ENVIRONMENT INTERNATIONAL
·
2019
·
IF 7.943
Lianqin Zhao,Xin Guan,Baowei Yu,Na Ding,Xinmei Liu,Qiang Ma,Shengnan Yang,Ailimire Yilihamu,Sheng-Tao Yang
Due to the strong interaction with pollutants and the huge adsorption capacity, graphene adsorbents are widely applied in water decontamination. However, graphene adsorbents are seldom used in soil remediation, because the adsorptive sites on graphene would be occupied by soil components. In this study, we prepared carboxylated graphene oxide-chitosan (GO-COOH/CS) spheres for the immobilization of Cu 2+ from water and soil. The pores in GO-COOH/CS allowed the internal diffusion of Cu 2+ solution, while they blocked the direct contact between the solid soil and the adsorptive sites on graphene sheets. Therefore, the high adsorption capacity of GO-COOH/CS spheres (78 mg/g) was largely retained for the soil Cu 2+ fixation. The partition coefficient (PC) for Cu 2+ adsorption onto GO-COOH/CS spheres was 4.2 mg/g/μM at C e of 0.48 mg/L and q e of 31 mg/g, while the PC value decreased to 0.096 mg/g/μM at C e of 91.4 mg/L and q e of 78 mg/g. At initial Cu 2+ concentrations of 120 mg/L and lower, the fixation efficiencies were all higher than 99% and the corresponding free Cu 2+ concentrations in leachates were lower than 1.0 mg/L. The Cu 2+ fixation on GO-COOH/CS spheres largely reduced its bioaccumulation in wheat roots from 127.8 μg/g to 51.2 μg/g. The toxicity evaluations suggested that GO-COOH/CS spheres were of low toxicity to wheat seedlings and did not amplify the toxicity of Cu 2+ . The implications to the design of graphene adsorbents for soil remediation are discussed. Overall, our results collectively indicated that porous GO-COOH/CS spheres were high-performance adsorbents for the immobilization of Cu 2+ to reduce Cu 2+ bioaccumulation in plants.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 21
·20833-20840
·
IF 2.8
Ma Qingqing,Cui Lin,Zhou Shuang,Li Yan,Shi Weijie,Ai Shiyun
In this work, we have developed a low-cost and green strategy for nanoscale zero-valent iron (ZVI) in situ encapsulated in lignin-derived hydrochar (Fe@HC) by a facile one-pot synthesis route. The as-synthesized Fe@HC was characterized for physicochemical properties by X-ray diffraction (XRD), X-ray photoelectron spectra (XPS), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), transmission electron microscope (TEM), thermal gravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FT-IR). Further catalytic experiment revealed that phenol could be completely degraded by Fe@HC-800 within 20 min with peroxymonosulfate (PMS) at mild temperatures. Fe@HC-800 catalyst also exhibited stable performance after three runs of regeneration. The XPS and XRD results proved the key role of Fe 0 in the degradation of phenol. This approach is of great potential to the development of green materials biomass-derived carbon materials for wastewater treatment applications.
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SYNTHETIC METALS
·
2020
·
IF 3.286
Yiwen Huang,Weilin Zhou,Ye Wang,Yiming Zhang
Due to the weak coordination of alkaline−earth metal ions (such as Mg 2+ , Ca 2+ and Sr 2+ ), the design for corresponding fluorescent probes in vitro is much harder than those for heavy metal ions (such as Cu 2+ , Hg 2+ and Pb 2+ ). In this paper, the crown ether-like structure was introduced in graphene quantum dots (C-GQDs) via the hydrothermal treatment of alizarin . With the strong coordination of crown ether-like structure in C-GQDs’ lattice, C-GQDs show much lower detection limit to Ca 2+ (2 pM) than that of surface modified graphene quantum dots (100 pM). Moreover, the selectivity of C-GQDs can be controlled by the size modulation of crown ether-like structure. Precursors with different structures were carried out to modulate the size of crown ether-like structure in C-GQDs. The obtained C-GQDs show good selectivity for Mg 2+ , Sr 2+ , and Ba 2+ , respectively. Finally, we also show the successful detection of Ca 2+ in vitro based on C-GQDs.
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Separations
·
2022
·Vol. 9
·期 11
·340
·
IF 3.344
Zhimin Cai,Yutao Luo,Lu Gan
Herein, we loaded cobalt-based zeolite imidazolate frameworks, ZIF-67 (Co), onto commercial filter paper to prepare catalytic filter paper (ZFP) for the in situ degradation of bisphenol A (BPA) in water by activating peroxymonosulfate. The results showed that ZIF-67 (Co) was densely and uniformly distributed on the surface of the filter paper. The prepared ZFP could effectively degrade BPA in situ through a gravity-driven filtration process. Specifically, when the flow rate of the BPA solution passing through ZFP was lower than 10 mL/min, 0.02 mM of BPA could be completely degraded by ZFP. Furthermore, ZFP showed promising water matrix adaptability, which could provide promising BPA degradation efficiency in a wide pH range or in the existence of multiple anions. The scavenging tests demonstrated that both sulfate radical and hydroxyl radical were generated for BPA degradation, in which hydroxyl radical was the dominant active species. The ZFP also exhibited promising long-time use stability with a high mineralization rate. This study provides a novel method to prepare high-efficient catalyst paper for the in situ organic pollutant removal in water media via a prompt filtration process.Keywords:peroxymonosulfate;degradation;catalytic filter paper;zeolite imidazolate frameworks
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COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
·
2011
·Vol. 14
·期 6
·488-499
·
IF 2.573
T.T. Luu Tien,Malcolm Noj,Nadassy Katalin
A pharmacophore is a model which represents the key physico-chemical interactions that mediate biological activity. There is a long history of using pharmacophore modeling methods to select subsets of compounds, focused towards a specific target of interest. This paper will review existing
computational methods for deriving and comparing pharmacophore models. We outline a new classification of pharmacophore methods based on the abstraction of the underlying chemical interactions which embody a pharmacophore, and the methods available to quantitatively compare them. Within the
context of this classification, example studies, using specific pharmacophore modeling methods for focused library selection, will be discussed.
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JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Yuzhen Zhao,Yang Zhao,Zemin He,Zhun Guo,Huimin Zhang,Zongcheng Miao,Haiquan Zhang
Three reaction mechanisms were reported in the replacement reaction of bay area dibromine atoms in perylene diimide derivatives in previous studies. However, the effect of the reaction solvents and intermediate compound (perylene diimide radical anion) on the reaction mechanisms and product structure had not been reported. Here, we report the role of the reaction solvents and the perylene diimide radical anion in replacement reactions of bay area dibromine atoms of perylene diimide. Two isomers in the replacement reactions of bay area dibromine atoms in perylene diimides were found when using proton solvents (such as ethanol), and presenting the about 41% 1-bromo-7- ethoxy substituted perylene diimide derivative changed into 1,6- diethoxy substutent perylene diimide derivative in double substituted reaction. In polar non-proton solvents, inorganic base (K 2 CO 3 ) can induce dibromo perylene diimide to form its radical anion. Further, the substitution reactions is a S N1 mechanism in proton solvents, and the substitution reactions is belong to a S N 2 and SRN1 mechanism in polar non-proton solvents.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 14
·4235-4244
·
IF 4.478
Wang Jianping,Wang Wang,Yang Linlin,Zhao Jun,Han Guangmei,Yu Xiaoping,ShenTu Xuping,Ye Zihong
Chemical sensing for the sensitive and reliable detection of mercury(II) ions (Hg 2+ ) is of great importance in environmental protection, food safety, and biomedical applications. Due to the bio-enrichment property of Hg 2+ in organisms, it is particularly meaningful to develop an effective tool that can in situ and rapidly monitor the level of Hg 2+ in living organisms. In this work, we report ligand functionalized gold-silver bimetallic nanoclusters with bright red fluorescence as intracellular probes for imaging Hg 2+ in living cells and zebrafish. The bimetallic nanoclusters of DTT-GSH@Au/AgNCs (DG-Au/AgNCs) with strong fluorescence that benefited from the synergistic effect of Au and Ag atoms were obtained through a one-pot synthesis method, incorporating glutathione (GSH) and dithiothreitol (DTT) as the reducers and functionalized ligands. Attractively, the bright red fluorescence of DG-Au/AgNCs could be rapidly and selectively quenched by Hg 2+ within 1 min with a very low detection limit of 1.01 nM. Additionally, DG-Au/AgNCs had a great advantage in the detection of Hg 2+ in living cells and zebrafish owing to its notably strong red fluorescence at 665 nm, which could avoid effectively auto-fluorescence interference from the organism. Such easily prepared bimetallic fluorescent nanoclusters would be expected to provide a noninvasive and sensitive approach in the detection of heavy metals in situ for environmental protection. Graphical abstract
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FOOD CHEMISTRY
·
2020
·
IF 6.306
Haizhou Wu,Shulan Xiao,Jie Yin,Jianhao Zhang,Mark P. Richards
The pro-oxidant and anti-oxidant effects of free fatty acids (FFA) in meat remain ambiguous. To clarify the role of FFA in lipid oxidation of muscle food, the FFA was added into two systems (turkey mince and washed turkey muscle (WTM)) and lipid oxidation was investigated. A mixture of FFA inhibited lipid oxidation in both systems. The absorbance spectrum of oxyHb and metHb was determined in the presence of C18:1 and C18:2. Conversion to hemichrome spectra was observed and was particularly rapid when metHb was mixed with C18:2. C18:2 was also reacted with metHb followed by a chromatography step to remove unbound C18:2, and termed ‘modified Hb’. Electron spin resonance (ESR) spectra of the modified Hb was indicative of hemichrome formation. The modified Hb did not promote lipid oxidation in washed turkey muscle during storage. This suggested that hemichrome formation due to added FFA diminished the lipid oxidation capacity of Hb.
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Advanced Healthcare Materials
·
2016
·Vol. 5
·期 21
·2799-2812
·
IF 5.76
Yiyan He,Jie Zhou,Shengnan Ma,Yu Nie,Dong Yue,Qian Jiang,Aisha Roshan Mohamed Wali,James Zhenggui Tang,Zhongwei Gu
Systemic gene delivery is a complicated and multistep process that confronts numerous biological barriers. It remains a formidable challenge to exploit a single gene carrier with multiple features to combat all obstacles collectively. Herein, a multi-responsive “turn-on” polyelectrolyte complex (DNA/OEI-SS x /HA-SS-COOH, DSS) delivery system is demonstrated with a sequential self-assembly of disulfide-conjugated oligoethylenimine (OEI-SS x ) and disulfide bond-modified hyaluronic acid envelope (HA-SS-COOH) that can combat multiple biological barriers collectively when administered intravenously. DSS is designed to effectively accumulate at the tumor tissue and to be internalized into tumor cells by recognizing CD44. The multi-responsive “turn-on” DSS can respond to the alterations of hyaluronidases and glutathione at both the tumor site and at the intracellular milieu. Sequential degradation and detachment of the HA-SS-COOH envelope followed by the dissociation of the OEI-SSx/DNA inner core contributes to the activation of the endosomal escape and gene release functions, thus greatly enhancing nuclear gene delivery. A systematic investigation of DSS has revealed that the tumor accumulation ability, internalization, and endosome escape of the DSS nanocarriers, DNA unpacking and nuclear transportation are all remarkably improved by the multi-responsive “turn-on” design resulting in highly efficient gene transfection in vitro and in vivo.
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Recent Patents on Anti-Cancer Drug Discovery
·
2021
·Vol. 16
·期 2
·258-272
·
IF 4.169
Zhang Xiangli,Shen Qin,Wang Yi,Zhou Leilei,Weng Qi,Li Qingyong
Background: E2 (Camptothecin - 20 (S) - O- glycine - deoxycholic acid), and G2 (Camptothecin - 20 (S) - O - acetate - deoxycholic acid) are two novel bile acid-derived camptothecin analogues, modified deoxycholic acid at 20-position of CPT(camptothecin) with greater anticancer activity
and lower systematic toxicity in vivo. Objective: We aimed to investigate the metabolism of E2 and G2 by Rat Liver Microsomes (RLM). Methods: Phase I and Phase II metabolism of E2 and G2 in rat liver microsomes were performed, respectively, and the mixed incubation of phase I and
phase II metabolism of E2 and G2 was also processed. Metabolites were identified by liquid chromatographic/mass spectrometry. Results: The results showed that phase I metabolism was the major biotransformation route for both E2 and G2. The isoenzyme involved in their metabolism had some
difference. The intrinsic clearance of G2 was 174.7 mL/min. mg protein, more than three times that of E2 (51.3 mL/min . mg protein), indicating a greater metabolism stability of E2. 10 metabolites of E2 and 14 metabolites of G2 were detected, including phase I metabolites (mainly via hydroxylations
and hydrolysis) and their further glucuronidation products. Conclusion: These findings suggested that E2 and G2 have similar biotransformation pathways except for some differences in the hydrolysis ability of the ester bond and amino bond from the parent compounds, which may result in
the diversity of their metabolism stability and responsible CYPs(Cytochrome P450 proteins).
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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
·
2018
·Vol. 51
·期 4
·1566-1583
·
IF 5.5
Zhao Boxian,Shen Chen,Zheng Zhixing,Wang Xiaoxiong,Zhao Wenyang,Chen Xin,Peng Fei,Xue Linmeng,Shu Mengting,Hou Xu,Wang Kaikai,Zhong Chen,Sun Jingxian,Wan Jinzhao,Zhao Shiguang
Background/Aims: Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumour in adults, with poor survival rate and high mortality rates. Existing treatments do not provide substantial benefits to patients; therefore, novel treatment strategies are required. Peiminine, a natural bioactive compound extracted from the traditional Chinese medicine Fritillaria thunbergii, has many pharmacological effects, especially anticancer activities. However, its anticancer effects on GBM and the underlying mechanism have not been demonstrated. This study was conducted to investigate the potential antitumour effects of peiminine in human GBM cells and to explore the related molecular signalling mechanisms in vitro and in vivo Methods: Cell viability and proliferation were detected with MTT and colony formation assays. Morphological changes associated with autophagy were assessed by transmission electron microscopy (TEM). The cell cycle rate was measured by flow cytometry. To detect changes in related genes and signalling pathways in vitro and in vivo, RNA-seq, Western blotting and immunohistochemical analyses were employed. Results: Peiminine significantly inhibited the proliferation and colony formation of GBM cells and resulted in changes in many tumour-related genes and transcriptional products. The potential anti-GBM role of peiminine might involve cell cycle arrest and autophagic flux blocking via changes in expression of the cyclin D1/CDK network, p62 and LC3. Changes in Changes in flow cytometry results and TEM findings were also observed. Molecular alterations included downregulation of the expression of not only phospho-Akt and phospho-GSK3β but also phospho-AMPK and phospho-ULK1. Furthermore, overexpression of AKT and inhibition of AKT reversed and augmented peiminine-induced cell cycle arrest in GBM cells, respectively. The cellular activation of AMPK reversed the changes in the levels of protein markers of autophagic flux. These results demonstrated that peiminine mediates cell cycle arrest by suppressing AktGSk3β signalling and blocks autophagic flux by depressing AMPK-ULK1 signalling in GBM cells. Finally, peiminine inhibited the growth of U251 gliomas in vivo. Conclusion: Peiminine inhibits glioblastoma in vitro and in vivo via arresting the cell cycle and blocking autophagic flux, suggesting new avenues for GBM therapy
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Journal of Integrative Agriculture
·
2018
·
IF 1.042
Xue-yuan HAN,Lin-chun MAO,Wen-jing LU,Xiao-ya TAO,Xiao-peng WEI,Zi-sheng LUO
Fruit wounding occurred at harvest and transportation requires rapid suberization as a major part of the healing process to prevent infection and desiccation. The focus of this work was to explore the mediation of abscisic acid (ABA) on wound-induced suberization and to determine expression profiles of specific genes involved in wound-induced suberization in tomato fruit. The measurements of weight loss and fruit firmness suggested wound-induced suberization started at 2 d after wounding. The suberization process with the accumulation of suberin polyphenolics (SPP) and polyaliphatics (SPA) observed through autofluorescence microscopy and Sudan IV staining was accelerated by ABA. Expressions of SlPAL5 and Sl4CL involved in the synthesis of SPP reached the highest at 4 and 8 d after wounding following ABA application, respectively. Associated with SPA biosynthesis, SlLACS1 and SlLACS2 showed the most abundant transcripts at 8 and 6 d in ABA group, respectively. Transcript levels including SlKCSs , SlCYP86B1 , SlFAR3 , and SlGPATs were up-regulated at 2 d after wounding by ABA. Activities of polyphenol oxidase and lipoxygenase were also enhanced during wound-induced suberization following ABA application. The results in this study proved that ABA accelerated the wound-induced suberization progress by increasing the transcript levels of relevant genes in postharvest tomato fruit.
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