DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Xiaoqin Chu,Xingqi Wang,Chunling Tian,Liu Liu,Mengqiu Xia,Jianqin Jiang,Shuangying Gui
The goal of this paper was to develop and evaluate dual component-loaded with the hydrophilic sinomenine hydrochloride (SH) and lipophilic cinnamaldehyde (CA) cubic liquid crystal gels for transdermal delivery. The gels was prepared with a vortex method using phytantriol/water (70:30, w/w) and characterized by polarized light microscopy, small-angle X-ray scattering and rheology. The inner structure of the gels were Pn3m cubic phase and exhibited a pseudoplastic fluid behavior. Furthermore, the in vitro release profile showed that the release behavior of the two drugs from cubic liquid crystal gels conformed to Higuchi equation and were dominated by Fick’s diffusion (n < 0.45). The ex vivo penetration experiment indicated that dual components-loaded liquid crystal gels can enhance and extend the skin permeation of these two drugs, especially the ratio of SH to CA is 1: 0.5. Finally, transdermal mechanisms were evaluated using laser scanning confocal microscopy and attenuated total reflectance-fourier transform infrared, hinting that hydrophilic and lipophilic drugs weaken each other’s transdermal velocity at the initial stage of penetration. In short, the dual drug-loaded liquid crystal gels was a promising strategy for transdermal applications in treatment of chronic disease.
研究领域:
药剂学
·
药物递送系统
·
材料科学
·
生物物理学
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Kun Jiang,Kai Li,Yun-Quan Liu,Shixiang Lin,Zhaolin Wang,Duo Wang,Yueyuan Ye
The generation of hydrogen from water electrolysis has been widely studied as a power-to-gas pathway for the change of energy consumption system, and has attracted a lot of scientific interest over the past several decades. However, the sluggish anodic oxygen evolution reaction (OER) leads to high overpotential in the electrolytic process. Therefore, using ammonia electrolysis to replace water splitting was recently considered as an advisable method for getting pure hydrogen, as ammonia electrocatalytic decomposition is thermodynamically more energy efficient than water splitting. Thus, in this work, a nanostructured transition metal binary (rather than the most widely used noble metals) deposited on nickel foam was developed through a hydrothermal method. The nickel-cobalt bimetallic catalyst was then further fabricated through the nitridation process annealed in an ammonia atmosphere at high temperatures to prepare nickel-cobalt nitride, which substantiated an optimal electrochemical performance on hydrogen evolution reaction (HER) in an alkaline ammonia system. The electrochemical tests indicated that the 1D nanoneedle nickel-cobalt nitride electrode offers favorable surface area and active sites leading to the hydrogen evolution onset potential close to zero, the overpotential 74 mV at 10 mA•cm −2 , 138 mV at 100mA•cm −2 , and the Tafel slope 67 mV/dec. In addition, it also demonstrated an excellent stability in long-term running, with the hydrogen generation rate slightly reduced after 10 h of chronoamperometry measurements. Moreover, the potential of ammonia electrolysis was 0.71 V at 100 mA•cm −2 in a two-electrodes system, lower than that of water splitting, suggesting the hydrogen production from ammonia electrolysis could be a promising alternative to water splitting.
研究领域:
电化学
·
材料科学
·
能源存储与转换
✓ 已验证
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2014
·
IF 2.829
Feng Chen,Hai-Long Li,Yin-Feng Tan,Yong-Hui Li,Wei-Yong Lai,Wei-Wei Guan,Jun-Qing Zhang,Yuan-Sheng Zhao,Zhen-Miao Qin
Alpinia oxyphylla (Yizhi) capsularfruits are commonly used in traditional medicine. Pharmacological studies have demonstrated that A. oxyphylla capsularfruits have some beneficial roles. Besides volatile oil, sesquiterpenes, diarylheptanoids and flavonoids are main bioactive constituents occurring in the Yizhi capsularfruits. The representative constituents include tectochrysin, izalpinin, chrysin, apigenin-4′,7-dimethylether, kaempferide, yakuchinone A, yakuchinone B, oxyphyllacinol and nootkatone. Their content levels in the fruit and its pharmaceutical preparations have been reported by our group. The nine phytochemicals are also the major components present in the Yizhi alcoholic extracts, which have anti-diarrheal activities. However, the fates of these constituents in the body after oral or intravenous administration remain largely unknown. In the present study, we focus on these phytochemicals albeit other concomitant compounds. The chemicals and their metabolites in rat plasma were identified using liquid chromatography/tandem mass spectrometry with selected reaction monitoring mode after orally administered Yizhi extract to rats. Rat plasma samples were treated by methanol precipitation, acidic or enzymatic hydrolysis. This target analysis study revealed that: (1) low or trace plasma levels of parent chemicals were measured after p.o. administration of Yizhi extract, Suoquan capsules and pills to rats; (2) flavonoids and diarylheptanoids formed mainly monoglucuronide metabolites; however, diglucuronide metabolites for chrysin, izalpinin and kaempferide were also detected; (3) metabolic reduction of Yizhi diarylheptanoids occurred in rats. Yakuchinone B was reduced to yakuchinone A and then to oxyphyllacinol in a stepwise manner and subsequently glucuronidated by UDP-glucuronosyl transferase. Further research is needed to characterize the UDP-glucuronosyl transferase and reductase involved in the biotransformation of Yizhi chemicals.
研究领域:
药理学
·
分析化学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Saiya Guo,Huihui Li,Manman Shi,Qianqian Zhu,Jieding Wei,Qingqing Zha,Yonghong Ni
Layered double hydroxides (LDH) have attracted great research interest as catalysts for electrochemical water splitting. However, further enhancing the electrocatalytic activity of LDH materials is still a huge challenge. Here, we designed a mild wet chemical route to successfully prepare conductive metal-organic frameworks (cMOFs) modified hollow CoNiFe-LDH nanocages.Firstly, ZIF-67 nanocubes were etched by Ni 2+ and Fe 3+ ions in turn to form hollow CoNiFe-LDH nanocages. Then, hollow CoNiFe-LDH nanocages reacted with 2,3,6,7,10,11hexahydroxytriphenylene (HHTP) to obtain cMOFs modified hollow CoNiFe-LDH nanocages (labeled as CoNiFe-HHTP). Electrochemical measurements showed that the as-obtained CoNiFe-HHTP exhibited excellent electrocatalytic oxygen evolution reaction (OER) performances. In 1 M KOH solution, the as-obtained CoNiFe-HHTP merely required 209 mV overpotential to deliver a current density of 10 mA cm -2 , with a low Tafel slope of 36.81 mV dec -1 . Also, the as-obtained CoNiFe-HHTP could stably run more than 240 h at a current density of 10 mA cm -2 , exhibiting superb long-term stability. The present work provides a promising strategy to promote the electrocatalytic activity of cheap transition metal LDH materials for electrochemical water decomposition.
研究领域:
材料科学
·
电化学
·
纳米技术
·
催化
·
能量转换
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Min Li,Sheng-Xia Yang,Yu-Feng Liu,Ya-Nan Zhou,Hai-Jun Liu,Xin-Yu Zhang,Bin Dong,Qun-Wei Tang
The hydrogen evolution reaction (HER) process of metal hydroxides is significantly limited by weak hydrogen adsorption and requires a large overpotential. This study presents coordination engineering strategy to activate inert copper hydroxide through the introduction of stoichiometric nitrate ligands (CuHN). Nitrate and Cu are coordinated in an atomic ratio of 1 to 2, leading to expanded lattice space compared to conventional Cu hydroxide. This modification facilitated the successful doping of numerous Co atoms to synthesize the Co-CuHN sample, which works synergistically with nitrate to enhance HER activity. Experimental and theoretical analyses demonstrate that nitrate and Co provide electrons to Cu, thereby modulating the d-band center and surface adsorption capability. Compared to Cu(OH) 2 , Co-CuHN exhibits a reduced water dissociation energy barrier of 0.54 eV, supplying abundant protons for hydrogen generation. Notably, the Gibbs free energy of hydrogen adsorption is optimized to approach zero. Consequently, Co-CuHN demonstrates a small Tafel slope of 40.0 mV dec −1 and requires a low overpotential of 18 mV (10 mA cm −2 ), which is 99 mV lower than control Cu(OH) 2 . This work is expected to provide a deeper understanding of anion coordination regulation of copper hydroxide.
研究领域:
电化学
·
材料科学
·
催化
·
纳米技术
·
能量转换
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
·
2025
·
IF 2
Chunying Xu,Chengbao Liu,Peimin Hou,Li Cheng
Coating microdamage and interfacial corrosion are inevitable for the metal/coating system during service, leading to the premature failure of the equipment and posing significant safety hazards. However, challenges remain regarding the achievement of early detection of corrosion and the visual monitoring of damage. Herein, a novel polymeric coating system exhibiting robust capabilities for corrosion sensing and visualization has been developed through the combination of meticulously designed nanosensors. These nanosensors were synthesized utilizing a zeolitic imidazolate framework that is infused with phenanthroline (Phen) corrosion probes. The onset of metal corrosion at the interface of coating damage can be promptly sensed and reflected by an apparent orange-red color, attributing to the formation of Phen-Fe 2+ coordinates. The impermeability and corrosion resistance of the epoxy coating have been greatly improved through introducing the synthesized nanosensors. This straightforward yet powerful strategy based on elaborate nanosensors, offering a new perspective for design of multifunctional and long-life protective materials.
研究领域:
材料科学
·
纳米技术
·
表面工程
·
腐蚀科学
·
智能涂层
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Jie Song,Yingnan Zhou,Lijun Chen,Zhiwen Yuan,Yuhua Niu,Xi Li,Liangxian Huang
This study employed β-cyclodextrin (β-CD) for the hydrophilic modification of iron tetraoxide (Fe3O4) magnetic materials. Subsequently, potassium humate (KHA) and carboxymethyl cellulose (CMC) were used as raw materials. A β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel with magnetic properties which can be easily recycled was synthesized for the slow release of glyphosate (GLY). FTIR, XRD, TG and VSM analyses demonstrated that the hydrogel possesses good thermal stability and magnetic properties with a saturation magnetization strength of 29.77 emu g−1. The equilibrium solubility of the hydrogel in pH = 7.4 and pH = 8.5 buffer was 24.58 g g−1 and 25.83 g g−1, respectively. The maximum release of GLY was recorded at 63.31% and 67.78%, with the drug release behavior under different loading gels following the Fickian diffusion mechanism. A pot planting experiment indicated that the water content of plants treated with the β-CD@Fe3O4/KHA/CMC/AM/MAH drug-loaded gel decreased by 51.69%. Additionally, soluble protein levels decreased to 2.69 mg g−1, chlorophyll content decreased to 0.486 mg g−1, SOD levels decreased to 43.81 U g−1, and MDA increased to 4.02 μmol g−1, effectively inhibiting the growth of grass and providing a theoretical basis for achieving slow drug release.
研究领域:
材料科学
·
高分子科学
·
环境科学
·
农业化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Yang Wang,Zhen Cao,Huai Lan,Bo Li,Qingmei Chen
Developing boosting as well as stable catalysts toward the oxygen evolution reaction (OER) is crucial for environmentally friendly hydrogen evolution via water decomposition. Herein, we report 3D CoMoO 4 /Ni 3 S 2 heterostructure constructed by sequential hydrothermal strategy to synergistically enhance OER capability and kinetics. In 1 M KOH, the CoMoNiS@NF exhibits efficient alkaline OER capability with ultralow overpotentials of 152 mV to achieve 100 mA cm −2 , surpassing CoMo@NF (384 mV), commercial RuO 2 @NF (500 mV), and NF (590 mV), with a Tafel slope of 46.5 mV dec −1 . In addition, it also demonstrates efficient OER capability with overpotentials of 445 mV and 1.3 V to achieve 100 and 20 mA cm −2 in 0.5 M H 2 SO 4 and 0.01 M PBS, respectively. From DFT calculations, it is noticed that this heterojunction accelerates charge transfer by forming a Schottky barrier through the close interface coupling between CoMoO 4 nanorods and Ni 3 S 2 nanosheets, thereby enhancing performance. Besides, regardless of the medium, the LSV curves do not change significantly after 300 CV cycles, further indicating the stable existence of the heterostructure interface during the catalytic process. This work provides a robust strategy for engineering heterostructured OER catalysts via interfacial electronic control.
研究领域:
材料科学
·
电化学
·
能量转换
·
纳米材料
·
催化
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Luyang Zuo,Huan Yang,Huirong Li,Yiwen Zhang,Linmei Gao,Yuxin Zhang,Fang Wang
Magneto–photo coupling offers a promising strategy to enhance the oxygen evolution reaction (OER) for efficient energy conversion. Here, a synergistic approach that integrates an external magnetic field with visible-light irradiation to regulate the electronic structure of hollow NiCo 2 O 4 microboxes is demonstrated. The unique hollow cubic architecture, assembled from 2D nanosheets, ensures abundant active sites and robust structural stability. Magnetic stimulation induces non-collinear spin reorientation and enhanced spin polarization, increasing the electronic density of states near the Fermi level to facilitate charge transport and optimize intermediate adsorption. Concurrently, light irradiation generates photocarriers that accelerate charge separation and reaction kinetics. Benefiting from this synergy, the catalyst delivers a 204.4 mV reduction in overpotential at 10 mA·cm −2 and a 115.8 mV·dec −1 improvement in Tafel slope, demonstrating superior activity and long-term stability. First-principles calculations confirm that the cooperative effect of magnetic and light fields optimizes intermediate adsorption and reduces energy barriers, thereby accelerating OER kinetics. This study highlights the unique advantages of magneto–photo coupling in electrocatalysis and provides insights into designing responsive catalysts and advancing multi-field coupling strategies for next-generation electrochemical energy technologies.
研究领域:
电催化
·
材料科学
·
能量转换
·
纳米材料
·
多场耦合
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yang Nan,Tianpeng Liu,Wenhao Liu,Dong Cao,Daojian Cheng
Constructing highly active and noble metal-free electrocatalysts is significant for the anodic oxygen evolution reaction (OER). Herein, uniform carbon-coated CoP nanospheres (CoP/C) are developed by a direct impregnation coupling phosphorization approach. Importantly, CoP/C only takes a small overpotential of 230 mV at the current density of 10 mA cm–2 and displays a Tafel slope of 56.87 mV dec–1. Furthermore, the intrinsic activity of CoP/C is 21.44 times better than that of commercial RuO2 under an overpotential of 260 mV. In situ Raman spectroscopy studies revealed that a large number of generated Co–O and Co–OH species could facilitate the *OH adsorption, effectively accelerating the reaction kinetics. Meanwhile, the carbon shell with a large number of mesoporous pores acts as the chainmail of CoP, which could improve the active surface area of the catalyst and prevent the Co sites from oxidative dissolution. This work provides a facile and effective reference for the development of highly active and stable OER catalysts.
研究领域:
材料科学
·
电化学
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2021
·Vol. 17
·期 13
·2007858
·
IF 13.281
Qiming Chen,Qicheng Zhang,Huibin Liu,Junmei Liang,Wenchao Peng,Yang Li,Fengbao Zhang,Xiaobin Fan
Transition metal phosphides (TMPs), especially the dual-metal TMPs, are highly active non-precious metal oxygen evolution reaction (OER) electrocatalysts. Herein, an interesting atom migration phenomenon induced by Kirkendall effect is reported for the preparation of cobalt–iron (Co–Fe) phosphides by the direct phosphorization of Co–Fe alloys. The compositions and distributions of the Co and Fe phosphides phases on the surfaces of the electrocatalysts can be readily controlled by Co x Fe y alloys precursors and the phosphorization process with interesting atom migration phenomenon. The optimized Co 7 Fe 3 phosphides exhibit a low overpotential of 225 mV at 10 mA cm −2 in 1 m KOH alkaline media, with a small Tafel slope of 37.88 mV dec −1 and excellent durability. It only requires a voltage of 1.56 V to drive the current density of 10 mA cm −2 when used as both anode and cathode for overall water splitting. This work opens a new strategy to controllable preparation of dual-metal TMPs with designed phosphides active sites for enhanced OER and overall water splitting.
研究领域:
材料科学
·
电化学
·
纳米技术
·
催化
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 16
·1216
·
IF 4.3
Ting Yang,Aiyi Dong,Weimin Liao,Xun Zhang,Yinhua Ma,Li Che,Honglin Gao
Hydrogen production by the electrolysis of water has become an important way to prepare green hydrogen because of its simple process and high product purity. However, the oxygen evolution reaction (OER) in the electrolysis process has a high overpotential, which leads to the increase of energy consumption. Developing efficient, stable and low-cost electrolytic water catalyst is the core challenge to reduce the reaction energy barrier and improve the energy conversion efficiency. CoS@NiS-80% nanosheets with rich heterogeneous interfaces were successfully synthesized by hydrothermal reaction and sulfuration. Heterogeneous interface not only promotes the effective charge transfer between different materials and reduces the charge transfer resistance but also accelerates the four-electron transfer process through the synergistic effect of nickel and cobalt atoms. Under alkaline conditions, the overpotential of CoS@NiS-80% nanosheets was only 280 mV at a current density of 10 mA cm−2, with a Tafel slope of 100.87 mV dec−1. Furthermore, it could work continuously for 100 h, exhibiting its outstanding stability. This work provides a novel approach for improving the OER performance of transition metal sulfide-based electrocatalysts through heterogeneous interface engineering.
研究领域:
材料科学
·
电化学
·
能量转换
·
纳米材料
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）