JOURNAL OF THE ENERGY INSTITUTE
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2023
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IF 5.7
Yongdi He,Jinou Song,Jiuzhong Yang,Yuan Zhuang,Liang Qiu,Zhijun Li,Shubao Song,Yongfeng Liu,Jibiao Xie
In order to investigate the species pool and primary channels of initiated pyrolysis of n- hexane, the low-pressure (30 Torr, 4.0 kPa) flow reactor pyrolysis of n- hexane initiated by 5% 1- nitropropane ( 1- NP) was studied experimentally in a wide range of temperature from 623 K to 1223 K. Combined with synchrotron vacuum ultraviolet (SVUV) photoionization mass spectra scanned at photon energies ranging from 9.0 to 14.7 eV and near-threshold photoionization efficiency (PIE) spectra, 29 pyrolysis species, covering C 1 –C 6 hydrocarbons and several pyrolysis species containing O or N atoms, were identified. Based on the ion signal intensities of the visible peaks in the mass spectra, the mole fraction profiles of all the experimental species were evaluated. The experimental results suggested that the initial pyrolysis temperature of n- hexane was reduced by approximately 275–325 K. On the basis of the mole fraction profiles and the initial formation temperatures reported in this work and rate coefficients proposed in previous studies, the 1- NP-initiated pyrolysis mechanisms of n- hexane were discussed. It was suggested that n- hexane was dominantly consumed by the H-abstraction reactions by the attack of OH radical in this work. The 1- NP-initiated pyrolysis of n- hexane mainly proceeded via reactions to produce C 3 H 6 + C 3 H 7 , or 1- C 4 H 8 + C 2 H 5 , or 1- C 5 H 10 + CH 3 .
研究领域:
化学工程
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物理化学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Guojun Lv,Yan Chen,Xuyang Zou,Jiangzhang Wang,Tao Wang,Xubin Zhang,Fumin Wang
There are few reports concentrated on the interactions between lipophilic surfactants and hydrophobized hollow TS-1 zeolite particles in the stabilization of emulsions. In this study, hydrophobized hollow TS-1 zeolite particles were synthesized and applied as emulsifier to stabilize the W/O Pickering emulsions employing cyclohexanone and water, and the influence of addition of lipophilic Span 80 on the stability of the W/O Pickering emulsions was systematically studied. Surprisingly, a phase inversion was induced by simply changing the Span 80 concentration. At fixed concentration of TS-1 zeolite particles (2 wt%), emulsions are water in oil (W/O) when the concentration of Span 80 is lower than 0.5 mM. Then the emulsions invert to oil in water (O/W) when the Span 80 concentration is between 1 mM and 8 mM. In this process, different emulsifiers dominate the composition of the interfacial layer, and the emulsion type is correspondingly controlled. When Span 80 concentration is lower than 0.5 mM, hydrophobized hollow TS-1 zeolite particles are in domination, and W/O emulsions are obtained. At Span 80 concentration of 1–8 mM, the emulsions are stabilized mainly by Span 80, and the emulsion type is O/W.
研究领域:
化学工程
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材料科学
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界面化学
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DOI
高影响因子
International Journal of Electrochemical Science
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2023
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IF 1.5
Yong Lu,Huixia Feng,Hou Xia,Wu Hai Xia
Polyaniline has a wide application in the field of corrosion protection, the poor solubility of polyaniline limited its application as a corrosion inhibitor. Water-soluble carboxymethyl cellulose -polyaniline composites was synthesized by chemical oxidation polymerization in a mild way without other inorganic or organic acids added. Corrosion inhibition performance of composites was evaluated for Q235 steel corrosion in 1 M HCl corrosive solution using weight loss and electrochemical measurements at various concentrations. The results show that carboxymethyl cellulose -polyaniline composites exhibit good inhibition properties and the remarkable increase in inhibition efficiency, i.e., 94.24% is achieved while the maximum concentration of the experiment is 1000 ppm. The composites in corrosive solution suppress the cathodic hydrogen evolution reactions and anodic metal dissolution of the substrate. Adsorption of the inhibitor on the steel surface follows a Langmuir adsorption isotherm.
研究领域:
材料科学
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腐蚀与防护
✓ 已验证
DOI
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
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2025
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IF 3.4
Xuemin Xian,Xin Zhao,Xingchen Zhou,Hanfang Liu,Changxi Li,Xinquan Wu,Yuhang Chen,Keyue Ye,Hongwei Yang,Mingxi Li,Jianyun Yan,Xiuli Zhang
Vascular calcification (VC) is a common complication of chronic kidney disease (CKD), with oxidative stress identified as a key contributor to VC progression. Honokiol (HKL), a biphenolic compound derived from plants, has been found to be effective in treating various models of cardiovascular disease through the mitigation of oxidative stress. However, its effects on VC remain unexplored. To elucidate the effects of HKL on VC, a CKD rat model, a vitamin D 3 -overload-induced mouse model of vascular calcification, and a high-phosphate-induced human vascular smooth muscle cell (VSMC) calcification model were established. Calcification levels were assessed using Alizarin Red staining, calcium quantification, and Western blotting of osteogenic markers. Oxidative stress was assessed by measuring reactive oxygen species. Furthermore, transcriptome sequencing was employed to identify molecules and pathways affected by HKL. HKL was found to significantly reduce calcification in both in vivo and in vitro models. It also mitigated oxidative stress induced by high phosphate in human VSMCs. Mechanistically, HKL upregulated heme oxygenase-1 (HMOX-1), thereby inhibiting oxidative stress and reducing calcification. Pharmacological inhibition of HMOX-1 counteracted the protective effect of HKL on vascular calcification. In summary, the findings suggest that HKL ameliorates VC by upregulating HMOX-1 and decreasing oxidative stress.
研究领域:
医学
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药理学
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产品关联
DOI
PubMed
高影响因子
Materials Today Bio
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2025
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IF 10.2
Qiang Zhang,Tuo Wang,Junyu Ren,Yanru Guo,Ziyi Yin,Chenrui Zhang,Honglin Fan,Yinting Ren,Junlong Da,Narisu Hu
Oral ulcers, a prevalent mucosal disorder with high recurrence rates, remain challenging to treat due to the oral cavity’s dynamic environment and the multifactorial nature of ulcer progression. Here, we report a multifunctional microneedle (MN) patch loaded with astragalus polysaccharide (APS-MN) that integrates rapid mucosal penetration, reactive oxygen species (ROS) scavenging, and ferroptosis inhibition to accelerate ulcer healing. Unlike conventional MN systems reliant on synthetic drugs or prolonged dissolution, APS-MN leverages the natural antioxidant and immunomodulatory properties of APS-a traditional Chinese medicine-derived polysaccharide-enabling complete drug release within 2 minutes and targeted delivery to ulcer bases. In vitro and in vivo studies demonstrate that APS-MN promotes M2 macrophage polarization, suppresses pro-inflammatory cytokines (TNF-α, IL-1β), and inhibits ferroptosis via the Nrf2/HO-1/SLC7A11 axis, achieving 88.2% wound closure in rats within 6 days. Notably, this work combined herbal polysaccharides with MN technology for oral ulcer therapy, offering a biocompatible, non-invasive alternative to corticosteroids and antibiotics. The rapid dissolution, dual antioxidant/anti-ferroptotic action, and scalability of APS-MN position it as a transformative platform for managing recurrent oral ulcers and other redox-imbalanced mucosal diseases.
研究领域:
药学
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生物医学工程
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免疫学
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产品关联
DOI
PubMed
高影响因子
Bioengineered
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2022
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IF 6.832
Yazhou Sun,Weiguo Wan,Xin Zhao,Xueyu Han,Tianxin Ye,Xiaoli Chen,Qian Ran,Xiukun Wang,Xin Liu,Chuan Qu,Shaobo Shi,Cui Zhang,Bo Yang
Sigma 1 receptor (S1R) has shown a preferable protective effect on left ventricular function, but whether it protects right ventricular (RV) function is still elusive.This study aimed to determine the effects of S1R on RV dysfunction secondary to pulmonary arterial hypertension.Sixty wild-type male Sprague–Dawley rats were randomly divided into the control group, the fluvoxamine group, the pulmonary arterial hypertension group and the pulmonary arterial hypertension combined with fluvoxamine group. Monocrotaline (60 mg/kg) was administered to induce pulmonary arterial hypertension, and fluvoxamine was given for 21 consecutive days to activate S1R after one week of monocrotaline administration. Echocardiographic, serologic, and histologic parameters, qRT-PCR, and western blotting were conducted after 4 weeks of monocrotaline administration.The expression of S1R was decreased in the right ventricle in pulmonary arterial hypertension. TAPSE, and the FAC of the right ventricle were significantly decreased, and RV EDP and the plasma concentration of N-terminal pro-B-type natriuretic peptide was increased in the pulmonary arterial hypertension group, but fluvoxamine partly restored those abnormalities (all P < 0.05). Moreover, pulmonary arteriole remodeling, and fibrosis and hypertrophy in the RV were shown in the pulmonary arterial hypertension group; interestingly, fluvoxamine recovered RV structural remodeling (all P < 0.05) but neither alleviated pulmonary arteriole remodeling nor reduced pulmonary artery pressure. Furthermore, S1R activation protects RV function by upgrading the NRF 2/HO 1-mediated antioxidant stress pathway. In conclusion, chronic S1R activation ameliorates structural remodeling and RV dysfunction secondary to pulmonary arterial hypertension without altering pulmonary artery pressure.
研究领域:
心脏病学
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药理学
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分子生物学
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DOI
PubMed
高影响因子
International Journal of Nanomedicine
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2023
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IF 8
Xiaofeng Chen,Yu Liu,Leiying Miao,Yangyang Wang,Shuangshuang Ren,Xuebin Yang,Yong Hu,Weibin Sun
Periodontitis is a major cause for tooth loss, which affects about 15% of the adult population. Cementum regeneration has been the crux of constructing the periodontal complex. Cementum protein 1 (CEMP1) is a cementum-specific protein that can induce cementogenic differentiation. In this study, poly(ethylene glycol) (PEG)-stabilized amorphous calcium phosphate (ACP) nanoparticles were prepared by wet-chemical method and then loaded with recombinant human CEMP1 (rhCEMP1) for controlled release. An electrospun multiphasic scaffold constituted of poly(ε-caprolactone) (PCL), type I collagen (COL), and rhCEMP1/ACP was fabricated. The effects of rhCEMP1/ACP/PCL/COL scaffold on the attachment proliferation, osteogenic, and cementogenic differentiations of human periodontal ligament cells, (PDLCs) were systematically investigated. A critical size defect rat model was introduced to evaluate the effect of tissue regeneration of the scaffolds in vivo. The results showed that PEG-stabilized ACP nanoparticles formed a core-shell structure with sustained release of rhCEMP1 for up to 4 weeks. rhCEMP1/ACP/PCL/COL scaffold could suppress PDLCs proliferation behavior and upregulate the expression of cementoblastic markers including CEMP1 and cementum attachment protein while downregulating osteoblastic markers including osteocalcin and osteopontin when it was cocultured with PDLCs in vitro for 7 days. Histology analysis of cementum after being implanted with the scaffold in rats for 8 weeks showed that there was cementum-like tissue formation but little bone formation. These results indicated the potential of using electrospun multiphasic scaffolds for controlled release of rhCEMP1 for promoting cementum regeneration in reconstruction of the periodontal complex.
研究领域:
口腔医学
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组织工程学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Wei Chen,Pengfei Wang,Weike Jia,Huidan Zeng
Membrane-based pervaporation process is the most time- and energy-saving method for the separation of xylene isomers. However, developing easily prepared membrane with a high separation factor still remains a significant challenge. Herein, the silicalite-1/polyvinyl alcohol (PVA) mixed matrix membrane (MMM) (SPMMM) with enhanced xylene isomers pervaporation separation performance was successfully fabricated via solution scraping method. The compactness and compatibility of the SPMMM were effectively tuned by optimizing the zeolite content and selecting appropriate cross-linker. Results showed that the SPMMM with 40 % zeolite content, cross-linked with fumaric acid (SPMMM-Fu), exhibited the densest and most continuous membrane structure, the lowest swelling degree and the best xylene compatibility. Pervaporation experiments demonstrated that the SPMMM-Fu exhibited superior xylene isomers selective separation performance compared to the templated-silicalite-1/α-Al 2 O 3 membrane. For the SPMMM-Fu, the maximum separation factor was achieved in binary xylene isomer solutions containing 10 % p-X. The total permeate fluxes in the aforementioned binary p-X/o-X and p-X/m-X isomer solutions were about 43.20 g m −2 h −1 and 34.66 g m −2 h −1 , respectively. The corresponding separation factors of p-X/o-X and p-X/m-X were about 34.65 and 39.73, respectively. The third-stage separation experiment demonstrated that the SPMMM-Fu could produce p-X with a purity ≥99.7 % from binary p-X/o-X isomer solutions. Long-term and variable-temperature pervaporation experiments suggested the SPMMM-Fu had excellent structural stability. Furthermore, reproducibility tests conducted on multiple batches of the SPMMM indicated that the SPMMM-Fu could be produced stably. The scalable experiment demonstrated that our strategy could produce large-area SPMMM-Fu (25 × 40 cm 2 ), exhibiting separation performance similar to that of small membrane coupons. This work presented a potentially low-cost and scalable approach for producing highly dense SPMMM with exceptional xylene compatibility, enabling efficient pervaporation separation of xylene isomers from their mixtures.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Ziqian Wang,Chunyu Du,Ruyu Yan,Shuying Li,Guanyu Zheng,Dahu Ding
Polyhydroxyalkanoates (PHA) are promising candidates for replacing petroleum-derived plastics; however, their high production costs limit their commercialisation. In this study, we successfully isolated an efficient PHA-producing strain from a salt lake, which was subsequently identified as Halomonas sp. WZQ-1. Notably, Halomonas sp. WZQ-1 could serve as a promising cell-factory platform for polyhydroxybutyrate (PHB) production, achieving a comparatively high PHB productivity (7.64 ± 0.4 g L −1 ) under moderate salt stress (60 g L −1 NaCl). We further realised semi-continuous PHB production in a bench-scale fermenter at a steady state by irregularly replenishing the organic substrate. The maximum PHB concentration reached 12.13 g L −1 . Finally, we realised the non-sterile conversion of typical biowastes (e.g. pomelo and cantaloupe residues) to PHB using Halomonas sp. WZQ-1. Encouragingly, 4.36 g L −1 PHB was directly obtained from the hydrolysate of pomelo residues with a characteristic melting temperature of 174.0 °C. Life cycle assessment was employed to systematically evaluate the environmental sustainability and potential challenges of biowaste-driven PHB biorefineries. Overall, our findings could serve as a pivotal step toward the commercialisation of PHB and provide a valuable reference for PHB biorefineries.
研究领域:
微生物学
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环境科学
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生物技术
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产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
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2020
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IF 4.825
Xiaojing Song,Xiaotong Yang,Tianjun Zhang,Hao Zhang,Qiang Zhang,Dianwen Hu,Xinyu Chang,Yingying Li,Ziyi Chen,Mingjun Jia,Peng Zhang,Jihong Yu
Developing an effective strategy to synthesize perfect titanosilicate TS-1 zeolite crystals with desirable morphologies, enriched isolated framework Ti species, and thus enhanced catalytic oxidation properties is a pervasive challenge in zeolite crystal engineering. We here used an amino acid l-carnitine as a crystal growth modifier and ethanol as a cosolvent to regulate the morphologies and the Ti coordination states of TS-1 zeolites. During the hydrothermal crystallization process, the introduced l-carnitine can not only tailor the anisotropic growth rates of zeolite crystals but also induce the formation of uniformly distributed framework Ti species through building a suitable chemical interaction with the Ti precursor species. Condition optimizations could afford the generation of perfect hexagonal plate TS-1 crystals and elongated platelet TS-1 crystals enriched in tetrahedral framework Ti sites (TiO4) or mononuclear octahedrally coordinated Ti species (TiO6). Both samples showed significant improvement in catalytic activity for the H2O2-mediated epoxidation of alkenes. In particular, the elongated platelet TS-1 enriched in “TiO6” species afforded the highest activity in 1-hexene epoxidation, with a turnover frequency (TOF) of up to 131 h–1, which is approximately twice as high as that of the conventional TS-1 zeolite (TOF: 65 h–1) and even higher than those of the literature-reported TiO6-containting TS-1 catalysts derived from the hydrothermal post-treatment of TS-1 zeolites. This work demonstrates that the morphologies and the titanium coordination states of TS-1 zeolites can be effectively tuned by directly introducing suitable crystal growth modifiers, thus providing new opportunities for developing highly efficient titanosilicate zeolite catalysts for important catalytic applications.
研究领域:
材料科学
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催化化学
·
晶体工程
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Jinhua Feng,Junnan Chen,Shuchang Wang,Miaomiao Jia,Zhiyu Zhang,Tongwen Yu,Ming Xue
Searching for the efficient and sustainable inhibitors to defend metal corrosion in the marine environment has received a great deal attention in both academia and industry. In this work, a new strategy was developed to encapsulate benzimidazole (BI) inhibitor guest molecules into the micropores of bio-MOF-1, which was constructed with the other natural adenine inhibitor. Electrochemical characterizations revealed that the slowly sustained release of BI and adenine inhibitors from the BI@bio-MOF-1 composite presented excellent anti-corrosion durability in the whole mild steel corrosion process. The impedance arc value attained approximately 5000 Ω·cm2 at initially 2 h and further increased to 6000 Ω·cm2 after 5 days immersion in 0.5 M NaCl solution, and the inhibition efficiency reached 85.36% due to the synergistic dual inhibitive effect of BI@bio-MOF-1 composite. The dual inhibition-based bio-MOF-1 composite equipped strong metal-chelating capability and response durability, exhibiting high potentiality for metal anti-corrosion applications.
研究领域:
材料科学
·
腐蚀工程
·
化学工程
✓ 已验证
DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2025
·
IF 8.2
Xiaomeng Ji,Jingquan Dong,Wenting Zhu,Shasha Zhang,Yaru Chen,Xiao Liu,Yan Cao,Panpan Zhao,Zibo Dong
Background Sepsis-associated encephalopathy (SAE) represents one of the most common neurological complications observed in sepsis patients, contributing to both increased mortality and long-term cognitive impairment. Microglial mitochondrial reactive oxygen species (mtROS) overproduction and NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation were key pathological drivers of SAE. Although PIM-1, a serine/threonine kinase, was known to regulate both mtROS generation and NLRP3 signaling, its specific contribution to SAE remained poorly defined. Methods This study established a SAE mouse model using cecal ligation and puncture (CLP) surgery, and screened the differentially expressed gene PIM-1 through immunohistochemistry, GEO database analysis, and etc. An in vitro model was established using Lipopolysaccharide + Adenosine(LPS + ATP) Triphosphate stimulated Mouse Microglia (BV-2), and the regulation mechanism of PIM-1 was analyzed through siRNA interference, RNA-seq, and etc. Potential drug Urolithin B (UB) targeting PIM-1 inhibition was screened through molecular docking, and its inhibitory effect on PIM-1 and therapeutic potential in SAE were evaluated through thermal stability experiments, behavioral experiments, etc. Results PIM-1 was upregulated in SAE, which was associated with brain damage. PIM-1 knockdown suppressed microglial activation and reduced inflammatory cytokines release. Further investigation indicated that PIM-1 modulated mtROS generation and facilitated NLRP3 inflammasome activation. Notably, pharmacological inhibition of PIM-1 by UB alleviated SAE both in vivo and in vitro , resulting in improved neuronal damage and cognitive impairment. Conclusion PIM-1 played a critical role in SAE progression, potentially through its mediation of microglial activation and neuroinflammation via the mtROS/NLRP3 axis. Notably, pharmacological inhibition of PIM-1 with urolithin B significantly alleviated SAE.
研究领域:
神经免疫学
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重症医学
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分子神经生物学
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炎症与感染
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转化神经科学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）