Heliyon
·
2023
·
IF 4
Peng Zhang,Fang Cao,Jiqin Zhang,Ying Tan,Shengtao Yao
The past decades have witnessed great progress in nanoparticle‐based cancer‐targeting drug delivery systems, but their therapeutic potentials is yet to be fully exploited. In this research, temozolomide (TMZ) and chloroquine (CQ) were loaded into the mesoporous silica nanoparticles (MSNs), the surface was coated with polydopamine (PDA), and the complex was coupled with arginine-glycine-aspartic (RGD) to successfully prepare TMZ/CQ@MSN-RGD. RGD-MSNs accumulated more in the cell and tumor models than in unmodified MSNs in the in vitro and in vivo experiments and can directly induce apoptosis and autophagy in tumor cells. In addition, TMZ/CQ@MSN-RGD therapy enhanced the apoptosis effect of the RGD-MSNs in glioma. Therefore, the combination of autophagy inhibitor with chemotherapy drugs in nanocarriers may promote therapeutic efficacy in treating glioma.
研究领域:
肿瘤学
·
纳米医学
·
药理学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Xiao Du,Shaoping Yin,Yang Wang,Xiaochen Gu,Guangji Wang,Juan Li
Biocompatible, pH-sensitive and charge-conversion micelles derived from hyaluronic acid (HA), poly(lactide) (PLA) and half-generation of sectorial poly(amidoamine) dendrimers (sPA G4.5) were designed and fabricated to target delivery of docetaxel (DTX) to cancer cells. The novel micelles (HA-PALA-DTX) possessed stability against rat plasma and were capable of reversing surface zeta potential under acidic conditions in the presence of HAase. Moreover, the blank micelles demonstrated satisfactory biocompatibility and viability for biomedical applications. A cellular internalization experiment indicated that HA played an important role in increasing intracellular accumulation of DTX delivered by the micelles. Compared to Taxotere ® and PALA-DTX, HA-PALA-DTX showed an enhanced anticancer activity in vivo, with a tumor growth inhibition rate of 72.32 ± 5.22%. Overall, the functionalized micelles could be utilized as an alternative carrier for effective targeted delivery of anticancer agents to improve therapeutic efficacy and minimize adverse effects.
研究领域:
药剂学
·
肿瘤学
·
生物材料
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 25
·期 10
·1435-1441
·
IF 1.174
Zhirong Chen,Weitao Yang,Hong Yin,Shenfeng Yuan
The uncatalyzed reaction of p -tolyl isocyanate ( p -TI) with water in N , N -dimethylformamide (DMF) was investigated by high performance liquid chromatography (HPLC). The reactions were carried out at different temperatures from 293 K to 323 K, using various molar ratios of water to p -TI. DMF, as a special amide , was proved to be an efficient catalyst for water–isocyanate reaction. Under the reaction conditions in this study, substituted urea was the only final product observed. An appreciable amount of intermediate p -toluidine was detected. Concentrations of the isocyanate group as well as the amine and urea were determined as a function of time. New kinetic equations were deduced for each of the substance on the basis of a multistep mechanism, instead of a simple second order reaction as usual. Kinetic constants were calculated using the software MATLAB . Furthermore, the effects of temperature and concentrations of reactants on the reaction rate and amine content were discussed. The activation energy of each step was also determined.
研究领域:
物理化学
·
有机化学
·
反应动力学
·
高分子化学
·
催化化学
·
分析化学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Kexiang Li,Hong Li,Qian Zhang,Dezhi Yang,Yaling Yang
In this work, a facile synthesis method for dopamine carbon dots-based Au nanoparticles (DA-CDs/AuNPs) by seed gold method was reported as the surface enhanced Raman scattering (SERS) booster. DA-CDs with rich in surface functional groups was synthesized using dopamine, citric acid and ethylenediamine as precursors by a facile hydrothermal method, and can be used as the capping agents and reducing agents for the synthesis of DA-CDs/AuNPs. Due to the electromagnetic “hot spots” effect, DA-CDs/AuNPs with core–shell structure exhibited strong SERS activity. Based on the specific interaction of DA-CDs/AuNPs and fenamidone, a detection method of fenamidone was established with a low detection limit of 0.05 μg/mL. Finally, the SERS sensor was successfully applied to the detection of fenamidone in fruit with recoveries between 90.6 % and 98.7 %. The method here proposed can be reliably applied for fenamidone detection on fruits.
研究领域:
材料科学
·
分析化学
·
纳米技术
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2022
·Vol. 45
·期 6
·2905-2915
·
IF 4.898
Zhang Xiaolei,Liu Lu,Chen Xiaoli,Li Ji,Chen Jiaxin,Wang Hongjie
With huge amount of plastic entering to the environment, microplastic pollution has become a great concern. Microplastic behavior in the environment is important to evaluate its harm to ecosystem and human beings. It has been found that microplastic can be used as a carrier to adsorb and enrich heavy metals or organic pollutants in water or soil. With the development of industry and medicine, antibiotics are improperly used in many countries and most of them end up in wastewater. This study investigates the adsorption behavior of sulfamethoxazole (SMX) antibiotic onto virgin and aged polyamide 6 (PA6) microplastics. The maximum adsorption amount was 0.089 mg SMX/g PA6 at 25 °C and pH 7 with initial SMX concentration of 2 mg/L. Results reveal that the adsorption was mainly due to the chemical bounding. The impact of pH, salinity, and humic acid on the adsorption have been studied, and it was found that the pH has significant impact on the adsorption. At pH 5, the adsorption amount was 0.27 mg/g which is two times higher than that at pH 7. The SMX adsorbed on PA6 tends to be more likely desorbed in reservoir water than in ultrapure water. For instance, the desorption amount of SMX from virgin PA6 was 0.15 mg/L in reservoir water but 0.10 mg/L in ultrapure water. The study indicates that microplastics have great threat to environment.
研究领域:
环境科学
·
生态毒理学
·
水污染
·
材料科学
·
化学风险评估
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Chenjie Wei,Zhifu He,Ligang Lin,Qi Cheng,Kai Huang,Sisi Ma,Li Chen
A simple strategy is proposed for high performance polyimide nanofiltration (PI-NF) membranes by optimization of a synergistic imidization reaction. Soluble poly(amic acid) polymers with partial imidization was successfully controlled and fabricated by chemical imidization. With the product as a matrix, NF membranes with an integrally skinned asymmetric architecture were obtained by phase inversion and subsequent thermal imidization. The brittle and ruptured defects caused by directly high temperature conversion for fabricating PI-NF membranes were effectively avoided. The prepared membrane showed high rejections for dye, PEG and typical salts. The fabricated PI-NF membranes were endowed with a high permeance of isopropyl alcohol [approximately 1 L/(m 2 h bar)] and a high rejection of rose Bengal (greater than 92%). The molecular weight cut-off of PI-NF membrane is below 800 Da. The pure water flux of PI-NF membrane prepared under optimized conditions was approximately 20 L/(m 2 h) and the rejection for Na 2 SO 4 was 93.91% at 5 bar. The rejection for different salts followed the order: Na 2 SO 4 > MgSO 4 > NaCl > MgCl 2 , revealed that Donnan exclusion theory and steric hindrance effect dominated the rejection mechanism. Furthermore, the NF membranes showed excellent stability over a long-term filtration process.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 42
·51233
·
IF 3.125
Jiali Xu,Li Yuan,Guozheng Liang,Aijuan Gu
It is still a challenge for simultaneously achieving high heat resistance, high strength and outstanding electrochemical performance for separators in power lithium-ion battery (PLB). Herein, new high performance electrospun separators are developed through building unique structure based on polyimide (PI) and poly (m-phenylene isophthalamide) (PMIA). Orthogonal tests (4 4 ) show that the magnitude order of electrospinning factors on the morphology of membrane is concentration>injection rate>receiving distance>voltage. With the optimum factors, the electrospun membrane (PI/PMIA) was prepared, which was further pressed at 100°C for 10 min to get treated membrane (H-PI/PMIA). Interestingly, the comprehensive performance of PI/PMIA is not a simple combination of those of PI and PMIA; instead, PI/PMIA has much better thermal and mechanical properties than both PI and PMIA, proving that PI/PMIA has a synergistic effect. PI/PMIA and H-PI/PMIA not only have good ionic conductivity and electrochemical stability, but also have superiorly high properties including dimensional stability (thermal shrinkage temperature>300°C), tensile strengths (24.1 MPa for PI/PMIA, 34.3 MPa for H-PI/PMIA) and capacity retentions (97.9%, 99.2%) compared with electrospun membranes for PLBs reported in the literature so far (SCI database). The mechanism behind these attractive performances is discussed from condensed structure of membranes.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 6
·2100048
·
IF 4.979
Huiting Jia,Xindong Wang,Zhaoming Chen,Shuai Liu,Tongtong Zhou,Hao Zhou,Tianying Guo
Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn 2+ complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. And the effects of different structural characteristics, such as the number of pyridinamine ligands, the hydrophilic-hydrophobicity of the adjacent groups, on the in vitro transfection performance of the ternary complex are systematically investigated. This ternary hybrid system provides an effective strategy to improve the gene delivery of cationic polymers.
研究领域:
生物化学
·
分子生物学
·
基因治疗
✓ 已验证
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2018
·
IF 2.559
Peng Zhang,Menghuan Tang,Qin Huang,Guanjian Zhao,Ning Huang,Xiang Zhang,Ying Tan,Yuan Cheng
Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas.
研究领域:
纳米技术
·
药学
·
肿瘤学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2019
·
IF 0
Jiawei Liu,Jiahui Liu,Feiyang Ma,Jiguang Liu
Particles with circumstance-responsive conductivity have an appealing performance in constructing sensors. Here, “smart” conducting polyaniline-doped poly(styrene-co-N-isopropylacrylamide) composite spheres, i.e. PANI/P(St-NIPAM) particles, are reported. A series of PANI/P(St-NIPAM) particles can be prepared with different ratios of N-isopropylacrylamide to monomers, i.e. N/M ratios. With the improved N/M ratios in polymerization, the amount of polyaniline (PANI) incorporating into the produced particles increased, resulting in an enhanced conductivity. With the improved N/M ratios, the hydrodynamic diameters of PANI/P(St-NIPAM) particles increased at a low temperature, whereas they decreased at a high temperature; resulting in the enhanced volume-change ability with the increasing poly(N-isopropylacrylamide) (PNIPAM) content in particles. Depending on the temperature-induced volume change, these particles exhibit “smart” conductivity in a homemade device, in which these particles can be used as a temperature-responsive conducting medium to construct an “on–off” circuit, and the switch of an LED lamp can be triggered by temperature. These particles with the smart conducting property provide wide potential applications in sensors, microelectronics, energy storage, and other fields.
研究领域:
材料科学
·
传感器技术
·
高分子化学
✓ 已验证
DOI
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jiajia Yang,Jiekai Wang,Junping Guo,Ying Zhang,Zhifeng Zhang
Graphene oxide (GO) as an emerging nanomaterial has been widely used in water purification. However, practical removal of GO from water environment and industrial waste liquid remains a critical challenge. Here, a poly (amide amine) dendrimer (PAMAM) modified composite magnetic nano-flocculant (Fe 3 O 4 @SiO 2 @PAMAM) was fabricated and a new strategy for removal of GO was proposed combining the advantages of flocculation with magnetic separation. Results showed that high removal efficiency of more than 82.41 % could be attained under the conditions of an initial GO concentration of 100 mg/L, flocculation time of 60 s, Fe 3 O 4 @SiO 2 @PAMAM dose of 100 mg/L, and pH of 6.0. The maximum removal capacity of Fe 3 O 4 @SiO 2 @PAMAM for GO was approximately 238.10 mg g −1 . Based on the charge neutralization and sweep flocculation, the prepared Fe 3 O 4 @SiO 2 @PAMAM demonstrated excellent application performance for removing GO in surface water, domestic sewage, and industrial waste liquid. A new magnetic nano-flocculant and an alternative technology strategy for treatment of GO was presented.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Wei Jin,Rongrong Wang,Xirong Huang
A bicontinuous microemulsion system consisting of sodium bis(2-ethylhexyl) sulfosuccinate (AOT), sodium dodecylsulfate (SDS), an aqueous solution (a 0.1 M disodium hydrogenphosphate/citric acid buffer solution of pH = 4.3), and decane was investigated in detail for applications as reaction medium for the horseradish peroxidase (HRP)/hydrogen peroxide-mediated synthesis of the conductive form of polyaniline (PANI). To formulate the optimal single-phase microemulsion with the phase inversion temperature being close to room temperature , the T - γ fishlike phase diagram of the AOT/SDS-buffer-decane pseudoternary system was determined. The effects of the surfactant concentration ( γ ), the oil-to-water ratio ( α ) and the temperature ( T ) on the conductivity of the resulting PANI and the underlying mechanism were investigated using UV–vis-NIR, ESR and small-angle X-ray scattering (SAXS) techniques. Results show that the bicontinuous microemulsion plays a template role in the PANI biosynthesis, and the PANI conductivity also depends on the activity and stability of the solubilized HRP, which are determined by the microdomain size of the microemulsions and the reaction temperature. As far as γ is concerned, it is found that as γ increases, the microdomain size of the bicontinuous microemulsion as well as the activity of the solubilized HRP decreases significantly, leading to a great decrease of the PANI conductivity. Compared with γ , the change of α has small effect on the PANI conductivity. As the α -dependent microdomain size changes little with increasing α , the small change of the PANI conductivity should be ascribed mainly to the HRP activity. For T , over the range of 20 °C–35 °C, it has a slight effect on the microdomain size of the bicontinuous microemulsion, but it has a marked effect on the enzymatic properties of HRP. As the temperature increases, the activity of HRP increases, but its thermal stability decreases greatly. Therefore, the thermal stability of HRP is the major factor causing that the PANI conductivity decreases significantly with increasing T . The present work deepens the understanding of the template effect of anionic surfactant aggregates in the biosynthesis of conducting PANI. To the best of our knowledge, this work is the first study of the use of bicontinuous microemulsions as reaction media for the enzymatic synthesis of a conducting polymer .
研究领域:
材料科学
·
生物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）