JOM
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2026
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IF 2.3
Deng Chuheng,Qin Yufeng,Shen Yi,Rao Longshi,Wang Shuangxi
Metallized ceramic substrates are essential for power electronics, offering superior thermal and electrical conductivity. However, traditional metallization techniques, such as thick printed copper (TPC), face significant challenges, including weak bonding strength, high sintering temperatures, and complications associated with glass frit, which ultimately compromise device reliability and performance. To address these issues, this study presents an efficient method for fabricating high-performance copper (Cu) films on Al 2 O 3 ceramic substrates using low-temperature, pressureless sintering. By incorporating a magnetron-sputtered copper interlayer combined with printed copper paste, we eliminate the need for glass frit, a conventional component that often introduces defects. Through careful optimization of copper powder synthesis and paste formulation, we achieved dense, low-porosity Cu films sintered at just 300°C, which demonstrate exceptional electrical conductivity (1.7 × 10 7 S m −1 ) and shear strength (31.5 MPa). The sputtered copper interlayer significantly enhances the adhesion between the copper film and the ceramic substrate, minimizing delamination and improving mechanical integrity when compared to traditional sintering methods. This approach addresses key challenges in power device packaging, providing a cost-effective, reliable solution for low-temperature, high-performance interconnections. The results have wide-reaching implications for advancing electronic packaging, especially in power electronics, by enabling durable, efficient, and scalable manufacturing processes.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Haijun Wu,Shenggui Ma,Dianhang Wei,Yaolin Wang,Quanwei Lv,Ziheng Jin,Xinrui Wang,Xin Tu,Xia Jiang
A strategy for plasma-coupled O v -rich catalytic hydrogen production is proposed. • The catalyst shows high activity and universality for hydrogen production. • Synergistic cascade from plasma dissociation to catalytic surface reforming. • The key mechanism of “hydrogen promotion and anti-coking” were revealed. Hydrogen production from plastics contributes to the circular economy by enabling both waste valorisation and green energy generation. Integrated pyrolysis-plasma catalytic technology offers notable advantages in improving hydrogen production, but it still faces challenges such as catalyst coking and limited understanding of the reaction mechanisms. This study proposes a water vapor plasma-coupled oxygen vacancy-rich (O v -rich) catalytic strategy to systematically investigate the improved hydrogen production from plastics over an anti-coking catalyst. The results show that the O v -rich catalyst exhibits outstanding hydrogen production activity, strong synergistic effect, and universality in the non-thermal plasma catalytic (NTP-C) reforming reaction of mixed model compounds in plastic pyrolysis oil. Crucially, its practical effectiveness was successfully validated in the NTP-C reforming of polyethylene (PE)/polypropylene (PP) pyrolysis oils. Moreover, the O v -rich catalysts significantly inhibited coking and maintained good stability for 1800 min in a multi-component mixed system. The mechanisms of hydrogen production and coking inhibition were revealed via Density Functional Theory (DFT) calculations, in situ plasma-coupled Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), and Optical Emission Spectroscopy (OES). A synergistic reaction pathway, coupling plasma gas-phase dissociation with catalytic surface reforming, was identified as a key mechanism for enhancing hydrogen yield in plasma-catalytic systems. The study offers valuable insights for advancing plasma-assisted hydrogen production technologies. Download: Download high-res image (150KB) Download: Download full-size image
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Ding Qian,Liu Shijie,Lin Kai,Zhao Lijun,Lee Jong-Hoon,Li Miaoyun,Liang Dong,Zhu Yaodi,Ma Yangyang
In this study, chicken was used as the base material, and a combination of fermentation regulation and whole egg incorporation was applied to systematically investigate the effects of protein degradation degree and whole egg synergism on the quality of chicken mince gels. First, chicken mince models with different degrees of protein degradation were constructed by controlling fermentation time. The degradation characteristics were evaluated by measuring pH, trichloroacetic acid (TCA)-soluble peptides, total volatile basic nitrogen (TVB-N), and SDS-PAGE, together with sensory evaluation to assess structural and flavor changes. Subsequently, composite gels were prepared by adding 10%, 20%, and 30% whole egg to the fermented chicken mince. The texture profile analysis (TPA), water-holding capacity (WHC), and cooking loss were systematically determined. The results showed that moderate protein degradation reduced gel hardness while generating a protein matrix suitable for subsequent gel modification. Whole egg incorporation subsequently improved gel texture, enhanced water-holding capacity, and reduced cooking loss, with the 30% addition level exhibiting the best overall quality. The addition of whole egg further optimized the gel network structure, increased gel strength, and reduced cooking loss, with the 30% addition level exhibiting the best overall quality. Finally, the swallowing properties were evaluated based on the International Dysphagia Diet Standardization Initiative (IDDSI). The results indicated that the optimized composite gels met the dietary requirements for individuals with dysphagia. Overall, this study elucidates the synergistic mechanism of protein degradation and whole egg incorporation in regulating the quality of chicken mince gels, providing a theoretical basis and technical support for the development of high-protein, animal-based gel foods tailored for dysphagia patients and the elderly population.
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Nature Water
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2026
·
IF 30.7
Liu Fu,Hao Fengkun,Sun Mingzi,Wang Helin,Yao Ning,Wang Yunhao,Wang Juan,Chen Peng,Ma Xintao,Zhou Jingwen,Xiong Yuecheng,Ma Yangbo,Wang Guozhi,Guo Liang,Meng Xiang,Shao Mingzheng,Wang Chaohui,Wang Miao,Qian Fangren,Ye Chenliang,Xi Shibo,Huang Bolong,Fan Zhanxi
Phase control of alloy nanomaterials can modulate their atomic/electronic structures towards various electrocatalytic applications. However, the controlled synthesis of high-entropy nanoalloys (HENAs) with unconventional phase remains challenging. Here we report the one-pot synthesis of RhCuNiInSb HENAs with the unconventional 2H phase through regulating the nucleation/growth kinetics. Compared with the face-centred cubic phase counterpart, 2H RhCuNiInSb HENAs exhibit superior electrocatalytic nitrate reduction performance at low nitrate concentration. Ex/in situ studies reveal the accelerated deoxygenation/hydrogenation kinetics and distinct reaction pathway. Theoretical calculations demonstrate the electronic optimizations induced by the face-centred-cubic-to-2H phase transition, where the electronic redistribution and p – d elemental interactions improve the surface electroactivity. When operated in flow cell, 0.5 l of simulated wastewater can be efficiently converted into the value-added ammonia-derived product within 10 h. With a 20-h electrolysis, the NO 3 − -N concentration in real industrial and agricultural wastewater can be both reduced above the World Health Organization standard for drinking water.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2026
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IF 2.6
Zheng Weiping,Xia Wenjun,Li Kangyuan,Wang Jingting,Hao Lifeng
A dual-interface engineering strategy is proposed to exploit the anticorrosion potential of cerium oxide fillers by combining an oxygen-vacancy-rich porous core with a fluorinated superhydrophobic shell. Porous CeO 2 (P-CeO 2 ) is synthesized via a P123-templated hydrothermal process and then functionalized with perfluoroalkyl silane to form fluorinated porous CeO 2 (F-CeO 2 ). Conventional CeO 2 , P-CeO 2 , and F-CeO 2 are dispersed into a fluorocarbon resin to prepare composite coatings at different filler loadings. Characterization confirms that fluorination preserves the mesoporous fluorite framework while converting the surface from hydrophilic to superhydrophobic (water contact angle 164°) and promoting an oxygen‑vacancy-enriched surface character. The fluorinated porous particles also show improved colloidal stability in xylene, enabling homogeneous dispersion in the coating matrix. Electrochemical tests in 3.5 wt.% NaCl identify 1.0 wt.% F-CeO 2 as the optimal formulation: The corrosion current density decreases from 5.226 μA·cm −2 for the neat resin to 0.00353 μA·cm −2 , corresponding to 99.93% inhibition efficiency and exceeding coatings with conventional CeO 2 (91.50%) or P-CeO 2 (94.03%). Electrochemical impedance spectroscopy shows that this coating maintains near-ideal capacitive behavior over 21 days of immersion, with coating and double-layer constant-phase exponents remaining ~ 0.92-1.00; a diffusion-controlled Warburg element emerges only after prolonged exposure, indicating delayed electrolyte access to the metal/coating interface. AFM and XRD support a synergistic mechanism in which the fluorinated shell suppresses wetting and ion ingress, while the oxygen-vacancy-rich porous core promotes active passivation. Here, the “dual-functional” design refers to the integration of a superhydrophobic physical barrier provided by the fluorinated shell and a chemical passivation effect induced by oxygen vacancies in the CeO 2 core, which operate synergistically to enhance corrosion resistance. This dual-interface design makes F-CeO 2 an efficient bifunctional filler for durable anticorrosion fluorocarbon coatings. Overall, the approach improves barrier integrity, durability under chloride attack.
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ELECTROCHIMICA ACTA
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2026
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IF 5.8
Yuting Zhang,Jia He,Shanshan Zhang,Qi Lin,Jieping Cao,Zhenping Liu,Huikai Shao,Jinxian Huang
A thiolated graphene/AuNPs nanointerface was constructed to enhance electron transfer. • An electropolymerized EMIP layer enabled selective epitope-based recognition of AFP. • A sensitive epitope-imprinted electrochemical biosensor was developed for AFP analysis. • The sensor exhibited a wide linear range (0.001–100.0 ng mL −1 ) and a low LOD of 0.069 pg mL −1 . • The biosensor enabled reliable AFP determination in spiked human plasma samples. Alpha-fetoprotein (AFP) is a clinically important serum biomarker for the early diagnosis of hepatocellular carcinoma. However, conventional AFP detection methods often suffer from limited sensitivity, selectivity and operational complexity. In this work, an electrochemical biosensor based on an epitope molecularly imprinted polymer (EMIP) was developed for the sensitive and selective determination of AFP. The sensing interface was constructed by electropolymerization of o -phenylenediamine ( o -PD) on a gold electrode sequentially modified with thiolated graphene (G–SH) and gold nanoparticles (AuNPs), using the AFP C-terminal dodecapeptide (KLISKTRAALGV) as the epitope template. The excellent analytical performance of the biosensor can be attributed to the synergistic integration of the EMIP recognition layer, G–SH, and AuNPs, which provide highly selective molecular recognition, an enlarged electroactive surface area and accelerated interfacial electron transfer. Under the optimized conditions, the proposed biosensor exhibited a wide linear range of 0.001–100.0 ng mL −1 , and a low detection limit of 0.069 pg mL −1 , together with excellent selectivity against NMP22, bovine serum albumin (BSA), human serum albumin (HSA), and neuron-specific enolase (NSE), good reproducibility, and satisfactory storage stability. Satisfactory recoveries obtained in spiked human plasma samples demonstrated its potential applicability for AFP determination in complex biological matrices. This work provides a sensitive and robust platform for AFP determination and highlights the potential of epitope-imprinted electrochemical biosensors for hepatocellular carcinoma screening and clinical biomarker monitoring. An epitope-imprinted electrochemical biosensor integrating an electropolymerized EMIP film with a thiolated graphene/AuNPs nanointerface was developed for AFP detection. The biosensor combines highly selective molecular recognition with enhanced electron transfer, achieving a 0.069 pg mL −1 detection limit and successful analysis of spiked human plasma samples. Download: Download high-res image (303KB) Download: Download full-size image
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Luoyuan Shi,Xinying Jiang,Shuang Sun,Chunping Jia,Xiaojun Bian,Jianlong Zhao
Rapid and reliable detection of foodborne pathogens is essential for ensuring food safety, yet achieving high selectivity and sensitivity in complex matrices remains challenging. Herein, we report a sensitive and selective electrochemical sensing platform integrating a bacteria-imprinted polymer (BIP) capture interface with concanavalin A-functionalized Fe 3 O 4 (Fe 3 O 4 -ConA) for the detection of Escherichia coli O157:H7 ( E. coli O157:H7). The BIP film was electropolymerized in situ on glassy carbon electrode to generate recognition sites for efficient capture of E. coli O157:H7. Subsequently, Fe 3 O 4 -ConA bound to surface glycans on the captured bacteria through lectin-glycan interactions, forming a sandwich-like sensing interface. The anchored Fe 3 O 4 nanozyme catalyzed the H 2 O 2 -mediated oxidation of o -phenylenediamine, producing amplified electrochemical signals for bacterial quantification. Benefiting from the combination of imprinting-based recognition and catalytic amplification, the sensor achieved an ultrasensitive detection limit of 2.8 CFU mL −1 and a linear range from 10 1 to 10 5 CFU mL −1 . Recoveries of 93.29–113.62% were obtained in spiked milk, fish, and juice samples, with reliable detection down to 10 CFU mL −1 in complex food matrices. This work provides an effective strategy for constructing nanozyme-amplified electrochemical sensors for sensitive and selective monitoring of foodborne pathogens.
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Micromachines
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2026
·Vol. 17
·期 8
·966
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IF 3.5
Ke Wang,Mingna Xie,Yuyang Zhao,Jiuyi Wang,Leilei Zeng,Xiaogang Lin,Jie Jayne Wu
Acrylamide (AA) is a common contaminant in foods processed at high temperatures and has attracted significant attention due to its potential neurotoxicity and carcinogenicity. Therefore, the development of a highly sensitive, highly selective sensing technology suitable for on-site detection is of great importance for ensuring food safety. In this study, an aptamer (Apt)-based capacitive AA sensor was developed based on the alternating current electrokinetics (ACEK) effect. The sensor utilizes an aptamer as the biomimetic recognition element, which can specifically recognize AA, thereby enabling quantitative detection. Additionally, a detachable detection fixture and data acquisition system were designed to enhance the detection stability and convenience of sensor. Within the linear range of 1 nmol/L to 10 µmol/L, the sensor response (dC/dt) exhibited a good linear relationship with AA concentration, with a detection limit as low as 0.4235 nmol/L. The sensor exhibits good selectivity toward structural analogs of AA, with a recovery relative standard deviations (RSDs) of less than 5.42% in spiked coffee samples. This portable detection system provides a sensitive and user-friendly tool for the analysis of acrylamide in food and holds great potential for application in food safety.
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Letters in Drug Design & Discovery
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2026
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IF 1.6
Chunxiu Tian,Ruihua Wang,Yuewei Li,Yuxia Gao
Background Atherosclerosis is a leading cause of cardiovascular morbidity and mortality. It is initiated by endothelial injury and progresses through persistent oxidative stress, endothelial senescence, and macrophage foam cell formation. Although current therapies primarily target lipid metabolism and inflammation, effective strategies that catalytically eliminate reactive oxygen species (ROS) and alleviate vascular senescence remain limited. Objective This study aimed to develop biocompatible copper indium selenium nanozymes (CIS NPs) with antioxidant enzyme-mimicking activities and evaluate their therapeutic potential against oxidative stress, cellular senescence, and atherosclerosis progression. Methods CIS NPs were synthesized and comprehensively characterized for morphology, crystallinity, elemental composition, and colloidal stability. Their superoxide dismutase (SOD)- and glutathione peroxidase (GPx)-like catalytic activities were evaluated in cell-free systems. The antioxidant and anti-senescent effects of CIS NPs were investigated in hydrogen peroxide-induced human umbilical vein endothelial cells (HUVECs). Their effects on foam cell formation were assessed in RAW 264.7 macrophages using Dil-oxLDL uptake and Oil Red O staining. Therapeutic efficacy and biosafety were further evaluated in high-fat diet-fed ApoE -/- mice. Results CIS NPs exhibited dual SOD- and GPx-like catalytic activities, enabling sequential scavenging of superoxide anion (O 2 • − ) and hydrogen peroxide (H 2 O 2) . In HUVECs, CIS NPs significantly reduced intracellular ROS levels, attenuated oxidative injury, and alleviated cellular senescence, as evidenced by decreased SA-β-gal staining. In RAW 264.7 macrophages, CIS NPs reduced Dil-oxLDL uptake and lipid accumulation, thereby suppressing foam cell formation. In ApoE -/- mice, repeated intravenous administration of CIS NPs markedly decreased atherosclerotic plaque burden, vascular ROS accumulation, and senescent cell abundance, without obvious abnormalities in the preliminary histological, biochemical, and hemolysis assessments. Conclusions CIS NPs function as efficient antioxidant nanozymes that mitigate oxidative stress, endothelial senescence, and macrophage foam cell formation. By targeting multiple pathological processes involved in atherosclerosis, CIS NPs effectively attenuate disease progression in vivo and represent a promising nanotherapeutic strategy for the prevention and treatment of atherosclerosis.
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Advanced Science
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2026
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IF 14.1
Hongyi Zhang,Jinwei Li,Shan Hua,Shengming Wu,Chenlong He,Yuan Zhu,Ming Yin,Han Zhou,Huawei Liu,Chika Hasegawa,Jun Lyu,Keyue Xiao,Hua Jiang,Yilong Wang,Yuxin Qian
During skin wound healing, complex interactions among multiple cell types and dynamic phase evolution make it difficult for biomaterial scaffolds to balance late‐healing and over‐healing, often resulting in delayed wound healing, persistent inflammatory responses, and hypertrophic scars due to spatiotemporal mismatch. Precise regulation of fibroblast‐to‐myofibroblast transformation and macrophage polarization is therefore essential yet challenging. Fibroblast activation protein (FAP) has been identified as a key bio‐cue in pulmonary and hepatic fibrosis, but whether FAP‐targeting peptide (FTP) within a biomimetic system can address this dilemma remains unclear. Here, a methacrylated hyaluronic acid hydrogel microneedle patch (CAF@MN) integrating a dual‐targeting biomimetic nanozyme system (Cu‐CeO 2 @ABs‐FTP) modified with apoptotic bodies (ABs) membranes and FTP is developed. Cu‐CeO 2 nanocomposites activate fibroblast functions and exhibit anti‐inflammatory, antibacterial, antioxidant, and pro‐angiogenic activities. The ABs membrane enables macrophage targeting and M2 polarization, while FTP specifically modulates myofibroblast activation. The microneedle architecture enhances deep local delivery and nanozyme utilization. In mouse and rabbit full‐phase wound models, the system achieves accelerated wound healing, reduced inflammation, and attenuated hypertrophic scars. Single‐cell RNA sequencing further elucidates the dual‐targeted regulatory mechanisms underlying anti‐inflammation and scar suppression. This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO 2 @ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid, anti‐inflammatory, and scarless wound healing.
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PubMed
高影响因子
Materials Today Communications
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2026
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IF 4.9
Yang Xiang,Haoqian Guo,Kun Jia,Zixin Zhao,Yong You,Yuqi Guo,Xulin Yang,Ying Li,Mengna Feng,Kui Li,Pan Wang
Self-healing coatings have attracted considerable attention for metal protection. Specifically, the development of coating fabrication technologies that provide multiple functional properties can effectively mitigate the substantial economic and resource losses caused by corrosion. In this study, a novel sandwich-structured composite coating was realized by functionalizing different layers. The core-shell nanofibers interlayer embedded between two epoxy (EP) resin layers were prepared via coaxial electrospinning, with polyarylene ether nitrile (PEN) polymer serving as the shell, and benzotriazole/oleic acid (BTA/OA) encapsulated as the corrosion inhibitor within the core. Adhesion testing demonstrated that the fabricated composite coating exhibited strong adhesion between the layers as well as to the substrate, thereby satisfying the Grade 1 requirement. Owing to the well loading of BTA/OA inhibitors within the polymer shell and the efficient released through the microvascular network, electrochemical impedance spectroscopy results indicated that the impedance reached 6.31 × 10 5 Ω·cm 2 after 14 days of immersion in a 3.5% NaCl solution, indicating effective self-healing anti-corrosion performance. Additionally, the surface EP layer was modified through blending with and surface embedding of silver-based (Ag-based) glass antibacterial agents, achieved antibacterial efficacies exceeding 99% against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Overall, this study presents an efficient strategy for fabricating sandwich-structured anti-corrosion coatings that integrate self-healing capability and antibacterial activity, and robust structural stability, thereby demonstrating good potential for advanced metal protection applications.
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Journal of Environmental Chemical Engineering
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2026
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IF 7.5
Yang Li,Yaling Zeng,Zhendong Ouyang,Yunxiao Wen,Jian Yang,Ximei Fan
The complete mineralization of aromatic VOCs via photocatalysis remains a grand challenge, limited by severe photogenerated carrier recombination and the easy formation of toxic refractory phenolic intermediates. Here, we demonstrate a solvent-mediated crystal facet engineering strategy to construct a Bi 2 WO 6 -BiOCl S-scheme heterojunction with oriented exposure of high-activity facets and abundant surface hydroxyl sites. The facet-tailored heterojunction achieves efficient spatial separation of photogenerated carriers via a strong built-in electric field, while retaining the strong redox capacity to generate abundant reactive oxygen species. The optimal catalyst delivers over 95% gaseous toluene removal and 94.9% mineralization efficiency within 1 h irradiation, with 99.7% of removed toluene converted to CO 2 , exceeding the aqueous-synthesized control, pure-phase counterparts, and most reported bismuth-based photocatalysts. In-situ diffuse reflectance infrared Fourier transform spectroscopy combined with theoretical calculations reveals that facet-induced surface hydroxyl sites act as specific adsorption and activation centers for toluene molecules, steering the degradation toward a benign benzyl alcohol-benzaldehyde-benzoic acid pathway and inhibiting the generation of toxic phenolic byproducts. This work clarifies the critical role of crystal facet engineering in coordinating heterojunction charge transfer and surface reaction pathway modulation, providing a new avenue for designing high-performance photocatalysts for the complete mineralization of aromatic VOCs.
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