COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Rao Qin,Yuhan Jing,Tianqi Wan,Guangliang Lu,Dabiao Zhai,Xingyu Li,Feng Zhang,Jiangang Jiang,Dan Zhang,Ping Zhang,Yiping Wang,Yong Wang,He Wang
A composite consisting of upconversion nanoparticles (UCNPs) and methylene blue (MB)-loaded zeolitic imidazolate framework-8 (ZIF-8), referred to as UCNP@ZIF-8@MB, was synthesized via a simple hydrothermal and one-pot approach for the targeted control of Sclerotinia sclerotiorum ( S. sclerotiorum ) in oilseed rape ( Brassica napus L. ). Taking advantage of the pH-responsive nature of ZIF-8, the composite responds selectively to the acidic microenvironment associated with pathogen infection. Upon 980 nm excitation, UCNPs emit at 650 nm, which activates MB to generate reactive oxygen species (ROS) via photolysis, thereby exerting antifungal effects. The physicochemical properties of UCNP@ZIF-8@MB, including its optical behavior, MB release profile, and adhesion capacity, were systematically characterized. Under mildly acidic conditions (pH 5.5–4.0), MB release exceeded 80 %, indicating efficient responsiveness to the infection milieu. In vitro antifungal assays demonstrated a minimum inhibitory concentration (MIC) of approximately 10 μg/mL under 980 nm laser irradiation. Pot experiments further confirmed significant antifungal activity under light exposure. Additionally, UCNP@ZIF-8@MB exhibited targeted release and favorable biocompatibility with plant tissues and the surrounding environment. These results underscore the potential of UCNP@ZIF-8@MB as an environmentally friendly nanopesticide for the precise management of sclerotinia disease, offering a promising strategy for sustainable agriculture.
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高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Dan Yang,Xiaoshan Zheng,Jinlan Xin,Junhua Ning,Zefeng Lin,Xingxing Liu,Huanling Li,Kangle Jia,Longfei Yu,Linjia Huang,Yuepeng Cai
BACKGROUND Various strategies have been developed to reduce pesticide usage while enhancing efficacy. However, the current formulation systems face several challenges such as complex system compositions, low encapsulation efficiency, unavoidable use of organic solvents, poor wettability and retention, and particularly the difficulty in addressing these issues simultaneously, which limits their practical applications. RESULTS An imine-based dynamic covalent phospholipid was synthesized to construct pH-responsive avermectin (PC@AVM) liposomes to achieve nanodispersion, complete wettability, efficient deposition, and precise on-demand delivery. Under neutral or alkaline conditions, AVM is released slowly from the liposomes, whereas rapid release occurs under acidic conditions. And the formed liposomes exhibit excellent storage stability and photostability. The residual rate of PC@AVM liposomes is about 30% higher than that of unencapsulated AVM after 75 h of ultraviolet (UV) irradiation, because the hydrophobic AVM can be embedded in the hydrophobic regions of phospholipid bilayers to prevent photodegradation. The PC@AVM liposomes exhibit strong adhesion to leaf surfaces, resulting in exceptional rainfastness with a retention rate of nearly 90% after washing. Meanwhile, the vesicle-like liposome can strongly interact with surface microstructures/nanostructures during the high-speed impact process, thereby also suppressing splashing and ensuring complete deposition of droplets on hydrophobic surfaces. Moreover, PC@AVM liposomes show long-term insecticidal activity and exhibit excellent biosafety for environmental organisms. CONCLUSION This work provides an innovative carrier and constructs multifunctional, on-demand release pesticide liposomes, thereby potentially reducing pesticide use and promoting the development of sustainable agriculture. © 2025 Society of Chemical Industry.
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高影响因子
Acta Biomaterialia
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2017
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IF 6.319
Linhua Zhang,Wenbo Hao,Lv Xu,Yongfeng Gao,Xusheng Wang,Dunwan Zhu,Zhuo Chen,Xudong Zhang,Hongbo Chen,Lin Mei
Methenamine mandelate is a urinary antibacterial agent, which can be converted to formaldehyde in urine that has a relatively low pH of average 5.5–6.8. Here, we prepare a pH-sensitive PLGA-based nanoparticle containing both methenamine mandelate and NaHCO 3 . Methenamine mandelate/NaHCO 3 -coloaded nanoparticle could enter cells via endosome/lysosome pathway. The pH in lysosomes and endo-lysosomes is approximately 5.0. In the acidic environment, NaHCO 3 reacts with proton and produce CO 2 bubbles, which burst nanoparticles and lead to the rapidly release of methenamine mandelate. Meanwhile, methenamine mandelate was then quickly converted to a sufficient amount of formaldehyde in this acidic environment, which induced DNA damage and DNA damage response (DDR). Consequently, methenamine mandelate/NaHCO 3 -coloaded nanoparticles caused cell cycle arrest , cell growth inhibition and apoptosis of cancer cells. Moreover, methenamine mandelate/NaHCO 3 -coloaded nanoparticles also show intensive inhibitory effect on the growth of MCF-7 xenograft tumor in vivo . Therefore, methenamine mandelate/NaHCO 3 -coloaded nanoparticle is a promising type of formulation for the treatment of cancer, which could give the “old drug” methenamine mandelate a new anti-cancer function in clinical. Statement of Significance Methenamine mandelate is a urinary antibacterial agent, which can be converted to formaldehyde in urine that has a relatively low pH of average 5.5–6.8. Here, we prepare a pH-sensitive PLGA-based nanoparticle containing both methenamine mandelate and NaHCO 3 . Methenamine mandelate/NaHCO 3 -coloaded nanoparticle could enter cells via endosome/lysosome pathway. The pH in lysosomes and endo-lysosomes is approximately 5.0. In the acidic environment, NaHCO 3 reacts with proton and produce CO 2 bubbles, which burst nanoparticles and lead to the rapidly release of methenamine mandelate. Meanwhile, methenamine mandelate was then quickly converted to a sufficient amount of formaldehyde in this acidic environment, which induced DNA damage and DNA damage response (DDR). Methenamine mandelate/NaHCO 3 -coloaded nanoparticle is a promising type formulation for the treatment of cancer, which could give the “old drug” methenamine mandelate a new anti-cancer function in clinical.
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高影响因子
Small
·
2025
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IF 12.1
Bochuan Chen,Yuandong Yan,Shicheng Yan,Zhigang Zou
Water electrolysis faces critical efficiency and cost challenges, primarily due to the high energy demand and low economic value of the oxygen evolution reaction (OER). To overcome this limitation, we introduce an innovative electrochemical-chemical sequential strategy that replaces OER with methanol oxidation (MOR). Our decoupled process comprises cathodic hydrogen evolution reaction (HER) paired with anodic Ni(OH) 2 oxidation to NiOOH in 1 M KOH electrolyte, followed by spontaneous NiOOH reduction via MOR, selectively generating formic acid (HCOOH) with 95% formic acid Faraday efficiency in neutral electrolyte. Crucially, we developed a scalable bottom-up method to electrochemically prepare the active NiOOH catalyst directly from Ni(OH) 2 particles. This catalyst achieved a HCOOH yield of 48.25 mmol per kg catalyst. Collectively, this strategy establishes an efficient and recyclable pathway for alkaline hydrogen production integrated with high-value formic acid synthesis in neutral media.
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高影响因子
Journal of Functional Biomaterials
·
2025
·Vol. 16
·期 12
·450
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IF 5.2
Yuting Ji,Qian Wang,Rujing Lin,Mimi Pang,Liya Sun,Jiameng Gong,Huiqiang Ma,Shan-Yu Fung,Hong Yang
The overactivation of endosomal Toll-like receptor (TLR) in macrophages plays an important role in the pathogenesis of acute lung injury (ALI). There is currently still a lack of nano-formulated and macrophage-targeted endosomal TLR inhibitors that have been approved for clinical uses. We previously discovered that the elevation of endosomal pH using nanodevices provides a promising strategy to specifically inhibit endosomal TLRs in macrophages. The weakly basic drug hydroxychloroquine (HCQ) has been reported for its capability to accumulate in endolysosomes and modulate the acidity in these compartments. To enhance its macrophage-targeting ability and the therapeutic efficacy in vivo, herein we formulated HCQ into a nanoform using liposomes, named HCQ-L. We found that HCQ-L was less cytotoxic and more effective in inhibiting endosomal TLRs (including TLR3, TLR4, TLR 7/8) than the molecular HCQ. Subsequently, a hexapeptide, Pep12, was inserted onto the surface of HCQ-L to form HCQ-L-P12. Interestingly, Pep12 modification significantly improved the stability of liposomes in aqueous solution for at least 2 years; while having enhanced inhibitory effects on TLR7/8 signaling, HCQ-L-P12 displayed similar effects on inhibiting the TLR4 pathway and down-stream pro-inflammatory cytokine production when compared with HCQ-L. Furthermore, both HCQ nanoformulations potently elevated the endosomal pH. In vivo evaluation showed that HCQ-L-P12 and HCQ-L (but not molecular HCQ) were able to alleviate lung inflammation and injuries by decreasing inflammatory cell infiltration upon intratracheal instillation in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. This research provides a new strategy to fabricate lipid-based nanocarriers for targeted delivery of endosomal pH modulators to treat ALI and other acute and chronic inflammatory disorders.
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高影响因子
Water
·
2025
·Vol. 18
·期 1
·97
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IF 3
Zhe Chen,Dandan Rao,Jian Zhang,Bo Sun
Peroxynitrite (ONOOH/ONOO−) is increasingly recognized as a key intermediate in advanced oxidation processes (AOPs), yet its role in water treatment remains insufficiently defined. This study provides mechanistic insights into peroxynitrite-mediated AOPs through competition kinetics method, demonstrating that both decomposition and pollutant degradation are strongly pH-dependent, with ONOOH dominating stability and radical pathways across pH 5.0−9.0, while its decay rate decreases from 1.2 s−1to 0.0022 s−1. The interplay of HO•and diverse reactive nitrogen species (RNS, including reactive nitrogen radicals and peroxynitrite) dictates pollutant-specific degradation efficiencies, with RNS showing a unique reliance in degrading bisphenol A—contributing up to 66.7% at pH 8.0. Buffer chemistry further modulates these pathways: bicarbonate accelerates peroxynitrite decay via CO2and CO3•−-mediated acceleration (resulting in a 361.9% increase at pH 9.0), while borate promotes reactive nitrogen radical formation but suppresses HO•contributions. Importantly, peroxynitrite was shown to facilitate N-nitrosodimethylamine formation in the presence of dimethylamine, with yields maximized under alkaline conditions and attenuated by bicarbonate. These quantitative findings underscore the critical roles of pH and buffer chemistry in optimizing peroxynitrite-based water treatment while mitigating byproduct risks.
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高影响因子
CARBOHYDRATE POLYMERS
·
2025
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IF 12.5
Shuang Gao,Xinyu Guo,Fengrui Li,Yu Zhang,Yanan Yu,Ying Fu,Fei Ye
Conventional pesticides are easily lost, and poorly targeted deposition causes pollution and economic losses because of their large particle sizes. Cellulase/pH Responsiveness Hollow Mesoporous Silica Nanoparticles (Hex/HMSN–CMC) was developed to respond rapidly to changes in the environment. The particle size of Hex/HMSN–CMC was 133.44 nm. The characterization results confirmed the introduction of CMC and a Hex loading capacity of 12 %. Controlled-release kinetics indicated that the drug-loaded system could exhibit specific responses to pH and cellulase, with the cumulative release rate exceeding 80 %. Bioactivity assays showed that the EC₅₀ values of Hex/HMSN nanoparticles and the commercial hexaconazole suspension against Rhizoctonia solani were 0.638 mg/L and 1.281 mg/L at 5 days, and 1.404 mg/L and 2.454 mg/L at 10 days after application, respectively. Furthermore, Hex/HMSN–CMC demonstrated the ability to transport within mycelium and rice plants. Contact angle experiments showed that the wetting ability increased with the introduction of CMC. Additionally, Hex/HMSN–CMC increased rice seed germination than Hex alone. Zebrafish toxicity assays indicated the LC₅₀ value of Hex/HMSN-CMC to zebrafish was increased by 16.65 % compared with Hex SC. These results indicate hexaconazole delivery system with dual responsiveness to pH and cellulase could achieve targeted transportation and reduce pesticide runoff.
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ACS Applied Polymer Materials
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2025
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IF 4.7
Ning Yang,Jian Qin,Xue Li,Yule Song,Junliang Song,Tingjun Dong,Huan Xu
Renal fibrosis (RF) is a primary pathogenic process that propels the advancement of chronic kidney disease (CKD) to end-stage renal failure. Irrespective of the origin of CKD, both renal tubulo-interstitial tissue and glomeruli experience fibrotic alterations. In this study, two functionalized amphiphilic polymers based on the specific ligand of the sigma1 receptor (σ1Rs)-aminoethyl anisidine (AEAA) were innovatively developed: pH-responsive AEAA-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (AEAA-PEtOz-CHMC, APC) and long-circulation AEAA-polyethylene glycol-1,2-distearoyl-sn-glycerol-3-phosphoethanolamine (AEAA-PEG-DSPE, APD) for renal-targeted delivery of tanshinone IIA (Tan IIA). The therapeutic efficacy of different Tan IIA nanoemulsions (Tan IIA-NEs) was systematically evaluated in two established RF models: the unilateral ureteral obstruction model, which simulates renal interstitial fibrosis, and the doxorubicin hydrochloride-triggered glomerulonephritis model, which mimics human focal segmental glomerulosclerosis. In these RF models, compared to the model, Tan IIA-NE, and APD-Tan IIA-NE groups, the APC-Tan IIA-NE group demonstrated a marked improvement in kidney function, reduced oxidative damage, inhibited inflammation, mitigated fibrogenesis, and reversed the epithelial–mesenchymal transition. The pH-responsive drug release in acidic fibrotic environments together with σ1Rs-mediated cellular uptake facilitated effective therapeutic outcomes. This dual-targeting strategy reduced the degree of fibrosis by 36.83% in progressive RF models compared to conventional treatments. Our research demonstrates that microenvironment-responsive nanocarriers serve as a model for precision RF therapy by enabling spatial-temporal regulation of medication bioavailability.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Seongeom Jeong,Siyoung Byun,Sanghyun Jeong
A pH-responsive membrane represents a promising avenue for sustainable water treatment, yet its broader application remains limited by stability and reusability concerns. In this study, a polyvinyl alcohol/chitosan (PVA/CS) hydrogel membrane was fabricated and systematically evaluated for its pH-dependent transport behavior and dye removal performance. The hydrogel membrane exhibited distinct pH responsiveness, achieving the highest water flux (22.45 ± 0.66 L m −2 h −1 bar −1 ) at neutral pH (6.5) when tested using pure water. Flux declined under acidic conditions (3.43 ± 0.26 L m −2 h −1 bar −1 ) due to CS swelling and under alkaline conditions due to polymer chain densification. At pH 2, the membrane removed both cationic and anionic dyes with efficiencies exceeding 99.9 % removal. Under neutral conditions, cationic dyes (crystal violet, methylene blue) were consistently removed (>97 %). In contrast, anionic dyes, including Congo red and methyl orange, showed significantly lower rejection (66.04 % and 24.57 %, respectively), attributable to electrostatic repulsion and size-dependent transport. Importantly, the PVA/CS hydrogel membrane demonstrated regeneration capability, enabling up to three reuse cycles with >99 % dye rejection and limited flux decline for cationic dyes at pH 6.5. CS's reversible swelling-contraction behavior facilitated the recovery of membrane performance. Overall, these findings demonstrate that PVA/CS hydrogel membranes functions as pH-responsive separation platforms capable of chemical-free regeneration and limited reuse across a range of pH conditions. In particular, this study experimentally clarifies how intrinsic pH responsiveness can be leveraged to enable regeneration without chemical treatment, while also highlighting the need for further optimization to address performance limitations toward anionic contaminants.
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ACS Sensors
·
2025
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IF 9.1
Qingwen Zhang,Danfeng Jiang,Zhe Sun,Xiaohan Shi,Xuzhou Chen,Qian Li,Xiaohu Liu,Yuancai Ge,Liang Hu,Yi Wang
Sweat glucose detected by wearable sensors can serve as a potential reference factor for diabetes management. However, inefficient sweat collection and fluctuating sweat pH hinder the precise detection of glucose. Herein, we designed a wearable sensing system comprising an ant-nest-structured sensor and a pH-responsive microchannel with multiple sweat inlets to continuously and accurately monitor the glucose level in sweat. Compared with the traditional planar electrode, this internally interconnected biomimetic structure provided a large number of accessible pores for contact with glucose molecules and electrolytes, remarkably decreasing the diffusion resistance. Furthermore, due to the formation of adjacent distributed cascade sensing units, the electron transmission distance from the catalytic center to the electrode surface was shortened, and the inoperative diffusion of H2O2 in the sensor was also weakened. The microchannel could convey the perspiration from the epidermis to the sensing zone within 250 s, while the coated pH indicator in the microchannel monitors the liquid’s pH in a colorimetric zone. As a result, our wearable sensor integrated with a pH-responsive microchannel accurately tracked the change of glucose levels in sweat before and after a diet, displaying reliable results after calibration similar to those of commercial colorimetric kits. In addition, a longitudinal investigation of the relationship between blood and sweat glucose from healthy people and diabetic patients revealed a good correlation in glucose between the two. Wearable biosensors for real-time noninvasive analysis of glucose in sweat may significantly facilitate diabetes management at home.
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高影响因子
Journal of Pharmaceutical Innovation
·
2025
·Vol. 20
·期 1
·1-18
·
IF 2.7
Wang Kaibin,Li Yanqiang,Zhao Xiaoliang,Zhu Tianke,Luo Li,Zhang Hanwen,Wang Yonggang,Zhang Jing,Wang Cunjin,Zhang Weijie
Purpose Chinese medicine polysaccharide are considered as promising medical materials due to their good biocompatibility and safety. The aim of this study was to develop a novel amphiphilic drug carrier based on astragalus polysaccharide (APS) to optimise the delivery of paclitaxel. Methods The pH-sensitive histidine (His) and hydrophobic stearic acid (SA) were grafted onto astragalus polysaccharide and self-assembled into nanoparticles by ultrasonication. The nanoparticles were characterised by Fourier transform infrared (FTIR), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), and X-ray diffraction, and tested for encapsulation efficiency (EE%), drug loading capacity(LC%) and in vitro release of paclitaxel. The effects of nanoparticles on the proliferation of immune cells RAW264.7 and breast cancer cells SUM149 were assessed by cck-8 assay, and their effects on SUM149 cell cycle block and apoptotic protein expression were detected. Results The EE% of nanoparticles on paclitaxel was 77.61% and the LC% was 9.96%. Under acidic conditions, the surface charge of nanoparticles was reversed and the structure was swollen to promote drug release. Cellular experiments showed that blank nanoparticles could promote the proliferation of immune cells, and the anticancer effect of drug-loaded nanoparticles was significantly better than that of paclitaxel alone. Conclusion The prepared pH-sensitive nanoparticles can effectively enhance the uptake of paclitaxel by tumour cells and induce apoptosis in breast cancer cells, making them a promising new type of paclitaxel drug carrier.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Xiaoyu Zhang,Hongji Zhu,Min Xu,Shengzhu Cao,Runze Hu,Lin Peng,Chunyu Zhang,Dong Zhang
Developing high-performance gas sensors through facile synthesis remains challenging. Here, a pH-mediated hydrothermal strategy for precisely engineering SnO 2 nanostructures toward exceptional ethanol sensing is reported. By systematically tuning hydrothermal pH from 2 to 13, hierarchical control of crystallinity (XRD), particle morphology (SEM/TEM), and band structure (UV-Vis) are achieved. The strong alkaline condition (pH=13) yielded monodisperse 5–10 nm nanoparticles with optimized (101) facet exposure, delivering record-high response of 97.2 toward 400 ppm ethanol at 300°C, improvements over acidic (pH=2) and neutral (pH=7) counterparts, respectively. Mechanistic studies reveal that extreme pH conditions promote charge-driven crystallization kinetics , suppressing particle agglomeration while increasing oxygen vacancies . The obtained sensitivity (20.64 ppm −1 ) and linearity (96.95 %) surpass some multifactor-modified SnO 2 sensors reported. This single-variable approach demonstrates cost reduction compared to composite modification methods, establishing a generalizable paradigm for transition metal oxide optimization. The fundamental insights into pH-dependent growth mechanisms provide new design principles for scalable nanofabrication .
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危险品化学品经营许可证（带存储）