JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2019
·
IF 4.027
Wen-Jia Dan,Qiang Zhang,Fan Zhang,Wei-Wei Wang,Jin-Ming Gao
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging from 1.68 to 7.88 µM. Among all tested compounds, 7u was found to be the most efficient, being 32-fold more active than the standard drug acarbose, which significantly attenuated postprandial blood glucose in mice. In addition, the compound 7u also induced the fluorescence quenching and conformational changes of enzyme, by forming α-glucosidase–7u complex in a mixed inhibition type. The thermodynamic constants recognised the interaction between 7u and α-glucosidase and was an enthalpy-driven spontaneous exothermic reaction. The synchronous fluorescence and CD spectra also indicate that the compound 7u changed the enzyme conformation. The findings identify the binding interactions between new ligands and α-glucosidase and reveal the compound 7u as a potent α-glucosidase inhibitor.
研究领域:
药理学
·
有机化学
·
代谢疾病研究
✓ 已验证
DOI
PubMed
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2016
·Vol. 32
·期 1
·373-379
·
IF 0.844
QI Yan-Yu,SUN Xiao-Huan,CHANG Xing-Mao,KANG Rui,LIU Kai-Qiang,FANG Yu
A new and optically stable fluorescent derivative (OPBMQ) of 1,4-bis(phenylethynyl)benzene (BPEB) with 8-hydroxyquinoline (8-HQ) as a capturing unit and cholesterol (Chol) as an auxiliary structure was designed and synthesized. Fluorescence studies demonstrated that the fluorescence
emission of the compound in the aqueous phase is characterized by two distinct and independent emissions, of which one originates from 8-HQ and the other from BPEB. Importantly, the emission is highly selective and sensitive to the presence of diethyl chlorophosphate (DCP), a simulant of Sarin.
The calculated detection limit (DL) is lower than 1 × 10-9 mol·L-1. Moreover, no significant response was observed when the probe was exposed to simulants of other nerve agents, relevant organophosphorus pesticides, or even their mixtures. More importantly,
regardless of whether Milli-Q water, tap water or even sea water was employed as solvent, the presence of the mixture of the interferents studied did not show any significant effect on the detection of DCP. In particular, the sensitive and highly selective detection of DCP was also realized
by naked-eye observation, providing a simple and low-cost protocol for the on-site and real-time detection of the chemical. Based on this discovery, a DCP monitoring device was successfully developed.
研究领域:
有机化学
·
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 14
·1486-1494
·
IF 3.4
Chenqi Zhao,Penghua Yan,Ruofan Liu,Wei Li,Yushun Jin,Qisong shi,Yibo Wu
The cationic polymerization of isobutene vinyl ether(IBVE) contains waters system was achieved by using triphenylmethylium tetrakis-(pentafluorophenyl)borate [Ph 3 C][B(C 6 F 5 ) 4 ], which overcame the harsh experimental requirements of traditional cationic polymerization. The influences of water content, solvent polarity, and reaction temperature on polymerization were studied. The end structure of the polymer was analyzed by 1 H-NMR. Combined with the effect of the proton trapping agent and triethylamine salt which can trap [H + ], it was found that there was a reversible equilibrium between [Ph 3 C + ] and [H + ] active species during the polymerization process. The cationic polymerizations of isobutyl vinyl ether were initiated by these two active species simultaneously. The controllable cationic polymerization of isobutyl vinyl ether was achieved by the addition of ethyl methyl carbonate and ethyl benzoate. Gaussian 09 W simulation confirms the polymerization mechanism. Graphical
研究领域:
高分子化学
·
有机化学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 138
·期 11
·49992
·
IF 2.52
Xiaoying Wang,Lili Wang,Bingyan Sun,Xiaomeng Chu,Xuteng Xing,Shaojie Liu,Erjun Tang
In this work, the sulfonated polystyrene brushes were grafted onto magnetic nanoparticles to obtain recoverable catalysts for efficient synthesis of ethyl N-phenylformimidate. First, the surface modification of Fe 3 O 4 with a particle size of about 10 nm was performed with the silane coupling agent of vinyl triethoxysilane (SG-151) to obtain Fe 3 O 4 with carbon–carbon double bonds on the surface (SG-Fe 3 O 4 ). Subsequently, SG-Fe 3 O 4 , styrene (St) and chloromethyl styrene (CMSt) were polymerized to obtain the magnetic chloromethylated polystyrene sphere (SG-Fe 3 O 4 @PS-Cl) with core-shell structure by solution copolymerization. Using St as monomer and SG-Fe 3 O 4 @PS-Cl as macromolecular initiator, the magnetic polystyrene brush of SG-Fe 3 O 4 @PS-PSt was obtained by activated regenerated electron transfer catalyst atom transfer radical polymerization. Finally, SG-Fe 3 O 4 @PS-PSt was sulfonated with sulfuric acid to form a magnetic sulfonated polystyrene brush of SG-Fe 3 O 4 @PS-PSH. SG-Fe 3 O 4 @PS-PSH was used as a recoverable acid catalyst to synthesize ethyl N-phenylformimidate. Due to the high loading of the sulfonic acid group of this catalyst, its added amount was lower than other solid acids such as p-toluenesulfonic acid. The results showed that the catalytic performance of SG-Fe 3 O 4 @PS-PSH was better than p-toluenesulfonic acid and commercial macroporous sulfonic acid resin. The external magnetic field can directly recover SG-Fe 3 O 4 @PS-PSH, simplifying the recovery of catalyst and reducing the catalyst loss. After recycling, the yield of ethyl N-phenylformimidate was not significantly decreased.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
TALANTA
·
2019
·
IF 4.916
Hailin Cong,Jie Xing,Xin Ding,Shuai Zhang,Youqing Shen,Bing Yu
Monodisperse cross-linked poly (styrene-divinylbenzene) (P(S-DVB)) porous microspheres with a particle size of about 10 μm were obtained by using the improved two-step seed swelling polymerization method. The influence of different crosslinking degree on specific surface area of porous microparticles was carefully investigated. The surface morphology and pore structure of seed microspheres and porous microspheres were characterized by scanning electron microscopy (SEM), accelerated surface area and porosimetry analyzer. Porous P(S-DVB) microparticles were sulfonated and used as a hydrophilic column packing material for high performance liquid chromatography (HPLC). The separation of oxalic acid , formic acid , acetic acid and acrylic acid was achieved by using the sulfonated-P(S-DVB) particles as packing materials in HPLC. The back pressure of sulfonated-P(S-DVB) column could be maintained at especially low level even at high flow rates due to the excellent permeability of the fillers. Moreover, the separation of chiral drugs was successfully carried out by using the chitosan coated sulfonated-P(S-DVB) microspheres as a column packing material in HPLC. By using water soluble non-toxic photosensitive diazoresin (DR) as linker, a green and facile way to modify packing materials was developed.
研究领域:
化学
·
分析化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
SYNLETT
·
2018
·Vol. 29
·期 09
·1244-1248
·
IF 2.369
Xiangwen Kong,Lihua Liu,Siqin Luo,Shilu Fan,Haisheng Qian,Hua Xiao
A triphenylphosphine-promoted [3+2] cycloaddition of α,γ-bis-substituted allenoates and N-tosylaldimines followed by alkene isomerization was disclosed, affording a series of functionalized 2-pyrroline derivatives in moderate chemical yields with random diastereoselectivities.
研究领域:
有机化学
·
药物化学
·
合成方法学
·
杂环化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2020
·Vol. 58
·期 5
·756-765
·
IF 0
Miao Zhang,Nairong Hao,Yating Gao,Lianwei Li,Xiaodong Ye
Separation and characterization on mixed solutions of hyperbranched and linear polystyrenes was achieved using size-exclusion chromatography (SEC) as the first dimension and analytical ultracentrifugation (AUC) as the second dimension. The results show that linear and hyperbranched polystyrenes with similar hydrodynamic sizes (one fraction from SEC) can be separated by AUC according to the molar mass, and the separation efficiency decreases with the increasing of the retention volume in SEC. Moreover, the molar masses determined by AUC are consistent with the values measured by SEC-refractive index (RI) and SEC-multi-angle light scattering (MALS) detection. Furthermore, the result shows that the separation efficiency decreases with the increasing of the subchain length of hyperbranched polystyrenes. Our study lays a solid foundation for future studies to separate polymers with different topologies by a combination of SEC and AUC. Graphical Separation and characterization of mixed solutions of hyperbranched and linear polystyrenes has been achieved using size-exclusion chromatography (SEC) as the first dimension and analytical ultracentrifugation (AUC) as the second dimension. The results show that linear and hyperbranched polystyrenes with similar hydrodynamic sizes (one fraction from SEC) can be separated by AUC according to the molar mass, and the separation efficiency decreases with the increasing of the retention volume in SEC.
研究领域:
高分子化学
·
分析化学
✓ 已验证
DOI
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Jiangwei Ma,Huiqing Fan,Zhexin Li,Yuxin Jia,Arun Kumar Yadav,Guangzhi Dong,Weijia Wang,Wenqiang Dong,Shuren Wang
The flexible room-temperature gas sensors are highly desirable to apply in wearable and portable equipment owing to their wearability. The research mainly focuses on the gas-sensing materials and few studies paid attention to the conjunction between flexible substrates and sensing materials. In this work, the polyethylene terephthalate (PET) fibers substrate is modified by ethylenediamine (EDA) to expose the amino group on the surface (PET-NH 2 ). This method is simple, cost-efficient, and easy to operate. The positively charged amino group could interact with negatively charged carboxyl (−COOH) of multi-walled carbon nanotubes (MWCNTs) by electrostatic attraction. The EDA treatment on PET effectively strengthens the connection between the flexible PET substrate and gas sensing materials with carboxyl as evidenced by SEM images. After the in situ polymerization process, the polyaniline (PANI) is successfully decorated on the MWCNTs. The fabricated PET-NH 2 -MWCNTs/PANI sensor exhibits strongly enhanced ammonia (NH 3 ) sensing performance as compared to the PET-MWCNTs/PANI sensor without the EDA treatment. The results suggest that the EDA treatment is an effective method to conjunct between flexible substrates and sensing materials, which shows great potential in the field of flexible gas sensors.
研究领域:
材料科学
·
传感器技术
✓ 已验证
DOI
高影响因子
Journal of Sulfur Chemistry
·
2020
·
IF 1.963
Lin Yan,Jun Yang,Xu-Feng Liu,Yu-Long Li,Xing-Hai Liu,Zhong-Qing Jiang
In this article, two new binuclear iron compounds [Fe2(CO)5PPh(C6H11)2{µ-SCH2CH(CH2CH3)S}] (2) and [Fe2(CO)5PPh2(C6H11){µ-SCH2CH(CH2CH3)S}] (3), which can be regarded as the biomimics for the active site of [FeFe]-H2ases, have been synthesized by CO exchange of compound [Fe2(CO)6{μ-SCH2CH(CH2CH3)S}] (1) with cyclohexyldiph-enylphosphine or dicyclohexylphenylphosphine and their structures have been confirmed by spectroscopy, elemental analysis, and X-ray crystallography. They also exhibited good electrocatalytic activities for the generation of H2.
研究领域:
无机化学
·
材料科学
·
生物无机化学
✓ 已验证
DOI
高影响因子
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY
·
2014
·Vol. 40
·期 10
·764-767
·
IF 0.629
Li G. B.,Wang S. X.,Su W. Y.,Pan R. K.,Liu K. D.,Liu S. G.
A new cationic complex, [Co(Bpbp) 2 ](ClO 4 ) 2 · DMF · H 2 O, was synthesized by treatment Co(ClO 4 ) 2 · 6H 2 O with 2,6- bis (1-phenylbenzimidazol-2-yl)pyridine (Bpbp) in DMF solvent at room temperature. Its structure was characterized by element analysis, IR, and X-ray single crystal structure analyses (CIF file CCDC no. 970498). For complex, crystal system, triclinic, space group, \(P\bar \imath\) , a = 11.585(13), b = 13.939(16), c = 19.236(2) \(\mathop {\AA}\limits^\prime\) , α = 97.938(2)°, β = 102.814(2)°, γ = 90.556(2)°, V = 2861.1(6) Ǻ 3 , Z = 2. The Co 2+ ion octahedral geometry is coordinated by six nitrogen atoms from two ligand (Bpbp). The antiproliferative activities of the complex were screened by MTT assay against HepG2, Huh7, Eca109 and Eca9706 cancer cell. The complex exhibits inhibition on Eca9706 and Eca109 cancer cell but no HepG2 and Huh7 cancer cell.
研究领域:
无机化学
·
药物化学
·
肿瘤学
✓ 已验证
DOI
高影响因子
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
·
2021
·
IF 0.896
Xiangfei Kong,Ronggen Luo,Hongkang Gong,Dong Chen,Shijun Yang,Shiqing Li,Guixia Wang,Zhiqun He
A novel aggregation-induced emission active molecules (TP-Cn-PETPE, n = 4 and 10) were synthesized, which contain a tetraphenylethene derivative as the emission active moiety, a pentahexyloxytriphenylene core as the mesogenic unit and an alkoxy spacer. Experimental results revealed that these two compounds both had AIE properties, even in the liquid state at room temperature. While only TP-C4-PETPE showed a monotropic liquid crystal phase upon heating. In addition, these two compounds were fully characterized by 1H and 13C NMR, IR, EA and MS.
研究领域:
材料科学
·
化学
·
液晶
✓ 已验证
DOI
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 10
·5223-5229
·
IF 6.739
Xiaojun Liu,Ligui Li,Meixia Ye,Yang Xue,Shaowei Chen
Gold nanoparticles were stabilized by a polyaniline:poly(sodium 4-styrenesulfonate) (PANI:PSS) matrix and readily dispersed in water over a wide range of pH. In contrast to nanoparticles passivated by alkanethiolates that formed a compact capping layer on the nanoparticle surface, the PANI:PSS–Au nanocomposites exhibited apparent catalytic activity in the reduction of 4-nitrophenol in the presence of excessive NaBH4, with reasonably good recyclability, which was likely due to the large accessible surface area. In addition, the PANI:PSS–Au nanocomposites also demonstrated peroxidase-like catalytic activity as evidenced by the colorimetric detection of H2O2 and glucose with PANI:PSS–Au as the enzymatic mimic. The present method may find potential applications in the design, preparation and functionalization of noble nanoparticles as efficient, versatile, and recyclable catalysts with high dispersibility and stability in aqueous media.
研究领域:
材料科学
·
催化化学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）