CARBOHYDRATE POLYMERS
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2014
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IF 3.916
Yajuan Zhang,Airong Xu,Benlian Lu,Zhiyong Li,Jianji Wang
The development of highly efficient cellulose solvents is imperative to the effective utilization of cellulose. In this work, ionic liquids (ILs) with the same 1-allyl-3-methylimidazolium cation ([Amim] + ) but different carboxylate anions, such as formate ([HCOO] − ), acetate ([CH 3 COO] − ), propionate ([CH 3 CH 2 COO] − ), butyrate ([CH 3 CH 2 CH 2 COO] − ), glycollate ([HOCH2COO] − ), lactate ([CH 3 CHOHCOO] − ) and benzoate ([C 6 H 5 COO] − ) were synthesized, and their thermal properties and viscosities were determined. Then these ILs were used to investigate the effect of anion structure on solubility of cellulose in the ILs. It was shown that the viscosity and cellulose solubility depended strongly on the anion structure of the ILs. For example, at 30 °C solubility of cellulose in [Amim][CH 3 CH 2 COO] was as high as 19.0%, whereas cellulose was not soluble in [Amim][HOCH 2 COO], [Amim][CH 3 CHOHCOO] and [Amim][C 6 H 5 COO]. In addition, solvatochromic UV/vis probe and 13 C NMR measurements were performed to demonstrate dissolution mechanism of cellulose in the ILs. The results suggested that although cations of the ILs have un-negligible contribution to the highly efficient dissolution of cellulose, hydrogen bonding interactions of anions of the ILs with cellulose is predominant.
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Chemical Engineering Journal Advances
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2022
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IF 0
Hiu Lam So,Wei Chu
Degradation of 1-Naphthol by combined photocatalysis and adsorption in column reactor was studied, and the performance could be predicted by employing a proposed multiple regression model. The model includes four variables: concentration of 1-Naphthol, concentration of peroxymonosulfate (PMS), FeOOH dosage and pH, along with their second-order effects and interactions. Statistical analyses were performed to verify the statistical significance of the regressors, and extra experimental sets were conducted to validate the proposed model. The mathematical model proposed exhibited good reproducibility with no significant statistical difference between the experimental and predicted values. Response surface methodology was used to explore the relationship between the four variables and the response. The process optimal ranges can be further refined at pH 2–2.5; [PMS] = 1.2–1.4 mM; and FeOOH 2.75–3 g respectively, according to the proposed overlaid contour plots.
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CHEMOSPHERE
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2020
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IF 5.778
Yifei Leng,Henglin Xiao,Zhu Li,Ying Liu,Jun Wang
Enzyme catalyzed coupling with redox mediators are considered as great interesting and viable technologies to transform antibiotics. This work demonstrated the horseradish peroxidase (HRP) was effective in transforming sulfadiazine (SDZ) transformation coupled with 1-hydroxybenzotriazole (HBT) at varying conditions. The removal of SDZ was independent of Na + and its ionic strength, but Ca 2+ could enhance transformation efficiency by increasing the enzyme activity of HRP. The presence of humic acid (HA) and polystyrene (PS) microplastics showed inhibition on the transformation of SDZ, and the transformation rate constants ( k ) decreased with the concentration of HA and PS particles increased. These primarily attributed to covalent coupling and electrostatic interaction between SDZ and HA, SDZ and PS, respectively, which reduced the concentration of free SDZ in the reaction solution. The presence of cation recovered the inhibition of SDZ transformation by HA and PS particles, which ascribed to compete between cation and SDZ. The divalent cations (Ca 2+ ) showed more substantial competitiveness than mono (Na + ) due to more carried charge. Eight possible transformation products were identified, and potential SDZ transformation pathways were proposed, which include δ-cleavage, γ-cleavage, carbonylation, hydroxylation, SO 2 extrusion and SO 3 extrusion. In addition, HA and PS particles couldn’t affect the transformation pathways of SDZ. These findings provide novel understandings of the transformation and the fate of antibiotics in the natural environment by HRP coupled with redox mediators.
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Science China-Chemistry
·
2013
·Vol. 57
·期 3
·397-401
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IF 1.327
Zhang QiBo,Hua YiXin,Wang Rui
Direct electroreduction of solid cuprous chloride to prepare copper powder in a “neutral” ambient-temperature ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid (BMIMBF 4 ) was investigated. Cyclic voltammetry of the CuCl powder in a Pt-powder cavity microelectrode exhibited that solid CuCl can be electrochemical reduced in the ionic liquid. Chronoamperometry of the salt powder filled Mo-cavity electrode (current collector) in the ionic liquid further demonstrated the conversion of chloride-to metal inside the cavity, as confirmed by scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction spectra.
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CORROSION SCIENCE
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2016
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IF 5.154
Zhiyong Hu,Yanbin Meng,Xuemei Ma,Hailin Zhu,Jun Li,Chao Li,Duanlin Cao
Two benzothiazole derivatives, namely 2 - ( n -hexylamino)-4-(3′- N,N -dimethylamino-propyl)amino-6-(benzothiazol-2-yl)thio-1,3,5- s -triazine (BTC 6 T) and 2-( n -octylamino)-4-(3′- N,N -dimethylamino-propyl)amino-6-(benzothiazol-2-yl)thio-1,3,5- s -triazine (BTC 8 T), were synthesized to study their corrosion inhibiting effect against steel in a 1 M HCl solution. The corrosion inhibition efficiency was measured using electrochemical impedance spectroscopy (EIS), potentiodynamic polarization , and weight loss methods. Both inhibitors offered extra stability and higher inhibition efficiencies again steel corrosion than previously reported benzothiazole family inhibitors. These inhibitors can be adsorbed onto surfaces by both physical and chemical means. Finally, quantum chemical parameters were calculated using the density functional theory method (DFT) and the correlation between the theoretical and experimental results are discussed.
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ACTA PHARMACOLOGICA SINICA
·
2024
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IF 6.9
Hu You-tian,Liu Zhi-wei,Zhang Tong-hui,Ma Yu-e,He Lei,Zhang Jie,Zhou Yue-yang,Vidal-Puig Antonio,Pan De-jing,Wu Fang
Thymic egress is a crucial process for thymocyte maturation, strictly regulated by sphingosine-1-phosphate lyase (S1PL). Recently, cystathionine γ-lyase (CSE), one of the enzymes producing hydrogen sulfide (H 2 S), has emerged as a vital immune process regulator. However, the molecular connection between CSE, H 2 S and thymic egress remains largely unexplored. In this study, we investigated the regulatory function of CSE in the thymic egress of immune cells. We showed that genetic knockout of CSE or pharmacological inhibition by CSE enzyme inhibitor NSC4056 or D , L -propargylglycine (PAG) significantly enhanced the migration of mature lymphocytes and monocytes from the thymus to the peripheral blood, and this redistribution effect could be reversed by treatment with NaHS, an exogenous donor of H 2 S. In addition, the CSE-generated H 2 S significantly increased the levels of S1P in the peripheral blood, thymus and spleen of mice, suppressed the production of proinflammatory cytokines and rescued pathogen-induced sepsis in cells and in vivo. Notably, H 2 S or polysulfide inhibited S1PL activity in cells and an in vitro purified enzyme assay. We found that this inhibition relied on a newly identified C 203 XC 205 redox motif adjacent to the enzyme’s active site, shedding light on the biochemical mechanism of S1PL regulation. In conclusion, this study uncovers a new function and mechanism for CSE-derived H 2 S in thymic egress and provides a potential drug target for treating S1P-related immune diseases.
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PubMed
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Huan-Yu Sui,Dong Chen,Jia-Ping Huang,Zhe-Ying Hu,Lu Hu,Jie-Hua shi,Shao-Liang Jiang
Approval in 2019 was granted for the highly selective, targeted agent lorlatinib, which primary target is ROS1 and ALK. The purpose of this work was to examine the binding mechanism between lorlatinib (LOR) and HAG employing multispectral and molecular modeling techniques. Fluorescence data demonstrated that LOR quenched HAG fluorescence as a static quenching, interecalated into the hydrophobic cavity of HAG with a moderate affinity. Thermodynamic and competitive experiments pointed out that LOR bound with HAG primarily through hydrogen bonding, hydrophobic, and van der Waals forces. Circular dichroism, three-dimensional and synchronous fluorescence spectroscopic studies noted that the secondary structure of HAG and microenvironments around tyrosine (Tyr) and tryptophan (Trp) residues were altered due to binding with LOR. The contribution of each energy involved in binding process of LOR and HAG has been analyzed by molecular simulation techniques. Besides, the environmental conditions with metal ions have also been studied. The present study is expected to provide a theoretical basis for further studying the metabolism of LOR in vivo, which may help to gain a deeper understanding of the general pharmacological activity of the drug.
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ChemSusChem
·
2019
·Vol. 12
·期 10
·2231-2239
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IF 7.804
Ying Pan,Xiaofei Zhai,Jian Yin,Tianqi Zhang,Liujia Ma,Yi Zhou,Yufeng Zhang,Jianqiang Meng
Graphical A metal-ion-crosslinked PIM-1 framework as heterogeneous catalyst is reported for promoting the CO 2 cycloaddition with epoxides. The new catalyst PIM-COONa-Zn demonstrates both high catalytic efficiency and good recyclability. CO 2 cycloaddition to epoxides is an effective and economical utilization method to alleviate the current excessive CO 2 emission situation. The development of catalysts with both high catalytic efficiency and high recyclability is necessary but challenging. In this context, a heterogeneous catalyst was synthesized based on a zinc-ion-crosslinked polymer with intrinsic microporosity (PIM-1). The high microporosity of PIM-1 promoted a high Zn 2+ loading rate. Additionally, the relatively stable ionic bond formed between Zn 2+ and the PIM-1 framework through electrostatic interaction ensured high loading stability. In the process of CO 2 cycloaddition with propylene epoxide, an optimized conversion of 90 % with a turnover frequency as high as 9533 h −1 could be achieved within 0.5 h at 100 °C and 2 MPa. After 15 cycles, the catalytic efficiency did not demonstrate a significant decline, and the catalyst was able to recover most of its activity after Zn 2+ reloading. This work thereby provides a strategically designed CO 2 conversion catalyst based on an ionic crosslinked polymer with intrinsic microporosity.
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Food Science & Nutrition
·
2024
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IF 3.5
Ruixi Luo,Yudie Hu,La Wang,Zunli Ke,Wenjia Wang,Ping Wang,Weiyi Tian
The primary catalyst for nonalcoholic fatty liver disease (NAFLD) is widely recognized as the induction of lipotoxicity in hepatocytes by an excess of fatty acids. In China, Penthorum chinense Pursh (PcP) is commonly employed as a functional food due to its known hepatoprotective properties. The present study aimed to investigate the influence of PcP extract on in vivo and in vitro models of NAFLD. We found that PcP extract can attenuate palmitic acid (PA)-induced lipotoxicity in HepG2 cells. PA was observed to trigger pyroptosis, as indicated by the increased expression of NLRP3 and GSDMD/N, activation of Caspase-1, and subsequent release of IL-1β and IL-18. However, these changes were reversed after PcP was administered. Furthermore, the application of an NLRP3 agonist inhibited the protective effects of PcP on lipotoxicity, indicating that PcP decreased lipotoxicity by inhibiting the NLRP3/Caspase-1/GSDMD pathway. Ultimately, we established a rat model of NAFLD through the administration of a high-fat diet (HFD), followed by the oral delivery of PcP extracts. The results demonstrated that the administration of PcP extract effectively decreased dyslipidemia and hepatic steatosis, which coincided with a decrease in hepatic pyroptosis through modulation of the NLRP3/Caspase-1/GSDMD pathway in liver tissues. Overall, our findings provide insight into the mechanism by which PcP extracts alleviate hepatic steatosis, highlighting the potential significance of modulating the NLRP3/Caspase-1/GSDMD pathway in the context of pyroptosis.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2024
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IF 4.8
Xi Ma,YuZheng Yang,Hao Li,ZeHong Luo,QiuYi Wang,XueMing Yao,Fang Tang,Ying Huang,Yi Ling,WuKai Ma
Although the pathogenesis of rheumatoid arthritis (RA) remains unclear, an increasing number of studies have confirmed that pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) is an important factor affecting the progression of RA. Periplogenin (PPN) is a natural cardiac glycoside; reportedly, it exerts anti-inflammatory and analgesic effects in diseases by inhibiting cell growth and migration. This study aimed to determine the effect of PPN on the growth, migration, and invasion of RA-FLS and the potential mechanism of pyroptosis regulation. We discovered that PPN could inhibit the migration and invasion abilities of RA-FLS and block their growth cycle, down-regulate the secretion and activation of NLRP3, Caspase-1, GSDMD, IL-1β, and IL-18, and reduce the number of pyroptosis. In summary, PPN inhibited pyroptosis, reduced the release of inflammatory factors, and improved RA-FLS inflammation by regulating the NLRP3/Caspase-1/GSDMD signaling pathway.
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PubMed
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ACS Synthetic Biology
·
2025
·
IF 3.9
Hong-Rui Li,Ying Zhou,Bang-Ce Ye
Bacteriophages, leveraging phage display and chemical modification, have the potential to deliver large payloads of antitumor agents with precision and to advance vaccine development. However, systemic phage administration often induces neutralizing antibodies, which accelerate phage clearance and reduce accumulation at the target site. To address this limitation, we propose a genetically modified nonpathogenic bacterial strain that specifically targets tumors and releases programmed death ligand 1 (PD-L1)-specific M13 bacteriophage within tumor tissue. We assessed the antitumor efficacy of this phage-expressing strain as an adjunctive therapeutic strategy along with a therapeutic bacterial strain engineered for the controlled release of an immunotoxin. The combination of these strains demonstrated synergistic effects in eliciting antitumor immune responses and inhibiting tumor growth in a murine model of colorectal cancer (CRC). Moreover, when combined with Folfox, the phage-expressing strain significantly extended the survival. This strategy of in vivo expression and tumor-specific release mediated by nonpathogenic bacterial strains provides an effective and safe method for targeted therapeutic phage delivery to tumors.
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PubMed
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Hengyang Liu,Wanyuan Li,Yong Xu,Enzhu Hu,Guangchao Qin,Kunhong Hu
A 1 T/2H-MoS 2 (THM) lubricant additive was synthesized via a solvothermal method to improve the lubrication of poly-alpha-olefin (PAO) and reduce the negative influence of diesel carbon soot (CS). The THM was then modified with Cu to further enhance the wear resistance. The average interlayer spacing of MoS 2 in THM and the Cu-modified THM (CTHM) was 0.99 nm, significantly larger than the 0.63 nm of 2H-MoS 2 nanoparticles. In PAO, CTHM demonstrated a 45 % improvement in friction reduction and a 77 % increase in wear resistance compared to 2H-MoS 2 . While the friction reduction of CTHM was similar to that of THM, CTHM exhibited 36 % superior wear resistance. In CS-contaminated PAO, CTHM outperformed 2H-MoS 2 with a 37 % reduction in friction and a 29 % enhancement in wear resistance. The Cu modification reduced the oxidation of CTHM and the conversion of 1 T-MoS 2 to 2H-MoS 2 in the tribofilm, contributing to improved wear resistance. The CS contamination negatively influenced the lubrication by accelerating MoS 2 oxidation, catalyzing the transition from 1 T-MoS 2 to 2H-MoS 2 , and inhibiting Cu incorporation into the tribofilm. Nonetheless, the effect of CS on CTHM and THM was less severe than on 2H-MoS 2 . This work provides an alternative method to alleviated the antagonism between MoS 2 and CS.
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