MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Hong Qian Dai,Yuan Lu,Zhi Hin Ou,Min Xu
Fe3O4-APTES-CS2 was prepared by modification of Fe3O4 with 3-aminopropyltriethoxysilane (APTES) and carbon disulfide (CS2). Lipase was covalently bonded to Fe3O4-APTES-CS2 to obtain the immobilized lipase Fe3O4-APTES-CS2-lipase. The textural characteristic of Fe3O4-APTES-CS2-lipase was assessed by scanning electron microscopy. The optimal immobilization conditions were 2.5 mg/mL lipase, pH 7.0, 35 °C, 3 h. The loading amount of lipase was 119.0 mg/g carrier. The immobilization efficiency reached 57%. (R)-(+)-N-acetyl-1-methyl-3-amphetamine was synthesized by Fe3O4-APTES-CS2-Li- pase. The conversion, enantiomeric excess of (R)-(+)-N-acetyl-1-methyl-3-amphet-a- mine and E value reached 36.8%, 98.5% and 132, respectivel.
研究领域:
化学
·
生物化学
·
材料科学
·
催化
✓ 已验证
DOI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 10
·5715
·
IF 6.208
He Wang,Jingjing Li,Qian Yang,Lan Wang,Jing Wang,Yaxin Zhang,Yanjing Guo,Rui Li,Ruiqi Zhang,Xiaorong Tao,Bernal E. Valverde,Sheng Qiang,Hazem M. Kalaji,Shiguo Chen
2-Amino-3-methylhexanoic acid (AMHA) was synthetized as a non-natural amino acid more than 70 years ago; however, its possible function as an inducer of plant resistance has not been reported. Plant resistance inducers, also known as plant elicitors, are becoming a novel and important development direction in crop protection and pest management. We found that free AMHA accumulated in the mycelia but not in fermentation broths of four fungal species,Magnaporthe oryzaeand threeAlternariaspp. We unequivocally confirmed that AMHA is a naturally occurring endogenous (2S, 3S)-α-amino acid, based on isolation, purification and structural analyses. Further experiments demonstrated that AMHA has potent activity-enhancing resistance against extreme temperature stresses in several plant species. It is also highly active against fungal, bacterial and viral diseases by inducing plant resistance. AMHA pretreatment strongly protected wheat against powdery mildew,ArabidopsisagainstPseudomonas syringaeDC3000 and tobacco againstTomato spotted wilt virus. AMHA exhibits a great potential to become a unique natural elicitor protecting plants against biotic and abiotic stresses.Keywords:agricultural production;natural product;plant resistance inducer;biopesticide;biotic and abiotic stress
研究领域:
植物学
·
农业科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
PeerJ
·
2019
·
IF 2.353
Hongli Yin,Ji Ma,Jichun Han,Maoru Li,Jing Shang
Background Quercetin (Qr), isoquercitrin (IQ), and quercetin-3-O-β-D-glucuronide (QG) are powerful phytochemicals that have been shown to exhibit disease prevention and health promotion properties. However, there may exist transformations between Qr, IQ, and QG in vivo . And the pharmacokinetic profiles of Qr, IQ, and QG have not been systematically compared. The pharmacokinetics study would be helpful to better understand the pharmacological actions of them. Methods Herein, we developed a reliable HPLC-MS method to compare the pharmacokinetics of Qr, IQ, and QG after separate (50 mg/kg) oral administration of them in rats, using puerarin as internal standard. The detection was performed using negative selected ion monitoring. This method was validated in terms of selectivity, linearity, precision, accuracy, extraction recovery, matrix effect, and stability; and shows reliabilities in monitoring the pharmacokinetic behaviors of these three compounds. Results Our results showed that after separate oral administration of Qr, IQ, and QG, all of the compounds could be detected in plasma. In addition, QG could be detected in the Qr group; Qr and QG could be measured in the IQ group; and Qr could be found in rat plasma after 1.5 h of QG administration. Moreover, the AUC 0− t of Qr in the; Qr group (2,590.5 ± 987.9 mg/L*min), IQ group (2,212.7 ± 914.1 mg/L*min), and QG group (3,505.7 ± 1,565.0 mg/L*min) was larger than the AUC 0− t of QG in the; Qr group (1,550.0 ± 454.2 mg/L*min), IQ group (669.3 ± 188.3 mg/L*min), and QG group (962.7 ± 602.3 mg/L*min). The AUC 0− t of IQ was the lowest among all groups. Discussion Quercetin, IQ, and QG can all be absorbed into plasma. A mutual transformation exists between Qr and QG, and IQ can be metabolized into Qr and QG in SD rats. These results would provide a meaningful basis for understanding the pharmacological actions of these three compounds.
研究领域:
药理学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Biomolecules
·
2023
·Vol. 13
·期 10
·1464
·
IF 5.5
Xiaoyan Yuan,Junting Yang,Yuling Huang,Jia Li,Yuanyuan Li
There has been a growing interest in studying the communication of gut microbial metabolites between the gut and the liver as liver fibrosis progresses. Although 3-Indolepropionic acid (IPA) is regarded as a clinically valuable gut metabolite for the treatment of certain chronic diseases, the effects of oral administration of IPA on hepatic fibrosis in different animal models have been conflicting. While some mechanisms have been proposed to explain these contradictory effects, the direct impact of IPA on hepatic fibrosis remains unclear. In this study, we found that IPA could directly activate LX-2 human hepatic stellate cells in vitro. IPA upregulated the expression of fibrogenic marker genes and promoted the features associated with HSCs activation, including proliferation and contractility. IPA also increased reactive oxygen species (ROS) in mitochondria and the expression of inflammation-related genes in LX-2 cells. However, when a ROS-blocking agent was used, these effects were reduced. p38 and JNK, the downstream signaling cascades of ROS, were found to be required for the activation of LX-2 induced by IPA. These findings suggest that IPA can directly activate hepatic stellate cells through ROS-induced JNK and p38 signaling pathways.Keywords:gut–liver axis;3-Indolepropionic acid;HSCs;liver fibrosis
研究领域:
胃肠病学
·
肝病学
·
分子生物学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Na Wang,Gaoyi Han,Hua Song,Yaoming Xiao,Yanping Li,Ying Zhang,Hongfei Wang
Thin layers of continuous gold have been deposited on the both sides of porous polypropylene films (PPF) via electroless plating method to form a sandwich structure with two conductive surfaces and an intermediate insulating layer (Au/PPF/Au). Then poly (3, 4-ethylenedioxy thiophene) (PEDOT) layers are electrodeposited on the two conductive sides via cyclic voltammetry method to form the sandwich-structured PEDOT-Au/PPF/Au-PEDOT. Gel electrolyte of H 3 PO 4 /polyvinyl alcohol (H 3 PO 4 /PVA) is then added to the sandwich-structured PEDOT-Au/PPF/Au-PEDOT to form the integrated flexible supercapacitor of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au. The PEDOT-Au/PPF/Au-PEDOT sandwiched structures are characterized and the capacitive performances of the integrated flexible cells are investigated in detail. The results show that the optimum integrated flexible cell exhibits excellent cycling stability (91.8% capacitance retention after 20000 cycles) and relatively high areal specific capacitance. Furthermore, the cells of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au not only exhibit excellent bending endurance (99.1% capacitance retention after 5000 repeated bending cycles), but also can be conveniently connected in series without additional wires. This integrated flexible cell may exhibit potential application in portable electronics.
研究领域:
材料科学
·
能源存储
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Yannan Du,Hongjun Zang,Yimo Feng,Kai Wang,Yaxin Lv,Zhipeng Liu
This paper briefs the emerging strategies for the designing of catalytic systems, which direct conversion of chitin biomass monomer N -acetyl- d -glucosamine (NAG) to 3-acetylamino-5-acetylfuran was studied systemically. Twelve catalysts were investigated, and pyrazine hydrochloride ([Pyz]Cl) ionic liquid exhibited the good performance-achieving 3A5AF with yields of 36.94% from NAG . Further adding boric acid and CaCl 2 , treating at 190 °C for 60 min, the conversion rate of NAG is 100%, and the yield of 3A5AF can be increased to 69.54% in DMA. Furthermore, functional group changes before and after the reaction have been characterized by FTIR, HPLC-MS and 13 C NMR were applied to monitor the reaction process with [Pyz]Cl as the catalyst. The reactive intermediate was clearly detected by these techniques. Accordingly, a possible reaction pathway was proposed. The results of this experiment provide a mild and efficient reaction route for the degradation of biomass, and enrich the theoretical research of quaternary amine catalysts in the conversion of biomass waste into high value-added chemicals.
研究领域:
生物化学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Baolai Wang,Kaili Wei,Fuming Chen,Yinzhen Wang,Guannan He,Wei Li,Junming Liu,Qinyu He
It has been found it more difficult in completely degrading A-ring of tetracycline (TC) than completely degrading B-D rings of tetracycline. Thus, it is very necessary to find an effective route to completely degrading A-ring of tetracycline. In this work, a Z-scheme heterojuncted core-shell La(OH) 3 @BaTiO 3 composite (LB) was designed and fabricated through hydrothermal method . Many characterization techniques were employed to investigate the microstructure, phases, composition, energy band structure , and the lifetime of photogenerated carriers. In the mean time, the photocatalytic properties, including the degradation of A-ring and B-D rings of TC, as well as active species during photo-degradation were investigated. It is found that the as-prepared LB has an improved lifetime of photo-produced carriers, as well as high photocatalytic properties, being attributed to the core-shell structured heterojunction La(OH) 3 @BaTiO 3 . In addition, it is also found that ·O 2 − is more effective on degrading A-ring of TC than other active species, likely owed to the PKa3 value (3.3) of A-ring in TC. This work has supplied a route to completely degrading the A-ring of TC: rationally design and prepare a Z-scheme heterojuncted composites which supply very negative conduction band bottom potential.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 22
·15192-15202
·
IF 3.906
Jinggao Wu,Maowen Xu,Chun Tang,Guannan Li,Hong He,Chang Ming Li
F-Doping effects on polyaniline-derived carbon coated Li3V2(PO4)3 (Li3V2(PO4)3−xFx@C) as a cathode for high performance Li rechargeable batteries are systematically investigated with a combined experimental and DFT theoretical calculation approach. The results clearly indicate that the doping amount has a significant impact on the rate capability and long cycle life. The optimal material (Li3V2(PO4)2.88F0.12@C) delivers 123.16 mA h g−1@2C, which is close to the theoretical value (133 mA h g−1), while showing a greatly improved cycle stability. Rietveld refinements show that the F− doping does not obey Vegard's Law, which may be attributed to the generated lower valence of V ions. AC impedance spectroscopy shows that the F-doping can achieve faster interfacial charge transfer for higher reaction reversibility. DFT calculations confirm that the lower V2+ (t2g↑)3 does exist in Li3V2(PO4)2.88F0.12, and the mean nearest neighbor Li–O bond length also increases for faster electrochemical kinetics, and further reveal that there is a tendency for a transition from the insulator to the n-type semiconductor due to the F dopant. The combined experimental and calculated results suggest that F-doping indeed greatly facilitates the charge transfer rate of the Li+ insertion/de-insertion process for better reversibility and enhances the Li+ diffusion rate to access the reaction sites, thus resulting in high rate capacity and cycling stability. This work not only offers a facile and effective approach to synthesize high performance Li-ion battery material for very promising practical applications, but also discloses scientific insights on element coating and doping to guide the electrode material design for fast electrode kinetics in energy storage devices.
研究领域:
材料科学
·
电化学
·
理论计算
✓ 已验证
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 21
·7456-7463
·
IF 4.39
Zhen-Li Yang,Yue-Mei Wu,Piao He,Wen-li Cao,Saira Manzoor,Jian-Guo Zhang
The development of green energetic materials is based on environmental friendliness, safety and performance improvement. It is of great significance to design and synthesize new nitrogen rich salts for a new generation of green energetic materials. In the present work, a series of 3-amino-5-hydrazinopyrazole energetic salts comprising energetic anions were synthesized and were characterized using elemental analysis, IR spectroscopy and differential scanning calorimetry (DSC). Compounds 1–5 were further confirmed by single crystal X-ray diffraction and the sensitivities were measured by the standard BAM methods. Additionally, the structure–property relationship was elucidated from the experimental results and theoretical calculations. Energetic salts of 2 and 5 exhibited high heat of formation (5, 1160.06 kJ mol−1), high decomposition temperature (2, 172 °C; 5, 186 °C), excellent detonation performance (2, Dv, 9076 m s−1, P 34.1 GPa; 5, Dv, 8974 m s−1, P 31.9 GPa), moderate sensitivity towards outer stimuli and high nitrogen contents (2, 41.03%; 5, 63.84%). This work increases future prospects for the design of insensitive and novel high-energy green energetic material.
研究领域:
含能材料化学
·
有机化学
·
材料科学
·
热分析
·
计算化学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 1
·1-14
·
IF 2.8
Zhang Yajuan,Lu Yang,Shan Yiting,Wang Jie,Feng Jingmin,Zhou Hongqing
Herein, (1 − x )CaO–Al 2 O 3 –B 2 O 3 –SiO 2 (CABS)/ x Ba(Mg 1/3 Nb 2/3 )O 3 (BMN; x = 0.4, 0.45, 0.5, 0.55, and 0.6) composites were prepared, and the impact of the BMN and low-softening-point glass content in CABS/BMN composites on the sintering, dielectric, thermal, and mechanical properties of the prepared composites was investigated. The main crystal phases of the CABS/BMN composites are BMN and Ba 2 NaNb 5 O 15 (BNN). The crystallization temperature of the composite was reduced by an appropriate amount of BMN. BMN ceramics (40–60 wt%) was added to the CABS glass, and the composites were sintered at 800 °C, 825 °C, 850 °C, 875 °C, and 900 °C. To elucidate the influence mechanism of different glass contents and sintering temperatures on the properties of the composites, different qualitative and quantitative instruments were used to study the composite properties. The CABS/BMN composite containing 50 wt% CABS glass sintered at 875 °C exhibits the following ideal properties: volumetric density of 3.57 g/cm 3 , dielectric constant of 17.97, dielectric loss of 6 × 10 −4 , \(Q \times f\) value of 10,947 at 9.5 GHz, bending strength of 157.7 MPa, and coefficient of thermal expansion of 5.9 ppm/K. Microstructure analysis reveals that the microstructure of the composite is dense, the pores are few, the surface morphology is uniform and flat, and the composite does not react with silver electrodes, making it suitable for applications utilizing medium dielectric constant low-temperature co-fired ceramic materials at low sintering temperatures.
研究领域:
材料科学
·
电子工程
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Xiankun Liu,Shiqiang Wen,Weichen You,Xiaofei Wang,Qing X. Li,Qiang Bian,Pei Lv,Rimao Hua
An efficient synthesis method will allow a large number of tetramic acid analogues to be synthesized for property and potency optimization. In this study, a facile and efficient method was described for the synthesis of 3-acyltetramic acids. The synthesis was accomplished mainly via (1) mild intramolecular cyclization and (2) the formation of β-ketoamides between nucleophiles and acyl Meldrum’s acids. 3-Acyltetramic acid exhibited phytotoxicity against Echinochloa crusgalli and Portulaca oleracea. At a dosage of 750 g ha–1, 6k and 6a showed high herbicidal activity against E. crusgalli, Digitaria sanguinalis and P. oleracea, Amaranthus retroflexus, respectively. 6k inhibited the synthesis of endogenous abscisic acid, thus seedling germination and plant growth. The incorporation of various acyl Meldrum’s acids and amino acid esters was applicable to the parallel synthesis of 3-acyltetramic acids. The mode of action and herbicidal activity indicate that 3-tetramic acid had good herbicidal performance and was a promising herbicide candidate. This study will provide a reference for novel herbicide development.
研究领域:
化学
·
农业科学
·
植物生理学
✓ 已验证
DOI
PubMed
高影响因子
Nanoscale Research Letters
·
2020
·Vol. 15
·期 1
·1-8
·
IF 3.578
Lv Fengzhen,Ling Kang,Zhong Tingting,Liu Fuchi,Liang Xiaoguang,Zhu Changming,Liu Jun,Kong Wenjie
High-quality CH 3 NH 3 PbI 3− x Cl x (MAPIC) films were prepared using potassium chloride (KCl) as an additive on indium tin oxide (ITO)-coated glass substrates using a simple one-step and low-temperature solution reaction. The Au/KCl-MAPIC/ITO/glass devices exhibited obvious multilevel resistive switching behavior, moderate endurance, and good retention performance. Electrical conduction analysis indicated that the resistive switching behavior of the KCl-doped MAPIC films was primarily attributed to the trap-controlled space-charge-limited current conduction that was caused by the iodine vacancies in the films. Moreover, the modulations of the barrier in the Au/KCl-MAPIC interface under bias voltages were thought to be responsible for the resistive switching in the carrier injection trapping/detrapping process.
研究领域:
材料科学
·
电子工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）