OPTICAL MATERIALS
·
2022
·
IF 3.754
Tian Zhang,Zhiwen Gan,Shujun Zhen,Yongmei Hu,Xiaoli Hu
Due to the well-known side effects on human health caused by 6-Mercaptopurine (6-MP), it is necessary to develop a simple to operate method for determination of 6-MP. In this work, a simple and easy ratiometric fluorescence probe was fabricated based on two kind of quantum dots with different emission. The probe was composed of blue emission carbon dots (CDs) and yellow emission Zn-doped CdTe quantum dots (ZnCdTe QDs) capped with GSH. The fluorescence intensity of ZnCdTe QDs could be selectively quenched by 6-MP based on fluorescence resonance energy transfer (FRET). At the same time, the fluorescence intensity of CDs basically stayed constant, and the fluorescence intensity ratio ( F 445 / F 565 ) showed a linear response to the concentration of 6-MP. The designed probe of ZnCdTe QDs/CDs displayed a wide and comparable detection range from 1.0 to 100.0 μmol L −1 , and the detection limit reached 0.46 μmol L −1 . Furthermore, the method has been realized for monitoring the concentration of 6-MP in human serum samples.
研究领域:
分析化学
·
生物医学
·
材料科学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2017
·
IF 2.096
Louis Patrick Conway,Fang Fang Liu,Qian Li,Josef Voglmeir
Galactokinases are a class of enzymes which belong to the GHMP (galactokinase, homoserine kinase, mevalonate kinase , and phosphomevalonate kinase) superfamily and catalyse the phosphorylation of galactose in the first step of the Leloir pathway . Here we report the discovery of three enzymes from Shewanella woodyi which have been classified as galactokinases based on sequence similarity. However, each of these enzymes show little to no significant activity towards galactose and instead exhibit a strong preference for glucose. Furthermore, in contrast to the usual galactose-1-phosphate product of the galactokinase-catalysed reaction, these enzymes produce glucose-6-phosphate. This radical change in enzyme functionality is postulated to be linked to the mutation of a glycine residue which is conserved in all other sequenced galactokinases.
研究领域:
生物化学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Rehan Khan,Ihtisham Ul Haq,Heng Mao,Ao-Shuai Zhang,Li-Hao Xu,Hong-Gang Zhen,Zhi-Ping Zhao
Phenol is highly toxic and carcinogenic even at low concentrations. This study focused on preparing high-performance mixed matrix membranes (MMMs) for the pervaporation separation of phenol from its aqueous solution. A highly-efficient zeolitic metal azolate framework, RHO-[Zn(Heim) 2 ] (MAF-6, Heim = 2-ethylimidazole) was incorporated into the polyether block amide (PEBA-2533) supported on the polyvinylidene fluoride (PVDF) ultrafiltration membrane. The MAF-6 was chosen as the filler due to its inherent hydrophobic surfaces and aperture size (7.6 Å), which is larger than the molecular kinetic diameter of phenol (6.6 Å). Effects of the casting solution concentration, active layer thickness, MAF-6 loading, operating temperature, and phenol concentration were systematically investigated. With the increase of the MAF-6 loading ratio X from 0 to 7, the phenol flux of the membrane was gradually enhanced, but the water flux was reduced. For 1000 ppm phenol aqueous solution at 80 °C, MAF-6–7@MMM displayed the optimal separation factor of 25.9 with a phenol flux of 89.2 g∙m −2 ∙h −1 . The pervaporation separation index (PSI) of the MAF-6–7@MMM was 1317.7 kg∙µm∙m −2 ∙h −1 at 80 °C, which was much higher than the PEBA/PVDF membrane (787 kg∙µm∙m −2 ∙h −1 ). Impressively, an increasing feed temperature enhanced the phenol flux more prominently than water, owing to the hydrophobicity and porosity of MAF-6. Consequently, the resultant MAF-6-X@MMMs broke the trade-off limitation between phenol permeability and selectivity. The as-prepared membrane also exhibited exceptional long-term stability, suggesting its prospect of industrial application.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 185
·期 1
·1-6
·
IF 4.58
Liu Xing-Pei,Xie Xing-Li,Wei Yu-Ping,Mao Chang-jie,Chen Jing-Shuai,Niu He-Lin,Song Ji-Ming,Jin Bao-Kang
A film of perovskite-type LaFeO 3 nanoparticles (NPs) was deposited on fluorine-doped tin oxide (FTO) conducting glass via dipping-lifting and calcination. Scanning electron microscopy shows that the NPs are evenly distributed on the surface of the glass. The modified glass was further coated with antibody against human interleukin 6 (IL-6) to result in a photoelectrochemical immunosensor for IL-6. The well-established photoelectrochemical immunoassay has a linear current response in the range of 0.1 pg·mL −1 to 0.1 μg·mL −1 and a detection limit as low as 33 fg·mL −1 . Schematic of a novel photoelectochemical immunoassay for the measurement of IL-6 based on perovskite-type LaFeO3 nanoparticles. The immunoassay had a higher sensitivity and may also be applied to other bioanalysis and environment monitoring.
研究领域:
生物化学
·
分析化学
·
生物传感器
·
免疫分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2017
·
IF 1.753
Kai Chen,Jing Xu,Sheng-Chao Qiu,Yuan Wang,Min-Dong Chen,Yun-Qian Zhang,Xin Xiao,Zhu Tao
We investigated the interactions in an inverted cucurbit[6]uril ( i Q[6]) with a series of 1, ω -alkyldimins and their supramolecular assemblies in the presence of the tetrachlorozincate anion ([ZnCl 4 ] 2− ) structure directing agent . i Q[6] forms an outer surface interaction with [ZnCl 4 ] 2− to form different i Q[6]/[ZnCl 4 ] 2− -based supramolecular assemblies with different length 1,ω-alkyldimins. Interestingly, most 1,ω-alkyldimins were not visible in crystals structures in the presence of concentrated HCl. The porous i Q[6]/[ZnCl 4 ] 2− -based supramolecular assemblies could be used as materials for adsorbing volatile compounds .
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Inflammation
·
2014
·
IF 0
Hang Yang,Haili Qi,Jingli Ren,Jing Cui,Zhenfeng Li,Helge L. Waldum,Guanglin Cui
Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes.
研究领域:
分子生物学
·
肿瘤学
·
免疫学
✓ 已验证
DOI
PubMed
POLYMER ENGINEERING AND SCIENCE
·
2017
·Vol. 57
·期 12
·1301-1310
·
IF 1.449
Xianming Zhang,Menghan Sun,Wenxing Chen
This study examines the selective dispersion of nano-SiO 2 in polystyrene (PS) and polyamide 6 (PA6) blends. With the coupling assistance of 3-methacryloylpropyl trimethoxysilane (MPS), nano-SiO 2 surfaces are grafted with PS chains of different molecular weights (SiO 2 –MPS–PS) or reactive random copolymer of styrene (St) and 3-isopropenyl-α,α′-dimethylbenzene isocyanate (TMI) to produce SiO 2 –MPS–P(St–co–TMI). The isocyanate groups of the reactive copolymer can react with the terminal group of the PA6 to form a graft copolymer, which helps in controlling the location of nano-SiO 2 between the PS and PA6 phases. Field-emission scanning electron microscopy imaging combined with the rheological method was used to investigate the location and dispersion of nano-SiO 2 , as well as the morphology of the PS/PA6 blends, at low nano-SiO 2 loading. Compared with pristine SiO 2 , the modified SiO 2 with different chain lengths adjusted the PA6 phase with refined size and narrow size distribution because of the strong interaction with both phases. The SiO 2 –MPS–PS with appropriate length is the most effective. The use of nano-SiO 2 along with the reactive compatibilizer provides synergistic effects for improving the compatibilization of PS/PA6 blends. POLYM. ENG. SCI., 57:1301–1310, 2017. © 2017 Society of Plastics Engineers
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Jianan Cai,Zhipeng Liu,Bo Cao,Xiaoxiao Guan,Shumei Liu,Jianqing Zhao
Simultaneously improving the mechanical properties and processability of polyamide-6 (PA6) by chain extension in melting extrusion is usually very difficult. To address this issue, a novel small-molecule triepoxy chain extender (D1) is designed, synthesized, and used to modify PA6. The rheological measurements show that the shear viscosity of PA6 containing 2 wt % D1 decreases by 52.2% compared with that of the original PA6 at a shear rate of 1000 s–1, which is in the shear rate range of thermoplastic processing in the industry. This interesting result is attributed to the generation of a long-chain-branched structure of the macromolecular chains of chain-extended PA6, which reduces the power-law index and aggravates the shear-thinning behavior of the PA6 melt. In addition, the corresponding notched impact strength increases from 62.4 to 105.9 J/m. As a result, this work provides a feasible way to prepare PA6 with excellent mechanical properties and processability in industrial production.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 5
·3331-3338
·
IF 4.6
Dinghua Yu,Jianqiang Wang,Guowei Wang
Silane coupling agents play an indispensable role in improving interfacial adhesion of composite materials, but their interaction mechanism is often unclear. This article combines experiments and theoretical calculations to reveal the importance of hydrogen bonds between silane coupling agents and the matrix polyamide 6 in improving the mechanical properties of composite materials. Firstly, glycine bridged silane (GBSilane) was synthesized and the structure was confirmed by FT-IR, 1H NMR and HRMS. Secondly, with glass fiber treated using GBSilane as a filler, the mechanical properties of glass fiber/PA6 composite materials were studied. Compared with untreated glass fiber/PA6 composites, under the optimal treatment concentration of 1.5%, the tensile strength of glass fiber/PA6 composites treated with 3-aminopropyl triethoxysilane (APTES) and GBSilane increased by 41% and 67%, respectively, and the notch impact strength increased by 55% and 96.5%, respectively. Lastly, density functional theory (DFT) calculations revealed that stronger hydrogen bonds have formed between GBSilane and PA6 than APTES, which have induced the stronger PA6–GBSilane binding energy of 58.20 kJ mol−1. By comparison, the binding energy of PA6–APTES is only 30.91 kJ mol−1. These results demonstrated that the as-synthesized GBSilane could improve the mechanical properties of PA6 composites through an enhanced hydrogen bonding mechanism.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 21
·46302
·
IF 1.901
Wenqi Wang,Jie Ying,Jikui Wang
In this article, a novel method has been successfully developed to prepare the anionic polyamide 6/polystyrene (APA6/PS) blends. The macroactivator P(St- co -IEM) was synthesized by the free radical polymerization of 2-isocyanatoethyl methacrylate and styrene (St), then the graft copolymer of PS and APA6 (PS- g -APA6) can be obtained by the anionic polymerization of ɛ-caprolactam activated by the macroactivator P(St- co -IEM). The X-ray diffraction analysis, differential scanning calorimetry, scanning electron microscopy analysis, contact angle measurement, water absorption measurement, molau test, thermogravimetric analysis, and mechanical properties test were performed separately to study the effects of P(St- co -IEM) on crystallinity, morphology, water resistance, thermal stability, and mechanical properties. The results indicate the synthesis of macroactivator can promote the formation of the γ-phase. Moreover, it can improve the interfacial compatibility, water resistance, thermal stability, and toughness. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46302.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Yanfei Jia,Jianwen Wei,Yuan Yuan,Xiaobin zhou,Linlin Geng,Lei Liao
Using KIT-6 as the silica source, a series of Li 4 SiO 4 adsorbents (KIT-6-Li 4 SiO 4 ) were synthesized by impregnation precipitation method for high temperature CO 2 capture. Then, the KIT-6-Li 4 SiO 4 -800–4 (KL-800–4) material, was selected to analyze the improvement of the adsorption performance by Ca 2+ /Na + eutectic doping modification. These adsorbents were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and low temperature N 2 adsorption/desorption, and the CO 2 adsorption capacity of them was explored. At 600 °C and under 15 vol% CO 2 , KL-Ca0.03 and KL-Na0.06 sorbents resulted in a CO 2 uptake of 29.17 wt% and 35.35 wt% (close to the theoretical maximum), respectively，which are much higher than that of KL-800–4 (14.73 wt%). After 10 adsorption/desorption cycles, the adsorption capacity of KL-Na0.06 increased by 1.35 wt%. We found that KL-Na0.06 has more advantages compared with traditional lithium orthosilicate and undoped adsorbents, including lower energy consumption, higher CO 2 adsorption capacity and better cycling ability. Finally, the double exponential model had a high degree of fit for the adsorption of CO 2 by Li 4 SiO 4 .
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Wang Cai,Xin Dongyuan,Yue Qianwen,Wan Huiyu,Li Qian,Wang Ying,Wu Jingguo
Introduction: Interleukin-6 (IL-6) is a multifunctional polypeptide cytokine composed of two glycoprotein chains, which plays an important role in many cellular reactions, pathological processes, diagnosis and treatment of diseases and so on. The detection of IL-6 plays a promising role in the cognition of clinical diseases.Methods: 4-mercaptobenzoic acid (4-MBA) was immobilized on the gold nanoparticles modified platinum carbon (PC) electrode with the linker IL-6 antibody, and finally formed an electrochemical sensor that specifically recognized IL-6. Through the highly specific antigen-antibody reaction, the IL-6 concentration of the samples to be detected. The performance of the sensor was studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV).Results: The experimental results showed that the linear detection range of the sensor for IL-6 was 100 pg/mL–700 pg/mL and the detection limit was 3 pg/mL. In addition, the sensor had the advantages of high specificity, high sensitivity, high stability and reproducibility under the interference environment of bovine serum albumin (BSA), glutathione (GSH), glycine (Gly) and neuron specific enolase (NSE), which provided a prospect for specific antigen detection sensor.Discussion: The prepared electrochemical sensor successfully detected the content of IL-6 in standard and biological samples, showing excellent detection performance. No significant difference was found between the detection results of the sensor and that of ELISA. The sensor showed a very broad prospect in the application and detection of clinical samples.
研究领域:
生物医学工程
·
免疫学
·
临床检验
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）