ENVIRONMENTAL RESEARCH
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2026
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IF 8.2
Lin Yue,Shiqi Xing,Mengfei Wang,Hongxue An,Yunlong Yao,Yuxuan Li,Jing Lian
In this paper, the bimetallic zeolite imidazolate framework Ce-Fe-MI as a high-performance catalyst for ozonation-based degradation of tetracycline (TC) was investigated. During the catalytic process, electron transfer occurred between the two metal ions on the catalyst, and the mixed-valence state induced charge imbalance and unsaturated bonds, thereby forming catalytically active sites. Through comprehensive characterization and experimental evaluation, the Ce-Fe-MI catalytic ozonation process significantly enhanced the removal efficiency of COD and TOC, achieving a mineralization rate of 50% higher than ozonation alone. EPR identified the presence of uperoxide radicals (•O 2 - ) and singlet oxygen ( 1 O 2 ) as the main active species; however, quantitative analysis revealed hydroxyl radicals (•OH) was the main contributor to the degradation of pollutants, indicating the involvement of all three reactive oxygen species (ROS) in the catalytic ozonation reaction process. Density functional theory (DFT) calculations further demonstrated that the synergistic Ce-Fe interactions promoted electron transfer and facilitated ozone activation, leading to enhanced generation of reactive oxygen species. These findings emphasize the potential of Ce-Fe-MI catalyzed O 3 as an efficient and advanced oxidation process for antibiotic wastewater treatment.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2026
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IF 5.3
Nannan Wang,Yiting Wang,Han Jiang,Zonglun Chen,Yulong Tang,Wenwei Chen,Guangrong Huang
The illicit use of clorprenaline and zilpaterol as livestock feed additives leads to harmful residues in food. With the use of polydopamine-coated gold nanoparticles (Au@PDA) quenching quantum dots (QDs), we developed a dual-signal immunochromatographic technique that allows for signal readout in 15 min using both colorimetry and fluorescence. The method exhibited high quantitative sensitivity, with limits of quantification (LOQ) of 5.5 μg/L for clorprenaline and 1.2 μg/L for zilpaterol, and limits of blank (LOB) of 0.56 μg/L and 0.24 μg/L, respectively. Notably, for potential semi-quantitative or rapid screening applications, the method demonstrated low visual limits of detection (vLOD): as low as 0.01–0.1 μg/L in fluorescence mode and 1–5 μg/L in colorimetric mode for zilpaterol and clorprenaline. The technique also showed strong stability and good specificity, with test strip findings comparable to those of commercially available ELISA kits, in spiking recovery tests, which primarily target their monitoring in pork. It was also successfully applied to swine urine. Therefore, the proposed method enables rapid detection of clorprenaline and zilpaterol, demonstrating promising potential for on-site sample screening.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Ke Cheng,Yangyang Li,Hong Ni,Rui Zhang,Wei Wei,Jing Zhou,Jing Yuan
Solar-driven interfacial evaporation (SDIE) is widely regarded as a promising and sustainable approach for water resource regeneration. However, most studies primarily focus on optimizing photothermal materials or device configurations to enhance evaporation performance, whereas the efficient utilization of incident solar energy remains underexplored. In this work, highly transparent sponge-like hydrogels (HTSH) were fabricated via NaCl-regulated photopolymerization of acrylamide under a semi-frozen, temperature-controlled condition. Owing to their macroporous architecture and high water content within the gel matrix, the resulting polyacrylamide sponge-like hydrogels effectively suppress interfacial optical scattering, enabling deeper light penetration and enhanced solar light utilization. Polydopamine was polymerized in situ onto the hydrogel substrate to construct an integrated SDIE device. As a result, the synergistic integration of enhanced light utilization, efficient water transport, and tailored surface morphology enabled a water evaporation rate of 1.92 kg·m −2 ·h −1 under one-sun irradiation, demonstrating the effectiveness of evaporative architectures derived from HTSH substrates.
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FOOD CHEMISTRY
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2026
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IF 10.4
Han Xie,Wenfeng Li,Zhenan Rao,Jichun Zhao,Fuhua Li,Wenjun Wang,Jian Ming
This research investigated how native starches in batters affect texture and oil absorption of “Pepper-salt Pleurotus ostreatus ”. Corn starch (CS), potato starch (PS), glutinous rice starch (GRS), pea starch (PES), sweet potato starch (SPS) and cassava starch (CAS) were evaluated. GRS and CS coated products showed better sensory quality; PES coated samples were greasy with poor texture. GRS exhibited the highest pick-up and apparent viscosity, forming a stable coating that converted into a porous, crispy crust. CS generated a compact and stable crust with the lowest oil content (13%) due to its dense crystalline structure and limited swelling, while high b* produced bright, attractive golden-yellow color. In contrast, PES formed a coarse-pored crust with the highest oil content (30%), resulting in less durable crispness. SEM, FTIR, SAXS and LF-NMR confirmed these findings. A blend of CS and GRS is recommended to optimize crispness while minimizing oil content in pre-fried foods
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Xiao-Qing Ling,Xin-Yan Zhao,Qi-Yan Lv,Jun-Yang Chen,Hai-Yang Dai,Hui-Fang Cui,XiaoJie Song
Cuproptosis has gained significant attention in cancer therapy. Use of copper-overloaded combination therapy that employs a variety of cell death mechanisms has emerged as a promising avenue in the treatment of cancer. However, integrating different modes in a system with optimal synergy and minimal side effects remains a challenge. In this study, a multifunctional copper ion-overloaded nanoparticle was fabricated via one-pot self-assembly for enhanced cuproptosis, chemo- and phototherapy. Molecular dynamics simulation was performed to study the self-assembly mechanism, demonstrating they assembled into stable nanoparticles (NPs) in 50 ns. The NPs possess dual-targeting capabilities towards tumor cells and mitochondria, and exhibit excellent stability in neutral PBS, while showing responsive payload release under acidic conditions or NIR laser irradiation. Upon reaching the mitochondria, the NPs release their payloads, where accumulated copper ions trigger aggregation of lipoylated proteins, etc. Released disulfiram chelates excessive copper ion to form toxic Cu(DTC) 2 , which induces apoptosis combining with hydroxycamptothecin. Meanwhile, indocyanine green-generated ROS and photothermal effects further enhance cuproptosis for synergistic therapy. In vitro results revealed potent cytotoxicity of the NPs against CT26 cells while negligible effects on normal cells. Furthermore, significant reactive oxygen species generation, mitochondrial membrane potential alteration, increased apoptosis, and modulated protein mRNA expression levels, confirmed the synergistic combination of chemotherapy, cuproptosis, and photothermal/photodynamic therapies. Notably, in vivo experiments demonstrated selective tumor accumulation and outstanding antitumor efficacy (89.5% inhibition rate) with excellent biosafety profile. The NPs provide a novel strategy for cuproptosis-based combination cancer therapy and shows significant clinical translation potential.
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ELECTROCHIMICA ACTA
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2026
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IF 5.8
Zhen-Fu Lin,Yu-Qi Ge,Yu-Zhu Zhao,Mei-Na Chen,Hao Li,Nai-Cui Liu,Zhencheng Chen,Guo-Cheng Han,Xiao-Zhen Feng,Heinz-Bernhard Kraatz
Beta-2-Microglobulin (β2M) is a critical biomarker for diseases such as kidney disorders and cancer. However, electrochemical detection methods for β2M remain scarce. Therefore, a novel electrochemical immunosensor for the ultrasensitive detection of β2M was developed in this study. It is based on a ternary composite of polyaniline (PANI), poly- l -cysteine (PL-Cys), and molybdenum disulfide (MoS₂) functionalized onto screen-printed carbon electrodes (SPCE). Through the specific recognition between Beta2-microglobulin antibody (anti-β2M) and its target antigen, and utilizing bovine serum albumin (BSA) to block non-specific binding sites, a BSA/anti-β2M/PANI/PL-Cys/MoS₂/SPCE immunosensor was constructed. Experimental results demonstrate that the sensor exhibits excellent linearity within the 0.001–500 ng/mL (R²=0.9924), with a detection limit as low as 0.33 pg/mL. It shows outstanding selectivity (RSD=2.69%), repeatability (RSD=0.74%), and long-term stability (30-day RSD=2.64%). Recovery rates in serum samples range from 100.40% to 103.76%, confirming its reliability in complex biological matrices. The sensor combines the signal amplification effect of the conductive substrate (PANI/L-Cys/MoS₂) with the impedance effect of the insulating biological layer (antibody-antigen complex), utilizing the quantitative relationship between target analyte concentration and signal attenuation to achieve detection. This approach provides an efficient and low-cost new strategy for on-site rapid screening.
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BIOMACROMOLECULES
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2026
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IF 5.9
Yafang Xu,Shihao Wang,Huanli Gao,Tingting Xu,Shilong Yang,Junlong Song,Jiaqi Guo
Temperature-responsive hydrogels are ideal intelligent carriers for drug delivery due to their ability to enable precise and on-demand drug release. Compared to synthetic polymers with similar thermoresponsive properties, hydroxypropyl cellulose (HPC) offers distinct advantages for drug delivery applications due to its wider availability from natural sources, lower cost, and superior biocompatibility and biodegradability. However, the lower critical solution temperature (LCST) is relatively high (40–50 °C), and it cannot form a cross-linked network by itself, which limits its practical application in drug delivery. Herein, we innovatively developed an injectable, thermoresponsive, drug-loaded hydrogel microsphere (HPC-AGE/PVA@DS). This system achieves on-demand drug release via thermoresponsive hydrogel shrinkage at a physiological temperature (37 °C). Poly(vinyl alcohol) (PVA) effectively prevents microsphere fracture during shrinkage, thereby avoiding burst drug release. The microspheres also exhibit excellent lubricity, along with outstanding biocompatibility and superior anti-inflammatory efficacy compared to nonthermosensitive hydrogels. This stimuli-responsive localized drug delivery system offers a promising platform for treating osteoarthritis (OA) and other chronic diseases.
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Materials Today Bio
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2026
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IF 11
Yun Qu,Jingjing Zhang,Haixia Ou,Yuting Yan,Ruiping Zhang,Jinghua Sun
Reactive oxygen species (ROS)-triggered oxidative stress, inflammatory responses, and overactivation of immune cells are critical factors exacerbating acute lung injury (ALI). Conventional clinical therapies are often limited by non-specificity, single-target limitations, and significant side effects to precisely modulate the complex pathological microenvironment. Here, we designed a hyaluronic acid-engineered nanoreactor (HA@MZ) through in situ encapsulation of melanin (MA) within ZIF-67, allowing multi-target synergistic therapy of ALI. The HA coating facilitates mucus penetration and targeted accumulation in injured lungs, exhibiting good biocompatibility. Under acidic inflammatory conditions, HA@MZ responsively releases MA, which efficiently scavenges ROS. This process activates Nrf2/HO-1 and GPX4 pathways while inhibiting NF-κB driven inflammation and M1 macrophage polarization, leading to reduced lipid peroxidation and recovery of redox and immune balance. Both in vitro and in vivo results confirm the lung microenvironment-balancing capacity of HA@MZ, offering a promising nanotherapeutic strategy for ALI and other inflammatory diseases.
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BRITISH JOURNAL OF PHARMACOLOGY
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2026
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IF 7.5
Wen-yuan Zhang,Qian-qian Wei,Tao Zhang,Chunmei Geng,Hai-yan Wu,Chang-shui Wang,Jing Chen,Lei Feng,Pei Jiang
Background and Purpose Despite breakthroughs in immunotherapy and targeted therapies, chemotherapy remains indispensable in oncology. Experimental Approach This study seeks to pinpoint key pathways in doxorubicin (DOX)-treated mouse hippocampus, utilising comprehensive transcriptomic and metabolomic analyses, and validating the mechanisms in vitro and in vivo. Key Results Our multi-omics investigation revealed that sustained DOX exposure induced significant down-regulation of 5-aminolevulinate synthase 2 (ALAS2) and its catalytic product 5-aminolevulinic acid (5-ALA) in the hippocampal region. ALAS2 deficiency was specific to hippocampal neurons, which were more sensitive to oxidative damage than astrocytes or microglia. In vivo and in vitro studies demonstrated that 5-ALA administration or ALAS2 overexpression protected the brain from DOX-induced neurotoxicity. ALAS2 catalyses the condensation of glycine and succinyl-CoA to form 5-ALA, the key precursor of haem. Beyond its role in erythropoiesis, haem is a metabolite that modulates cellular redox homeostasis through interactions with the BACH1 (BTB and CNC homology 1)/NRF2 (nuclear factor erythroid 2 like 2) pathway. We found that DOX suppressed the ALAS2/5-ALA axis, thereby enhancing BACH1 stability. This stabilised BACH1 competes with NRF2 for binding to antioxidant response elements (AREs) in target gene promoters. Conversely, reinforcing the ALAS2/5-ALA axis elevated intracellular haem levels, promoting BACH1 degradation and enhancing NRF2 activity. Using a zebrafish model, we further highlighted the antioxidant and neuroprotective role of 5-ALA against DOX-induced neurotoxicity. Conclusions and Implications In conclusion, this study elucidates a novel endogenous neuroprotective mechanism wherein the ALAS2/5-ALA axis modulates the BACH1/NRF2 pathway. 5-ALA shows promise for repurposing to mitigate chemotherapy-associated neurotoxicity. Graphical
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Advanced Healthcare Materials
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2026
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IF 11
Yanlin Li,Xiaotian Jiang,Jiale Li,Hanwen Gu,Qi Li,Jiaxin Li,Yunqing Ji,Xiang Min,Bin Chen,Qingjia Xu,Junhao Lin
Osteoarthritis (OA), a prevalent degenerative joint disorder characterized by articular cartilage deterioration, represents a major global health challenge. Recent studies highlight the pivotal role of reactive oxygen species (ROS)-mediated ferroptosis in OA pathogenesis. Here, we report a microenvironment-adaptive hydrogel system based on 2D vanadium nitride (V 2 N) MXene nanoenzyme (hereafter denoted as V 2 N MXenzyme@Gel). This system features a dual-crosslinked network that optimally balances between mechanical robustness and flexibility. Crucially, the V 2 N MXenzyme establishes a self-sustaining “capture-conversion-recycling” catalytic cycle, mimicking both superoxide dismutase (SOD) and catalase (CAT) activities. The cycle not only neutralizes detrimental ROS into water (H 2 O) and oxygen (O 2 ) but also generates nitric oxide (NO), collectively alleviating oxidative damage. Mechanistically, V 2 N MXenzyme@Gel effectively scavenges ROS, attenuates oxidative stress, and suppresses ferroptosis by regulating the Hspa5/GPX4 axis, while concurrently restoring the metabolic homeostasis of chondrocyte extracellular matrix (ECM). Meanwhile, intra-articular administration of V 2 N MXenzyme@Gel significantly attenuates cartilage degradation and inflammation levels in OA rats. Collectively, our work presents a V 2 N MXenzyme@Gel with dual capabilities for ROS elimination and ferroptosis blockade, demonstrating its efficacy in arresting OA progression and proposing a novel precision strategy for managing chronic joint diseases.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Hu Jiale,Li Wei,Luo Pei,Nan Yihong,Liu Yimin,Yang Yashi,Zou Jianmei,He Huijun,Zhang Yun
In this work, an innovative Tyndall-effect-based (TE-based) colorimetric strategy was developed to detect the activity of alkaline phosphatase (ALP) via enzyme-triggered degradation of MnO₂ nanosheets (MnO₂ NSs), and it was further extended to construct a TE-based colorimetric enzyme-linked aptamer assay (ELAA) for monitoring thrombin (TB) concentrations. In the presence of ALP, ascorbic acid 2-phosphate (AAP) was hydrolyzed to ascorbic acid (AA), which in turn reduced MnO₂ NSs to Mn 2+ and led to their structural decomposition. Under the irradiation of a handheld laser pointer, the TE signal of the detection solution gradually diminished with increasing ALP concentration. The quantitative measurement of ALP was further achieved using a smartphone to read out the TE signal, with a limit of detection (LOD) of 0.35 mU/mL. Furthermore, this strategy effectively functioned as an exquisite signal generation mechanism to devise a TE-based colorimetric ELAA for TB detection. The results demonstrated that the proposed method exhibited high specificity and sensitivity for TB, capable of linear detection over a concentration range of 1–25 nM with a LOD of 0.38 nM (3σ). In actual human serum samples, the recovery of TB ranged from 93.40 to 109.30%. To our knowledge, this work presents the first TE-based colorimetric ELAA for instrument-free protein analysis by leveraging enzyme-triggered MnO₂ nanosheet degradation. This approach establishes a novel signal transduction mechanism for colorimetric ELAA, thereby offering significant potential to expand the theoretical scope of this assay format and broaden its applications in various resource-limited settings. Graphical abstract
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Liang Ye,Wenming Liu,Bo Yao,Guobo Li,Lizhi Zhang,Jian Ji,Yupeng Liu,Jia Li,Fangruo Ding,Jingda Li,Ying Zhang,Honggen Peng
Dry reforming of methane (DRM) to produce syngas can effectively address environmental issues caused by the greenhouse effect. Nevertheless, sintering and coking of catalysts under high-temperature operating conditions continue to be critical challenges that hinder practical applications. Herein, this work develops a CoRh alloy catalyst (Co 7 Rh 3 /DMS) confined in dendritic mesoporous silica (DMS) that displays an 89.1 % CH 4 and 92.4 % CO 2 conversion, approaching the thermodynamic equilibrium limit. Under a continuous operation at 800 °C for 100 h, the Co 7 Rh 3 /DMS catalyst shows a CH 4 and CO 2 deactivation rates of merely 0.022 %·h −1 and 0.011 %·h −1 , respectively, with negligible coke formation (<0.1 wt%) and metal sintering. Notably, the surface spatial confined structures of DMS effectively suppress the migration and agglomeration of active sites. Comprehensive mechanistic investigations indicate that the synergistic mechanism of CoRh alloy reduces the CH 4 dissociation energy barrier and promotes CO 2 activation, thereby facilitating the in-situ elimination of carbonaceous precursors. This work provides a rational design strategy for advancing the efficient resource utilization of greenhouse gases.
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