JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Bo Luo,Yuerui Wu,Xinran Ren,Huimin Li,Xuanru Li,Gege Wang,Mengjia Wang,Luqi Dong,Mengxing Liu,Wei Zhou,Lailiang Qu
In the search for novel succinate dehydrogenase inhibitor (SDHI) fungicides to control Rhizoctonia solani, thirty-five novel pyrazole-4-carboxamides bearing either an oxime ether or an oxime ester group were designed and prepared based on the strategy of molecular hybridization, and their antifungal activities against five plant pathogenic fungi were also investigated. The results indicated that the majority of the compounds containing oxime ether demonstrated outstanding in vitro antifungal activity against R. solani, and some compounds also displayed pronounced antifungal activities against Sclerotinia sclerotiorum and Botrytis cinerea. Particularly, compound 5e exhibited the most promising antifungal activity against R. solani with an EC50 value of 0.039 μg/mL, which was about 20-fold better than that of boscalid (EC50 = 0.799 μg/mL) and 4-fold more potent than fluxapyroxad (EC50 = 0.131 μg/mL). Moreover, the results of the detached leaf assay showed that compound 5e could suppress the growth of R. solani in rice leaves with significant protective efficacies (86.8%) at 100 μg/mL, superior to boscalid (68.1%) and fluxapyroxad (80.6%), indicating promising application prospects. In addition, the succinate dehydrogenase (SDH) enzymatic inhibition assay revealed that compound 5e generated remarkable SDH inhibition (IC50 = 2.04 μM), which was obviously more potent than those of boscalid (IC50 = 7.92 μM) and fluxapyroxad (IC50 = 6.15 μM). Furthermore, SEM analysis showed that compound 5e caused a remarkable disruption to the characteristic structure and morphology of R. solani hyphae, resulting in significant damage. The molecular docking analysis demonstrated that compound 5e could fit into the identical binding pocket of SDH through hydrogen bond interactions as well as fluxapyroxad, indicating that they had a similar antifungal mechanism. The density functional theory and electrostatic potential calculations provided useful information regarding electron distribution and electron transfer, which contributed to understanding the structural features and antifungal mechanism of the lead compound. These findings suggested that compound 5e could be a promising candidate for SDHI fungicides to control R. solani, warranting further investigation.
研究领域:
植物病理学
·
药物化学
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Shuo Song,Liwei Wang,Xinxin Guo,Hongyu Liu,Bingqiang Cao,Jinkai Li,Wenzhi Wang
The application of all inorganic halide perovskite quantum dots (PQDs) in the field of optoelectronic devices has made exciting progress. However, the preparation of CsPbX3·PQDs with high water stability is still a great challenge. In this article, the direct synthesis of CsPbCl3·PQDs in water using 4-chlorobutyric acid (CBA) and oleamine (OLA) as surface ligands was proposed for the first time. Transmission electron microscopy spectra show that the QDs synthesized in water have good crystallinity and monodispersity. At the same time, CBA-CsPbCl3·PQDs synthesized by this method continuously emitted light in water for more than 400 h. In contrast, OA-CsPbCl3·PQDs were almost completely quenched after only 20 min of mixing with water. X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and hydrogen spectroscopy nuclear magnetic resonance were used to verify the passivation effect of CBA on the surface of QDs. The carboxyl ligands provided by CBA form a stable hydrophobic shell on the surface of CsPbCl3·PQDs, which makes CsPbCl3·PQDs have excellent water stability. In this study, CsPbCl3·PQDs with excellent water stability were synthesized with CBA/OLA as the surface ligand for the first time, which provides an effective way to explore perovskite light-emitting diodes with good water stability.
研究领域:
材料科学
·
光电子学
·
纳米技术
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DOI
高影响因子
PROCEEDINGS OF THE COMBUSTION INSTITUTE
·
2022
·
IF 6.535
Wen-luan Xie,Bin Hu,Ying Liu,Hao Fu,Ji Liu,Bing Zhang,Qiang Lu
Lignin pyrolysis involves complex radical reactions, whereas the radical chain process, especially the influence of aliphatic substituents , has been rarely studied. Herein, the typical β -O-4 lignin dimer, phenethyl phenyl ether (PPE), and three aliphatic substituted derivatives of PPE, namely α -OH substituted, β -CH 2 OH substituted, and α,β -disubstituted PPE ( α PPE, β PPE, and αβ PPE) were employed as model compounds. DFT calculations, electronic analyses, and fast pyrolysis experiments were combined to investigate three core steps of the radical chain mechanism in lignin pyrolysis, i.e., homolysis, hydrogen abstraction , and radical decomposition. The pathway involving successive C β -O homolysis → α -hydrogen abstraction → C β -O breakage of α -dehydrogenated radical is dominated for the pyrolysis of aliphatic substituted β -O-4 linked lignin, with the formation of phenolics . The hydrogen abstraction reactions at the C α site are obviously superior to those at other sites for PPE derivatives, due to the p- π conjugate stability. Notably, α -hydrogen abstraction can be significantly promoted by the π -electron-dispersing α -OH substitution. The decomposition step of dehydrogenated radicals can be facilitated by the electron-donating β -CH 2 OH substitution, where the C β -O breakage of the α -dehydrogenated radical is dominant. Totally, aliphatic substituents can improve the radical growth stage and change the competitiveness of the hydrogen abstraction and radical decomposition reactions. The fast pyrolysis experiments of PPE and α PPE gave direct proof that the generation of characteristic products from the radical chain process, i.e., benzaldehyde and phenylacetaldehyde, was enhanced by the α -OH substitution. The present work offers the potential to give a comprehensive image of the radical chain mechanism in lignin pyrolysis.
研究领域:
化学工程
·
能源科学
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DOI
高影响因子
Cell Reports
·
2023
·Vol. 42
·期 9
·113090-113090
·
IF 8.8
Wang D,Zhu Z,Fu Y,Zhang Q,Zhang Y,Wang T,Weng Y,Wen Y,Cao W,Tao G,Wang Y
Polycystic ovary syndrome (PCOS) is an endocrine disorder and the main cause of anovulatory infertility, in which persistent activation of androgen receptor (AR) due to aberrant acetylation modifications of transcription is a potential trigger; however, the precise mechanisms of AR activation are poorly understood. In this study, AR activation in dehydroepiandrosterone- and letrozole-induced rat PCOS ovaries coincided with a marked increase of a chromatin acetylation "reader" BRD4. Further bioinformatic analysis showed that the AR promoter contained highly conserved binding motifs of BRD4 and HIF-1α. BRD4 and HIF-1α inducibly bound to the histone 3/4 acetylation-modified AR promoter, while administration of a BRD4-selective inhibitor JQ1 reduced the binding and AR transcription and improved the adverse expression of the core fibrotic mediators in PCOS ovaries and DHT-treated granulosa cells. Our data indicate that BRD4 upregulation and the resultant AR transcriptional activation constitute an important regulatory pathway that promotes ovarian fibrosis in PCOS.
研究领域:
内分泌学
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生殖医学
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分子生物学
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DOI
PubMed
高影响因子
Catalysts
·
2020
·Vol. 10
·期 7
·746
·
IF 3.52
Yuxiang Lu,Jikai Mao,Zelin Wang,Yazhou Qin,Jianguang Zhou
Controllable morphological metal catalytic materials have always been a focus in research. In the previous work, hexapod AgCl was successfully synthesized. In this paper, hexapod Ag@AgCl microstructures with diverse Ag contents are prepared through NaBH4reduction. They are characterized by scanning electron microscopy (SEM) and the element distribution is proved by an energy dispersive X-ray spectrometer (EDS). They are porous dendritic microstructures with a large specific surface area and a rough surface, which display high catalytic performance and surface-enhanced Raman spectroscopy (SERS) activity. Furthermore, the hexapod Ag@AgCl microstructure is devoted as a dual catalyst to monitor the reduction of 4-nitrothiophenol (4-NTP) to 4-aminothiophenol (4-ATP) in situ using SERS. Ultraviolet–visible (UV–Vis) spectroscopy was employed to evaluate the catalytic performance of the hexapod Ag@AgCl microstructures. The consequences show that the velocity of reaction became faster with a corresponding increase in silver content and the reaction mechanism was cleared. In addition to preparing a good catalyst, this work also promotes the combination of micro-nano materials and spectroscopy technology.Keywords:Ag@AgCl microstructure;in situ monitoring;surface-enhanced Raman spectroscopy;4-nitrothiophenol reduction
研究领域:
材料科学
·
光谱学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 12
·12237-12246
·
IF 2.914
Yang Mi,Shi Xianyang
Biosynthesized nanocomposites are attracting growing interests because they are environmentally friendly. Ag 2 S nanoparticles (Ag 2 S NPs) are deposited in situ on the surfaces of TiO 2 nanotubes (TNTs) via Shewanella oneidensis MR-1 to form Ag 2 S/TNT nanocomposites. The prepared Ag 2 S/TNTs nanocomposites are characterized using high-resolution transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and energy-dispersive X-ray spectroscopy. The results show that Ag 2 S NPs smaller than 8 nm are successfully synthesized and fabricated on the TNT surfaces with relatively uniform distribution. The catalytic performance of the Ag 2 S/TNT nanocomposites is evaluated for catalytic reduction in the presence of NaBH 4 and the photocatalytic degradation of 4-nitrophenol (4-NP) under visible light. The Ag 2 S/TNT nanocomposites show excellent catalytic activity and good stability in the 4-NP reduction process. The 4-NP degradation ratio reaches 98.3% in 50 min, and 87% conversion was achieved after eight cycles. The Ag 2 S/TNT nanocomposites also exhibit excellent photocatalytic activity for 4-NP at a rate of 0.69 h −1 , and the complete degradation of 4-NP was observed within 5 h. Therefore, this study offers an environmentally friendly approach to synthesize nanocomposites for practical applications.
研究领域:
环境科学
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纳米生物学
·
催化化学
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DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Lichen Gou,Xiaoliang Zeng,Huan Du,Ling Li,Yunfei Tian,Xiandeng Hou,Li Wu
Herein, a facile and fast surface-enhanced Raman scattering (SERS) method with ratiometric strategy was developed for detection of 4-methylimidazole (4-MI). Via a chemical derivatization reaction with 3-amino-5-mercapto-1,2,4-triazole (AMTA) diazonium salts, 4-MI could be converted to SERS-sensitive species. The SERS intensity ratio between the peaks at 1243 cm −1 and 1110 cm −1 (I 1243 /I 1110 ) was used for the quantification of 4-MI. In addition, the method sensitivity was further improved by the aggregation of beta-cyclodextrin-modified Ag nanoparticles (beta-CD-AgNPs). Under the optimal conditions, the limit of detection (LOD) and the limit of quantification (LOQ) for 4-MI were 1.7 nM (S/N = 3) and 5.7 nM (S/N = 10), respectively. The relative standard deviation (RSD) for 0.5 μM 4-MI was 8.2% (n = 20). This method was successfully used for the determination of 4-MI in cola samples with recoveries ranging from 92% to 106%. The present method is convenient, sensitive, selective, reliable and may have a promising application in determination of the compounds with an imidazole ring containing active hydrogen atoms .
研究领域:
分析化学
·
食品安全检测
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DOI
PubMed
高影响因子
Catalysts
·
2024
·Vol. 14
·期 11
·797
·
IF 3.8
Hanyang Zhang,Wen Liu,Jiale Hu,Qian Zhang,Zeguo Fang,Dong Li
An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization ofN-phenylpent-4-enamides using readily available and stable AgSCF3as the trifluoromethylthiolating reagent is described. The method enables the synthesis of a series of potential medicinally valuable trifluoromethylthio-substitutedγ-lactams and relative 2-oxazolidinone derivatives with broad functional group compatibility. Mechanistic investigations indicated that this reaction involved amidyl radical-initiated cascade5-exo-trigcyclization followed by trifluoromethylthiolation, resulting in the formation of new C-N and C-S bonds.
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
CHEMICAL PAPERS
·
2016
·Vol. 70
·期 11
·1521-1528
·
IF 1.326
Mei-Hang Chen,Xiao-Bing Wang,Bang-Cheng Tang,Xun Zhang
A series of novel Schiff base derivatives containing 4(3 H )-quinazolinone moiety were synthesised and their antibacterial activities against tobacco and tomato bacterial wilts evaluated in vitro. Out of the synthesised compounds, 5g , 5j , 5n , 5m and 5p exhibited excellent antibacterial activities against tobacco bacterial wilt, with half maximal effective concentrations (EC 50 ): 160.34, 158.03, 125.94, 148.09 and 133.67 (all in μg mL −1 ), respectively, which were better than the EC 50 of thiodiazole–copper (216.70 μg mL −1 ). Compounds 5j , 5n and 5o also showed good antibacterial activities against tomato bacterial wilt, with EC 50 of 95.20, 90.03 and 83.21 (all in μg mL −1 ) respectively, which were better than the EC 50 of thiodiazole–copper (99.80 μg mL −1 ). These compounds may prove to be useful as potential antibacterial agents.
研究领域:
有机化学
·
植物病理学
·
药理学
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DOI
高影响因子
CATALYSIS LETTERS
·
2024
·Vol. 154
·期 8
·4756-4767
·
IF 2.3
Liu Kande,Wang Sitan,Zheng Lishan,Lou Shifeng,Meng Xuan,Cao Fahai,Liu Naiwang,Shi Li
The catalytic performance of Hβ zeolite treated with different concentration of NaOH on the alkylation of tert-butanol with phenol was studied. The effect of NaOH concentration on the crystallinity, morphology, textural property and acidity of Hβ zeolite was studied by X-ray diffraction (XRD), scanning electron microscope characterization (SEM), N 2 adsorption–desorption, Fourier transform infrared spectroscopy (FT-IR) and pyridine adsorption infrared spectra (Py-IR) techniques. A certain concentration of NaOH treatment can regulate the pore structure of Hβ zeolite and remove part of framework aluminum and framework silicon, thus achieving the purpose of regulating the pore structure and acidity of the catalyst. Though lower Bronsted to Lewis acid amount ratio when treated NaOH concentrations were 0.15 mol/L, leading to the increasing of selectivity to 4-TBP. The Hβ-0.2 M showed the high selectivity of 90.21% for synthesis of 4-tert-butyl-phenol (4-TBP), compared with the unmodified parent zeolite, the selectivity of 4-TBP improved 16.7%. Graphical Abstract
研究领域:
催化化学
·
材料科学
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DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2023
·Vol. 25
·期 11
·1-17
·
IF 2.5
Qian Xingcan,He Xiu,Zhang Shilu,Yang Yongsheng,Liu Jun,Dong Jun,Liang Shiwei
Herein, a novel electrochemical biosensor has been proposed for highly sensitive and simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA) based on 4-sulfocalix[6]arene–functionalized carbon nanotubes (CNTs/SCX6) decorated with AuPt bimetallic nanoparticles. Ultraviolet–visible (UV–Vis) spectrophotometry, transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS) mapping, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) have been applied to characterize the morphology and structure of CNTs/SCX6-AuPt. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometric i–t curve reveal that CNTs/SCX6-AuPt–modified glassy carbon electrode (GCE) possesses excellent electrooxidation activity toward AA, DA, and UA. The obtained detection ranges of CNTs/SCX6-AuPt for simultaneous detection of AA, DA, and UA are 0.1–2 mM, 1.5–20 μM, and 2–40 μM with corresponding detection limits of 5.4 μM, 0.08 μM, and 0.37 μM, respectively. The high electrocatalytic activity and rapid electronic transfer ability of CNTs/SCX6-AuPt result in high selectivity, stability, reproducibility, and repeatability. The constructed electrochemical sensor has been used to simultaneously determine AA, DA, and UA in urine samples with good recoveries, which may become a promising method for trace analysis of biological molecules in the complex physiological environment.
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2013
·
IF 0.596
Zhiping Du,Tianhua Shen,Haibo Dang,Zhenfang Fu,Qingbao Song
A simple efficient method for synthesis of Schiff bases in good yields from aromatic aldehydes and 2-(4-aminophenyl)acetonitrile catalysed by 3,5-difluoroarylboric acid at room temperature for 2 hours is reported.
研究领域:
有机化学
·
合成化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）