Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·5
·
IF 2.7
Lee Serim,Kim Moonsu,Shin Seong-Ah,Moon Sun Young,Choi Seyeon,Kim Minji,Lee Jun Hyuck,Youn Ui Joung,Lee Chang Sup
An allergy is an exaggerated immune response to an otherwise harmless substance. These reactions are triggered largely by mast cell activation and the subsequent release of inflammatory mediators. Although current allergy therapies effectively relieve symptoms, they are generally accompanied by side effects, highlighting the need for safer alternatives. In this study, we investigated the anti-allergic effect of ethyl-2-oxo-2H-chromene-3-carboxylate (EtCC), a coumarin derivative. Rat basophilic leukemia (RBL-2H3) cells and a passive cutaneous anaphylaxis (PCA) model were used for in vitro and in vivo evaluations, respectively. In RBL-2H3 cells sensitized with dinitrophenyl (DNP)-specific-immunoglobulin (Ig) E and stimulated with DNP-human serum albumin (HSA), EtCC inhibited histamine and beta-hexosaminidase release, and downregulated mRNA expression of interleukin (IL)-4, IL-13, and TNF-α. EtCC also suppressed phosphorylation of MAPK, AKT, and NF-kB. In vivo, EtCC attenuated ear edema and Evans blue extravasation in a PCA model. These findings demonstrate that EtCC effectively suppresses mast-cell-mediated allergic responses, suggesting its potential as a novel allergy treatment.
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MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Shufang Ren,Runyan Feng,Shounian Cheng,Liqiu Huang,Qingtao Wang,Zhixiang Zheng
In this work, an ultrasensitive electrochemical sensor towards quantitative detection of acetaminophen (AP) based on hybrid of metallic 1 T and semiconductive 2H phase molybdenum disulfide (1 T/2H MoS 2 ) anchored on rGO sensing platform was constructed. The XRD, FESEM, FETEM and XPS analysis indicates that nanoflowers 1 T/2H MoS 2 with walnut-like fold structure were in-situ loaded onto the surface of rGO nanosheets by the hydrothermal approach. The formation of stabilized 1 T MoS 2 is associated with the influence of GO. The electrochemical tests of CV, EIS and DPV show that the hybrid composite MoS 2 /rGO remarkably promoted the detecting performance owing to the increased conductivity of 1 T MoS 2 that can facilitate charge transfer kinetics, the great active sites on both basal and edge of planes of 1 T/2H MoS 2 and the synergic effect of 1 T/2H MoS 2 and rGO. After the test condition optimization, MoS 2 /rGO/GCE sensor has great electrocatalytic activity towards AP with wide linear range of 0.005–300 μM and low limit of detection of 1.7 nM (S/N = 3). Furthermore, the sensor shows excellent stability, repeatability, reproducibility and anti-interference performance. All results proved that the GO-assisted hydrothermal prepared hybrid 1 T/2H MoS 2 /rGO is promising material for electrochemical analysis.
研究领域:
分析化学
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材料科学
·
药物分析
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2018
·
IF 11.698
Yunpeng Liu,Yuhang Li,Feng Peng,Yuan Lin,Siyuan Yang,Shengsen Zhang,Hongjuan Wang,Yonghai Cao,Hao Yu
Recently, MoS 2 as an efficient co-catalyst has attracted much attention for photocatalytic water splitting. MoS 2 has two polymorphs: semiconducting phase (2H) and metallic phase (1T). The 2H- and 1T- MoS 2 show different reaction mechanism in photocatalytic H 2 evolution. However, so far, very few experiments have clearly evidenced the electron transfer process between TiO 2 and mixed phase MoS 2 . This study for the first time has reported a simple hydrothermal synthesis method to prepare mixed phase few-layer MoS 2 nanosheets coated on TiO 2 nanorod arrays (MoS 2 @TiO 2 ) with a conductive fluorine-doped tin oxide (FTO) as a substrate. The structure of mixed phase MoS 2 was characterized carefully. The designed MoS 2 @TiO 2 exhibits two times higher activity than Pt@TiO 2 for photocatalytic H 2 evolution. The reliable conclusion that the photo-generated electrons from TiO 2 to MoS 2 nanosheets has clearly been evidenced by photoelectrochemical analyses and in-situ KPFM experiments, and the mixed phase MoS 2 here is a co-catalyst such like Pt rather than as a semiconductor. This study not only presents a series of solid experimental evidences to verify the electrons transfer process and photocatalytic mechanism, but also provides a new method in substituting MoS 2 for noble metal Pt as co-catalyst in high-efficiency photocatalytic water splitting into hydrogen.
研究领域:
材料科学
·
能源科学
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yanhua Lei,Jie Wang,Bochen Jiang,Hui Liu,Haifeng Lan,Yuliang Zhang,Guanhui Gao
In this study, we present the successful development of a unique photo-Fenton catalyst, 1T-2H MoS 2 @TP/PPy (MTP), achieved through the coating of a copolymer of tea polyphenol (TP) and polypyrrole (PPy) onto the surface of heterophase molybdenum disulfide (1T-2H MoS 2 ). This innovative approach involves the integration of hydrothermal synthesis with copolymerization techniques. Our strategy utilizes nanoflower-like 1T-2H MoS 2 as the foundational framework, which is then enveloped in TP and PPy copolymer. This innovative approach involves the integration of hydrothermal synthesis with copolymerization techniques. Our strategy utilizes nanoflower-like 1T-2H MoS 2 as the foundational framework, which is then enveloped in TP and PPy copolymer. This distinctive architecture demonstrates exceptional catalytic performance owing to the hetero-phase entanglement of 1T-2H MoS 2 , which provides a diverse array of active sites. The coupled structure of TP and iron (TP-Fe 2+ /Fe 3+ ) effectively overcome the limitation associated with the iron source. The incorporation of PPy not only reduces the recombination of photogenerated electron-hole pairs but also enhances the stability of 1T-2H MoS 2 . Remarkably, our experiments on the degradation of methylene blue (MB) and tetracycline (TC) degradation demonstrate that TP-Fe 2+ /Fe 3+ significantly expands the pH applicability range of the MTP composite catalyst. Additionally, we examine several factors, including different catalysts, H 2 O 2 addition, variations in light intensity, solution pH, temperature fluctuations, and the role of active species, to comprehensively understand their impact on the photo-Fenton degradation process. In conclusion, MTP composite exhibits robust catalytic stability and demonstrates a broad pH utilization range in the photo-Fenton oxidation process, highlighting its promising potential for a wide range of applications.
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Analytical Methods
·
2022
·Vol. 14
·期 5
·549-559
·
IF 3.532
Qiaoling Wu,Chun Ji,Lingli Zhang,Qili Shi,Yuangen Wu,Han Tao
The work presented here describes a highly sensitive and simple electrochemical sensor for the detection of Sudan I dye based on a nanocomposite made of MoS2 heterogeneous nanosheets (1T@2H-MoS2) and carboxylated carbon nanotubes (cMWCNTs) (1T@2H-MoS2/cMWCNTs). XPS results indicate that the content of 1T phase MoS2 was estimated to be 72% in 1T@2H-MoS2. Electron microscopy results show that the tubular cMWCNTs are uniformly interwoven in MoS2 nanosheets to form a three-dimensional network structure. Due to the synergistic electrocatalytic ability and high electroactive surface area, the 1T@2H-MoS2/cMWCNTs modified electrode demonstrated excellent analytical performance for Sudan I, including simple operation, good stability and a wide linear range from 5.00 × 10−9 to 2.00 × 10−6 mol L−1 and 2.00 × 10−6 to 1.00 × 10−4 mol L−1 with an ultra-low detection limit of 1.56 × 10−9 mol L−1. The recoveries of Sudan I from spiked real samples (chilli powder and ketchup) were in the range of 95.60% to 106.10% with low RSD (<5%), indicating that the 1T@2H-MoS2/cMWCNTs modified electrode is a promising tool for the analysis of illegal Sudan I in food samples.
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DYES AND PIGMENTS
·
2021
·
IF 4.889
Kai Wang,Ya-Xi Ye,Cheng-Yan Jiang,Meng-Ya Guo,Xiang-Yang Zhang,Ai-Qin Jiang,Yu-Shun Yang,Qing-Cai Jiao,Hai-Liang Zhu
Hydrazine is a very important industrial chemical with high toxicity to the human body. In this work, a fluorescent probe HZ , based on the substitution-cyclization-elimination cascade which initiated by hydrazine, was designed and synthesized. HZ had various characteristics such as high selectivity, high sensitivity, fast detection speed, wide application range, and so on. After treating with hydrazine, the fluorescence signal of HZ at 520 nm in aqueous solution was significantly enhanced. Furthermore, HZ had the linear range of 1–10 equivalent for monitoring hydrazine, and the solution showed a colorless to yellow color change. In practical application, the detection limit of HZ for the detection of hydrazine was only 0.75 μM, which could be utilized for trace detection of hydrazine in different water samples. These indicated that HZ had a broad application prospect in the fields of environmental protection and water treatment. This work not only provided a useful instrument for the detection of the ecological environment but also supplied important information for the system optimization of other ecological environment detectors. In addition, HZ could monitor endogenous and exogenous hydrazine in MCF-7 cells successfully, which demonstrated its potential for practical application in complex biological systems.
研究领域:
环境科学
·
分析化学
·
生物学
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Journal of Energy Storage
·
2025
·
IF 9.8
Qianqian Zhang,Yaru Zhu,Min Yang,Yanru Zhang,Jialin Wang,Shanshan Liu,Ye Liu,Xin Yang,Kai Feng,Wenzuo Li
Aqueous zinc-ion batteries (AZIBs) have good application prospects in the field of large-scale energy storage. The design and synthesis of high-performance cathode materials are key to promoting the development and application of AZIBs. In this work, the combination of redox active V 4+ cation and HPO 3 2− anion provides excellent zinc-ion (de)intercalation ability. In addition, HPO 3 2− and C 2 O 4 2− anion groups collaborate to construct a stable framework with multi-dimensional zinc-ion transport channels, providing fast and robust pathway for zinc-ion transport. Carbon composites further improve electronic conductivity, shorten ion transport distance, and increase the electrochemical reaction area of Na 2 [(VO) 2 (HPO 3 ) 2 (C 2 O 4 )]·2H 2 O@C (NVPCO@C) cathode material. As a result, NVPCO@C cathode material delivers a high specific capacity over 180 mAh·g −1 at a current density of 40 mA·g −1 . Moreover, NVPCO@30%C cathode material maintains 100 % capacity after 100 cycles. Ex-situ X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Raman spectra confirm the electrochemical activity of V 4+ /HPO 3 2− ions and reveal the zinc-ion storage mechanism.
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BIOCHEMICAL PHARMACOLOGY
·
2021
·
IF 5.858
Xiaohua Lu,Ge Yan,Sabine M. Klauck,Edmond Fleischer,Anette Klinger,Yoshikazu Sugimoto,Letian Shan,Thomas Efferth
After decades of research, multidrug resistance (MDR) remains a huge challenge in cancer treatment. In this study, the cytotoxic of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide (MCC1734) has been investigated towards multidrug-resistant cancer cell lines. MCC1734 exerted cytotoxicity on cell lines expressing different mechanisms of drug resistance (P-glycoprotein, BCRP, ABCB5, EGFR, p53 knockout) to a different extent. Interestingly, sensitive CCRF-CEM cells and multidrug-resistant P-gp-overexpressing CEM/ADR5000 cells represented similar sensitivity towards MCC1734, indicating MCC1734 can bypass P-gp-mediated resistance. Microarray-based mRNA expression revealed that MCC1734 affected cells by multiple pathways, including cell cycle regulation, mitochondrial dysfunction, apoptosis signaling, and EIF2 signaling. MCC1734 stimulated the generation of excessive reactive oxygen species and the collapse of mitochondria membrane potential in CCRF-CEM cells, companied by the arrest of the cell cycle in the G 2 M phase and apoptosis induction as determined by flow cytometry. In addition, our immunoblotting analysis highlighted that MCC1734 triggered endoplasmic reticulum (ER) stress, evidenced by the activation of p-PERK, p-eIF2α, ATF4 and CHOP. The anti-cancer effects of MCC1734 were further observed in vivo using human xenograft tumors transplanted to zebrafish, providing further support for MCC1734 as a promising new candidate for cancer drug development.
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RSC Advances
·
2013
·Vol. 3
·期 11
·3677-3682
·
IF 2.562
Hongli Xu,Wenli Zhang,Zaijun Lu,Guangzhao Zhang
The difunctional urushiol-based benzoxazine (U-da) was synthesized by utilizing urushiol, 4,4′-diaminodiphenyl methane (DDM) and formaldehyde. The 3,3′-phenylmethanebis(3,4-dihydro-2H-1,3-benzoxazine) (P-da) was prepared by the similar procedure with DDM, phenol and formaldehyde. The U-da and P-da were cured into hybrid polybenzoxazine with different U-da fractions, where the alkyl chains in urushiol can improve the ductility of the polybenzoxazines. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) studies demonstrate that the thermally activated ring-opening polymerization can happen at a relatively low temperature (∼180 °C) without addition of catalyst. The hybrid polybenzoxazines were measured by thermal gravimetric analysis (TGA). It shows the temperatures corresponding to the 5% and 10% weight loss are slightly affected by the U-da content whereas the residual weight at 800 °C increases with P-da content. Dynamic mechanical analysis (DMA) studies indicate that the hybrid polybenzoxazine with U-da content of 50 wt% has a relatively high elongation (10%) and stress (101 MPa) at break. The properties of the hybrid polybenzoxazine can be tuned by the composition.
研究领域:
材料科学
·
高分子化学
·
热分析
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JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
·
2019
·
IF 3.202
Nan Zhao,Mengchun Cheng,Shuai Huang,Dan Liu,Qiang Zhao,Yunpeng Bai,Xiaozhe Zhang
When characterizing components from ginseng, we found a vast number of multicharged anions presented in the liquid chromatography–mass spectrometry (LC-MS) chromatograms. The source of these anions is unclear yet, while ginsenosides, the major components of ginseng, are the main suspected type of molecules because of their sugar moiety. Our investigation using 14 pure ginsenosides affirmed that the multicharged anions were formed by ginsenosides rather than other types of ingredients in ginseng. Various anions could be observed for each ginsenoside. These anions contain ions ([M-2H]2−, [M+Adduct]2−), as well as those formed by polymerization of at least two ginsenosides, such as [nM-2H]2−, [nM-H+Adduct]2−, and [nM-3H]3−. The presence of so different types of ions from a ginsenoside explains the reason for the large number of anions in the LC-MS analysis of ginseng. We further found that formation of [nM-2H]2− ions was influenced by the number of sugar chains: ginsenosides containing two sugar chains produced all [nM-2H]2− ion types, whereas ginsenosides containing one sugar chain did not produce [2M-2H]2−. Thus, [2M-2H]2− and [3M-2H]2− can be utilized to rapidly identify monodesmosidic and/or bidesmosidic ginsenosides as joint diagnostic anions. The position of the glycosyl radical might be the key factor affecting the formation of multicharged multimer ions from monodesmosidic ginsenosides. Consequently, three groups of ginsenoside isomers were differentiated by characteristic [nM-2H]2− anions. Using concentration-dependent characteristics and collision-induced dissociation (CID), we confirmed that [nM-2H]2− ions are non-covalently bound multimers whose aggregation has marked distinction between monodesmosidic and bidesmosidic ginsenosides, accounting for the differentiated formation of [nM-2H]2− between them.
研究领域:
分析化学
·
药物分析
·
质谱学
·
天然产物化学
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Carbon Energy
·
2022
·Vol. 5
·期 2
·e255
·
IF 21.556
Yunke Wang,Yige Zhao,Kangli Liu,Shaobin Wang,Neng Li,Guosheng Shao,Feng Wang,Peng Zhang
Sophisticated efficient electrocatalysts are essential to rectifying the shuttle effect and realizing the high performance of flexible lithium-sulfur batteries (LSBs). Phase transformation of MoSe 2 from the 2H phase to the 1T phase has been proven to be a significant method to improve the catalytic activity. However, precisely controllable phase engineering of MoSe 2 has rarely been reported. Herein, by in situ Li ions intercalation in MoSe 2 , a precisely controllable phase evolution from 2H-MoSe 2 to 1T-MoSe 2 was realized. More importantly, the definite functional relationship between cut-off voltage and phase structure was first identified for phase engineering through in situ observation and modulation methods. The sulfur host (CNFs/1T-MoSe 2 ) presents high charge density, strong polysulfides adsorption, and catalytic kinetics. Moreover, Li-S cells based on it display capacity retention of 875.3 mAh g −1 after 500 cycles at 1 C and an areal capacity of 8.71 mAh cm −2 even at a high sulfur loading of 8.47 mg cm −2 . Furthermore, the flexible pouch cell exhibiting decent performance will endow a promising potential in the wearable energy storage field. This study proposes an effective strategy to precisely control the phase structure of MoSe 2 , which may provide the reference to fabricate the highly efficient electrocatalysts for LSBs and other energy systems.
研究领域:
材料科学
·
电化学
·
储能技术
·
纳米技术
·
电池技术
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