Biomaterials Science
·
2017
·Vol. 6
·期 1
·179-188
·
IF 4.21
Jing Li,Cuiting Zhang,Weiming He,Hongzhi Qiao,Jiahui Chen,KaiKai Wang,David Oupický,Minjie Sun
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial–mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated a kidney-specific biodistribution of the nanocomplex. The anti-fibrosis effect of HChi-Ca-Sal B was tested in a mouse model of unilateral ureteral obstruction (UUO). Significant attenuation of the morphological lesions and the levels of extracellular matrix (ECM) proteins in the tubulointerstitium was observed in mice treated with HChi-Ca-Sal B, suggesting that the nanocomplex was able to prevent fibrosis better than the treatment with free Sal B. It was concluded that the HChi-Ca-Sal B nanocomplex showed a specific renal targeting capacity and could be utilized to enhance Sal B delivery for treating renal fibrosis.
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JOURNAL OF POWER SOURCES
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2017
·
IF 6.395
Ying Chang,Conghui Yuan,Cheng Liu,Jie Mao,Yuntong Li,Haiyang Wu,Yuzhe Wu,Yiting Xu,Birong Zeng,Lizong Dai
A novel strategy has been developed to generate B, N co-doped carbon materials (CNBs) through the pyrolysis of boronate polymer nanoparticles (BPNs) derived from the condensation reaction between catechol and boronic monomers . The morphology, surface area and heteroatom ( viz . B and N) content of the CNBs can be easily adjusted by altering the molar ratio between catechol and boronic monomers. The supercapacitor and oxygen reduction reaction (ORR) performance of the CNBs are optimized. CNBs derived from equal molar ratio of catechol and boronic monomers exhibit favorable performance for supercapacitor, featuring a specific capacitance of up to 299.4 F/g at 0.2 A/g, an improved rate capability and excellent cycle stability. Notably, CNBs prepared using 1/2 molar ratio of catechol to boronic monomers show excellent ORR performance, as they demonstrate good electrocatalytic activity , high tolerance for methanol and long durability. Our findings may be of interest in the design of carbon materials with optimized electrochemical properties through the control over surface area and the content of heteroatom.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 11
·1-9
·
IF 2.1
Jing Fengyang,Zhang Shuping,Wu Yaoyao,Lin Jiuyang,Zhou Chenliang,Yuan Wenjing
The capture of formaldehyde (HCHO) is a crucial step in the HCHO purification system that requires an adjustable surface structure of adsorbent to enhance the HCHO adsorption ability. Carbon material, known to contain high surface area and structural tunability, provides an extremely valuable candidate to eliminate indoor HCHO pollutant. Herein, a novel electron acceptor–donor structure is constructed to the surface of nanoporous carbon based on the B, N doping theory. The mechanism of HCHO adsorption and activation on the surface of B, N co-doped nanoporous carbon (BNC) is systematically investigated by experimental tests that the B–N Lewis pair sites contribute a larger adsorption capacity than that of nitrogen-doping and non-doping samples. The present study gives an in-depth understanding about the contribution of the B–N Lewis pair for HCHO adsorption, and also corresponding positive impacts on the transformation into less toxic intermediate species of adsorbed HCHO at room temperature.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2015
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IF 2.353
Qi Huang,Qingyou Zhang,Enze Wang,Yanmei Zhou,Han Qiao,Lanfang Pang,Fang Yu
In this paper, a new fluorescent probe has been synthesized and applied as “off–on” sensor for the detection of Al 3+ with a high sensitivity and excellent selectivity in aqueous media. The sensor was easily prepared by one step reaction between rhodamine B hydrazide and pyridoxal hydrochloride named RBP. The structure of the sensor has been characterized by nuclear magnetic resonance and electron spray ionization-mass spectrometry. The fluorescence intensity and absorbance for the sensor showed a good linearity with the concentration of Al 3+ in the range of 0–12.5 μM and 8–44 μM, respectively, with detection limits of 0.23 μM and 1.90 μM. The sensor RBP was preliminarily applied to the determination of Al 3+ in water samples from the lake of Henan University and tap water with satisfying results. Moreover, it can be used as a bioimaging reagent for imaging of Al 3+ in living cells.
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ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Yong Yang,Mei Wang,Peili Zhang,Weihan Wang,Hongxian Han,Licheng Sun
Modification of p-type Si surface by active and stable earth-abundant electrocatalysts is an effective strategy to improve the sluggish kinetics for the hydrogen evolution reaction (HER) at p-Si/electrolyte interface and to develop highly efficient and low-cost photocathodes for hydrogen production from water. To this end, Si nanowire (Si-NW) array has been loaded with highly efficient electrocatalysts, M-B (M = Ni, Co), by facile and quick electroless plating to build M-B catalyst-modified Si nanowire-array-textured photocathodes for water reduction to H2. Compared with the bare Si-NW array, composite Si-NWs/M-B arrays display evidently enhanced photoelectrochemical (PEC) performance. The onset potential (Vphon) of cathodic photocurrent is positively shifted by 530–540 mV to 0.44–0.45 V vs RHE, and the short-circuit current density (Jsc) is up to 19.5 mA cm–2 in neutral buffer solution under simulated 1 sun illumination. Impressively, the half-cell photopower conversion efficiencies (ηhc) of the optimized Si-NWs/Co–B (2.53%) and Si-NWs/Ni–B (2.45%) are comparable to that of Si-NWs/Pt (2.46%). In terms of the large Jsc, Vphon, and ηhc values, as well as the high Faradaic efficiency, Si-NWs/M-B electrodes are among the top performing Si photocathodes which are modified with HER electrocatalysts but have no buried solid/solid junction.
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ELECTROCHIMICA ACTA
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2017
·
IF 4.798
Xiuping Ju,Lingqian Kong,Jinsheng Zhao,Guoyi Bai
Two novel donor-acceptor-donor type monomers were synthesized by using thieno[3,4-b]pyrazine (TPZ) as the acceptor units (A) and 3-methylthiophene or 3-methoxythiophene as the donor units (D). The as-prepared D-A-D monomers were named as MOTP and MTP, respectively. These two monomers could be facilely polymerized on the glass carbon electrode (GCE) via a potentiostatic method, and the resultant D-A-D alternative conjugated polymers were referred as PMOTP and PMTP. The obtained conjugated polymers were routinely characterized by FT-IR, SEM and TGA at first. Then, as supercapacitor electrode materials, they were further investigated in detail by cyclic voltammetry (CV), constant galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS) methods The GCD results showed that the polymer-modified GCEs had high specific capacitances of 678.2 and 319.1 F/g, for PMOTP and PMTP, respectively, at a current density of 1 A/g. Excellent switching stabilities were also observed for both polymer-modified GCEs, with the high retention rates of 77.3% and 53.4% for PMOTP and PMTP, respectively, after 1000 times of charge-discharge cycling at a current density of 10 A/g. Notably, the maximum energy densities of 22.4 Wh/kg and 7.94 Wh/kg were attained at the power density of 0.55 kW/kg for the symmetric supercapacitor based on PMOTP and PMTP, respectively. The excellent performances of these two D-A-D type conjugated polymers make them to be the promising electrode materials for energy-storage and conversion applications.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2017
·
IF 3.133
Nagaraj Basavegowda,Kanchan Mishra,Yong Rok Lee
Novel FeAgPt alloy nanoparticles were biosynthesized via ultra-sonication using the root extract of Platycodon grandiflorum . The nanoparticles exhibited enhanced catalytic activities in the reduction of 4-nitroaniline (4-NA) to p -phenylenediamine with a significantly reduced reaction time and increased rate constant because of their high number of active surface sites. In addition, the same catalyst exhibited enhanced catalytic activity in the decolorization of an environment polluting dye, rhodamine B (RhB). The time taken for the complete conversion of 4-NA to p -phenylenediamine was 25 min with an apparent rate constant of 10.06 × 10 −2 min −1 . Similarly, the catalytic decolorization of RhB took 15 min for complete decolorization of the dye molecules with a rate constant 25.60 × 10 −2 min −1 . The performance difference of mono, bi and trimetallic nanoparticles for both the reduction of 4-NA and decolorization of RhB was also examined. These trimetallic alloy nanostructures with excellent catalytic efficiency can also be used for other applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2017
·
IF 3.359
Yang Liu,Hongguang Guo,Yongli Zhang,Xin Cheng,Peng Zhou,Gucheng Zhang,Jingquan Wang,Peng Tang,Tingling Ke,Wei Li
This study represents the first investigation on the application of persulfate (PS)/vis-light for the degradation of Rhodamine B (RhB) using bismuth oxyiodide magnetic composites (BiOI/Fe 3 O 4 , BOMCs). The 3D flower sphere-like BOMCs were successfully fabricated via a hydrothermal method, proving to be an excellent photocatalyst under visible light when evaluated by various characterization methods. The results demonstrated that BOMCs had a high photodegradation efficiency at pH 3.0–9.0 and the BiOI/Fe 3 O 4 (5:1) composite displayed the optimal catalytic performance. Inorganic ions such as Cl − showed promotion at a lower concentration, while significant inhibition was observed for higher concentrations of Cl − and HCO − 3 in the Vis/BOMCs/PS process due to the quenching effect. Moreover, 44.9% mineralization efficiency for total organic carbon and the excellent stability of BOMCs were demonstrated with limited iron leaching. Based on the scavenger experiments, the photocatalytic mechanism in the coupled system determined· SO − 4 and OH as the main reactive species. Eventually, the major intermediates are detected by GC/MS, and a possible photocatalytic degradation pathway of RhB is proposed in the Vis/BOMCs/PS process.
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Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 11
·1614-1621
·
IF 0
Yan Zhang,Jianjing Liu,Yutong Fu,Ke Tan,Zhaoyang Ye,Meidong Lang
A novel polyion complex (PIC) drug carrier was developed via electrostatic self-assembly in aqueous media based on our previous copolymer methoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone) (mPEG-b-PACL) and anti-hepatotoxic drug ammonium glycyrrhizinate (AMG). The formation and the physicochemical properties of the polyion complex nanoparticles in aqueous solution were investigated by various methods. The results demonstrated that AMG was encapsulated successfully and the nanoparticles had a core–shell or tri-layer spherical structure based on the length of the PACL. The AMG/PACL PIC also displayed a high loading capacity and encapsulation efficiency of up to 41.8% and 91.7%, respectively. Furthermore, the nanoparticles enabled a continuous and sustained in vitro AMG release and the release half time was about 3 times that of the free AMG's. Results obtained by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, flow cytometry and fluorescence microscopy revealed that AMG loaded nanoparticles demonstrated greater prevention of liver cell apoptosis induced by lipopolysaccharide (LPS). These findings indicated that methoxy poly(ethylene glycol) (mPEG)-b-poly(γ-amino-ε-caprolactone) could be an efficient AMG carrier and could even be used as a delivery template for some other negatively charged water-soluble drugs or gene delivery systems.
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PLoS One
·
2015
·Vol. 10
·期 4
·e0118274
·
IF 3.234
Xin Peng,Wei Qi,Renliang Huang,Rongxin Su,Zhimin He
Salvianolic acid B and rosmarinic acid are two main water-soluble active ingredients from Salvia miltiorrhiza with important pharmacological activities and clinical applications. The interactions between salvianolic acid B (or rosmarinic acid) and bovine serum albumin (BSA) in the presence and absence of gold nanoparticles (Au NPs) with three different sizes were investigated by using biophysical methods for the first time. Experimental results proved that two components quenched the fluorescence of BSA mainly through a static mechanism irrespective of the absence or presence of Au NPs. The presence of Au NPs decreased the binding constants of salvianolic acid B with BSA from 27.82% to 10.08%, while Au NPs increased the affinities of rosmarinic acid for BSA from 0.4% to 14.32%. The conformational change of BSA in the presence of Au NPs (caused by a noncompetitive binding between Au NPs and drugs at different albumin sites) induced changeable affinity and binding distance between drugs and BSA compared with no Au NPs. The competitive experiments revealed that the site I (subdomain IIA) of BSA was the primary binding site for salvianolic acid B and rosmarinic acid. Additionally, two compounds may induce conformational and micro-environmental changes of BSA. The results would provide valuable binding information between salvianolic acid B (or rosmarinic acid) and BSA, and also indicated that the Au NPs could alter the interaction mechanism and binding capability of drugs to BSA, which might be beneficial to understanding the pharmacokinetics and biological activities of the two drugs.
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ACS Catalysis
·
2013
·
IF 5.265
Liang Xu,Wei Wei,Hexing Li,Hui Li
In this paper, one-pot dextrin hydrolysis to glucose and the subsequent glucose hydrogenation to sorbitol is successfully conducted by using amyloglucosidase and Ru–B amorphous alloy highly dispersed onto the ordered mesoporous silica encapsulated by a porous silica shell. The porous outer silica shell prevents the larger amyloglucosidase and colloidal hydrolysis substances from contacting Ru–B, which avoids the poisoning effect on each other. Meanwhile, the small glucose can directly access the Ru–B cores through the pores within the silica shells, and the produced sorbitol can readily exit through these pores. Thus, both the amyloglucosidase-aided dextrin hydrolysis and the Ru–B-catalyzed glucose hydrogenation proceed efficiently in bulk solution and inside the chamber, respectively, leading to high sorbitol yield and strong durability. The catalyst design concept used in such a yolk-shell structured configuration opens a new avenue for the development of a highly efficient catalyst system for one-pot cascade reactions containing incompatible parameters.
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ENZYME AND MICROBIAL TECHNOLOGY
·
2014
·
IF 2.966
Chuan-Yang Shang,Wei-Xun Li,Rui-Feng Zhang
ZnO nanowires were successfully introduced into a macroporous SiO 2 by in situ hydrothermal growth in 3D pores. The obtained composites were characterized by SEM and XRD, and used as supports to immobilize Candida antarctica lipase B (CALB) through adsorption. The high specific surface area (233 m 2 /g) and strong electrostatic interaction resulted that the average loading amount of the composite supports (196.8 mg/g) was 3–4 times of that of macroporous SiO 2 and approximate to that of a silica-based mesoporous material. Both adsorption capacity and the activity of the CALB immobilized on the composite supports almost kept unchanged as the samples were soaked in buffer solution for 48 h. The chiral resolution of 2-octanol was catalyzed by immobilized CALB. A maximum molar conversion of 49.1% was achieved with 99% enantiomeric excess of ( R )-2-octanol acetate under the optimal condition: a reaction using 1.0 mol/L ( R , S )-2-octanol, 2.0 mol/L vinyl acetate and 4.0 wt.% water content at 60 °C for 8 h. After fifteen recycles the immobilized lipase could retain 96.9% of relative activity and 93.8% of relative enantioselectivity .
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