INDUSTRIAL LUBRICATION AND TRIBOLOGY
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2024
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IF 1.5
Hui Zhao,Shunzhen Ren,Zhengbo Zhong,Zhipeng Li,Tianhui Ren
PurposeThis study aims to reveal the tribological mechanism of synergistic effect between MoDTC and P-containing additives in aluminum-based grease.Design/methodology/approachThe authors prepared a molybdenum dialkyl dithiocarbamate (MoDTC) and revealed the tribological mechanism of synergistic effect between MoDTC and P-containing additives in aluminum-based grease by combining with ZDDP and P-containing and S-free additives.FindingsThe MoDTC the authors prepared has good friction-reducing and anti-wear properties in aluminum-based grease and has an obvious synergistic effect with ZDDP. MoDTC and ZDDP have a significant synergistic effect on the tribological properties in aluminum-based grease, mainly because of the formation of phosphates and metaphosphates as well as more MoS2in the friction film. P element plays a facilitating role in the chemical conversion of MoDTC to MoS2.Originality/valueThe experiments of MoDTC with tributyl phosphate and trimethylphenyl phosphate confirm that the P element plays a facilitating role in the chemical conversion of MoDTC into MoS2.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-12-2023-0410
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-12
·
IF 14.919
Han Cuiping,Li Hongfei,Li Yu,Zhu Jiaxiong,Zhi Chunyi
Rechargeable calcium-ion batteries are intriguing alternatives for use as post-lithium-ion batteries. However, the high charge density of divalent Ca 2+ establishes a strong electrostatic interaction with the hosting lattice, which results in low-capacity Ca-ion storage. The ionic radius of Ca 2+ further leads to sluggish ionic diffusion, hindering high-rate capability performances. Here, we report 5,7,12,14-pentacenetetrone (PT) as an organic crystal electrode active material for aqueous Ca-ion storage. The weak π-π stacked layers of the PT molecules render a flexible and robust structure suitable for Ca-ion storage. In addition, the channels within the PT crystal provide efficient pathways for fast ionic diffusion. The PT anode exhibits large specific capacity (150.5 mAh g -1 at 5 A g -1 ), high-rate capability (86.1 mAh g -1 at 100 A g -1 ) and favorable low-temperature performances. A mechanistic study identifies proton-assisted uptake/removal of Ca 2+ in PT during cycling. First principle calculations suggest that the Ca ions tend to stay in the interstitial space of the PT channels and are stabilized by carbonyls from adjacent PT molecules. Finally, pairing with a high-voltage positive electrode, a full aqueous Ca-ion cell is assembled and tested.
研究领域:
材料科学
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电化学
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能源存储
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-14
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IF 3.9
Zhou Lei,Zhang Mengting,Sun Huinan,Duan Liyuan,Meng Qingwei
This study establishes the first reversed-phase HPLC-UV method for simultaneous baseline separation of 12 structurally diverse water-soluble vitamins (WSVs) within 25 min. The eco-friendly approach utilizes a methanol–potassium dihydrogen phosphate (pH 4.85) gradient on a ChromCore C18 column (250 × 4.6 mm, 5 μm) with dual-wavelength detection (210/266 nm), eliminating environmentally detrimental ion-pairing reagents. Rigorous validation per ICH Q2(R1) guidelines confirmed excellent linearity (R² > 0.999), precision (RSD < 2.1%), accuracy (spike recoveries: 93.9–106.8%), and sensitivity (LODs: 0.01–0.78 µg/mL). The method resolved key analytical challenges including polarity disparities, matrix interference, and vitamin instability. Successful quantification of endogenous vitamins in DMEM medium showed ≤ 5.1% deviation from certified values for 11/12 analytes. Applied to five commercial MDCK cell culture media, the method revealed significant inter-product variability in vitamin composition – notably universal under-supplementation of riboflavin (0.576–0.741 µg/mL, 10× lower than other vitamins) and inconsistent biotin/adenine supplementation. This robust, cost-effective platform provides biomanufacturers with a powerful quality control tool for optimizing vitamin supplementation in vaccine production systems, addressing a critical gap in cell culture analytics.
研究领域:
分析化学
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生物化学
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生物技术
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药学
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细胞生物学
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PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
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2020
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IF 4.545
Jie Zhao,Xiangyu Piao,Yue Wu,Shanshan Liang,Fang Han,Qian Liang,Shujuan Shao,Dewei Zhao
Cepharanthine (CEP) is a potential candidate for treatment of cerebral ischemia/reperfusion (I/R) injury, due to its anti-inflammatory and anti-oxidative properties. To investigate the effect of CEP on cerebral I/R injury, we established a mouse model of transient middle cerebral artery occlusion (tMCAO) and a microglia cell model of oxygen and glucose deprivation/reoxygenation (OGD/R). Administration of CEP attenuated neurological deficits, reduced infarct volume and edema, and decreased microglia activation in MCAO mice. Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Containing 3 (NLRP3) immunoreactivity in Iba1-labled microglia together with total Iba1 and NLRP3 expression in the brain following tMCAO, while down-regulated by CEP treatment. In both tMCAO-induced mice and OGD/R-treated BV-2 cells, CEP exhibited dose-dependent inhibition on the expression of NLRP3, ASC and cleaved caspase-1. Importantly, CEP attenuated tMCAO or OGD/R-induced overproduction of M1 microglia-regulated pro-inflammation cytokines IL-1β and IL-18, suggesting that CEP might involve in suppressing microglia polarization to M1 phenotype in vivo and in vitro . Moreover, CEP dose-dependently inhibited tMCAO-induced arachidonate 15 lipoxygenase (ALOX15) together with Iba1-labled microglia. The subsequent ALOX15-mediated oxidative stress was decreased by CEP treatment in vivo and in vitro , as evidenced by reduced ROS generation and MDA level, and increased SOD activity. Taken together, we demonstrate that CEP attenuates cerebral I/R injury probably by inhibiting microglia activation and NLRP3 inflammasome-induced inflammation and reducing oxidative stress via suppressing 12/15-LOX signaling.
研究领域:
神经科学
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药理学
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炎症生物学
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氧化应激
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Qi Shen,Yibin Liu,Jiarong Lu,Mengnan Ma,Zhonghao Qu,Xianbang Yin,Hao Yan,Shenliang Hou,Zhiyu Zhao,Shurong Wang,Xiang Feng,Chaohe Yang,Xiaobo Chen
The catalytic upgrading of bio-oil via hydrogen transfer deoxygenation necessitates catalysts capable of simultaneously activating C H bonds and oxygen-containing functionalities. Herein, we report a confined Ni@Y zeolite catalyst synthesized through a hydrothermal encapsulation approach, wherein NiO clusters are predominantly confined within the FAU micropore network and preferentially stabilized near the 12-membered ring junction regions connecting supercages and sodalite cages. Structural characterization confirms that this spatial confinement enhances metal dispersion, generates additional Lewis acid sites, and strengthens synergistic effect of metal and acid sites. Spectroscopic analyses combined with density functional theory calculations suggest that the intracrystalline NiO fraction stabilized in the 12-membered ring junction environment facilitate the activation of C H bonds and oxygen-containing functionalities. Owing to the synergistic interplay between well-dispersed metal sites and proximal acid centers, the Ni@Y zeolite exhibits superior catalytic activity in the hydrogen-transfer deoxygenation of salicylaldehyde with tetralin, achieving the highest deoxygenation efficiency (63.4%), highest water yield (3.6%), and lowest coke yield (6.1%), outperforming conventional HY and impregnated Ni/Y-IM zeolites. These findings provide mechanistic insights into the molecular-scale role of confined metal-acid synergy and offer theoretical guidance for the rational design of zeolite-based catalysts for bio-oil valorization.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
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IF 2.1
Jianhui Du,Yunlu Li,Guoliang Jin,Jianlong Wang,Lizhen Chen
2,4,6,8,10,12-Hexacyclopropyl-2,4,6,8,10,12-hexaazaisowurtzitane (HCPIW) is a novel nitration precursor used in the synthesis of CL-20 (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane). Investigating the solubility of HCPIW is of significant importance for optimizing its synthesis and crystallization processes, as well as for advancing the development of the CL-20 synthetic route. However, to the best of our knowledge, no studies have been reported on the solubility of HCPIW. To support downstream processing, its solubility in 12 pure solvents (dichloromethane, chloroform, carbon tetrachloride, 1,1,2-trichloroethane, 1,2-dichloroethane, n-hexane, cyclohexane, ethyl acetate, acetone, methanol, ethanol, and acetonitrile) was determined by the gravimetric method over the temperature range of 278.15 to 318.15 K. The experimental solubility data were correlated using the Apelblat equation, Yaws model, van’t Hoff equation, and a polynomial empirical model. All four models exhibited excellent agreement with the experimental data, with correlation coefficients (R2) exceeding 0.99 and root-mean-square deviations (RMSD) approaching zero. These models are thus suitable for accurately describing the solubility behavior of HCPIW. This study provides essential thermodynamic data to support further research and process development involving HCPIW.
研究领域:
化学工程
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热力学
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材料科学
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有机合成
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工艺优化
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INORGANIC CHEMISTRY
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2020
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IF 4.825
Siru Guo,Wenbin Zhang,Min Zhang,Zhihua Yang,Shilie Pan
Owing to the tendency to form the glass state in growing crystals in the ternary tin(II) borate system, hitherto, very few single crystals in ternary tin(II) borate were reported. In this paper, a single crystal of Sn3B8O15 was obtained via a high temperature solution method in a closed system. The structure features a flexible fundamental building block [B8O18]12– constructed by one [BO3]3– unit and one [B7O16]11– group that contains three hexatomic rings, which further connect to compose a two-dimensional 2∞[B8O15] layer structure. The connection mode and flexibility of the three hexatomic B-O rings were analyzed, verifying the structural diversity of the B-O configuration. Moreover, the synthesis, crystal structure, and various characterizations were comprehensively presented. Also, theoretical calculations were employed to discuss structure-property relationships, and we use the real-space atom-cutting techniques to explain the origin of the birefringence of Sn3B8O15.
研究领域:
无机化学
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晶体学
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材料科学
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光学材料
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固态化学
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CNS Neuroscience & Therapeutics
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2026
·Vol. 32
·期 9
·e71134
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IF 6.6
Xueyan Liu,Huiling Lin,Jian Zhong,Xili Chen,Zonglin Wang,Meng Shi,Hang Shi,Hui Zhang,Ping Chen,Zu-Cheng Ye
Background Sleep deprivation (SD) has been increasingly implicated in age-related cognitive decline. However, the mechanisms linking SD duration to progressive disruption of glial homeostasis, synaptic vulnerability, and metabolic dysregulation remain poorly defined. Methods We employed 12-month-old Thy1-EGFP and Cx3CR1-EGFP mice to investigate the effects of short-term sleep deprivation (SSD) and long-term sleep deprivation (LSD) on neuronal architecture, microglial morphology, and astrocytic homeostasis. Quantitative analyses included dendritic spine density, synaptic protein expression, glial morphological and transcriptional markers, and untargeted plasma metabolomics. The neuroprotective effects of D30, a novel small molecule compound, were also evaluated. Results SSD induced relatively transient oxidative stress and glial suppression, whereas LSD led to sustained reductions in dendritic spine density, synaptic protein levels, and microglial/astrocytic morphological complexity. LSD further disrupted mitochondrial metabolism, notably involving the TCA cycle, AMPK-associated signaling, and lipid homeostasis. Treatment with D30 significantly ameliorated LSD-induced deficits by preserving glial homeostatic features, restoring synaptic protein expression, maintaining dendritic spine density, and rebalancing systemic metabolism, ultimately improving cognitive performance. Conclusions LSD impairs glial homeostatic integrity and synaptic stability in association with systemic metabolic dysfunction in middle-aged mice. D30 effectively alleviates these impairments, highlighting its potential as a protective intervention for chronic SD-related neurocognitive dysfunction.
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Journal of Energy Chemistry
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2022
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IF 13.599
Qi Liu,Junming Qiu,Xianchang Yan,Yuemeng Fei,Yue Qiang,Qingyan Chang,Yi Wei,Xiaoliang Zhang,Wenming Tian,Shengye Jin,Ze Yu,Licheng Sun
All-inorganic CsPbIBr 2 perovskite solar cells (PSCs) have attracted considerable research attention in recent years due to their excellent thermal stability. However, their power conversion efficiencies (PCEs) are relatively low and still far below the theoretical limit. Here, we report the use of an organic dye molecule (namely VG1-C8) as a bifunctional interlayer between perovskite and the hole-transport layer in CsPbIBr 2 PSCs. Combined experimental and theoretical calculation results disclose that the multiple Lewis base sites in VG1-C8 can effectively passivate the trap states on the perovskite films. Meanwhile, the π-conjugated dye molecule significantly accelerates the hole extraction from the perovskite absorber as evidenced by the photoluminescence analysis. Consequently, the VG1-C8 treatment simultaneously boosts the photovoltage and photocurrent density values from 1.26 V and 10.80 mA cm −2 to 1.31 V and 12.44 mA cm −2 , respectively. This leads to a significant enhancement of PCE from 9.20% to 12.10% under one sun irradiation (AM 1.5G). To our knowledge, this is the record efficiency reported so far for CsPbIBr 2 PSCs. Thus, the present work demonstrates an effective interfacial passivation strategy for the development of highly efficient PSCs.
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APPLIED SURFACE SCIENCE
·
2021
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IF 6.707
Rongtao Liu,Xingwen Huang,Xiu Wang,Xiaokang Peng,Shiyang Zhang,Yidong Liu,Dong Yang,Yonggang Min
The synergistic effect of endogenous electric field and electrical stimulation (ES) has promising application in the repair and regeneration of injured peripheral nerve. Conducting polymers-based (especially polypyrrole (PPy)) nanofibers have received more attention due to the promotive effects on cell behaviors under ES. However, the conductivity of PPy is unstable and the inferior hydrophilicity hinders its broad applications. Herein, the stable conductive polylactic acid/reduced graphene oxide/polypyrrole (PLA/rGO/PPy) composite nanofibers were prepared by incorporating rGO into PLA, by the following in-situ PPy polymerized on the surface of the PLA/rGO nanofibers. The results show that PPy on the surface of composite nanofibers are dense and continuous, the wettability is significantly improved. With the presence of PPy and rGO, the conductivity and stability of PLA/rGO/PPy composite nanofibers increase, and the conductivity of PLA/rGO 3.5/PPy composite nanofibers was the highest conductivity (1.46 × 10 −1 S/cm). The proliferation and differentiation of PC-12 cells seeded on the surface of PLA/rGO3.5/PPy composite nanofibers reach the highest level under 400 mV/cm. These results are beneficial for improving biomaterial properties and provide guidance to ES application in peripheral nerve repair.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
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IF 2.369
Guoquan Zhou,Ke Chen,Zehui Yang,Danfeng Shao,Huajun Fan
The present study investigating the experimental equilibrium solubility of 2-chloro-4-amino-6,7-dimethoxyquinazoline (CADQ) dissolved in 12 kinds of neat organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutyl alcohol, ethyl acetate, toluene, N,N-dimethyl formamide (DMF), N-methylpyrrolidone (NMP), 1,4-dioxane, and cyclohexanone, was determined in an equilibrium state by means of the isothermal saturation method at temperature ranges of 273.15–313.15 K under normal atmospheric conditions of 101.2 kPa. The rising temperature showed the obvious positive effect on the increasing CADQ solubility gradually, and the maximum value (0.01370 at 313.15 K, in mole fraction) was observed in NMP for the studied temperature ranges. The equilibrated solid state of CADQ was characterized by applying the Fourier transform infrared (FT-IR) spectrometer, resulting in no existences of crystal transition, solvate formation, or polymorphic transformation in the experimental process. Results showed that the mole fraction solubility of CADQ abiding the order from high to low is as follows: NMP (0.01370, 313.15 K) > DMF (0.01157, 313.15 K) > cyclohexanone (3.847 × 10–3, 313.15 K) > ethyl acetate (1.010 × 10–3, 313.15 K) > n-butanol (9.288 × 10–4, 313.15 K) > isobutyl alcohol (8.408 × 10–4, 313.15 K) > n-propanol (7.692 × 10–4, 313.15 K) > ethanol (6.934 × 10–4, 313.15 K) > isopropanol (6.220 × 10–4, 313.15 K) > methanol (5.437 × 10–4, 313.15 K) > 1,4-dioxane (2.535 × 10–4, 313.15 K) > toluene (2.174 × 10–5, 313.15 K). Then, the achieved CADQ solubility values were correlated and calculated by mathematical models containing the modified Apelblat equation and λh equation, respectively. As a consequence, the largest root-mean-square deviation (RMSD) and average relative deviation (ARD) were 1.020 × 10–4 and 2.352%, respectively, which turned out to be that the calculated data agreed well with the experimental ones.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
·
IF 2.369
Shengzheng Guo,Yang He,Gang Wang,Weibing Dong,Xuxing Wan,Yanxiao Zhao,Shichao Du
The solubility of N-acetyl-l-leucine in 12 mono organic solvents (methanol, ethanol, n-propanol, 2-propanol, 1-butanol, isobutanol, 2-butanol, methyl acetate, ethyl acetate, propyl acetate, acetone, and acetonitrile) was determined by the gravimetric method over the temperatures ranging from 283.15 to 323.15 K at 0.1 MPa. The solubility of N-acetyl-l-leucine in each experimental solvent increases with increasing temperature. Moreover, the solubility is an order of magnitude higher in alcohol solvents than in other solvents, which is mainly attributed to the hydrogen bond formation. In addition, the experimental solubility data are correlated by three models, including the modified Apelblat equation, λh equation, and the nonrandom two-liquid (NRTL) model. All of the average relative deviation % values are less than 3.72%, which indicates that the three models have satisfactory correlations. Furthermore, the mixing thermodynamic properties of N-acetyl-l-leucine in 12 mono solvents including ΔmixG0, ΔmixH0, and ΔmixS0 are calculated based on the NRTL model, indicating that the mixing process was spontaneous.
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