Nature Communications
·
2019
·Vol. 10
·期 1
·1-8
·
IF 11.878
Cui Bin-Bin,Han Ying,Huang Bolong,Zhao Yizhou,Wu Xianxin,Liu Lang,Cao Guangyue,Du Qin,Liu Na,Zou Wei,Sun Mingzi,Wang Lin,Liu Xinfeng,Wang Jianpu,Zhou Huanping,Chen Qi
As one of next-generation semiconductors, hybrid halide perovskites with tailorable optoelectronic properties are promising for photovoltaics, lighting, and displaying. This tunability lies on variable crystal structures, wherein the spatial arrangement of halide octahedra is essential to determine the assembly behavior and materials properties. Herein, we report to manipulate their assembling behavior and crystal dimensionality by locally collective hydrogen bonding effects. Specifically, a unique urea-amide cation is employed to form corrugated 1D crystals by interacting with bromide atoms in lead octahedra via multiple hydrogen bonds. Further tuning the stoichiometry, cations are bonded with water molecules to create a larger spacer that isolates individual lead bromide octahedra. It leads to zero-dimension (0D) single crystals, which exhibit broadband ‘warm’ white emission with photoluminescence quantum efficiency 5 times higher than 1D counterpart. This work suggests a feasible strategy to modulate the connectivity of octahedra and consequent crystal dimensionality for the enhancement of their optoelectronic properties.
研究领域:
材料科学
·
光电学
·
半导体
✓ 已验证
DOI
高影响因子
STAR Protocols
·
2021
·
IF 0
Ke Li,Ao Wang,Huijuan Liu,Baojie Li
Summary N-Methyl-N-nitrosourea, an N-nitroso compound converted from dietary nitrite by Helicobacter pylori , causes somatic mutations in epithelial cells and induces gastric premalignancy. Here, we describe a detailed protocol for induction of gastric tumor and analysis of tumor phenotypes in mice. This model can be widely used for studying the initiation and growth of gastric cancer. For complete details on the use and execution of this protocol, please refer to Li et al. (2021) .
研究领域:
癌症研究
·
胃肠病学
·
分子生物学
✓ 已验证
DOI
PubMed
RSC Advances
·
2014
·Vol. 4
·期 80
·42252-42259
·
IF 3.708
Shengbo Zhu,Zhongwei An,Xinbing Chen,Pei Chen,Qianfeng Liu
The modification of π-linkers represents a viable strategy to improve the performance of organic dye in dye-sensitized solar cells (DSSCs). On the basis of the π-linker modification, four cyclic thiourea functionalized dyes (AZ260, AZ261, AZ262, and AZ263) were synthesized and their effects on the short-circuit current density (Jsc) and open-circuit voltage (Voc) were investigated. The results showed that AZ261 bearing an n-hexyl chain on the π-linker generated higher Jsc (16.02 mA cm−2) and Voc (739.4 mV) than AZ6 without a substituent on the bithiophene (Jsc = 15.89 mA cm−2, Voc = 729.2 mV, PCE = 7.20%), and a higher PCE of 7.42% was obtained from AZ261. Furthermore, insertion of a double-bond into the π-linker (AZ263) yielded the highest Jsc (17.83 mA cm−2) with a somewhat lower Voc (719.2 mV), and delivered the highest PCE up to 8.24%. In addition, the function of mesoporous spherical TiO2 on the photoanodes were also systematically examined and proven to be beneficial in increasing the Jsc.
研究领域:
材料科学
·
光伏技术
·
有机化学
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2023
·Vol. 13
·期 1
·1-11
·
IF 4.6
Li Hongwei,Chen Xin,Ren Kang,Wu Lihao,Chen Gong,Xu Ling
Diabetes may leave patients more prone to skin problems, and minor skin conditions can more easily turn into serious damage to the extracellular matrix, which further impairs the skin's mechanical properties and delays wound healing. Therefore, the aim of the work is to develop extracellular matrix substitution to remodel the mechanical properties of diabetic cutaneous wound and thus accelerate diabetic wound healing. A green fabrication approach was used to prepare radiation crosslinked bilayer collagen scaffold from collagen dispersion. The morphological, mechanical and swelling characteristics of radiation crosslinked bilayer collagen scaffold were assessed to be suitable for cutaneous wound remodeling . The feasibility of radiation crosslinked bilayer collagen scaffold was performed on full-skin defect of streptozotocin-induced diabetic rats. The tissue specimens were harvested after 7, 14, and 21 days. Histopathological analysis showed that radiation crosslinked bilayer collagen scaffold has beneficial effects on inducing skin regeneration and remodeling in diabetic rats. In addition, immunohistochemical staining further revealed that the radiation crosslinked bilayer collagen scaffold could not only significantly accelerate the diabetic wound healing, but also promote angiogenesis factor (CD31) production. Vascularization was observed as early as day 7. The work expands the therapeutic ideas for cutaneous wound healing in diabetes.
研究领域:
生物材料
·
组织工程
·
糖尿病研究
·
伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Can Wu,Xiaodong Wang,Junying Zhang,Jue Cheng,Ling Shi
A novel type of microencapsulated ammonium polyphosphate (MAPP) with a triallyl cyanurate (TAC)/SiO2 double-layered shell was synthesized through in-situ polymerization, followed by the thiol–ene photograted reaction. With a double bond in the TAC outer shell, MAPP could be utilized as a highly efficient flame retardant for intumescent flame-retarded natural rubber (NR). The chemical structure, morphology, and performance of MAPP were characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, water contact angle (WCA), scanning electron microscopy, and thermogravimetric analysis. MAPP exhibited a hydrophobic feature with a WCA of 101° because of its organic outer shell, which made MAPP well dispersed in the NR matrix as well as enhanced the compatibility between the MAPP and NR matrix. The resulting intumescent flame-retardant NR compounds not only achieved excellent flame-retardant performance but also obtain improved mechanical properties because of the presence of 3D-cross-linking networks between the MAPP and NR matrix. The NR/MAPP compounds also presented good water resistance because of the microencapsulation of APP with an SiO2 inner shell, which provided a waterproof barrier for APP. Based on the cone calorimetric results, the NR/MAPP compounds also presented a decline in total heat release and heat release rate but an improvement in ignition time due to the fact that both the SiO2 inner layer and TAC outer shell could enhance the formation of a high-strength thermally stable char layer during combustion, thus preventing heat transmission and diffusion. The significant enhancement in flame-retardant performance was principally ascribed to the synergistic char-forming effect derived from the APP core and TAC/SiO2 shell. This work provides a new idea for development of APP-based flame-retardant additives and also explores their potential applications in intumescent flame-retardant polymeric systems.
研究领域:
高分子材料科学
·
阻燃化学
·
功能材料
·
纳米复合材料
·
表面工程
·
热稳定性分析
·
聚合物改性
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Yingchao Cai,Chunmei Li,Yumin Yang,Haonan Li,Yuhang Wang,Qiuyu Zhang
Owing to excessive energy consumption and environmental deterioration, thermosets with permanent covalent crosslinks have encountered unprecedented challenge in the sustainable development. An effective method to address this intractable problem is to construct covalent adaptive networks that contain dynamic covalent bonds. Herein, self-healable and reprocessable cross-linked poly(urea-urethane) elastomers with high mechanical performance were simply developed by introducing dynamic oxime–carbamate bonds (POUUs). The studies on nuclear magnetic resonance indicated that the sufficient exchange rather than the reversible dissociation of oxime–carbamate bonds was the key to network arrangement at elevated temperatures. Due to the incorporation of strong polar urea bonds, POUUs showed excellent mechanical performance with a tensile strength of 27.8 MPa and toughness of 52.5 MJ m–3. The good self-healing ability of POUUs was demonstrated by the disappearance of scratches at 80 °C after 15 h. All POUUs were easily remolded (130 °C, 5 MPa) into transparent films with a maximum recovery efficiency of 80%. Furthermore, complete dissolution in N,N-dimethylformamide was achieved at 100 °C after 4 h, exhibiting high recyclability of the cross-linked POUUs.
研究领域:
高分子科学
·
材料工程
·
化学合成
·
可持续发展
·
力学性能研究
✓ 已验证
DOI
高影响因子
FASEB JOURNAL
·
2024
·Vol. 38
·期 17
·e70019
·
IF 4.4
Yuxue Xu,Yue Peng,Xiaojun Wu,Feixue Ni,Daxi Sun,Pengfei Zhang,Yang Yang,Miao Yan,Jia Mi,Geng Tian
Non-proliferative diabetic retinopathy (NPDR) is the early stage of diabetic retinopathy (DR) and is a chronic oxidative stress-related ocular disease. Few treatments are approved for early DR. This study aimed to investigate the pathogenic mechanisms underlying the retinal micro-vasculopathy induced by diabetes and to explore an early potential for treating early DR in a mouse model. The mouse model of type 1 diabetes was established by intraperitoneal injection of streptozotocin (STZ, 180 mg/kg), which was used as the early DR model. The body weight and blood glucose mice were measured regularly; The retinal vascular leakage in the early DR mice was determined by whole-mount staining; Label-free quantitative proteomic analysis and bioinformatics were used to explore the target proteins and signaling pathways associated with the retinal tissues of early DR mice; To detect the effects of target protein on endothelial cell proliferation, migration, and tube formation, knockdown and overexpression of VEGF-B were performed in human retinal vascular endothelial cells (HRECs); Western blotting was used to detect the expression of target proteins in vitro and in vivo; Meanwhile, the therapeutic effect of VEGF-B on vascular leakage has also been evaluated in vitro and in vivo. The protein expressions of vascular endothelial growth factor (VEGF)-B and the Rho GTPases family member CDC42 were reduced in the retinal tissues of early DR. VEGF-B upregulated the expression of CDC42/ZO1/VE-cadherin and prevented hyperglycemia-induced vascular leakage in HRECs. Standard intravitreal VEGF-B injections improved the retinal vascular leakage and neurovascular response in early DR mice. Our findings demonstrated, for the first time, that in diabetes, the retinal vessels are damaged due to decreased VEGF-B expression through downregulation of CDC42/ZO1/VE-cadherin expression. Therefore, VEGF-B could be used as a novel therapy for early DR.
研究领域:
糖尿病
·
眼科学
·
分子生物学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 14
·5371-5381
·
IF 6.482
Qianyun Zhong,Xingxing Chen,Yuxuan Yang,Chenhui Cui,Li Ma,Zhen Li,Qiang Zhang,Xiaoming Chen,Yilong Cheng,Yanfeng Zhang
Transparent and degradable polyurethane elastomers with high strength and toughness are in demand for various applications, such as tissue engineering and flexible electronics. However, designing specific chemical structures is challenging, and thus fabricating novel elastomers is sometimes unattainable. An effective approach to develop elastomers is through the introduction of sacrificial bonds, e.g. hydrogen bonds, to enhance their mechanical properties and toughness, which provide hidden lengths and hierarchical structures for energy dissipation. This study introduced a facile and efficient strategy by employing imidazolidinyl urea (IU) as a multiple hydrogen-bonding motif to fabricate transparent and degradable polyurethane elastomers (PHI) with superior breaking strength and excellent toughness. The resultant breaking strength and toughness reached up to 24.9 MPa and 168.2 MJ m−3, respectively. Additionally, the breaking strength increased to 49.9 MPa after the sample was pre-stretched to 600% strain due to strain-induced crystallization (SIC). Moreover, the PHI film with degradability and good biocompatibility showed potential application in post-operative anti-adhesion.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
DRUG METABOLISM AND DISPOSITION
·
2016
·Vol. 44
·期 1
·40-49
·
IF 3.21
Ning Zhou,Yuanting Zheng,Junfen Xing,Huiying Yang,Hanmei Chen,Xiaoqiang Xiang,Jing Liu,Shanshan Tong,Bin Zhu,Weimin Cai
Currently used in vitro models for estimating liver metabolism do not take into account the physiologic structure and blood circulation process of liver tissue. The Bio-PK metabolic system was established as an alternative approach to determine the in vitro intrinsic clearance of the model drug tolbutamide. The system contained a peristaltic pump, recirculating pipeline, reaction chamber, and rat liver microsomes (RLMs) encapsulated in pluronic F127-acrylamide-bisacrylamide (FAB) hydrogel. The metabolism of tolbutamide at initial concentrations of 100, 150, and 200 μM was measured in both the FAB hydrogel and the circular medium. The data from the FAB hydrogel and the circular medium were fitted to a mathematical model to obtain the predicted intrinsic clearance of tolbutamide after different periods of preincubation. The in vitro clearance value for tolbutamide was incorporated into Simcyp software and used to predict both the in vivo clearance value and the dynamic process of elimination. The predicted in vivo clearance of tolbutamide was 0.107, 0.087, and 0.095 L/h/kg for i.v. injection and 0.113, 0.095, and 0.107 L/h/kg for oral administration. Compared with the reported in vivo clearance of 0.09 L/h/kg (i.v.) and 0.10 L/h/kg (oral), all the predicted values differed by less than twofold. Thus, the Bio-PK metabolic system is a reliable and general in vitro model, characterized by three-dimensional structured RLM and circulation and perfusion processes for predicting the in vivo intrinsic clearance of low-extraction compounds, making the system more analogous with the rat in terms of both morphology and physiology
研究领域:
药代动力学
·
药物代谢
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Letters in Drug Design & Discovery
·
2019
·Vol. 16
·期 9
·1020-1030
·
IF 0.953
Liang Zhaochang,Huang Yuping,Wang Shiben,Deng Xianqing
Background: Several series of pyrazole derivatives containing (thio) semicarbazide (4a-4h, 5a-5l, 6a-6f, 7a-7c) were designed and synthesized to screen dual inflammatory and antimicrobial activities. Methods: The products were characterized by1H NMR, 13C NMR and HRMS. In vitro
LPS-induced TNF-α model and in vivo xylene-induced ear-edema model were used to evaluate their antiinflammatory activity. Their in vitro antimicrobial activities were evaluated using a serial dilution method against several gram-positive strains, gram-negative strains and a fungi strain.
Results: Bioassays indicated that most of the compounds markedly inhibited the expression of TNF- α at the concentration of 20 μg/mL Compounds 5i, 6b, and 7b had comparable in vivo antiinflammatory activity to the reference drug dexamethasone at the dose of 50 mg/kg. In addition,
several compounds showed antimicrobial activity against different strains, and compounds 5g and 5h exhibited potent inhibitory activities with the MIC value of 8 μg/mL against the Streptococcus pneumoniae CMCC 31968 and Staphylococcus aureus CMCC 25923, respectively. Compound 7b, which
exhibited both anti-inflammatory and antimicrobial activities, should be studied as it is or after derivatization. Conclusion: It can be concluded that pyrazoles, with (thio)-semicarbazone moieties, have the potential to be developed into new anti-inflammatory agents.
研究领域:
药理学
·
药物化学
·
传染病学
·
炎症研究
✓ 已验证
DOI
高影响因子
Foods
·
2024
·Vol. 13
·期 17
·2729
·
IF 4.7
Xiaoqing Xu,Lingling Du,Meng Wang,Ran Zhang,Junjie Shan,Yu Qiao,Qing Peng,Bo Shi
Agrobacteriumsp. are notable for their ability to produce substantial amounts of exopolysaccharides. Our study identified an exopolysaccharide (Galacan, 4982.327 kDa) fromAgrobacteriumsp. FN01. Galacan is a heteropolysaccharide primarily composed of glucose and galactose at a molar ratio of 25:1. The FT-IR results suggested that Galacan had typical absorption peaks of polysaccharide. The results of periodate oxidation, Smith degradation, and NMR confirmed the presence of structural units, such as β-D-Galp(→, →3)β-D-Galp(1→, →2,3)β-D-Glcp(1→, β-D-Glcp(1→, and →2)β-D-Glcp(1→. Galacan demonstrated significant biological activities. In experiments conducted with zebrafish, it facilitated the proliferation ofLactobacillus brevisin the intestinal tract, suggesting potential prebiotic properties. Moreover, in vivo studies revealed its antihyperglycemic effects, as evidenced by significant reductions in blood glucose levels and enhanced fluorescence intensity of pancreatic β cells in a streptozotocin (STZ)-induced hyperglycemic zebrafish model. Additionally, antiaging assays demonstrated Galacan’s ability to inhibit β-galactosidase activity and enhance telomerase activity in a hydrogen peroxide (HP)-induced aging zebrafish model. These findings emphasized the potential of Galacan as a natural prebiotic with promising applications in diabetes prevention and antiaging interventions.
研究领域:
微生物学
·
生物化学
·
药理学
·
分子生物学
·
水生生物学
✓ 已验证
DOI
PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2024
·
IF 3.8
Liangzhen Shu,Ya Lv,Zhongyin Chen,Yixian Huang,Meng Zhang,Zhichao Jin,Tingting Li,Yonggui Robin Chi
BACKGROUND Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, a class of planar chiral thiourea molecules through the key step of N -heterocyclic carbene-catalyzed nitrile formation reaction was synthesized with excellent optical purities for antiviral evaluations against plant virus PVY. RESULTS The absolute configurations of the planar chiral compounds exhibited obvious distinctions in the anti-PVY activities. Notability, compound ( S )- 4u exhibited remarkable curative activities against PVY, with a half maximal effective concentration (EC 50 ) of 349.3 μg mL −1 , which was lower than that of the ningnanmycin (NNM) (EC 50 = 400.8 μg mL −1 ). Additionally, The EC 50 value for the protective effects of ( S )- 4u was 146.2 μg mL −1 , which was superior to that of NNM (276.4 μg mL −1 ). Furthermore, the mechanism-of-action of enantiomers of planar chiral compound 4u was investigated through molecular docking, defensive enzyme activity tests and chlorophyll content tests. CONCLUSION Biological mechanism studies have demonstrated that the configuration of planar chiral target compounds plays a crucial role in the molecular interaction with PVY-CP, enhancing the activity of defense enzymes and affecting chlorophyll content. The current study has provided significant insights into the roles played by planar chiralities in plant protection against viruses. This paves the way for the development of novel green pesticides bearing planar chiralities with excellent optical purities. © 2024 Society of Chemical Industry.
研究领域:
植物病理学
·
有机化学
·
药学
·
生物化学
·
农业科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）