and molecular docking study.
The effect of shikonin on the proliferation, migration, and invasion of gastric cancer cells was detected by the CCK8 method, and wound healing and transwell assays. The expression levels of c-Myc and Yap-1 were detected via western blotting in gastric cancer cells after shikonin intervention.
Results: The results of network pharmacology revealed the key target genes of shikonin on gastric cancer cells to be c-Myc, Yap-1, AKT1, etc. GO and KEGG analysis showed regulation of cell migration, proliferation, adhesion, and other biological processes, including the PI3K-Akt signaling
pathway, HIF-1 signaling pathway, necroptosis, and other cancer pathways. Molecular docking showed shikonin to be most closely combined with protooncogenes c-Myc and Yap-1. In vitro experiments showed that the proliferation rate, migration, and invasion ability of the gastric cancer cell group
decreased significantly after shikonin intervention for 24h. The expression levels of c-Myc and Yap-1 in gastric cancer cells were found to be significantly decreased after shikonin intervention. Conclusion: This study showed protooncogenes c-Myc and Yap-1 to be the core target genes
of shikonin on gastric cancer cells. Shikonin may suppress gastric cancer cells by inhibiting the protooncogenes c-Myc and Yap-1. This suggests that shikonin may be a good candidate for the treatment of gastric cancer.
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PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Zhengshan Gao,Xiang Liu,Chengli Zhang,Zhiyong Tang,Jun Chen,Chao Yu
A novel label-free electrochemical sensing strategy for detecting monocyte chemoattractant protein-1 (MCP-1) was developed by using single-walled carbon nanohorns (SWCNHs) functionalized with Pt nanoparticles (PtNPs-SWCNHs). After modification with the PtNPs-SWCNHs, the electrode could serve as an effective platform for antibody immobilization and electron transfer owing to the large surface area and excellent conductivity of PtNPs-SWCNHs. Moreover, the PtNPs-SWCNHs composite could provide an obvious electrochemical signal through amperometric i–t curve method, due to its high catalytic activity for the reduction of hydrogen peroxide (H 2 O 2 ). Under optimal conditions, the amperometric i-t curve signals had a strong linear relation with the logarithm of the MCP-1 concentration ranging from 0.06 pg mL -1 to 450 pg mL -1 , and the detection limit was 0.02 pg mL -1 . Furthermore, the proposed immunosensor could detect MCP-1 in serum samples with desirable results. Overall, this immunosensor may provide a new alternative strategy for rapid detection of MCP-1.
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高影响因子
ChemNanoMat
·
2022
·Vol. 8
·期 10
·e202200268
·
IF 3.82
Mengmeng Liu,Jingjing Li,Pengfei Wang,Shuai Chen,Zhengping Dong,Fengwei Zhang
Graphical The encapsulation of Pt/TiO 2 -450H catalyst with SMSI into zeolite silicalite-1 (S-1) is reported. The resulting Pt/TiO 2 @S-1 catalyst dispalyed superior catalytic performance especially for halogenated nitroaromatics and without degradation in selectivity after 7 cycles. It is attributed to the high surface area, SMSI effect in confined space and the pore structure of S-1 with selective adsorption of substrates. The encapsulation of metal nanoparticles (NPs)-based active sites and homogeneous catalysts in nanoporous materials has been of highly research focus for tuning their catalytic activity, selectivity and stability. Although the catalysts with strong metal-support interaction (SMSI) hold the reversible encapsulation feature in a certain atmosphere, there is still a lack of systematic research on them in a real confined environment. Herein, we present a highly selective and stable Pt/TiO 2 @S-1 catalyst, which is prepared by in-situ growth of classical silicalite-1 on the external surface of Pt/TiO 2 -450H pre-catalyst with SMSI effect. Encouragingly, the encapsulated 20Pt/TiO 2 @S-1 catalyst demonstrates unprecedented catalytic performance for various nitroaromatics and without any degradation in selectivity after 7 cycles (>99%) for the hydrogenation of 1-chloro-4-nitrobenzene. Such situation is attributed to the high surface area, SMSI effect in confined space as well as the pore structure of silicalite-1 with selective adsorption of substrates.
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高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Dewei Ma,Xiaoyang Qin,Ning Dai,Xiuhua Cao
In contrast with three-dimensional perovskites , their two-dimensional (2D) analogues have been demonstrated to effectively improve the moisture tolerance due to the hydrophobicity of the long-chain organic layers. However, the insulating property of the long-chain organic layers will deteriorate the charge transport properties of the materials, limiting their applications in photovoltaics and optoelectronics . Short-chain organic cation with less carbon atoms may be a good substitution for the preparation of 2D perovskites with superior environmental stability and optoelectronic properties. In this research, quasi-2D (C 3 H 7 NH 3 ) 2 (MA) n-1 Pb n Br 3n+1 perovskite nanocrystals with an average size smaller than 10 nm were synthesized by a one-pot method, showing tunable emissions in the range of 406–524 nm for n = 1∼∞, with corresponding band-gaps of 3.63–2.30 eV. Time-resolved photoluminescence (PL) decays show that (C 3 H 7 NH 3 ) 2 PbBr 4 has the shortest average PL lifetime of 4.4 ns with the fast decay process occupying weighting proportion of 87.3%. When the nominal perovskite layers increases up to 2–4, the average PL lifetime raises up to 10.1–41.7 ns, with the slow decay process taking up most weighting percentage of >70%. MAPbBr 3 possesses the longest PL lifetime of 151.2 ns. The perovskite nanocrystals were then attempted to modify with oleic acid or to embed in PMMA matrix in order to improve their environmental stability. Results show that the stability of oleic acid and PMMA encapsulated nanocrystals improves greatly in comparison with bare nanocrystals.
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高影响因子
JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 60
·期 15
·2298-2308
·
IF 3.046
Zhaolai Huang,Jiaqi Li,Mengxiao Zhang,Weilin Feng,Chuanjie Fang,Liping Zhu
Polymers of intrinsic microporosity (PIMs) are promising materials for membrane separation because their special rigid and contorted structures contribute to high permeability. However, their chain rearrangement to fill excessive free volume makes the permeability stability a tough challenge. In this work, we report on a new use of rutile nano-TiO 2 to mitigate the physical aging of PIM-1 (a typical PIM) nanofilms for stable permeability by mixing matrix. It was shown that the PIM-1 membrane incorporated with nano-TiO 2 displayed remarkably higher aging resistance with a lower swelling degree in long-term ethanol soaking, having more stable ethanol permeance with only a 5% decrease after 35 days, lower than 25% of the pure one. The mechanism of anti-aging was revealed by molecular simulation, thermal, tensile mechanical, and dynamic mechanical analysis. It was found that nano-TiO 2 had good compatibility with PIM-1 due to strong coordination interaction, making its uniform dispersion in polymer. Additional solvent permeation channels were also created to increase solvent permeance without compromising solute rejection. Due to the reliable interaction of nano-TiO 2 , which makes particles serve as physical crosslinking points, the movement of PIM-1 chains was limited partially to mitigate aging, enabling PIM-1-based membranes to have robust solvent permeation. Graphical
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高影响因子
ELECTROPHORESIS
·
2018
·Vol. 39
·期 22
·2912-2918
·
IF 2.569
Deying Kong,Zilin Chen
Because of unique properties like permanent porosity, low density and large surface area, covalent organic frameworks are attractive microporous materials as stationary phase for CEC. Among them, COF-TpPa-1 possesses extraordinary chemical stability and common features of covalent organic frameworks. So, COF-TpPa-1 could be a promising material as stationary phase to enhance separation selectivity and tolerate the acid or alkaline electrochromatographic separation conditions. Here, we report the preparation of COF-TpPa-1 modified capillary column by in situ growth for electrochromatographic separation. The immobilization of COF-TpPa-1 on the inner wall of capillary column was confirmed by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction. The fabricated COF-TpPa-1 modified capillary column indicated good resolution for the separation of neutral analytes, nonsteroidal anti-inflammatory drugs and food additives in open-tubular CEC mode. Compared with bare capillary column, the COF-TpPa-1 modified capillary column improved separation selectivity remarkably for tested analytes, including hydrophobic, π–π and hydrogen bond interactions. Besides, the prepared capillary column showed excellent repeatability and stability. The intraday, interday and column-to-column relative standard deviations of migration time for neutral analytes were less than 3.54%. This work shows enamine-linked covalent organic frameworks have great potential as stationary phases in CEC.
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高影响因子
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