Small
·
2026
·
IF 11.8
Xinyue Kou,Juan Yue,Yingge Cong,Ruoqian Gao,Wenfei Dong,Li Li
Boron-doped aggregation-induced emission (AIE) nanomaterials (B@AIE NPs) were successfully synthesized via a facile one-pot solvothermal method for dual-modality fluorescence (FL) and magnetic resonance (MR) imaging. The as-prepared B@AIE NPs exhibited a uniform core–shell structure, excellent dispersibility, and strong NIR-II fluorescence emission at 984 nm upon aggregation, attributed to restricted intramolecular motion. Moreover, the boron doping conferred remarkable T 1 -weighted MR contrast capability, with a high longitudinal relaxivity (r 1 ) of 6.12 m m − 1 s − 1 . In vitro studies demonstrated excellent biocompatibility and efficient cellular uptake, with preferential localization in lysosomes. In vivo experiments in HeLa tumor-bearing mice revealed effective tumor accumulation via the enhanced permeability and retention (EPR) effect, enabling high-contrast NIR-II fluorescence and MR imaging. These results highlight the great potential of B@AIE NPs as a promising metal-free nanoprobe for precise tumor diagnosis through FL/MR dual-modal imaging.
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PubMed
高影响因子
Cell Reports Physical Science
·
2026
·Vol. 7
·期 2
·
IF 6.9
Xiangrong Li,Jiayi Niu,Yuanhang Zhang,Mengying Li,Pengfei Zhang,Boxin Wen,Hyunsun Jeong,Dongmei Xie,Yanyan Fang,Hong-Bo Cheng,Yuan Lin,Juyoung Yoon
Electrochemical corrosion threatens microelectronics, especially when coolant leakage occurs in liquid cooling systems, potentially causing short circuits and rapid interfacial degradation. Here, we report an aggregation-induced emission (AIE)-active, stimuli-responsive acrylic resin (AR) copolymer incorporating tetraphenylethylene (TPE) (AR-TPE) designed to address this issue through an electro-ion-coupled assembly mechanism at corrosion-prone interfaces. The amphiphilic polymer AR-TPE, incorporating AIE moieties, undergoes ion-specific conformational transitions upon exposure to H + , Zn 2+ , and Cu 2+ , enabling both optical feedback and adaptive interfacial passivation. While H + and Zn 2+ induce compact aggregates and enhance fluorescence, Cu 2+ promotes loose conformations and quenches fluorescence via charge-transfer complex formation and coordination diversity. Electrochemical tests on Cu/Sn circuit boards demonstrate that AR-TPE forms protective coatings on metal anodes that suppress corrosion and maintain circuit integrity under prolonged electrical stress. Overall, our work establishes a design paradigm for electro-ion-coupled smart polymers that autonomously respond to operational stressors, integrating molecular sensing, adaptive morphology, and functional durability.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yuhong Liu,Xuetao Zhang,Xinhua Shi,Xiaoping Jiang,Jing Zhang,Hui Wang,Meng Gao
Due to the important role of H 2 O 2 in human health and environment safety, the development of portable optical sensors for real-time detection of H 2 O 2 in gas phase is highly anticipated. Herein, an electrospun ratio fluorescence film (PVA@Dual-SiO 2 ) with bead structure was constructed by dual Aggregation-induced Emission (AIE) featured silica nanoparticles for convenient detection of gaseous H 2 O 2 . In this system, the blue-emitted AIE silica nanoparticles (T-SiO 2 ) with H 2 O 2 recognition capability was embedded in the spinning fiber as the fluorescent responder. Meanwhile, the red-emitted AIE silica nanoparticles (F-SiO 2 ) was designed as the fluorescent reference unit in film. By exploiting the peroxide-mediated reaction between T-SiO 2 and H 2 O 2 , the dual-emitting PVA@Dual-SiO 2 could sense gaseous H 2 O 2 with high sensitivity and selectivity by ratiometric fluorescence signals. It proved that this film could be used for detecting H 2 O 2 in food samples. This work developed a bead like fiber film sensor with dual AIE emission, which provided a representative case of the fabrication of portable and integrated film sensor with high fluorescence performance.
研究领域:
分析化学
·
生物传感器
·
材料科学
·
环境监测
·
食品安全
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高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Shizeng Pei,Haoyang Li,Linfeng Chen,Gang Nie,Huiling Wang,Chunrong Liu,Caihong Zhang
Abnormal lipid droplets (LDs) are known to be intimately bound with the occurrence and development of cancer, allowing LDs to be critical biomarkers for cancers. Aggregation-induced emission luminogens (AIEgens), with efficient reactive oxygen species (ROS) production performance, are prime photosensitizers (PSs) for photodynamic therapy (PDT) with imaging. Therefore, the development of dual-functional fluorescent probes with aggregation-induced emission (AIE) characteristics that enable both simultaneous LD monitoring and imaging-guided PDT is essential for concurrent cancer diagnosis and treatment. Herein, we reported the development of a novel LD-targeting fluorescent probe (TDTI) with AIE performance, which was expected to realize the integration of cancer diagnosis through LD visualization and cancer treatment via PDT. We demonstrated that TDTI, with typical AIE characteristics and excellent photostability, could target LDs with high specificity, which enables the dynamic tracking of LDs in living cells, specific imaging of LDs in zebrafish, and the differentiation of cancer cells from normal cells for cancer diagnosis. Meanwhile, TDTI exhibited fast ROS generation ability (achieving equilibrium within 60 s) under white light irradiation (10 mW/cm2). The cell apoptosis assay revealed that TDTI effectively induced growth inhibition and apoptosis of HeLa cells. Further, the results of PDT in vivo indicated that TDTI had a good antitumor effect on the tumor-bearing mice model. Collectively, these results highlight the potential utility of the dual-functional fluorescent probe TDTI in the integrated diagnosis and treatment of cancer.
研究领域:
生物医学
·
肿瘤学
·
分子影像学
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PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Haoyu Ma,Xiaoling Niu,Wenlong Qu,Yongliang Liu,Zhen Feng,Shengbo Zhu
Aggregation induced emission luminogens (AIEgens) as one of the optimal alternatives for designing stimuli-responsive fluorophores for real-life applications have sparked much current interest in smart materials design. Herein, the “Star molecules” in AIEgens of α-cyanostilbene and Tetraphenylethylene (TPE) derivatives were constructed into one molecular, namely DC-TPE-tBu and DC-TPE-CN. Both compounds exhibited significant AIE properties. Moreover, the two compounds could change their luminescent colors and intensities under the stimulation of external mechanical force and UV light, showing excellent mechanochromic luminescent (MCL) and remarkable photo-responsive behaviors, respectively. The stimuli responsive mechanisms were investigated by powder X-Ray diffractometer (PXRD) spectra and density functional theory calculations (DFT). The MLC behaviors were associated with the crystalline-to-amorphous transitions after mechanical grinding. These remarkable features make them suitable for the application of mechano/photo-sensors. The studies provide a useful strategy for developing AIE-active functional materials.
研究领域:
材料科学
·
化学
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高影响因子
Science China-Materials
·
2021
·Vol. 64
·期 10
·2601-2612
·
IF 8.273
Wang Huanhuan,Pan Xiaohong,Wang Yaqi,Liu Wenzhen,Dai Tao,Yuan Binbin,Chen Xueyuan,Chen Zhuo
Photodynamic therapy (PDT) has been drawing more and more attention in the antibacterial field. Traditional photosensitizers (PSs) tend to aggregate in aqueous media, which reduces the generation of reactive oxygen species (ROS) and seriously affects the photodynamic efficacy. Many efforts have been made to prevent aggregation of traditional PSs. By contrast, aggregation-induced emission PSs (AIE-PSs) take advantage of aggregation to boost ROS generation and fluorescence intensity. However, the efficacies of the reported antibacterial AIE-PSs are poor. Herein, we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid structure. TTVBA, a negatively charged AIE-PS, can not only selectively kill spherical bacteria ( Staphylococcus aureus ( S. aureus )) rather than rod-shaped bacteria ( Escherichia coli ( E. coli )), but also be easily extended to several AIE-PSs (TTVBP1-3) with positive charges and broad-spectrum antibacterial activity. We demonstrate that TTVBP2 can kill 3.0 log 10 of S. aureus at very low concentration (125 nmol L −1 ), TTVBP3 can kill 4.7 log 10 of Staphylococcus epidermidis ( S. epidermidis ) at a concentration of 1 µmol L −1 and 3.8 log 10 of E. coli at 5 µmol L −1 , thus enabling them among the most effective antibacterial AIE-PSs reported so far. Meanwhile, these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with bacteria. We thus envision that TTVBA, a nitrobenzoic acid-based extendable AIE PS, provides a new route for the design of AIE-PSs in antibacterial treatment.
研究领域:
化学
·
材料科学
·
微生物学
·
药学
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DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 35
·19701-19706
·
IF 2.936
Zhixiang Lu,Yunming Liu,Shuhan Lu,Yuan Li,Xiaolan Liu,Yu Qin,Liyan Zheng
The detection of Ag+ in the environment is very important to determine the level of pollution from silver complexes, which have caused various human health problems. Herein, an aggregation-induced emission (AIE) chromophore (tetraphenylethane, TPE) attached to a benzimidazole group (tetra-benzimidazole, TBI–TPE) is synthesized and utilized to detect Ag+ in the environment. The strong chelating effect between the benzimidazole group and Ag+ leads to the formation of aggregates, and strong yellow fluorescence signals were observed after adding Ag+ into a TBI–TPE solution. The stoichiometry of the complex of TBI–TPE and Ag+ was established to be 1 : 2 using photochemical and mass spectra measurements. The detection limit of the Ag+ assay is 90 nM with a linear range from 100 nM to 6 μM. This study provides a facile method to determine Ag+ in real environmental samples with satisfactory results.
研究领域:
环境科学
·
分析化学
·
生物医学
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DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2018
·
IF 3.767
Shengjie Jiang,Jiabin Qiu,Yunxiang Chen,Hongyu Guo,Fafu Yang
A series of novel tetraphenylethylene aromatic acylhydrazone derivatives 11 , 12 and 13 with 4, 8 or 12 alkyl chains were designed and synthesized in yields of 82–85%. Studies on the mesomorphic properties suggested the ordered hexagonal columnar mesophase for compounds 11 , 12 and 13 . The increase in the number of alkyl chains was favourable for decreasing the phase-transition temperatures and extending the mesophase temperature range. Further, samples 11 , 12 and 13 presented an excellent AIE effect. The fluorescence intensities increased by 70, 84 and 43 times for samples 11 , 12 and 13 , respectively. The absolute fluorescence quantum yields were 18.7%, 27.4% and 23.8% in solid films at room temperature and 6.7%, 24.2% and 17.3% in the mesophase. These results suggested that the number of alkyl chains greatly influenced the fluorescence emission and sample 12 with 8 alkyl chains exhibited the strongest fluorescence emission. Sample 12 also displayed the electroluminescence performance on OLED device.
研究领域:
材料科学
·
化学
·
光电
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DOI
高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Liying Pan,Shihua Wang,Mintao Xie,Manshan Liang,Lichao Yu,Bing Du,Xiaoxia Ye,Yanshu Luo,Yun-Yun Quan,Zu-Sheng Huang
Rational design of organelle targeted therapeutic platform in where the drug can be targeted to destroy tumor cells as much as possible, is one of the effective ways to improve the therapeutic outcomes and minimize the cytotoxicity to normal cells. Here, photosensitizer TSPy-B with aggregation-induced emission (AIE) feature, biotin receptor and mitochondria dual-targeted capability, and high reactive oxygen species (ROS) generation efficiency was designed for fluorescence imaging guided photodynamic therapy (PDT) by linking biotin group to D-π-A type AIE dyes via ester bonds. Notably, cell imaging experiments showed that TSPy-B could selectively target tumor cells with biotin receptor overexpression and further exhibit mitochondria targeting ability. The in vitro anticancer mechanism confirmed that after cell internalization, TSPy-B localized in the mitochondrial site and produced ROS resulting in mitochondrial dysfunction and cell death. ROS generation experiments showed that TSPy-B could simultaneously produce 1 O 2 and highly toxic free radicals which not depended on the oxygen level of solid tumor. The cell killing effect of TSPy-B was also confirmed in hypoxic culture model. In vivo photodynamic therapy experiments demonstrated that TSPy-B could effectively inhibit tumor growth and had good biological safety. This work provides a choice for development of highly targeted photosensitizers for clinical fluorescence imaging guided PDT.
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高影响因子
Inorganic Chemistry Frontiers
·
2023
·Vol. 11
·期 1
·237-245
·
IF 7
Yongjie Zhang,Luyao Feng,Jingyan Luan,Guomei Zhang,Ning Sheng,Jinglin Shen
Emission enhancement of gold nanoclusters protected with 6-propyl-2-thiouracil (PRT-AuNCs) is achieved through incorporating a suitable amount of Cu2+. Sophisticated mechanisms are involved in the modulation of emission properties of the PRT-AuNCs/Cu2+ system, instead of merely a metal ion induced aggregation. X-ray photoelectron spectroscopy, IR spectroscopy and mass spectroscopy reveal that the Cu2+ is reduced by 6-propyl-2-thiouracil to form a Cu(I)–thiolate complex, which then co-assembles with the AuNCs to form a PRT-Au/Cu composite at an appropriate Cu2+ concentration. Systematic microscopic characterization studies including scanning electron microscopy, X-ray diffraction etc. demonstrate the crucial effect of compact aggregation driven by metallophilic interactions on the emission enhancement of PRT-Au/Cu. Detailed analysis of the photophysical parameters validates that the presence of Cu(I) changes the radiative transition mechanisms of PRT-Au/Cu with respect to primitive PRT-AuNCs. As a result, a cooperative effect of copper-induction and aggregation induced emission (AIE) leads to a strongly emissive composite with bathochromic-shifted emission energy. Moreover, the high molar ratio between Cu and Au in PRT-Au/Cu can effectively reduce the cost of the material in production, and we have developed a WLED to exemplify the potential application of this composite material.
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高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 37
·7401-7407
·
IF 4.726
Haibo Wang,Gongyan Liu,Shihua Dong,Junjie Xiong,Zongliang Du,Xu Cheng
To construct a smart drug delivery system for simultaneous cellular imaging and cancer therapy, a pH-responsive amphiphilic polymer (MPEG-hyd-TPE) with aggregation-induced emission (AIE) character was designed and successfully synthesized. Polymeric micelles self-assembled from MPEG-hyd-TPE exhibited a significant AIE effect in an aqueous solution with excellent biocompatibility; thus, it can be used for potential bioimaging applications. Moreover, the drug-loaded micelles showed typical pH-regulated drug release behavior. DOX was released more rapidly after the drug-loaded micelles were internalized into cancer cells due to the cleavage of the hydrazone bond under acidic endosomal/lysosomal conditions. In addition, in vitro results demonstrated that the drug-loaded micelles exhibited dose-dependent cytotoxicity to HeLa cells.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
癌症研究
·
材料科学
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PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2015
·Vol. 16
·期 2
·223-230
·
IF 3.851
Qiulan Lv,Ke Wang,Dazhuang Xu,Meiying Liu,Qing Wan,Hongye Huang,Shangdong Liang,Xiaoyong Zhang,Yen Wei
Aggregation-induced emission (AIE) dyes have recently attracted much attention for biomedical applications for their remarkable AIE properties. However, the hydrophobic nature of AIE dyes made them difficult to be dispersed in physiological solution and problematic for biomedical application directly. Great efforts have been made to overcome this problem, and different strategies for preparation of water dispersible AIE based nanoprobes had been explored previously. However, a facile and effective strategy is still highly desirable and of great importance for the biomedical applications of AIE dye based on nanoprobes. In this work, the fabrication of amphiphilic hyperbranched fluorescent organic nanoparticles with a core–shell structure based on an AIE dye [tetraphenylethene acrylate (TPE-O-E)] and a hyperbranched polyamino compound [polyethylene imine (PEI)] through Michael addition reaction is described for the first time. The AIE dye as well as the final product PEI-TPE-O-E was characterized in detail by a number of techniques. To test their biomedical application potential, the cell viability as well as cell imaging properties of the PEI-TPE-O-E was also examined. The results showed that the PEI-TPE-O-E organic nanoparticles presented high water dispersiblity, ultrabright fluroerescence, low cytotoxicity and excellent biocompatibility, making them promising for biological imaging and gene delivery applications.
研究领域:
生物医学
·
材料科学
·
分子生物学
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PubMed
高影响因子
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