BIOSENSORS & BIOELECTRONICS
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2022
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IF 12.545
Yibo Yan,Long Jiang,Song Zhang,Xiantao Shen,Chuixiu Huang
Development of a specific “light-up” sensor for detection of psychoactive drug has been a great challenge in forensic analysis. To achieve this goal, an aggregation induced emission (AIE) functional monomer containing both phenylboronic group and double bond was synthesized for construction of molecularly imprinted polymers (MIPs) based fluorescent sensor. In this AIE-MIP sensor, the AIE fluorophore could vibrate freely in the absence of the target analyte (cathinone, CAT), while this vibration was restricted after the specific molecular recognition , leading to “light-up” character of the corresponding sensor. FT-IR and LC-MS characterizations proved the AIE monomer was successfully introduced onto AIE-MIPs. SEM analysis indicated the AIE-MIPs was ∼140 nm in diameter. Binding experiments indicated the AIE-MIPs owned high specificity towards CAT. Fluorescent studies confirmed that the “light-up” capability of the AIE-MIPs was highly selective. On this basis, the AIE-MIP sensor was applied in detecting CAT in forensic samples. The sensor reached a detection limit of 0.32 μmol L -1 and exhibited a linear range of 2–12 μmol L -1 . Compared to previously reported MIPs based electrochemical sensors and fluorescent sensors for measurement of CAT drug and its analogue, the present AIE-MIP sensor showed much higher sensitivity. To the best of our knowledge, this is the first time that an AIE functional monomer was synthesized for molecular imprinting , and also the first “light-up” AIE-MIP sensor to be reported. We believe that this versatile design of the specific “light-up” sensor can be used as a general protocol for construction of advanced sensor in various fields.
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高影响因子
COMBUSTION AND FLAME
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2022
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IF 5.767
Ling-Nan Wu,Zhen-Yu Tian,Kai-Ru Jin,Zhi-Hao Zheng,Du Wang,Bing-Zhi Liu,Qiang Xu,Zhan-Dong Wang
Pyridine is an important model compound of fuel-nitrogen during the coal combustion process . The lean oxidation of pyridine was studied over 800–1100 K at atmospheric pressure with the equivalence ratio of 0.4 in a jet-stirred reactor. Pyridine and its oxidation products were measured by tunable synchrotron vacuum ultraviolet photoionization molecular-beam mass spectrometry and gas chromatography analyzer. Three-stage consumption phenomenon of pyridine and O 2 was observed including a fast consumption stage at 910–920 K, a moderate consumption stage at 920–1000 K, and a slow consumption stage at 1000–1100 K. HCN, N 2, N 2 O, and HNCO are the major nitrogenous oxidation products of pyridine. CO, CO 2 , HCN, and HNCO are the dominant carbonaceous products. HNCO is uniquely detected in the lean oxidation of pyridine compared with rich oxidation. A new pyridine LTO 2.0 model comprising 210 species and 1349 reactions was proposed, providing a good prediction of pyridine and its major oxidation products against experimental data. N 2 O emission is larger than NO at 1100 K. HCN is the dominant nitrogenous intermediate under both fuel-lean and fuel-rich conditions. Results of this work provide a detailed analysis of the nitrogen evolution mechanism of pyridine oxidation under the fuel-lean condition, which is close to the real industrial low-temperature coal combustion processes including the MILD combustion, fluidized bed combustion , etc.
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高影响因子
GREEN CHEMISTRY
·
2022
·Vol. 24
·期 4
·1570-1577
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IF 11.034
Ruixue Yangcheng,Jiansu Ran,Zhaohui Liu,Yuntong Cui,Jianjian Wang
Efficient production of high value-added chemicals and biofuels via low-temperature chemoselective HDO of lignin derivatives in water is still a challenge. Here, we construct a low-cost, active and stable Pd/PCE catalyst using phosphoric acid-modified commercial Celite (PCE) as the support, and this catalyst exhibits excellent activity in low-temperature HDO of vanillin as well as other lignin derivatives in water. The superior catalytic performance is due to the presence of P species on the surface of Pd/PCE, accelerating the selective conversion of the intermediate into the final product. Detailed experimental and mechanistic studies reveal that the rapid conversion of the intermediate to the final product proceeds via a free-radical process in an interfacial microenvironment created by intimate interacting between the P species and Pd NPs. The insights of this work provide a new low-cost catalytic system for efficient production of valuable chemicals and future biofuels from lignin derivatives.
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高影响因子
CELLULOSE
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2022
·Vol. 29
·期 2
·879-891
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IF 6.123
Zhou Liang,Liu Qiyu,Ma Qiaozhi,Guan Mingzhao,Ouyang Xinping,Qiu Xueqing
Abstract Saccharification of cellulose into glucose is a key step for the utilization of lignocellulose. Molten salt hydrate (MSH) is unique in selective hydrolysis of cellulose into glucose but the separation of formed glucose from MSH is challenging due to the high solubility of glucose in MSH. To address this issue, this work developed a method where a small dosage of MSH was applied to impregnate cellulose and convert it into water-soluble sugar with the degree of polymerization (DP) lower than 6, which can be readily hydrolyzed into glucose under mild conditions without sacrificing selectivity. Under the optimized impregnation condition at 110 °C for 2 h, cellulose was selectively converted into water-soluble sugar with a yield of 87.5%. Then the MSH can be efficiently dissolved and removed by anti-solvent isolation with n -butanol, resulting in a sugar recovery of 84.3%. We showed that the separation efficiency was influenced by anti-solvent polarity and oligosaccharides chain-length. Moreover, the production and separation of water-soluble sugar from corn stover was also investigated. 88.9% yield of water-soluble sugar was obtained from the impregnation of corn stover under the optimized reaction conditions. With the addition of n -butanol as an anti-solvent, the water-soluble sugar can be recovered from MSH with a selectivity of 86.7%. Graphical Abstract
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高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 4
·2497-2511
·
IF 6.123
Xu Dezhong,Cheng Yanan,Wu Shuai,Zou Qiuxia,Mondal Ajoy Kanti,Ning Dengwen,Huang Fang
In this work, tunicate cellulose nanocrystals (tCNCs) were extracted from the tunicate by bleaching and acid hydrolysis. They were used as filler in the preparation of sodium alginate-based enteric capsules. The addition of tCNCs with a high aspect ratio (65) rendered the enteric capsule excellent physical properties. Compared with the control sample, when the addition of tCNCs were 10% (wt), the water contact angle of the capsule was enhanced by 46.0%, the opacity was increased by 356.8%, the maximum tensile stress was increased by 142.6%, the modulus of elasticity was increased by 240.3%, and the elongation at break was increased by 133.8%. In the in vitro degradation experiments, the capsule hardly degraded in the gastric environment (pH 1.2), while in the intestinal environment (pH 6.8), the degradation became slower with the increase of tCNC content, which was consistent with the properties of the enteric capsule. This research developed a new direction for the application of tCNCs in the pharmaceutical material productions. Graphical abstract
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高影响因子
Green Energy & Environment
·
2022
·
IF 12.781
Bolin Wang,Chunxiao Jin,Shujuan Shao,Yuxue Yue,Yuteng Zhang,Saisai Wang,Renqin Chang,Haifeng Zhang,Jia Zhao,Xiaonian Li
Rational design of catalytic sites to activate the C C bond is of paramount importance to advance acetylene hydrochlorination. Herein, Cu sites with electron-rich and electron-deficient states were constructed by controlling the impregnation solutions. The π electrons flowing from acetylene to Cu site are facilitated over the electron-deficient Cu sites, achieving high activation of C C bond. The contradiction between the increased activation of acetylene required for enhanced catalytic activity and the resistance of Cu site to reduction by acetylene required for maintaining catalytic stability can be balanced by establishing strong interactions of Cu site with pyrrolic-N species. The catalytic activity displays a volcano shape scaling relationship as a function of Cu particle size. Tribasic copper chloride is concomitantly generated with the construction of electron-deficient Cu sites. The H–Cl bond of HCl can be activated over the tribasic copper chloride, accelerating the surface reaction of vinyl chloride production. This strategy of inducing electron deficiency provides new insight into the rational design of catalysts for the synthesis of vinyl chloride with a high catalytic performance.
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高影响因子
FUEL
·
2022
·
IF 8.035
Linjie Guan,Chengming Huang,Dingmei Han,Binbin He,Linhua Zhu,Dedong He,Yi Mei,Yun Zu
A series of HZSM-5 zeolites are fabricated to make it cross-link with an external ultrathin siliceous layer by chemical liquid deposition and the corresponding thickness is measured by TEM and XPS analysis. In situ FTIR experiments disclose that the external surface acidic sites of HZSM-5 zeolite can be covered even by siliceous monolayer (0.7 ∼ 1.3 nm, HZ5-S1). In comparison to parent HZSM-5, the catalytic cracking performance of n-butane over the modified zeolites are evidently enhanced. In particular, the n-butane conversion rate per Brønsted acid site over the HZ5-S2 (16.02 min −1 ) at 550 °C is 2.82 times than that over the HZSM-5 (5.68 min −1 ). Meanwhile, the diffusion properties of n-butane over the zeolites are quantified by in situ FTIR spectroscopic analysis. Negative correlation between steady-state diffusivity and n-butane conversion rate per Brønsted acid site can be found, which unravels the origin of the progressive decrease in the catalytic stability. Under comparable conditions, more advantages can be greatly achieved by HZ5-S1 catalyst in the catalytic activity and the yields to light olefins due to the benign diffusivity and the elimination of external surface acidic sites. This study can provide a guidance for the understanding of diffusion intensification and the rational design of superior catalyst for the catalytic cracking reactions of alkanes.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yin Yan,Lihe Zhang,Xi Zhao,Siyu Zhai,Qian Wang,Cui Li,Xu Zhang
The study presents the preparation of novel biocomposites based on different lignin fractions and polylactic acid (PLA). Based on the improvement of PLA mechanical properties, we proposed a process to assemble a series of lignin samples and PLA matrix using melt blending to investigate the effects on PLA properties from the perspective of the structure and molecular weight for lignin. The lignin was extracted from pine residue using deep eutectic solvent (DES) and was subjected to fractionation with ethanol and acetone as well as esterification modification with succinic anhydride (SAn). The treated lignin samples were used as additives, which not only improved the mechanical properties of PLA on the basis of retaining its thermal stability , but also granted excellent antimicrobial and biocompatibility properties. The results showed that the molecular weight of lignin was negatively correlated with the phenolic hydroxyl content, and the mechanical properties of the composites were also significantly affected by different molecular weights of lignin, indicating that the inhomogeneity of lignin affects its value-added utilization. The enhanced mechanical properties, antibacterial effect, and steady biocompatibility provide potential possibilities for lignin-based composites in biomedical applications.
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高影响因子
SCIENTIA HORTICULTURAE
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2022
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IF 4.342
Xiaoya Tao,Qiong Wu,Suqing Huang,Beiwei Zhu,Feng Chen,Bin Liu,Luyun Cai,Linchun Mao,Zisheng Luo,Li Li,Tiejin Ying
Primary metabolites play crucial roles during fruit development and ripening. Phytohormone abscisic acid (ABA) has been reported to regulate postharvest tomato fruit ripening. However, knowledge about ABA in regulating primary metabolism in tomato fruit is obscure. In the present research, cherry tomato fruit were infiltrated with 1.0 mM ABA or deionized water under vacuum, and kept in darkness for 15 d. The changes of the relative contents of sugars, organic acids, and amino acids, as well as the expression levels of key genes involved in sugar and organic acid metabolisms, were analyzed. Results showed exogenous ABA accelerated tomato fruit ripening, accompanying with the enhanced changes of fruit color and firmness, the higher levels of respiration rate and ethylene production. Meanwhile, exogenous ABA enhanced the relative levels of some primary metabolites, such as glucose, lyxose and fructose; citric acid, citramalic acid, ascorbic acid and gluconic acid; also serine, pyroglutamic acid, GABA, glutamic acid, aspartic acid, asparagine and glutamine (1.69-3.25 folds). Furthermore, exogenous ABA stimulated the expression levels of most key genes (such as SPSs, SPP2, TIV1, Lins, SUSs, PPCs, MDH and CS ) (log 2 fold change ranged from 1.06 to 3.64). Results indicate ABA is systematically involved in the regulation of primary metabolism, which may provide valuable information for exploring technical means to improve tomato taste and flavor.
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高影响因子
PHYSIOLOGIA PLANTARUM
·
2022
·Vol. 174
·期 2
·e13650
·
IF 5.081
Hua Huang,Ying Hu,Ling Wang,Fengjun Li,Youxia Shan,Qiaoqiao Lian,Yueming Jiang
Plant cuticle as hydrophobic barrier covers almost all aerial plant organs. Herein the cuticular chemical components and the transpiration of various organs of Chinese flowering cabbage (CFC) and Chinese kale (CK) were comprehensively characterized. Numerous species- and organ-specific differences in morphological, chemical, and physiological levels were found. The various organs were relatively smooth in surface for CFC but glaucous with hollow tube- and plate-type crystals for CK. The chemical composition of cuticular waxes were very-long chain n -alkanes, ketones, secondary alcohols with a prominent carbon chain of C 29 in CK, primary alcohols dominated by C 26 , and aldehydes prominently C 30 in CFC. Cutin monomers accumulated with similar levels as waxes and were dominated by α , ω -dicarboxylic acids and fatty acids without added groups. The minimum water conductance differed considerably among species and various organs ranging between 8.9 × 10 −5 (CK leaf) and 3.7 × 10 −4 m s −1 (CFC leaf petiole). These differences in transpiration properties were proposed to be largely related to the cuticular chemicals in various organs and species. The presented results provide further insights to link the transpiration barrier functions with surface characteristics and cuticular chemicals.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Chao Fan,Jia Chen,Hui Li,Kaijun Quan,Hongdeng Qiu
Two new hydrophilic-hydrophobic and acid-base balanced liquid chromatographic stationary phases were obtained by using two long-chain monomers including undecylenic acid (UA) and oleic acid (OA) combined with short-chain 4-vinyl pyridine (Py) in-situ polymerized on silica microspheres surfaces, respectively. These two stationary phases can be used for reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC) modes. Hydrophilic, hydrophobic, acidic and basic analytes can be separated on two new stationary phases in RPLC or HILIC mode. Compared with commercial hydrophobic C18 columns and other HILIC columns, two new stationary phases have excellent selectivity and separation performance in the separation of 9 polycyclic aromatic hydrocarbons, 10 aromatic acids, 10 anilines and 5 oxazolidinones, respectively. This novel polymer-functionalized silica design strategy has opened up new ideas for the future of mixed-mode stationary phases with multiple functions and specificity.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2022
·
IF 6.51
Yu Zou,Quan Zhou,Yinan Zhao,Defu Zhi,Huiying Chen,Rui Wang,Benzhi Ju,Shubiao Zhang
Ionizable lipids are the leading vectors for gene therapy. Understanding the effects of molecular structure on efficient gene delivery is one of the most important challenges for maximizing the utility of such lipid vectors. We synthesized an array of pH-responsive and ionizable lipids to investigate the relationship between lipid structure and activity. The optimized lipid (EDM) has double tertiary amines in the headgroup and an ester linker. EDM exhibited efficient DNA and siRNA delivery to, and gene silencing of, A549 cells. EDM has a p K a value of 6.67, which enabled it to quickly escape from the endosome after entering the cell; the ester linkages rapidly degraded and enabled gene release into the cytoplasm. EDM also delivered IGF-1R siRNA to inhibit tumor growth and induce cancer cell apoptosis by efficient inhibition of IGF-1R expression in mice. Our study on the structure–activity relationships of ionizable lipids will facilitate clinical applications.
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