JOURNAL OF NANOPARTICLE RESEARCH
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2019
·Vol. 21
·期 2
·1-12
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IF 2.009
Xia Xiaoxiao,Li Wei,Li Song
Ionic liquids/metal-organic framework composites are recognized as promising adsorbents for CO 2 capture due to the outstanding adsorption performance, whereas their water stability, which is critical for the real application of ILs/MOF composites, has not been taken into consideration. In this work, the water stability of two ILs/Cu-BTC composites, i.e., 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]) /Cu-BTC and 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF 6 ]) /Cu-BTC, were investigated. We found that the loading of ILs does not impose remarkable impacts on the crystalline structure of Cu-BTC upon water exposure; whereas the thermal stability and surface area of Cu-BTC were decreased by the incorporation of ILs, thereby leading to the reduced CO 2 uptake in spite of the enhanced CO 2 heat of adsorption. Furthermore, it was revealed that the decomposition of Cu-BTC occurred within the first hour of water exposure. Nevertheless, the loading of ILs retarded the decomposition of Cu-BTC according to the variations in BET surface area upon water exposure.
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NPG Asia Materials
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2019
·Vol. 11
·期 1
·1-18
·
IF 8.052
Liang Jianming,Zhu Ying,Gao Caifang,Ling Chengli,Qin Jing,Wang Qi,Huang Yongzhuo,Lu Weigen,Wang Jianxin
Current chemotherapeutics for glioma are not sufficiently effective due to their low tolerance and poor blood–brain barrier (BBB) permeability. Energy restriction based on co-delivery of albendazole (Abz) and nano-silver has been proven to suppress tumor growth without adverse effects. Accordingly, menthol was conjugated to BSA (MeB) to overcome the BBB-permeability issue. In this study, Abz-loaded MeB-silver nanoparticles (MBS-Abz) were developed by self-assembly of MeB, albendazole and nano silver for glioma targeting therapy. The nanoparticle entered the brain across the BBB and specifically accumulated in the glioma region. MeB delivered the nanoparticles across the brain capillary endothelial cell monolayer by promoting internalization and BBB disruption. MBS-Abz hindered ATP generation via the inhibition of glycolytic and mitochondrial pathways both in vitro and in vivo. The anti-glioma mechanisms of energy restriction were related to the cytotoxicity, proliferation inhibition, cell cycle arrest, and apoptosis induced by ATP exhaustion, and the effects of MBS-Abz were significantly better than those induced by monotherapy nanoparticles or unmodified nanoparticles. These results demonstrated that by combining the energy restriction effect of albendazole and nano silver, as well as the BBB penetration ability of menthol, MBS-Abz achieves superior anti-glioma efficacy and can be an effective strategy for glioma therapy.
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RENEWABLE ENERGY
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2019
·
IF 5.439
Nisakorn Saengprachum,Dongren Cai,Mantian Li,Ling Li,Xiaocheng Lin,Ting Qiu
Via the crosslinking of chitosan and sulfosuccinic acid (SSA), the acidic chitosan membrane (ACM) was prepared for biodiesel production from esterification of oleic acid and methanol. ATR-FTIR, TGA, XRD, SEM and EDX were applied to characterize the prepared ACM. The acidic site density and swelling capacity of the prepared ACM were investigated. The ACM possessed the 4.62 mmol/g of acidic site density, which was just a little less than 4.76 mmol/g of Amberlyst-15, meanwhile, ACM was proven to be much higher than Amberlyst-15 in swelling capacity. Under the same reaction, the 98.76% of conversion can be obtained while the Amberlyst-15 only reached 44.30%. The optimization of process variables was conducted by the combination of single factor experiment and Box-Behnken design (BBD) response surface methodology . The catalytic activity of ACM in different esterification of fatty acids and alcohols was also investigated. And the catalytic mechanism of esterification catalyzed by ACM was clarified. Based on the catalytic mechanism, the kinetic model was established to describe the esterification and obtain relevant kinetic parameters ( E a + , E a − , A + and A - ), meanwhile, the kinetic results were compared to the same reaction with different catalysts in detail. Besides, the reusability of the prepared ACM was studied.
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Science Bulletin
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2019
·
IF 6.277
Yunbo Zhang,Wei Lv,Zhijia Huang,Guangmin Zhou,Yaqian Deng,Jun Zhang,Chen Zhang,Boyu Hao,Qi Qi,Yan-Bing He,Feiyu Kang,Quan-Hong Yang
The reviving use of lithium metal anode (LMA) is one of the most promising ways to upgrade the energy density of lithium ion batteries . In the roadmap towards the real use, besides the formation of the dendrite, various adverse reactions due to the high activity of LMA when exposed to air or the electrolyte limit its practical applications. Learning from the packaging technology in electronic industry, we propose a wax-based coating compositing with the ion conducting poly (ethylene oxide) by a simple dip-coating technology and the prepared LMA is featured with an air-stable and waterproof surface. The LMA thus remains stable for 24 h in ambient air even with the relative humidity of 70% while retaining about 85% its electrochemical capacity. More importantly, the LMA is accessible to water and when dipping in water, no obvious adverse reactions or capacity decay is observed. With the composite coating , a steady cycling performance for 500 h in symmetrical cells and a low capacity decay rate of 0.075% per cycle after 300 cycles in lithium-sulfur batteries assembled with the packaged anode have been achieved. This work demonstrates a very simple and effective LMA package technology which is easily scalable and is very promising for speeding up the industrialization of lithium-sulfur batteries and shows potentials for the large-scale production of air-sensitive electrode materials not limited to LMAs.
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ANALYTICAL CHEMISTRY
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2019
·
IF 6.35
Jiahui Zhao,Shuang Wang,Shasha Lu,Guoyong Liu,Jian Sun,Xiurong Yang
Alkaline phosphatase (ALP) usually acts as a signal transmitter in enzyme-linked immunosorbent assay (ELISA); therefore, developing an attractive ALP activity assay, especially using a preferable substrate, would help improve the efficiency and convenience of ELISA in practical applications. Herein we have first prepared an original and creative substrate, named m-hydroxyphenyl phosphate sodium salt (m-HPP), with a desirable dephosphorylation site for ALP. On the basis of the ALP-catalyzed hydrolysis of m-HPP to resorcinol and its subsequent specific nucleophilic reaction with dopamine, we have exploited a fluorometric and colorimetric dual-readout ALP activity assay and ALP-based ELISA system. Under the employed experimental conditions, highly sensitive and specific assay of ALP and cardiac troponin I (cTnI) has been accomplished in a straightforward way. Furthermore, the commendable sensing performance of our proposed ELISA in the determination of the cTnI level in diluted human serum unambiguously illustrates great potential in the early diagnosis of acute myocardial infarction.
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ANALYTICAL CHEMISTRY
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2019
·
IF 6.35
Yufeng Liu,Min Zhou,Wen Cao,Xiaoyu Wang,Quan Wang,Sirong Li,Hui Wei
Nanomaterials with enzyme-like characteristics (nanozymes) have been developed to mimic enzymes because of their low cost, high stability, and large-scale production. By using light as an external stimulation, one can modulate nanozymes’ catalytic activities with controlled spatial and temporal precision. A few inorganic photoactive materials have been investigated to construct light-responsive oxidase-like nanozymes. However, these materials suffered from limited absorbance of visible light. To address this challenge, herein we have developed a photosensitized metal–organic framework (PSMOF) by using a derivative of Ru(bpy)32+ with stronger visible-light absorption as a PS linker. The PSMOF exhibited excellent oxidase-like activity, which could be modulated by switching light on and off. Moreover, the PSMOF was used to detect glutathione levels in both normal and cancer cells with good selectivity and high sensitivity. This study not only provides a smart strategy to modulate nanozymes’ activities but also broadens the sensing applications of nanozymes.
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MOLECULAR IMAGING AND BIOLOGY
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2019
·Vol. 22
·期 2
·265-273
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IF 3.341
Zhao Chao,Liu Chunyi,Tang Jie,Xu Yingjiao,Xie Minhao,Chen Zhengping
Purpose The aim of this study was to optimize the radiolabeling method of [ 18 F]fluoropropyl-(+)-dihydrotetrabenazine ([ 18 F]FP-(+)-DTBZ) to fulfill the demand of preclinical and clinical application. Procedures Optimized labeling conditions were performed by altering the molar ratio of precursor to base (P/B), base species, solvents, reaction temperature, reaction time, and precursor concentration through manual radiosynthesis of [ 18 F]FP-(+)-DTBZ. The conditions with the highest radiochemical yield (RCY) were applied to automated radiosynthesis, and the crude product was purified with a Sep-Pak Plus C18 cartridge. Quality control and stability of [ 18 F]FP-(+)-DTBZ were carried out by HPLC. In vitro cellular uptake and blocking assays were conducted in human neuroblastoma cell line SH-SY5Y. In vivo imaging with small animal positron emission tomography (microPET) was performed with Sprague–Dawley rats. Results Under the optimized conditions (P/K 2 CO 3 = 1:8, heating at 120 °C for 3 min in dimethyl sulfoxide), an RCY of 88.7 % was obtained with 1.0 mg precursor. The optimized reaction conditions were successfully applied to an automated module and gave a high activity yield (AY) of 30–55 % in about 40 min with a > 99.0 % radiochemical purity (RCP) and a > 44.4 GBq/μmol molar activity ( A m ). Stability test displayed that the RCP retained > 98.0 % in 8 h in saline and in phosphate buffer saline (PBS, pH 7.4). In vitro cellular uptake assay showed accumulation of [ 18 F]FP-(+)-DTBZ in SH-SY5Y cells, which could be significantly inhibited by vesicular monoamine transporter 2 (VMAT2) inhibitor DTBZ. MicroPET images of rat brain displayed that the striatum showed the highest uptake with a standardized uptake value (SUV) of 3.91 ± 0.30 at ~ 70 min. Co-injection with DTBZ (1.0 mg/kg) resulted in a 75 % decrease of the striatal SUV, confirming the specificity of [ 18 F]FP-(+)-DTBZ to VMAT2. Conclusions We obtained an optimized radiolabeling method of [ 18 F]FP-(+)-DTBZ and successfully applied it to a commercial available module. The automated synthesis gave a high AY and RCP of [ 18 F]FP-(+)-DTBZ with high and specific binding to VMAT2, facilitating its routine application for VMAT2 tracing.
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FOOD AND AGRICULTURAL IMMUNOLOGY
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2019
·
IF 2.398
Pengjie Luo,Xia Chen,Jing Xiao,Yunfeng Zhao,Zifei Wang
In recent years, fungicides have been frequently detected in soil, water, and air because of their extensive use, with detrimental effects on the environment. Therefore, the screening of foods for iprodione (IPRO) has become mandatory. A rapid, specific and sensitive method based on an immunochromatographic strip test has been developed for the determination of IPRO residues in cucumber and apple. The antigen IPRO-ovalbumin and a goat anti-mouse IgG antibody were drawn onto a nitrocellulose membrane as the test and control lines, respectively. Under optimal conditions, the cut-off limits of the semi-quantitative strip test for IPRO was as low as 10 ng/mL in 0.01 M PBS pH 7.4, 20 ng/mL in cucumber juice, and 25 ng/mL in apple juice and the results were obtained within 5 min. Our data suggests that this immunochromatographic assay can be used for the sensitive, rapid, and specific on-site screening of IPRO in cucumber and apple.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2020
·
IF 5.774
Zhongde Wang,Sihang Tian,Junjian Niu,Wei Kong,Jianying Lin,Xiaogang Hao,Guoqing Guan
Desalination is an important way to provide fresh water for our life. In this study, an electrochemically switched ion exchange (ESIX) process based on self-electrical-energy recuperation concept was designed and realized for desalination, in which the self-generated electricity could provide the required energy for the ESIX process. As iron hexacyanoferrate (FeHCF) and polypyrrole (PPy) were used as electroactive Na + and Cl − ion exchange materials respectively, NaCl was successfully removed from the aqueous solution with a low energy consumption of 0.14 kWh·m −3 and a high ion exchange capacity of 79.6 mg·g −1 . Moreover, the system also exhibited an excellent stability. It is expected that such an ESIX process with self-electrical-energy recuperation could enable more efficient desalination applications.
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Molecular Catalysis
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2019
·
IF 2.938
Guochao Xu,Wei Dai,Yue Wang,Lu Zhang,Zewen Sun,Jieyu Zhou,Ye Ni
Structure-guided rational design revealed the molecular switch manipulating the Prelog and anti-Prelog priorities of an NADPH-dependent alcohol dehydrogenase toward prochiral ketones with bulky and similar substituents. Synergistic effects of unconserved residues at 214 and 237 in small and large substrate binding pockets were proven to be vital in governing the stereoselectivity. The ee values of E214Y/S237A and E214C/S237 G toward (4-chlorophenyl)-(pyridin-2-yl)-methanone were 99.3% ( R ) and 78.8% ( S ) respectively. Substrate specificity analysis revealed that similar patterns were also found with (4’-chlorophenyl)-phenylmethanone, (4’-bromophenyl)-phenylmethanone and (4’-nitrophenyl)-phenylmethanone. This study provides valuable evidence for understanding the molecular mechanism on enantioselective recognition of prochiral ketones by alcohol dehydrogenase.
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MOLECULES
·
2019
·Vol. 24
·期 20
·3747
·
IF 3.06
Weiyu Yang,Ling Guo,Fenfen Li,Xin Liu,Shaoping Nie,Mingyong Xie,Danfei Huang
Myricetin (Myr) is a phytochemical with many functional properties. However, its hydrophobicity, low bioavailability, and stability limit its application. In this study, octadecanoate oat β-glucan (OGE) was synthesized and gained recognition as a self-assembled micelle forming a polymer with a critical micelle concentration (CMC) of 59.4 μg/mL. The Myr-loaded OGE micelle was then prepared and characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), X-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FT-IR) spectra. The water solubility of Myr was greatly enhanced by forming the Myr/OGE inclusion complex. Consequently, compared to free Myr, the retention of Myr in Myr-loaded OGE micelle was effectively increased during the intestinal digestion phase, and its antioxidant activity was also improved. Overall, our findings demonstrated the potential applications of OGE polymer for the development of prospective micelle in health food, cosmetics, and pharmaceutical fields because they can aid in the delivery of hydrophobic functional compounds like Myr.Keywords:phytochemicals;myricetin;amphiphilicity;micelle;self-assembly
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2020
·Vol. 108
·期 5
·2167-2179
·
IF 2.831
Yan Li,Qian Li,Hongming Li,Xiao Xu,Xiaoming Fu,Jijia Pan,Hui Wang,Jerry Ying Hsi Fuh,Yanjie Bai,Shicheng Wei
Numerous bioactive molecules produced in cells are involved in the process of bone formation. We consider that appropriate, simultaneous application of two types of bioactive molecules would accelerate the regeneration of tissues and organs. Therefore, we combined aspirin-loaded liposomes (Asp@Lipo) and bone forming peptide-1 (BFP-1) on three dimensional-printed polycaprolactone (PCL) scaffold and determined whether this system improved bone regeneration outcomes. in vitro experiments indicated that Asp@Lipo/BFP-1at a 3:7 ratio was the best option for enhancing the osteogenic efficiency of human mesenchymal stem cells (hMSCs). This was confirmed in an in vivo cranial defect animal model. In addition, RNA-Seq was applied for preliminarily exploration of the mechanism of action of this composite scaffold system, and the results suggested that it mainly improved bone regeneration via the PI3K/AKT signaling pathway. This approach will have potential for application in bone tissue engineering and regenerative medicine.
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