Nature Communications
·
2020
·Vol. 11
·期 1
·1-9
·
IF 12.121
Kuai Long,Chen Zheng,Liu Shoujie,Kan Erjie,Yu Nan,Ren Yiming,Fang Caihong,Li Xingyang,Li Yadong,Geng Baoyou
Selective reduction of ketone/aldehydes to alcohols is of great importance in green chemistry and chemical engineering. Highly efficient catalysts are still demanded to work under mild conditions, especially at room temperature. Here we present a synergistic function of single-atom palladium (Pd 1 ) and nanoparticles (Pd NPs ) on TiO 2 for highly efficient ketone/aldehydes hydrogenation to alcohols at room temperature. Compared to simple but inferior Pd 1 /TiO 2 and Pd NPs /TiO 2 catalysts, more than twice activity enhancement is achieved with the Pd 1+NPs /TiO 2 catalyst that integrates both Pd 1 and Pd NPs on mesoporous TiO 2 supports, obtained by a simple but large-scaled spray pyrolysis route. The synergistic function of Pd 1 and Pd NPs is assigned so that the partial Pd 1 dispersion contributes enough sites for the activation of C=O group while Pd NPs site boosts the dissociation of H 2 molecules to H atoms. This work not only contributes a superior catalyst for ketone/aldehydes hydrogenation, but also deepens the knowledge on their hydrogenation mechanism and guides people to engineer the catalytic behaviors as needed.
研究领域:
化学工程
·
绿色化学
·
催化科学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2015
·Vol. 16
·期 6
·13507-13527
·
IF 2.862
Arshad Mehmood Abbasi,Xinbo Guo,Xiong Fu,Lin Zhou,Youngsheng Chen,Yong Zhu,Huaifeng Yan,Rui Hai Liu
Mango (Mangifera indicaL.), also called “the king of fruits”, is one of the most popular fruits in tropical regions. Pulp and peel samples of mango cultivars were analyzed to estimate total phenolic, total flavonoid and total anthocyanin contents. Phenolic acids, hydrophilic peroxyl radical scavenging capacity (hydro-PSC) and oxygen radical scavenging capacity (ORAC)in vitrowere also determined. Total phenolics and flavonoid contents were found maximum in the peel of Xiao Tainang and Da Tainang cultivars, respectively, whereas Xiao Tainang also exhibited significant antioxidant capacity. Noteworthy, concentrations of gallic acid, protocatechuic acid, ferulic acid, chlorogenic acid and caffeic acids at 79.15, 64.33, 33.75, 27.19 and 13.62 mg/100 g fresh weight (FW) were quantified for Da Tainang, Xiao Tainang and of Jidan cultivars, respectively. Comparatively, a higher level of phenolics and significant antioxidant capacity in mango peel indicated that it might be useful as a functional food and value-added ingredient to promote human health.Keywords:mango;phenolics;flavonoids;anthocyanins;phenolic acids;ORAC;hydro-PSC
研究领域:
食品科学
·
植物化学
✓ 已验证
DOI
PubMed
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Li Zhang,Yonghai Gan,Bingdang Wu,Zhihao Chen,Jie Ren,Chi Zhang,Shujuan Zhang,Chuncheng Chen,Bingcai Pan
Temporal and spatial segregations are two fundamental requirements for the successful synthesis of nanoparticles (NPs). To obtain colloidally stable selenium nanospheres (SeNSs), surfactants or polymers are generally needed as structure-directing agents or stabilizers in the reduction approaches for SeNP synthesis. The addition of such chemicals sacrifices the purity of the obtained SeNPs and, therefore, is detrimental to the applications. Here, for the first time, we report that low-molecular weight (less than six carbons) diketones are excellent photoreductants for green and tunable synthesis of SeNPs, owing to their merits in temporal and spatial control. With simple diketones as the photoreductants, the resultant SeNPs were pure and colloidally stable with nice photoelectronic properties. This finding not only provides a useful strategy for the synthesis of SeNPs but also might be a milestone in the development of ketone photochemistry.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Dan Lou,Xiao Cui,Su-Su Bao,Wei Sun,Wen-He Pan,Meng-Chun Chen,Yao-Yao Dong,Guo-Xin Hu,Rui-Jie Chen,Zhe Wang
We investigated the effect of azole antifungal drugs (ketoconazole, voriconazole, and itraconazole) on the pharmacokinetics of apatinib in rats. The rats in ketoconazole, voriconazole, and itraconazole groups received single-dose apatinib 30 mg/kg after the oral administration of ketoconazole, voriconazole, and itraconazole, respectively. Co-administration of ketoconazole or voriconazole significantly increased the apatinib Cmax and AUC(0–t) and decreased the clearance. Co-administration of itraconazole did not significantly affect the pharmacokinetics parameters of apatinib. It could be concluded that both ketoconazole and voriconazole significantly increase the exposure of apatinib, and affect the pharmacokinetics of apatinib in rat. Apatinib can be co-administered with itraconazole, but ketoconazole and voriconazole should be avoided if possible or be underwent therapeutic drug monitoring of apatinib. A further clinical study should be conducted to investigate the inhibitory effect of azole antifungal drugs on the apatinib plasma concentration.
研究领域:
药理学
·
临床医学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2021
·
IF 2.104
Ting Zhou,Wei Guo,Shengchao Ren,Yuming Li,Jinming Wu,Bao Yang
The peel of Citrus reticulate ‘Chachiennsis’ (Chachi) is a well-known functional food with multiple health benefits in Asia. There is an old saying “the longer time Chachi is stored, the better health benefits it has”. Is it convincible? What are the critical bioactive compounds in Chachi? To answer these questions, gas chromatography-mass spectrometry (GC-MS) and ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) were used to qualify and quantify the flavonoid glycosides and other bioactive compounds of Chachi with storage time of 5–20 years. Limonene was the representative volatile compound . The level of most volatile compounds decreased along with storage. Sixteen flavonoids glycosides and twenty flavonoids were identified. Nobiletin , hesperitin, tetramethoxy flavone and pentamethoxy flavone were characteristic bioactive compounds for Chachi. Most of them accumulated during 10-year storage, thereafter decreased. Ten years could be the optimal storage time. These results indicated that the old saying should be corrected.
研究领域:
食品科学
·
植物化学
✓ 已验证
DOI
高影响因子
POLYHEDRON
·
2022
·
IF 2.975
Xian-Hao Feng,Zhi-Chao Yu,Wei Zhang,Carl Redshaw,Timothy J. Prior,Tie-Hong Meng,Chun-Rong Li,Zhu Tao,Xin Xiao
In the work, we have studied the interaction of cucurbit[7]uril (Q[7]) with 1-[4-(dimethylamino)phenyl]-ethanone (DAPE) using a variety of techiniques including 1 H NMR spectroscopy, UV–vis adsorption and fluorescence spectroscopies, Isothermal titration calorimetry and single crystal X-ray diffraction. Results revealed the formation of a 1:1 complex, whilst the molecular structure of the species [(Q[7]@DAPE)Ca(H 2 O) 3 ] 2 (CdCl 4 ) 2 ·31(H 2 O) is reported.
研究领域:
化学
·
分子生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2014
·Vol. 52
·期 4
·2458-2463
·
IF 2.024
Zhou Xiaoli,Hao Tingfeng,Zhou Yiming,Tang Wen,Xiao Ying,Meng Xiaoxiao,Fang Xiang
Relationships of changes between major non-enzymatic antioxidant compounds and antioxidant capacities of tartary buckwheat during germination were evaluated by means of correlation analysis and principal component analysis in this paper. The changes of antioxidant compounds, including vitamin C, vitamin E, flavonoids, carotenoids, and chlorophyll, and antioxidant activities were detected. A good accumulation in the content of vitamin C (0.71 mg/g), total flavonoids (19.53 mg rutin/g), and rutin (11.34 mg/g) was found after 7-day germination, but germination decreased the vitamin E activity. Germination improved the activities of buckwheat extracts to scavenge DPPH, ABTS, and superoxide free radicals by 107, 144, and 88 %, respectively. Furthermore, the correlation and principal component analysis showed that the vitamin C, total flavonoids, and rutin contents were closely related positively with free radicals scavenging properties, indicating that the compounds which play a key role in the elevated antioxidant activities during germination consisted of vitamin C, total flavonoids, and rutin, but not vitamin E and quercetin.
研究领域:
食品科学
·
植物生理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Tianliang Lu,Zhiyun Yang,Hongji Li,Haijun Chen,Jun Xu,Chunbao Charles Xu,Jianshe Wang,Zhongjun Li,Yongsheng Zhang
Selective oxidation of ethyl lactate (EL) with molecular oxygen as oxidant is an alternative route to produce ethyl pyruvate (EP). However, to obtain pyruvate with high yield under mild conditions remains challenging due to the troublesome over oxidation issue. Here, a highly efficient photocatalytic strategy was firstly developed to obtain EP at room temperature. ZnIn sulfides (ZIS) with different Zn/In ratios were synthesized as the catalysts. Under the irradiation of visible light, 100% EL conversion with 88.4% EP yield could be obtained. The optimized ZIS catalyst shows the highest surface area (215.7 m 2 g −1 ) as well as much higher separation and transport efficiency of the electron-hole pairs. Combining radical trapping experiments with characterization results, a reaction mechanism was proposed. The mild reaction conditions with efficient generation of singlet oxygen contribute the high yield of EP. Kinetic isotope experiments indicate that the cleavage of C(OH)−H bond probably was involved in the rate determining step.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Systems Microbiology and Biomanufacturing
·
2022
·
IF 0
Zhu Jiufeng,Bai Yajun,Fan Tai-Ping,Zheng Xiaohui,Cai Yujie
Ethyl ( R )-4-chloro-3-hydroxybutyrate (( R )-CHBE), as a chiral intermediate, is widely used in the synthesis of various chiral drugs. In this study, we screened two aldo–keto reductases (LP-AKRs) from the probiotic Lactobacillus plantarum DSM20174, both with a molecular weight of approximately 31 kDa. Both enzymes could reduce 4-chloroacetoacetic acid ethyl ester (COBE) to produce ( R )-CHBE with an enantioselectivity value of 99%. When determining the kinetic parameter, the K m , K cat , and V max of LP-AKR5 and LP-AKR9 were 9.5 mM, 7.6 U/mg, 3.96 s −1 and 8.7 mM, 8.59 U/mg, 4.47 s −1 , respectively. Both LP-AKR5 and LP-AKR9 had an optimal reaction pH of 6 and could maintain a high level of stability at pH 6, allowing them to perform well in an acidic environment. LP-AKR5 and LP-AKR9 had optimal reaction temperatures of 30 °C and 40 °C, respectively. Metal ions had minimal influence on LP-AKR5 and LP-AKR9 enzyme activities. This series of enzymatic properties showed that LP-AKR5 and LP-AKR9 mined from Lactobacillus plantarum DSM20174 could asymmetrically catalyze the synthesis of ( R )-CHBE under weakly acidic circumstances, which could maintain product stability and provide a good foundation for industrial production.
研究领域:
生物化学
·
分子生物学
·
工业微生物学
✓ 已验证
DOI
JOURNAL OF MOLECULAR LIQUIDS
·
2017
·
IF 3.648
Gaoyin He,Liping Wang,Midong Shi,Qingsong Li,Yingmin Yu
The liquid–liquid equilibrium (LLE) data of the ternary systems (water + cyclopentanone + benzene or toluene) were determined at T = 303.2, 313.2, and 323.2 K, under 101 kPa. The reliability of the experimental tie-line data was sufficiently checked by the empirical Hand and Bachman equations. The distribution coefficient and separation factor were used to investigate the distribution of cyclopentanone between water and solvents. The results show that the separation factor decreases with increasing cyclopentanone amounts in organic phase and the influence of temperature is light in the study. The experimental tie-line data were correlated well with the NRTL and UNIQUAC activity coefficient models with a root mean square deviation (RMSD) as low as 0.81 and 0.50.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Tiantian Tao,Yumin Liu,Jiayin Zhang,Yu Zhou,Yanbo Liu,Zhenguo Gao
Experimental solubility data of dibenzoylmethane (DBM) in three pure solvents (ethyl acetate, acetonitrile, methylbenzene) and three binary solvents (methanol + water, ethanol + water, and isopropyl alcohol + water) were measured by the gravimetric method from 278.15 to 318.15 K under atmospheric pressure. The experimental results showed that the solubility of DBM increased with the increase of temperature. Moreover, the solubility of DBM was temperature-dependent when the type and composition of solvents remained unchanged. The solubility of DBM decreased with the increase of solvent polarity because the molecular structure of DBM was not conducive to the formation of hydrogen bonds between solute and solvent molecules. The solubilities of DBM were correlated by the modified Apelblat equation, the van’t Hoff equation, the λh equation, and the NRTL equation. The modified Apelblat model produced the best fitting results among these models.
研究领域:
物理化学
·
热力学
✓ 已验证
DOI
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2021
·Vol. 2021
·期 1
·2894306
·
IF 2.63
Hong Chang,Shujie Lv,Tengteng Yuan,Huan Wu,Lei Wang,Ran Sang,Caiyun Zhang,Weidong Chen
Gushuling (GSL), a well-known hospital preparation composed of traditional Chinese medicine (TCM), has been widely used in the clinical treatment of osteoporosis (OP) for decades due to its remarkable therapeutic effect. However, the chemical constituents of GSL are still unclear so far, which limits the in-depth study of its pharmacodynamic material basis and further restricts its clinical application. In this study, we developed a strategy for qualitative analysis of the chemical constituents of GSL in vitro and in vivo . Based on the results of ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS) and the UNIFI informatics platform, the chemical constituents of GSL can be determined quickly and effectively. By comparing the retention time, accurate mass, and fragmentation spectrum of the compounds in GSL, a total of 93 compounds were identified or preliminarily identified, including flavonoids, terpenoids, phenylpropanoids, steroids, etc. Among them, nine compounds have been confirmed by standard substances, namely epimedin A, epimedin B, epimedin C, icariin, ecdysterone, calycosin, calycosin-7-glucoside, ononin, and ginsenoside Ro. Fragment patterns and characteristic ions of representative compounds with different chemical structure types were analyzed. At the same time, 20 prototype compounds and 42 metabolites were detected in rat serum. Oxidation, hydration, reduction, dehydration, glutathione S-conjugation, and acetylcysteine conjugation were the main transformation reactions of GSL in rat serum. In this research, the rapid method to characterize the in vitro and in vivo chemical constituents of GSL can not only be used for the standardization and quality control of GSL but also be helpful for further research on its pharmacodynamic material basis.
研究领域:
中药学
·
分析化学
·
药理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）