Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 7
·1396-1404
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IF 5.344
Shang-Qing Zhang,Xun Liu,Qi-Xuan Sun,Omar Johnson,Ting Yang,Ming-Li Chen,Jian-Hua Wang,Wei Chen
In this study, CuS@PDA nanoparticles were synthesized and used to create a novel tumor-targeting nanocomposite platform composed of copper sulfide@polydopamine–folic acid/doxorubicin (CuS@PDA–FA/DOX) for performing both photothermal and chemotherapeutic cancer treatment. The nanocomposite platform has ultrahigh loading levels (4.2 ± 0.2 mg mg−1) and a greater photothermal conversion efficiency (η = 42.7%) than CuS/PDA alone. The uptake of CuS@PDA–FA/DOX nanocomposites is much higher in MCF-7 cells than in A549 cells because MCF-7 cells have much higher folic acid receptors than A549. Under near infrared (NIR) irradiation, the CuS@PDA–FA/DOX system using a synergistic combination of photothermal therapy and chemotherapy yields a better therapeutic effect than either photothermal therapy or chemotherapy alone. The treatment is very effective with the cell viability is only 5.6 ± 1.4%.
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高影响因子
NANO
·
2021
·
IF 1.556
Yucong Fan,Weihua Yu,Yue Hu,Yunwen Liao,Xiaohui Jiang,Zhengjun Cheng
Doping Ag-enhanced and glutathione-stabilized Au nanoclusters (GSH–Ag/AuNCs) were prepared by the one-step ultraviolet radiation combined with microwave heating method. The effects of the molar ratio of Au–Ag and different types of energy suppliers on the fluorescent performance of GSH–Ag/AuNCs were studied in detail. After that, a new ratio fluorescent probe (RF-probe) based on the mixing of GSH–Ag/AuNCs with carbon dots (CDs) was designed for sensitive and selective determination of copper gluconate (CG) and cupric sulfate (CS). For the CDs–GSH–Ag/AuNCs RF-probe, the fluorescence (FL) of CDs (at 440 nm) and that of alloy nanoclusters (NCs) (at 605 nm) were, respectively, unaffected and strongly quenched in the presence of CG/CS at λ ex = 3 7 0 nm coming from the dynamic quenching process. Corresponding linear ranges and limit of detection (LOD) of the RF-probe for the CG/CS assay were estimated to be 0.17–6.20/0.17–5.62 μ mol/L and 16.80/15.95 nmol/L, respectively. Furthermore, the proposed RF-probe was successfully used for the assays of CG in CG tablets and CG additive, and CS in infant formula and CS additive, respectively.
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Science China-Life Sciences
·
2021
·Vol. 65
·期 3
·561-571
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IF 6.038
He Meng,Lin Jie,Akakuru Ozioma Udochukwu,Xu Xiawei,Li Yanying,Cao Yi,Xu Yanping,Wu Aiguo
The detection of circulating tumor cells (CTCs) is a crucial tool for early cancer diagnosis, prognosis, and postoperative evaluation. However, detection sensitivity remains a major challenge because CTCs are extremely rare in peripheral blood. To effectively detect CTCs, octahedral Ag 2 O nanoparticles (NPs) with high dispersibility, good biocompatibility, remarkable surface-enhanced Raman scattering (SERS) enhancement, and obvious enhancement selectivity are designed as an SERS platform. Ag 2 O NPs with many oxygen vacancy defects are successfully synthesized, which exhibit an ultra-high SERS enhancement factor (1.98×10 6 ) for 4-mercaptopyridine molecules. The remarkable SERS activity of octahedral Ag 2 O NPs is derived from the synergistic effect of the surface defect-promoted photo-induced charge transfer (PICT) process and strong vibration coupling resonance in the Ag 2 O-molecule SERS complex, greatly amplifying the molecular Raman scattering cross-section. The promoted PICT process is confirmed using ultraviolet-visible (UV-Vis) absorption spectroscopy, demonstrating that obvious PICT resonance occurs in Ag 2 O SERS system under visible light. An additional growth step of SERS bioprobe is proposed by modifying the Raman signal molecules and functional biological molecules on Ag 2 O NPs for CTC detection. The Ag 2 O-based SERS bioprobe exhibits excellent detection specificity for different cancer cells in rabbit blood. Importantly, the high-sensitivity Ag 2 O-based SERS bioprobe satisfies the requirement for rare CTC detection in the peripheral blood of cancer patients, and the detection limit can reach 1 cell per mL. To our knowledge, this study is the first time that a semiconductor SERS substrate has been successfully utilized in CTC detection. This work provides new insights into CTC detection and the development of novel semiconductor-based SERS platforms for cancer diagnosis.
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BIOCONJUGATE CHEMISTRY
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2021
·
IF 4.774
Ruiyi Dai,Xiangrong Peng,Bi Lin,Danyang Xu,Ruichan Lv
In this research, a NIR II luminescence imaging and enhanced chemo-/photothermal therapy system of CuS–DOX–Nd/FA NPs for breast cancer and lymph node tracing under single 808 nm irradiation is proposed. Nd–DTPA molecular cluster with the NIR II imaging effect as the carrier was designed to load the ultrasmall CuS nanoparticles and chemotherapeutic drug doxorubicin hydrochloride (DOX). The composite probe is used for tumor lesion imaging and tracking the breast cancer sentinel lymph nodes with simultaneous chemo-/photothermal therapy (PTT) for breast cancer under the single 808 nm laser. This designed probe not only has high permeability and retention (EPR) targeting effect but also can respond to the tumor microenvironment (TME), realizing more precise and efficient release of DOX at the cancer focus. At the same time, CuS as a drug carrier has a good photothermal therapy effect (photothermal conversion efficiency: 27.9%). The serialized released chemotherapy DOX and synergistic PTT effect can be used to the treat the in situ breast cancer land and simultaneously kill the metastasis cancer. The system made the combined molecular clusters Nd–DTPA achieve NIR II imaging of tumor lesions of breast cancer and lymph node to obtain the integration of diagnosis of the transferred disease for better prognosis. The feasibility of the system had obvious tumor growth inhibition effect with NIR II imaging guided is verified by a series of in vitro and in vivo experiments.
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DYES AND PIGMENTS
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2021
·
IF 4.889
Peng Wu,Yuan Xiong,Chen Lei,Yuan Li,Xiang Liu,Cheng Zhang,Yudie Sun,Jian Zhang,Chun-Sing Lee,Kui Zhang
Carbon dots or Carbon quantum dots (herein after abbreviated as CDs) with bight luminescence, derived from carbohydrates such as citric acid , glucose or sucrose, have been widely reported in recent publications. However, as to which functional groups and structures in CDs are responsible for luminescence, most explanations in current references are normally based on assumptions, instead of being convinced by the accurate information resting on experimental facts. Herein, we conducted an experimental study targeting at finding the fluorophores of CDs prepared from citric acid and glycine by fluorescent quenching. The experimental results revealed that the essence of fluorescence was manipulated by fluorophores of conjugated C C double bonds and aldehyde groups. The destruction of aldehyde groups or C C double bonds in the CDs led to a complete decay of luminescence. In addition, the results of this experiment were similar to those of CDs prepared from the sole citric acid, glucose or sucrose, which predicted the analogy of the CDs in chemical structures . Such information about fluorophore of CDs was valuable for further exploring more extensive application of CDs in sense technologies.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 4
·6278-6293
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IF 4.223
Zhu
Jing,Zhao Xuan,Yang Mi,Zheng Bo,Sun Chengjun,Zou Xiaoli,Liu Zhen,Harada Kouji H.
Maternal exposure to benzene and related compounds, trichloroethylene, and polycyclic aromatic hydrocarbons has been suggested as risk factors for reproductive and developmental problem. In different countries and groups, there are differences in socioeconomic circumstances, consumer products, dietary habits, lifestyles, and so on, resulting in different exposure risks from these chemicals. This study investigated the correlation between their metabolite concentrations and socioeconomic, demographic, and dietary factors to explore the possible exposure source of the concerned pollutants in pregnant women. We conducted biological monitoring to assess the exposure of these chemicals using urine samples from 590 to 639 pregnant women during 2nd or 3rd trimester of pregnancy in six cities of China. Socioeconomic and demographic characteristics and dietary habits were collected from questionnaires. The detection rate was over 74% of the urine samples for all metabolites. Compared with the Fourth National Report on Human Exposure to Environmental Chemical concentrations for females (FNRHEEC, the US Centers for Disease Control and Prevention), the metabolite concentrations of benzene compounds and trichloroethylene, excluding MA reported here, were higher. Principal component analysis results showed that SBMA and MHA could be proxy of the principal sources of metabolites for benzene compounds. The concentrations of SBMA and MA were higher in Fuzhou and Wuhan, respectively. The concentration of DCVMA was higher in Shenzhen, Xi’an, and Nanning, and the concentration of PGA was higher in Fuzhou, Wuhan, and Xi’an. Also, the 1-OHPG concentration in Wuhan is higher than that in Fuzhou and Shenzhen. Unhealthy dietary habits, using cosmetics and indoor exposure, contacting chemical solvent during pregnancy were associated with increased benzene compounds, trichloroethylene, and PAH exposure. There were significant positive associations between 1-OHPG level and maternal BMI, low education status, and cooking without a range hood. Pregnant women in China may be at a greater risk of exposure to most of the target compounds than US females, and their exposure levels varied in different regions. Some adverse environmental and behavioral factors may increase the exposure of environmental toxins, which can urge people to take measures to reduce the health risk to pregnant women during pregnancy.
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Nanoscale
·
2021
·Vol. 13
·期 30
·12966-12978
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IF 7.79
Jie Yu,Xidong He,Zigui Wang,Yupeng Wang,Sha Liu,Xiaoyuan Li,Yubin Huang
Immune checkpoint blockade (ICB) therapy in combination with immunogenic death (ICD) triggered by photothermal therapy (PTT) and oxaliplatin (OXA) treatment was expected to elicit both innate and adaptive immune responses for tumor control and metastasis prevention. In this study, a photothermal agent (IR780), a folic acid (FA) linked oxaliplatin (OXA) prodrug, and PD-L1 inhibitors (BMS-1) were integrated into a liposomal system. The FA tumor-targeting and enhanced permeability and retention (EPR) effect of the liposomal system prolonged circulating times and increased accumulation in tumors, resulting in an enhanced photothermal effect and less systemic toxicity. In addition, PTT and OXA had a considerable synergistic effect in the induction of a combined ICD. The PD-1/PD-L1 checkpoint, which is a negative immune regulatory mechanism, could be blocked by the thermosensitive released BMS-1. Finally, ICD was harnessed to synergize with a small molecule PD-L1 inhibitor for activation of the immune system in the treatment of tumor relapse and metastasis.
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高影响因子
Nanoscale
·
2021
·Vol. 13
·期 46
·19399-19411
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IF 7.79
Jiankun Guan,Yuxin Wu,Huimin Wang,Haowen Zeng,Zifu Li,Xiangliang Yang
Imaging-guided diagnosis and chemo-photothermal combination therapy have promising applications for the treatment of cancer. Nevertheless, the accurate diagnosis and efficient treatment of tumors are not yet satisfactory. Herein, a tumor targeting DiR loaded cisplatin-icodextrin prodrug nanoparticle, with selective drug release, was fabricated as a multifunctional theranostic nanoplatform for chemo-photothermal combination therapy. By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects. Moreover, the DPtFIP NPs achieved real-time NIR fluorescence imaging of solid tumors with high contrast. By the accurate tumor imaging, local laser irradiation dramatically enhanced the chemotherapy for triple-negative breast cancer. Such a biocompatible nanotherapeutic holds great potential for tumor diagnosis and imaging-guided combinational cancer therapy.
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Nano-Micro Letters
·
2021
·Vol. 13
·期 1
·1-15
·
IF 16.419
Wang Yuci,Jiang Kai,Du Jiaren,Zheng Licheng,Li Yike,Li Zhongjun,Lin Hengwei
A facile method was developed to achieve visible light (green) and near infrared dual-mode afterglow emissions from carbon dots (CDs)-based materials at ambient conditions for the first time.
We proposed a promising method in advanced information security applications through a special manner of readout.
The as-developed method was confirmed to be applicable to many kinds of CDs for achieving or enhancing their afterglow performances.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 96
·期 1
·169-179
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IF 1.429
Ma Mingfang,Shang Wenqing,Jia Ruxiao,Chen Ruijiao,Zhao Min,Wang Chaoqun,Tian Mingyan,Yang Shulei,Hao Aiyou
Abstract Folic acid, as a significant vitamin, is essential for human bodies, especially for pregnant women. However, folic acid hydrogel for drug delivery has not been reported until now. Herein, folic acid hydrogel was prepared by ion inducing method firstly. Then β-cyclodextrin/camptothecin inclusion complex was loaded into folic acid hydrogel successfully by co-assembly. Camptothecin loading folic acid hydrogel has good rheological mechanical property and thermodynamic stability. Moreover, the possible mechanism of hydrogel formation was proposed by energy dispersive spectrometer and small-angle X-ray scattering. Besides, compared to camptothecin itself, camptothecin release rate from camptothecin loaded hydrogel was prolongated remarkably through dialysis experiment. Finally, the cell inhibitory rate of camptothecin loading folic acid hydrogel was increased observably compared to camptothecin itself. Hence, as a green drug delivery system, our folic acid hydrogel has important potential application in medical engineering material. Graphic Abstract Herein, a novel β-cyclodextrin/camptothecin inclusion complex loaded folic acid hydrogel was constructed by elaborate design and preparation, which can load camptothecin into folic acid hydrogel effectively. Moreover, compared to camptothecin itself, camptothecin release rate from camptothecin loaded hydrogel was prolongated remarkably through dialysis experiment. Finally, the cell inhibitory rate of camptothecin loading folic acid hydrogel was increased observably compared to camptothecin itself. Hence, as a green drug delivery system, our folic acid hydrogel has important potential application in medical engineering material.
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BIORESOURCE TECHNOLOGY
·
2019
·
IF 6.669
Tongjun Liu,Li Yang,Bin Liu,Liping Tan
Hydroxycinnamic acids released during alkaline pretreatment of lignocellulose, especially p- coumaric acid ( p -CA) and ferulic acid (FA), negatively affect the enzymatic hydrolysis and fermentation. However, the mechanism of this effect is not well understood. In this study, we investigated the releasing behavior and negative effect and examined the underlying mechanisms. The results demonstrated that the hydrogen peroxide concentration and biomass loading affected the release of p -CA and FA significantly during alkaline hydrogen peroxide (AHP) pretreatment of corn stover. p -CA and FA mainly inhibited the activity of endoglucanase, xylanase, and filter paper activity (FPA), while the amount of lignocellulolytic enzyme protein was not affected. Thus, they acted as inhibitors of enzyme activities. Molecular docking study indicated that p -CA and FA inhibited the lignocellulolytic enzyme activity and enzymatic hydrolysis efficiency mainly by forming non-covalent bonds to specific amino acids in the active sites of the lignocellulolytic enzymes.
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ACS Applied Bio Materials
·
2019
·
IF 0
Beibei Lu,Zhourui Xiao,Zhenyuan Wang,Binshen Wang,Weiwei Zhao,Xing Ma,Jiaheng Zhang
Redox-responsive ferrocene (Fc)-grafted supramolecular block copolymers functionalized with hyaluronic acid (HA-g-β-CD/Fc-polymers or HAP) or folic acid (FA-g-β-CD/Fc-polymers or FAP) were synthesized by host–guest interaction. The copolymer structures were characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance, and gel permeation chromatography. The block copolymers self-assemble into spherical micellar aggregates in aqueous solution, and exhibit reversible redox characteristics in the presence of an oxidant and reductant. The tunable redox response was evaluated by transmission electron microscopy, ultraviolet–visible spectroscopy, cyclic voltammetry and dynamic light scattering. The micelles rapidly release DOX under oxidative and acidic condition in vitro. Furthermore, presence of HA and FA on the micelles enabled effective uptake by the CD44 and FA receptor-overexpressing cancer cells. Taken together, the redox responsive Fc-block copolymer micelles have good biocompatibility, biodegradability, low toxicity, and high selectivity, and are a highly promising drug delivery system for cancer therapy.
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