Journal of Hazardous Materials Advances
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2026
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IF 9.1
Jiawei Li,Gaiyuan Chen,Min Chen,Zhengxin Wu,Yong Liu
Uranium (U) tailings, generated as byproducts of U mining and milling, pose significant disposal challenges owing to their large volume, radiotoxicity, and chemically heterogeneous mineral composition. Herein, we report a microwave–assisted route for preparing (1– x )Sr 0.5 Zr 2 (PO 4 ) 3 – x CePO 4 ( x = 0, 0.2, 0.4, 0.6, 0.8, 1) [strontium zirconium phosphate(SZP)–cerium phosphate(CP)] composite ceramics while incorporating real U tailings as a Si/Al–rich secondary waste component. The raw–batch U–tailing loading was 39.7–47.0 wt% for the designed compositions and 45.4 wt% for the optimized SZP–CP–0.8 batch. Compared with reagent–derived SZP–CP systems, the present work focuses on the practical utilization and stabilization of actual U tailings during ceramic waste−form preparation. The phase assemblage, microstructure, density, Vickers hardness, Ce surface valence, and 42–day PCT chemical durability were evaluated. The optimized SZP–CP–0.8 ceramic exhibited a density of 4.32 g ·cm –3 , a porosity of 0.12%, and low normalized leaching rates after 42 days, with Sr, P, and Si of approximately 10 −4 g ·m −2 ·d −1 , Ce of approximately 10 –7 g ·m –2 ·d –1 , and Zr of approximately 10 –8 g ·m –2 ·d –1 , supporting the feasibility of microwave–sintered SZP−CP composites for treatment and disposal of U tailings and simulated divalent/tetravalent radionuclides. Quantitative phase refinement, statistically representative grain–size analysis, replicate–vessel leaching uncertainty, and radionuclide–specific leaching of native trace elements from tailings are identified as future work rather than over interpreted from the present dataset.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Jiaozhong Cai,Jiacheng Li,Jiushuai Deng,Bozeng Wu,Ni Xiao,Junnan Chen,Wei Weng,Xiaopeng Chi,Wen Tan,Guangsheng Zeng,Shuiping Zhong
Selective depression of chalcopyrite while preserving molybdenite floatability remains challenging. Conventional sulfur-containing depressants may oxidize readily, require high dosages, or depend on strong alkalinity, prompting the development of new selective reagents. Sodium 3-mercapto-1-propanesulfonate (MPS), containing thiol and sulfonate groups, was introduced as a selective chalcopyrite depressant. At pH 7 and 1.5 × 10 −5 mol L −1 MPS, the maximum recovery difference in single-mineral flotation reached 87.6 percentage points. In artificial mixed-mineral flotation, Cu recovery decreased to 7.28%, whereas Mo recovery remained at 91.16%, increasing the separation index from 1.28 to 11.49. Contact angle, SEM–EDS, and FTIR analyses indicated preferential retention of MPS-related species on chalcopyrite, together with interaction between thiol S and surface Cu sites and enhanced surface hydrophilicity associated with the sulfonate group. Under the electrochemical test conditions, MPS attenuated the anodic response and reduced the corrosion current density of chalcopyrite by approximately 40%, with little effect on molybdenite. DFT calculations further identified the Cu site on chalcopyrite (112) as more favorable for MPS adsorption than the Fe site (−100.96 versus −86.02 kJ mol −1 ), whereas the modelled adsorption configuration on molybdenite (001) was energetically unfavorable (+47.61 kJ mol −1 ). This study elucidates a selective depression mechanism involving preferential adsorption, increased surface hydrophilicity, and altered chalcopyrite redox behavior, while demonstrating the potential of MPS for near-neutral Cu Mo flotation separation. Download: Download high-res image (142KB) Download: Download full-size image
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Surfaces and Interfaces
·
2026
·
IF 6
Hui Zhou,Bingxin Zhu,Xiang Li,Baolei Liu,Zhigang Liu,Shihua Yu
To recover the high value-added pharmaceutical intermediate tenofovir from wastewater efficiently and conveniently, a tailored magnetic composites of Fe 3 O 4 @SiO 2 @La(OH) 3 have been prepared via solvothermal and in-situ reduction methods. It exhibits the ability to remove tenofovir with high efficiency and easily separated from matrix. Batch sorption experiments demonstrated that Fe 3 O 4 @SiO 2 @La(OH) 3 can remove tenofovir with the maximum adsorption capacity of 64.53 mg/g, the largest removal of 93.07%, and fast equilibrium time of 5 min. The kinetics of tenofovir adsorption on the magnetic composite is in line with the pseudo-second-order model, while the isotherm is fitted well by the Langmuir model, and thermodynamic parameters represent that adsorption process is spontaneous and endothermic. Moreover, the saturated Fe 3 O 4 @SiO 2 @La(OH) 3 have been desorbed by mechanical stirring with the high desorption rate of 93.02%, and the adsorption capacity maintaining 47.72 mg/g after five cycles. Importantly, the composites can be used for tenofovir removal from crude extracts of pharmaceutical wastewater, with an adsorption capacity of 51.61mg/g in 5 min. Finally, the adsorption mechanisms are explored by pH experimental evidence and XPS analysis, which show that mainly involve electrostatic attraction and the inner-sphere complexation between La(OH) 3 and phosphate groups of tenofovir via ligand exchange. All the results prove that the proposed tenofovir recovery technique, providing new ideas for the recovery of high value-added substances and waste resources rationalization of the application of development. A magnetic Fe 3 O 4 @SiO 2 @La(OH) 3 was synthesized and realized the recovery of tenofovir with high economic value in pharmaceutical wastewater crude extracts. Download: Download high-res image (249KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Ting Zhao,Hang Liu,Gacao Dou,Dongting Zhang,Junqiang Qiao,Juan Yang,Pengjun Ma,Cuiying Lu,Hongxia Li,Hongruo Ma,Kunjie Wang,Bingjun Yang
The nanostructured process effectively boosts the rate capability of Fe 2 (MoO 4 ) 3 . • The FMO-4.25 maintains a high capacity of 74.5 mAh g −1 at 100C. • Even at −20 °C, it retains 65 mAh·g −1 at 1C after 500 cycles. • In-situ EIS tracked interface kinetics evolution and CEI formation. Fe 2 (MoO 4 ) 3 (FMO), a promising polyanionic cathode material for sodium-ion batteries (SIBs), offers a stable three-dimensional framework, high operating voltage, and exceptional thermal stability, positioning it as a suitable candidate for large-scale energy storage systems. However, its practical implementation is still hindered by sluggish reaction kinetics. In this study, we address the issues of low electronic conductivity and slow Na + migration in FMO cathode material by an electrospinning-based nano-Synthesis strategy. By precisely regulating the pH of the precursor solution and optimizing the sintering process, the as-prepared FMO-4.25 electrode delivers a high specific capacity of 83.4 mAh·g −1 at 2C after 100 cycles and maintains a discharge capacity of 74.5 mAh·g −1 even at an ultrahigh rate of 100C. Moreover, it exhibits remarkable rate capability and long-term cycling stability even under low-temperature conditions. The electrochemical analysis reveals that the nano structuring of the FMO-4.25 electrode effectively enhances the kinetics of ion diffusion and electron transfer. Furtherover, the nanostructure effectively suppresses volume strain during Na + (de)intercalation, promotes the formation of a stable cathode-electrolyte interphase (CEI), and preserves the integrity of the interfacial and conductive networks, thereby synergistically improving the structural stability of the material. This work provides new insights into the controlled synthesis and mechanistic understanding of high-performance iron molybdate-based cathode materials, offering a valuable reference for advancing the practical application of SIBs in high-power and low-temperature environments. Download: Download high-res image (88KB) Download: Download full-size image
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ACS Nano
·
2026
·
IF 17.3
Zhen Fang,Jianbo Wu
Ultrafine high-entropy intermetallics (HEIs), which synergistically combine high-entropy effect, size effect, and ordered intermetallic structure, have attracted considerable attention as promising candidates for highly active and durable catalysts. However, the sluggish diffusion inherent to the complex multielement environment of high-entropy systems necessitates high temperatures to drive atomic ordering, which typically leads to severe nanoparticle sintering in the traditional thermal process. Here, we address this challenge via a multithermal-pulse control strategy that effectively suppresses long-range atomic diffusion-mediated interparticle sintering and intraparticle phase separation during short-range atomic ordering, enabling the synthesis of uniform sub-3 nm HEI nanoparticles. By varying the number of thermal pulses to precisely control the chemical ordering degree of PtFeCuCoNi alloy nanoparticles, we discover a clear positive correlation between the ordering degree and oxygen reduction performance. The HO-PtFeCuCoNi nanoparticles with the highest ordering degree exhibit the best catalytic activity (MA of 0.95 A mgPt–1 and SA of 1.18 mA cmPt–2) and stability (MA retention of 70.8%, SA retention of 70.4%, and ΔE1/2 of 6 mV) compared to their less ordered counterparts and commercial Pt/C. This multipulse strategy provides a feasible route to utilize pulse dynamics for capturing ordered structures and regulating the sintering-ordering trade-off and offers useful guidance for the structural design of multicomponent alloys.
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ACS Nano
·
2026
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IF 17.3
Xinhao Li,Weikang Hu,Yao Huang,Yanmei Ma,Zuokun Yin,Tong Wang,Chengzhi Hu
Unraveling the precise kinetics of the intrinsic apoptotic pathway requires resolution of the temporal lag between mitochondrial permeabilization and downstream proteolytic execution. However, dissecting these distinct molecular events within the crowded cytosolic environment of a single live cell remains limited by the lack of nonperturbative, multiplexed sensing tools. Here, we report a dual-channel nanoprobe capable of label-free, simultaneous monitoring of Cytochrome c (Cyt c) translocation and Caspase-3 activation. The nanoprobe features physically isolated nanochannels allowing for orthogonal functionalization: one channel acts as an aptamer-based sensor for Cyt c, while the second functions via the enzymatic cleavage of a specific peptide substrate by Caspase-3. This design enables the synchronous transduction of protein binding and enzymatic activity into independent current signals. The probe exhibited high sensitivity, selectivity, and stability in complex biological fluids. We applied this platform to monitor the dynamics of Cyt c and caspase-3 in breast cancer cells, revealing significant heterogeneity in apoptosis and a spatiotemporal delay between Cyt c release and caspase-3 activation, consistent with the intrinsic apoptosis pathway. This dual-detection methodology provides a minimally invasive approach with high spatial and temporal resolution for probing apoptotic signaling at the single-cell level and enables quantitative assessment of heterogeneous cellular responses to apoptotic stimuli.
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Food Chemistry-X
·
2026
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IF 9.2
Weiyi Xu,Yutong Meng,Fan Yu,Huanfeng Ye,Xuejiao Xu,Jie Chen,Xianrui Liang,Sheng Fang
This study evaluated Osmanthus fragrans fruit (OFF) peel as a potential source of anthocyanin-based natural colorants. Anthocyanins were extracted using acidified ethanol and purified by macroporous resin adsorption, yielding a pigment-rich extract with a recovery of 10.4 ± 0.2% from dried peel. HPLC–MS/MS analysis indicated that cyanidin-3-O-rutinoside (C3R) was the predominant anthocyanin in the extract. The molar absorptivity of C3R was experimentally determined to enable more accurate quantification of C3R-rich systems. The purified extract exhibited typical pH-dependent color behavior, maintaining a stable red coloration under acidic conditions (pH 2.0–4.0). Thermal stability experiments showed that C3R degradation was strongly influenced by temperature and pH, and the degradation behavior followed first-order kinetics. In addition, the extract displayed measurable antioxidant capacity in DPPH and FRAP assays. These results demonstrate that O. fragrans fruit peel is a promising source of C3R-rich anthocyanins with potential applications as natural colorants in acidic food systems.
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Reaction Chemistry & Engineering
·
2026
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IF 2.9
Letao Guo,Mei Yang,Lixia Yang,Mei Han,Wenna Tang,Guangwen Chen
Lithium diisopropylamide (LDA)-mediated aldol condensation is a fundamental method for the synthesis of β-hydroxy esters. This strategy was applied in our previous synthesis of the general cap structure of Chidamide (3-(3-pyridyl)acrylic acid) using tert-butyl acetate (TBA) and 3-pyridine aldehyde, where the steric hindrance of the tert-butyl group effectively suppresses enolate self-condensation. However, this steric advantage also limits subsequent functionalization. In contrast, ethyl acetate (EA) offers greater synthetic flexibility due to the favorable leaving ability of the ethoxy group, but suffers from pronounced competing enolate consumption under batch conditions. Herein, we systematically investigated the limitations of batch LDA-mediated aldol condensation between EA and 3-pyridine aldehyde and developed a continuous-flow strategy to overcome these challenges. Under batch conditions at -60 oC, the major competing pathways involving ester enolates and 3-pyridine aldehyde were identified, and a comprehensive side reaction network was proposed. Based on this analysis, the use of a sufficient excess of LDA was found to be critical for improving product yield by suppressing proton transfer to ester enolates and ensuring sufficient deprotonation of EA. However, this strategy becomes ineffective at elevated temperatures, as evidenced by the decrease in yield from 90.1% at -60 oC to 45.8% at -20 oC, with 2.0 equiv of LDA. Then, a continuous-flow system was implemented to maximize LDA participation in EA deprotonation and suppresses enolate self-condensation and decomposition via precise residence time control. Product yields exceeding 90% were achieved at -20 oC for representative aldehydes using 1.2 equiv of LDA, together with good scalability.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Manman Yuan,Jing Ye,Xiangqiao Sun,Zhiwu Tong,Tingting Wang,Renxiang Tan,Xingxin Wu
Acaudiolide ameliorates liver fibrosis in mice • Acaudiolide inhibits TGF-β1/SMAD signaling in HSCs • Acaudiolide inhibits the nuclear translocation of p-SMAD2/3 • Acaudiolide weakens the interaction between SMAD4 and p-SMAD2/3 • SMAD4 is a candidate covalent target of acaudiolide Hepatic stellate cell (HSC) activation is a central driver of fibrosis progression in metabolic dysfunction-associated steatohepatitis (MASH), yet effective antifibrotic pharmacotherapies remain limited. Here, we identify acaudiolide, a sulfur-bridged symmetric dimeric macrodiolide isolated from the fungus Acaulium sp. H-JQSF, as a natural-product lead that suppresses HSC activation and experimental liver fibrosis. In a Western diet (WD)/CCl 4 murine model of MASH, acaudiolide reduced collagen deposition, alpha-smooth muscle actin (α-SMA) expression and fibrogenic gene expression. Transcriptomic profiling of HSCs showed that acaudiolide antagonized transforming growth factor-β1 (TGF-β1)-driven profibrotic programs. Mechanistically, acaudiolide did not measurably alter SMAD2/3 phosphorylation but markedly reduced the nuclear accumulation of phosphorylated SMAD2/3 (p-SMAD2/3). Integration of Connectivity Map (CMap) analysis with isotopic tandem orthogonal proteolysis-activity-based protein profiling (isoTOP-ABPP) chemical proteomics nominated SMAD4 as a candidate covalent target of acaudiolide. Covalent docking suggested Cys363 as a potential engagement site, and co-immunoprecipitation showed that acaudiolide weakened the association of SMAD4 with p-SMAD2/3. These findings support a model in which acaudiolide interferes with SMAD complex assembly, thereby attenuating TGF-β-dependent profibrotic transcription and HSC activation. Collectively, our data nominate acaudiolide as a preclinical antifibrotic lead and SMAD4 as a potentially tractable downstream node for pharmacological modulation of TGF-β signaling in MASH-related fibrosis. Download: Download high-res image (386KB) Download: Download full-size image
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Reaction Kinetics Mechanisms and Catalysis
·
2025
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IF 1.7
Guo Lirong,Yang Xiaodie,Shao Huijuan,Zhang Xuzhi,Wang Yating,Jiang Tao
We have investigated the effect of different impurities (CO, CO 2 , CS 2 , CH 3 OH, H 2 O, C 4 H 4 S) on the silicon-bridged diphosphine(PNSiP)/CrCl 3 (C 4 H 8 O) 3 /modified methylaluminoxane ethylene tri-/tetramerization system. The results showed that the addition of trace impurities has a certain inhibitory effect on catalytic activity. The influence of impurities on the catalytic activity of the catalyst system was as follows: CO > CO 2 > CS 2 > CH 3 OH > H 2 O > C 4 H 4 S. CO showed the most significant inhibitory effect in reducing activity from 1.75 × 10 6 g/(mol Cr h) to 0.74 × 10 6 g/(mol Cr h) at an addition of 0.2 ppm. Through the analysis of nuclear magnetic resonance (NMR) and ultraviolet–visible spectrophotometry (UV–vis), we found that carbon monoxide mainly inactivates the catalytic system by coordinating with chromium active sites, while methanol and water reduce the catalytic activity by destroying the structure of modified methylaluminoxane. Furthermore, we also proposed a possible reaction path between carbon monoxide and the chromium active center. Graphical abstract
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eFood
·
2025
·Vol. 6
·期 5
·e70086
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IF 5.7
Jun Hu,Weijie Zhou,Dawei Sun,Tingxin Yu,Kuanchen Huang,Chujie Liang,Xusheng Li,Jianxia Sun,Weibin Bai
Cyanidin-3-O-glucoside (C3G), widely reported for ameliorative effects on insulin resistance and blood glucose levels, is often attributed to modulating insulin signaling pathways. However, previous studies based on the target fishing method of chemical proteomics have identified C3G's ability to covalently bind target proteins, including insulin-degrading enzyme (IDE), an Alzheimer's disease pathway protein closely related to metabolism. The specific interactions of anthocyanins with their target proteins and their correlation with activity remain unverified. Therefore, elucidating the relationship between C3G's bioactivity and target proteins is crucial. In this study, we employed various methods to clarify the binding and activity effects of C3G on IDE. CETSA-WB revealed that C3G binds to IDE and significantly enhances its thermal stability. Insulin and fluorescent peptide substrate measurements identified C3G's enzymatic inhibitory activity with an IC 50 of 109.6 μM. The preparation of recombinant human IDE ( rh IDE) allowed us to directly confirm the covalent binding of C3G to IDE. Furthermore, the silencing of IDE in cells negated the significant improvement in insulin resistance by C3G. These findings unveil a potential novel molecular mechanism by which C3G may regulate metabolic pathways, offering guidance for understanding how anthocyanins exert their functions through interactions with target proteins.
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Pharmaceutics
·
2025
·Vol. 17
·期 10
·1307
·
IF 5.5
Ruoqing Guan,Xiangjun He,Yuxing Dai,Guangye Huang,Zhaoyun Xue,Jianwen Chen,Peiqing Liu
Background/Objectives: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive loss of lung function and poor prognosis. Cryptotanshinone (CTS), a small-molecule compound extracted from Salvia miltiorrhiza, possesses diverse pharmacological activities but suffers from poor oral bioavailability, which restricts its clinical development, particularly in pulmonary fibrosis. DST-3, a newly synthesized derivative of CTS, was designed to overcome these limitations.Methods: The antifibrotic effects of DST-3 were investigated in a bleomycin-induced pulmonary fibrosis model in C57BL/6 mice through lung function assessment, histopathological evaluation, hydroxyproline quantification, and cytokine profiling. In vitro, TGF-β1-stimulated MRC5 fibroblasts were employed to explore the mechanism of action, focusing on STAT3/Smad signaling via Western blotting and molecular binding assays. Furthermore, a validated HPLC–MS/MS method was developed for DST-3, and its pharmacokinetic profile was characterized in Sprague–Dawley rats and compared with that of CTS.Results: DST-3 markedly attenuated pulmonary fibrosis in vivo, as evidenced by improved lung function, reduced collagen deposition, and decreased proinflammatory cytokine levels. In vitro, DST-3 inhibited TGF-β1-induced fibroblast activation by directly binding to STAT3 and suppressing STAT3/Smad signaling. Pharmacokinetic analysis demonstrated that, compared with CTS, DST-3 exhibited more rapid absorption, a higher peak plasma concentration, a greater area under the curve (AUC), improved hepatic metabolic stability, and enhanced lung tissue exposure.Conclusions: Our study demonstrates that DST-3 exerts potent antifibrotic effects in vivo and in vitro, primarily through STAT3 pathway inhibition. Its improved pharmacokinetic characteristics further support its potential as a promising candidate for the treatment of pulmonary fibrosis.
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