FOOD CHEMISTRY
·
2025
·
IF 9.8
Xufang Huang,Jing Wu,Xiaorui Xing,Yi Wang,Changzheng Wu,Shijie Li,Shuo Wang
Heavy metals and mycotoxins are important contaminants in food pollution. Sensitive, reliable, and rapid detection of heavy metals and mycotoxins is crucial for human health. In this work, imidazole-functionalized aggregation-induced emission (AIE) molecule tetra-(4-pyridylphenyl) ethylene (TPPE) was used as a precise and specific probe for Ag + detection, with a limit of detection (LOD) of 0.0318 μM. Meanwhile, a large amount of hydrophobic TPPE molecules were loaded into the amphiphilic block copolymer F127 to form ultrabright fluorescent microspheres (TPPENPs). Lateral flow immunochromatography (LFIA) based on immunoprobe (TPPENPs-Ab) has been successfully developed. The LOD of TPPENPs-LFIA for T-2 toxin was 0.13 μg/L, which was 13.31-fold and 8.62-fold more sensitive than that of gold nanoparticles-based LFIA and ordinary fluorescent microspheres-based LFIA, respectively. TPPENPs-LFIA was employed to detect T-2 toxin in actual grain samples, with a spiked recovery rate of 71.69 - 111.13 %. This assay offers a promising strategy and new idea for multi-target detection.
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PubMed
高影响因子
Cancers
·
2024
·Vol. 16
·期 9
·1614
·
IF 4.5
Tiantian Song,Zheming Yu,Qitao Shen,Yu Xu,Haihong Hu,Junqing Liu,Kui Zeng,Jinxiu Lei,Lushan Yu
Simple SummaryAcute T-lymphoblastic leukemia is a disease with a very low survival rate after relapse, and the search for new therapeutic agents is important for the clinical benefit of patients with acute T-lymphoblastic leukemia. Our study developed YLS010, a small molecule that is more sensitive to acute T-lymphoblastic leukemia cells, based on the structure of the invented small molecule YLS004. This novel small molecule demonstrated good antitumor activity in vivo and in vitro with acceptable toxicity. These findings provide a new avenue for the development of clinical drugs for patients with acute T-lymphoblastic leukemia.Abstract(1) Background: The research group has developed a new small molecule, 6-Isopropyldithio-2′-deoxyguanosine analogs-YLS004, which has been shown to be the most sensitive in acute T-lymphoblastic leukemia cells. Moreover, it was found that the structure of Nelarabine, a drug used to treat acute T-lymphoblastic leukemia, is highly similar to that of YLS004. Consequently, the structure of YLS004 was altered to produce a new small molecule inhibitor for this study, named YLS010. (2) Results: YLS010 has exhibited potent anti-tumor effects by inducing cell apoptosis and ferroptosis. A dose gradient was designed for in vivo experiments based on tentative estimates of the toxicity dose using acute toxicity in mice and long-term toxicity in rats. The study found that YLS010 at a dose of 8 mg/kg prolonged the survival of late-stage acute T-lymphoblastic leukemia mice in the mouse model study. (3) Conclusions: YLS010 has demonstrated specific killing effects against acute T-lymphoblastic leukemia both in vivo and in vitro. Preclinical studies of YLS010 offer a new opportunity for the treatment of patients with acute T-lymphoblastic leukemia in clinical settings.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Wenting Wang,Zi Wang,Zhaojie Meng,Shuang Jiang,Zhi Liu,Hong-yan Zhu,Xin-dian Li,Jing tian Zhang,Wei Li
The current study aimed to assess the effectiveness of pharmacological intervention with Platycodin D (PD), a critically active compound isolated from the roots of Platycodon grandiflorum, in mitigating cardiotoxicity in a murine model of type 2 diabetes-induced cardiac injury and in H9c2 cells in vitro. Following oral administration for 4 weeks, PD (2.5 mg/kg) significantly suppressed the elevation of fasting blood glucose (FBG) levels, improved dyslipidemia, and effectively inhibited the rise of the cardiac injury markers creatine kinase isoenzyme MB (CK-MB) and cardiac troponin T (cTnT). PD treatment could ameliorate energy metabolism disorders induced by impaired glucose uptake by activating AMPK protein expression in the DCM mouse model, thereby promoting the GLUT4 transporter and further activating autophagy-related proteins. Furthermore, in vitro experiments demonstrated that PD exerted a concentration-dependent increase in cell viability while also inhibiting palmitic acid and glucose (HG-PA)-stimulated H9c2 cytotoxicity and activating AMPK protein expression. Notably, the AMPK activator AICAR (1 mM) was observed to upregulate the expression of AMPK in H9c2 cells after high-glucose and -fat exposure. Meanwhile, we used AMPK inhibitor Compound C (20 μM) to investigate the effect of PD activation of AMPK on cells. In addition, the molecular docking approach was employed to dock PD with AMPK, revealing a binding energy of −8.2 kcal/mol and indicating a tight interaction between the components and the target. PD could reduce the expression of autophagy-related protein p62, reduce the accumulation of autophagy products, promote the flow of autophagy, and improve myocardial cell injury. In conclusion, it has been demonstrated that PD effectively inhibits cardiac injury-induced type 2 diabetes in mice and enhances energy metabolism in HG-PA-stimulated H9c2 cells by activating the AMPK signaling pathway. These findings collectively unveil the potential cardioprotective effects of PD via modulation of the AMPK signaling pathway.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Mengyin Liao,Chao Wang,Xuanhua Zhang,Chao Luan,Wenyuan Xu,Zhongyi He
Novel Pt/Co(OH)2-NiO/C catalysts based on carbon black were successfully synthesized using the hydrazine hydrate reduction method and galvanic replacement strategies. They were subsequently tested for their activity in the electrocatalytic oxidation of methanol. It was observed that the peak current density of Pt/Co(OH)2-NiO/C (8.29 A mg-1Pt) was 22.4 times higher than that of commercial Pt/C-JM (0.37 A mg-1Pt). The electrocatalytic activities and durabilities of the synchronously synthesized Pt/Co(OH)2-NiO/C catalysts were significantly better than those of PtCo/C, PtNi/C, and PtCoNi/C-X (X = 200, 400, 600) catalysts synthesized by calcination in Ar at different temperatures. The reason is that the highly dispersed Pt helps to expose more active sites on the catalyst surface, and the addition of Co(OH)2 and NiO alters the electron density of Pt, which reduces the adsorption of intermediate CO, attenuates the toxic effect, and enables more efficient oxidation of methanol.
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高影响因子
ADVANCED MATERIALS
·
2018
·Vol. 30
·期 38
·1802489
·
IF 21.95
Ming Zhao,Hongxu Liao,Lixin Ning,Qinyuan Zhang,Quanlin Liu,Zhiguo Xia
The discovery of high efficiency narrow-band green-emitting phosphors is a major challenge in backlighting light-emitting diodes (LEDs). Benefitting from highly condensed and rigid framework structure of UCr 4 C 4 -type compounds, a next-generation narrow green emitter, RbLi(Li 3 SiO 4 ) 2 :Eu 2+ (RLSO:Eu 2+ ), has emerged in the oxide-based family with superior luminescence properties. RLSO:Eu 2+ phosphor can be efficiently excited by GaN-based blue LEDs, and shows green emission at 530 nm with a narrow full width at half maximum of 42 nm, and very low thermal quenching (103%@150 °C of the integrated emission intensity at 20 °C), however its chemical stability needs to be improved later. The white LED backlight using optimized RLSO:8%Eu 2+ phosphor demonstrates a high luminous efficacy of 97.28 lm W −1 and a wide color gamut (107% National Television System Committee standard (NTSC) in Commission Internationale de L'Eclairage (CIE) 1931 color space), suggesting its great potential for industrial applications as liquid crystal display (LCD) backlighting.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 34
·期 8
·2310124
·
IF 19
Xinyu Li,Chengfeng Ma,Naiyun Liu,Chunxu Xiang,Shuxia Wei,Weibo Yan,Wei Huang,Hao Xin
Solution-processed chalcopyrite thin film solar cells have made great progress but still lag behind the vacuum-based ones due to inferior absorber quality and non-ideal interfaces. Here, plasma treatment of the molybdenum (Mo) substrate is reported to modify the back interface and improve the efficiency of solution-processed copper indium sulfoselenide (CuIn(S,Se) 2 , CISSe) solar cells. The results show plasma treatment oxides the surface Mo/MoO 2 to high oxidation oxides MoO 3-x (0 ≤ x < 1). The higher surface polarity greatly improves the wettability of the substrate to the precursor solution and results in formation of more compact and uniform precursor film, which grows to void-free larger grains absorber film with better adhesion to the substrate. In addition, the much higher chemical stability of MoO 3-x than Mo significantly reduces the thickness of high resistive MoSe 2 layer. The improved absorber quality and back interface property decreases charge carrier recombination in the absorber and back contact interface, resulting in 14.53% efficiency solution-processed CISSe solar cell, which is improved by 13% compared to device without plasma treatment.
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高影响因子
NATURE MATERIALS
·
2025
·Vol. 24
·期 8
·1186-1194
·
IF 38.5
Shi Zude,Qin Wen,Hu Zhili,Ma Mingyu,Liu Hong,Shu Zhiwen,Jiang Yubing,Xia Hang,Shi Wenyan,Zhang Chao Yue,Sang Xiaoru,Guo Cui,Li Yunxin,Liu Chengzhi,Gong Chengshi,Wang Hong,Liu Song,Tapasztó Levente,Gao Caitian,Liu Fucai,Tang Pengyi,Liu Yuan,Duan Huigao,Xie Erqing,Zhang Zhuhua,Liu Zheng,He Yongmin
Atom-thin amorphous materials (for example, amorphous monolayer carbon) offer a designable material platform for fundamental studies of the disorder system, as well as the development of various applications. However, their growth at a single layer remains challenging since their thermodynamically favourable grains are neither two dimensional nor layered. Here we demonstrate the growth of 1-nm-thick, amorphous metal chalcogenides at a wafer scale using a nanodroplet-driven nanoribbon-to-film strategy. Metal clusters are initially liquified into 1–2 nm droplets at 120 °C, and they then orchestrate the growth of amorphous single-layer nanoribbons, which eventually merge into a continuous centimetre-scale film. Phase-field simulations, combined with our characterizations, suggest a non-equilibrium kinetic growth mechanism, which can be applicable to various films, for example, PtSe x , IrSe x , PdSe x and RhSe x . The synthesized films exhibit a range of unique properties, including tunable conductivity through disorder modulation, high work functions and remarkable catalytic activity, making them promising candidates for hole-injection contacts in p-type transistors and hydrogen production applications. This work opens a pathway for the synthesis of non-layered materials approaching the single-layer limit.
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高影响因子
ANALYST
·
2025
·
IF 3.3
Jingwen Li,Yifei Li,Kai Zhang,Xiaomei Liu,Yuguo Tang,Kun Han
We developed a novel fluorescence detection method utilizing graphene quantum dots (GQDs) and manganese dioxide (MnO2) nanocomposites to enhance the sensitivity and specificity of in vitro monitoring of Bcl-2 gene expression, a key factor in tumor survival and treatment resistance. This method leverages the interplay between reduced glutathione (GSH) and hairpin DNA structures (H1 and H2) to simulate a cellular environment, enabling the redox-mediated disintegration of MnO2 nanosheets and the release of GQDs, restoring fluorescence. The presence of the Bcl-2 gene triggers a catalytic hairpin assembly (CHA) reaction, amplifying the Cy3 fluorescence signal and achieving a detection limit of 20.7 pM. The system demonstrated high specificity and stability, validated through control experiments with various DNA sequences. Optimization of key parameters, including MnO2 nanosheet concentration, GSH levels, and the ratio of hairpins H1 and H2, was critical for maximizing assay performance. The MnO2 nanosheets quench GQDs fluorescence and act as carriers for DNA probes, which are released upon reduction by GSH, mimicking intracellular redox conditions. The CHA reaction further amplifies the signal, allowing sensitive detection of low target gene levels. This biosensing platform integrates the unique properties of GQDs and MnO2 nanosheets, offering a real-time, sensitive, and selective method for monitoring Bcl-2 gene expression. This approach holds significant promise for early cancer diagnosis and personalized treatment strategies.
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高影响因子
ChemSusChem
·
2019
·Vol. 12
·期 24
·5274-5281
·
IF 7.804
Lulu Jia,Hao Wan,Xiaohe Liu,Gen Chen,Ning Zhang,Junhui Li,Wei Zhou,Yijun Cao,Renzhi Ma,Guanzhou Qiu
Morphology and composition tuning of layered materials is evaluated to influence their electrochemical performance for energy storage and conversion applications. Layered Co 1− x Ni x hydroxides ( x= 0, 1/2, 1/3, 1/4, 1) of three different morphologies—nanocones, 2 D nanosheets obtained by the rapid exfoliation of nanoconical counterparts, and 2 D superlattice-like nanostructures alternately restacked by the oppositely charged hydroxide and graphene oxide (GO) nanosheets—have been systematically investigated for electrocatalytic oxygen oxidation. High activity is obtained with the 2 D Co 2/3 Ni 1/3 hydroxide nanosheets/GO superlattice (Co 2/3 Ni 1/3 NS–GO), achieving a current density of 10 mA cm −2 at a low overpotential of 259 mV accompanied by a small Tafel slope of 35.7 mV dec −1 , surpassing nanocones and 2 D nanosheets, as well as the congeneric heterostructured Co 1− x Ni x hydroxide nanosheets/GO nanoarchitectures (Co 1− x Ni x NS–GO; x= 0, 1/2, 1/4, 1) and the commercial RuO 2 electrocatalyst. The outstanding activity of Co 2/3 Ni 1/3 NS–GO superlattice uncovers the combined merits of 2 D superlattice-like structure and composition optimization for electrocatalysis, providing a strategy for developing high-performance electrochemical materials by rational morphology and composition design. Graphical A super lattice : Composition and morphology optimization was used to develop a 2 D Co 2/3 Ni 1/3 hydroxide/graphene oxide superlattice with high activity for oxygen evolution, achieving a current density of 10 mA cm −2 at a low overpotential of 259 mV accompanied by a small Tafel slope of 35.7 mV dec −1 . The outstanding activity of the superlattice highlights the importance of morphology and composition optimization for electrocatalysis.
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高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2022
·Vol. 28
·期 54
·e202201687
·
IF 5.02
Jiaqi Ke,Yufei Zhang,Yibo Zhang,Minghui Ye,Zicheng Zhang,Yongchao Tang,Xiaoqing Liu,Cheng Chao Li
Rechargeable zinc-ion batteries (ZIBs) are potential for grid-scale applications owing to their safety, low price, and available sources. The development of ZIBs cathode with high specific capacity, wide operating voltage window and stable cyclability is urgently needed in next-generation commercial batteries. Herein, we report a structurally crystalline-stable Mn(VO 3 ) 2 nanobelts cathode for ZIBs prepared via a facile hydrothermal method. The as-synthesized Mn(VO 3 ) 2 exhibited high specific capacity of 350 mAh g −1 at 0.1 A g −1 , and maintained a capacity retention of 92 % after 10,000 cycles at 2 A g −1 . It also showed good rate performance and obtained a reversible capacity of up to 200 mAh g −1 after 600 cycles at 0.2 A g −1 under −20 °C. The electrochemical tests suggest that Mn(VO 3 ) 2 nanobelts impart fast Zn 2+ ions migration, and the introduction of manganese atoms help make the structures more indestructible, leading to a good rate performance and prolonged cycle lifespan. Graphical The crystalline-stable Mn(VO 3 ) 2 nanobelts cathode presents the specific capacity of 350 mAh g −1 at 0.1 A g −1 and maintain a capacity retention rate of 92 % for 10,000 cycles at a current density of 2 A g −1 . It also rendered good rate performance and obtained a reversible capacity of up to 200 mAh g −1 after 600 cycles at 0.2 A g −1 even under −20 °C. Benefiting from the unique tunnel type nanobelts structure, the Mn(VO 3 ) 2 nanobelts show high Zn 2+ migration kinetics and stable framework for reversible ions de-/insertion.
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高影响因子
ChemElectroChem
·
2023
·Vol. 10
·期 16
·e202300184
·
IF 4
Yang Su,Hai-Lin Ren,Shuai Zhao,Ping-Ping Sun,Jia-Qi Li,Xiao-Min Wang
In this paper, [Ni 0.9 Co 0.1 ](OH) 2 precursor is used to dope H 3 BO 3 to synthesize positive electrode material when mixing lithium in wet method, and to explore the best doping by testing the microscopic morphology and electrochemical performance of the positive electrode material amount and calcination temperature. After doping with B, the microstructure of the material is improved, and the primary crystal grains are oriented and agglomerated into a needle shape. This good crystal structure can slow down the generation of grain microcracks and mechanical fracture, and improve the cycle stability of the positive electrode material. After doping B, the discharge specific capacity was slightly improved. When the calcination temperature is 750 °C and the doping amount of B is 1.0 mol%, the first discharge specific capacity reaches 223 mAh g −1 . More importantly, the capacity retention rate of the battery after 100 cycles has been greatly improved, from 74 % without doping B to 87 %. Graphical Li-ion Batteries : The B-doping improves the microstructure of the material, and the primary grains are oriented and agglomerated into a long needle shape. This good crystal structure can slow down the generation of grain microcracks and mechanical breakage, and improve the cycling stability of the cathode material.
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高影响因子
Journal of Physical Chemistry C
·
2019
·
IF 4.309
Xueyang Song,Li Huang,Wenxue He,Chengyong Liu,Fengchun Hu,Yong Jiang,Zhihu Sun,Shiqiang Wei
Electronic metal–support interactions (EMSIs) have opened a new way to tailor the electronic and catalytic properties of supported catalysts. Herein, we demonstrate the EMSIs between Pt nanoparticles and Co(OH)2 flakes grown on SiO2 and show its beneficial effect on enhancing the CO oxidation activity. The EMSI characteristics of the Pt–Co(OH)2/SiO2 catalyst are identified by in situ X-ray absorption fine structure (XAFS) spectroscopy, in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), and transmission electron microscopy. Quantitative XAFS analysis reveals the presence of metallic-like Pt–Co bonds. The formation of Pt–Co intermetallic bonds allows for electron donation form Co to Pt, leading to the negative charging of the Pt atoms as evidenced by reduced Pt 2p-to-5d electron-transition intensity detected by XAFS spectroscopy and the emergence of a CO adsorption band at 2063 cm–1 in DRIFTS. The significance of EMSIs is manifested by comparing the CO oxidation activity over the Pt–Co(OH)2/SiO2 and Pt/SiO2 catalysts with similar Pt loadings. Pt–Co(OH)2/SiO2 is superior to Pt/SiO2 in both the apparent activation energy (19 vs 64 kJ/mol) and the turnover frequency (0.03 vs 0.003 s–1 at 37 °C). The enhanced activity is attributed to the negative charging of Pt, which downshifts the d-band center and reduces the CO adsorption strength.
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高影响因子
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