CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Haixue Jia,Yuna Shang,Hongmei Cao,Yang Gao,Jinjian Liu,Lijun Yang,Cuihong Yang,Chunhua Ren,Zhongyan Wang,Jianfeng Liu
Compared with vaccines comprising inactivated or attenuated whole pathogens, the subunit vaccines based on protein antigens are safer and easier to manufacture. Yet subunit vaccines usually exhibit weak and nondurable immune responses, which is mainly due to their poor uptake by antigen-presenting cells. To address this issue, we develop a fluorinated aromatic peptide (F-AP), in which electronegativity of fluorine is to enhance its affinity with antigens and ability of transmembrane. In mice model, F-AP demonstrated over 4-fold and 501-fold higher antibody titers than AP and conventional aluminum adjuvant, respectively. Consistent with the antibody responses, F-AP greatly promoted the proliferation of T follicular helper cell and mature B cell. Intriguingly, conventional type 1 dendritic cells (cDC1) were also increased in lymph nodes with F-AP vaccination. And antigens localization experiments showed that F-AP help antigens escape from cell lysosomes, indicating that F-AP could potentially induce cellular immune responses through cDC1′s antigen cross-presentation function. Collectively, the data suggest that simple fluorine group modification on aromatic peptide, F-AP, could improve the immune response of subunit antigens. Thus, fluoridation strategy may provide a novel approach for nanomaterials enhancing the vaccination immune response of vaccines or immunotherapies.
研究领域:
免疫学
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疫苗学
·
纳米生物技术
·
肽化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2024
·
IF 3.7
Xin Zhao,Yishuai Jing,Zhonghua Dai,Yuanbo Chu,Zhenyu Liu,Yu Cong,Jiaming Song
As a wide-bandgap rare-earth oxide, Eu2O3 was often utilized as an auxiliary material of other photocatalysts because its photocatalytic performance was limited by the luminescence characteristics of Eu3+ and low light utilization. In this study, we improved the photocatalytic degradation performance of the Eu2O3 nanoparticles by doping with Fe cations. The Eu2O3 nanoparticles with different Fe-doping concentrations (1, 3, and 5%, noted as EF1.0, EF3.0, and EF5.0, respectively) were synthesized via chemical precipitation and calcination methods. It was found that doping could reduce Eu2O3’s bandgap, which probably originated from the introduction of oxygen vacancies with lower energy levels than the conduction band of Eu2O3. Compared with the undoped Eu2O3 nanoparticles with a removal efficiency of 22% for degrading rhodamine B dye within 60 min, the photocatalytic degradation efficiencies of EF1.0, EF3.0, and EF5.0 were demonstrated to be improved to 42, 48, and 33%, respectively, and EF3.0’s performance was the best. The enhanced photocatalytic performance of the doped samples was related to the oxygen vacancies acting as capture centers for electrons, such that the photogenerated electron–hole pairs were efficiently separated and the redox reactions on the surface of the nanoparticles were enhanced accordingly. Additionally, the enhanced light absorption and broadened spectral band further improved EF3.0’s degradation efficiency.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Yuanyuan Zhang,Jing Wang,Wanxiang Yi,Aliya Tiemuer,Hui Yu,Yi Liu,Dan Su
Monoamine oxidase B (MAO-B) activity has been observed abnormally elevated in Parkinson’s disease patients and can be used as a potential biomarker. Herein, we report an activatable frequency upconversion luminescence (FUCL) MAO-B nano-probe (NIR-MNP) capable of highly specific and real-time MAO-B imaging in biological samples. The turn-on FUCL effect is beneficial to obtaining high-quality imaging and penetrating tissue to achieve in vivo imaging, making it stand out from the existing probes. Moreover, we used NIR-MNP to confirm the role of MAO-B inhibitor in delaying Parkinson’s disease (PD) progression in mouse PD models through bio-imaging technique in vivo. Finally, our study may offer a visual way help researchers to gain further insight into the involvement of MAO-B in PD onset and progression in animals.
研究领域:
医学
·
神经科学
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生物化学
✓ 已验证
DOI
高影响因子
FIBERS AND POLYMERS
·
2022
·Vol. 23
·期 10
·2809-2819
·
IF 2.347
Yang Yuhui,Chen Hongbin,Zhang Ruquan,Huang Jingjing,Bai Zhikui,Xiao Shili
The ferric ions sludge produced during pollutants degradation was an obstacle for large scale application of Fenton oxidation technology. Herein, we reported a facile method using 2,2,6,6-tetramethylpiperidine-1-oxygen radical (TEMPO)-oxidized cotton fabric as a substrate for anchoring Fe(II) ions to produce Fe(II)-anchored cotton fabric. The formation of Fe(II)-anchored cotton fabric was confirmed using EDS analysis and FTIR measurement. Bath experiments indicated that Fe(II)-anchored cotton fabric could Fenton oxidize rhodamine B (RhB) dye in a high efficient rate (95.9 %) within 60 min without second pollution. Fe(II)-anchored cotton could be reused without any physical/chemical treatment and its decolorization efficiency was retained at 89.9 % even after the third cycle. Moreover, the decolorization behavior of Fe(II)-anchored cotton fabric for the RhB solution was affected by H 2 O 2 dosage, Fe(II) ion content, and inorganic salts. Kinetic study indicated that the RhB decolorization process fits a pseudo-first order well and the sorption isotherm assessment revealed that the reactive sorption of RhB dye on Fe(II)-anchored cotton fabric fits the Freundlich model.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2019
·
IF 10.159
Ziyan Wu,Qiqi Zhang,Binghan Li,Zhifang Shi,Kaimin Xu,Yi Chen,Zhijun Ning,Qixi Mi
All-inorganic metal halide perovskites are noted for their excellent optoelectronic properties and good chemical stability but also a propensity to transform into nonperovskite phases. A case in point is lead-free CsSnCl3, whose perovskite Phase I is metastable at room temperature and could not be stabilized by partial substitution of Cs+ or Cl–. Judging from the radii of the constituent ions of CsSnCl3, we paid attention to octahedral cations smaller than Sn2+ and selected Mn2+ and In3+ for substitution at the B-site. A quantitative structural indicator, volume per formula unit (V/Z), guided the syntheses of CsSn0.9Mn0.1Cl3 (CTMC) and CsSn0.9In0.067Cl3 (CTIC), which are shown by single-crystal X-ray diffraction and differential scanning calorimetry to be homogeneous, stable perovskite phases at room temperature. CTMC turns into a disordered perovskite structure at 193 K, lower than the corresponding transition temperature of CsSnCl3 by nearly 100 K. Vacancies in CTIC result in a more flexible crystal structure than CTMC and CsSnCl3. CTMC and CTIC appear bright yellow with a steep absorption edge at ∼450 nm, and their photoluminescence peaks are located at 645 and 484 nm, respectively, with intensities significantly enhanced from CsSnCl3. Energy transfer processes are proposed to account for the Stokes shifts in the photoluminescence of CTMC and CTIC. Thin films of CTMC glow red under ultraviolet excitation and hold promise for electroluminescence devices. This study gives insights into the structural and electronic effects of ionic substitution in CsSnCl3 and can be extended to other metastable perovskite phases.
研究领域:
材料科学
·
光电
·
固体化学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Fenqi Du,Dongmei Yang,Yue Sun,Yang Jiao,Feng Teng,Haibo Fan
Ultrawide band gap semiconductor materials have attracted considerable attention in recent years owing to their great potential in the photocatalytic field. In this study, Zn-doped Ga 2 O 3 nanofibers with various concentrations were synthesized via electrospinning; they exhibited a superior photocatalytic degradation performance of rhodamine B dye compared to that of undoped Ga 2 O 3 nanofibers. The Zn dopant replaced Ga sites via replacement doping, which could increase the concentration of oxygen vacancies and lead to enhanced photocatalytic properties. When the Zn concentration increased, a Ga 2 O 3 /ZnGa 2 O 4 hybrid structure formed, which could further enhance the photocatalytic performance. The separation of photogenerated carriers due to Zn doping and heterojunctions were the primary causes of the enhanced photocatalytic performance. This study provides experimental data for the fabrication of high-performance photocatalysts based on Ga 2 O 3 nanomaterials .
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Baosong Li,Xiao Li,Yuxing Huan,Wenzhe Xia,Weiwei Zhang
Influences of alumina nanoparticles on the microstructure and properties of Ni-B nanocomposite coating prepared by electro-co-deposition were studied. The effects of Al 2 O 3 nanoparticles, current density and electrodeposition time on microstructure, corrosion resistance , hardness and surface electronic state of Ni-B nanocomposite coating were revealed by SEM, EDX , XRD , XPS and electrochemical methods. The results demonstrate that the inclusion of Al 2 O 3 nanoparticles in Ni-B coating could improve the hardness and wear resistance accompanied with the grain refinement of the composite matrix . The incorporation of Al 2 O 3 nanoparticles alters the crystal orientation and then the microstructure of the Ni-B matrix. This enhances the corrosion resistance of Ni-B/Al 2 O 3 which is attributed to the compact structure and the reduction in the active surface area. XPS spectra indicate that the coating contains Ni, B, Al, N, O, and C. Under the influence of the grain refinement, hardening of the nanoparticles and the reduction in the active surface area, Ni-B/Al 2 O 3 composite coating exhibits excellent corrosion resistance and hardness.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2020
·Vol. 55
·期 11
·2000093
·
IF 1.169
Hongjun Chen,Zi Wang,Zeyang Xue,Chunhu Yu,Lizhai Pei,Chuangang Fan
A Bi 2 O 3 /In 2 O 3 heterojunction is successfully fabricated via a facile hydrothermal method using sodium bismuthate and indium nitrate as the source materials. The crystal structure, composition, micromorphology, and optical property of the Bi 2 O 3 /In 2 O 3 heterojunction are analyzed by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectrum, scanning electron microscopy, transmission electron microscopy, and solid ultraviolet-visible (UV-vis) diffuse reflectance spectra. The Bi 2 O 3 /In 2 O 3 heterojunction exhibits a remarkable photocatalytic degradation capacity for Rhodamine B, which is better than that of pure Bi 2 O 3 and In 2 O 3 . The photogenerated charges separation and transfer process of the Bi 2 O 3 /In 2 O 3 heterojunction follows a direct Z-scheme mechanism under UV–vis light irradiation. The trapping experiment indicates that oxidative radicals including •OH, h + , and •O 2 − play crucial roles in the photodegradation process. The outstanding photodegradation capacity is ascribed to spatially separated charge carriers, fast-charge transportation characteristic, and special bandgap structure of the Bi 2 O 3 /In 2 O 3 heterojunction. The introduction of H + and OH − ions into the reaction system promotes the formation of •OH and •O 2 − radicals, significantly enhancing the photodegradation rate of RhB. This study presents a new insight into the construction of the Z-scheme Bi 2 O 3 /In 2 O 3 heterojunction photocatalyst with potential application in wastewater treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Wenqin Ling,Zhengguang Zou,Shuchao Zhang,Xiaoxiao Peng,Shiying Luo,Xin Tang,Jing Geng
Heteroatom doping has always been a common modification method for lithium-ion batteries (LIBs) cathodes. The addition of guest heteroatoms to the material can adjust the microstructure of the host material, and enlarge the lattice spacing or form the vacancy defect of oxygen, which can effectively improve the Electrochemical performance of materials. Herein, CO 2 -modified VO 2 (B) nanorods were synthesized via a simple one-step hydrothermal method . Thanks to the extended layer spacing in VO 2 (B) that results from CO 2 small molecules, the synthesized CO 2 -VO 2 electrode exhibits a high initial capacity of 251.1 mA g −1 at 100 mA g −1 , and a capacity retention of 81.8 % after 80 cycles. It is worth noting that the CO 2 -VO 2 electrode also has a high rate capacity (170.0 mAh g −1 at 1 A g −1 ), and the capacity recovery rate can reach 84.5 % even under the condition of variable current. Further studies showed that the role of CO 2 small molecules as a pillar in the interlayer of VO 2 (B) and a weak electrostatic attraction between O CO2 and Li + existed, resulting in a robust crystal structure and convenient Li-ion diffusion conditions during the (de)intercalation of lithium ions in VO 2 (B). This study opens the way for further exploration of the application of small molecule doping in the field of lithium-ion batteries.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 53
·39700-39707
·
IF 3.9
Jianling Huang,Xiuwen Hong,Yunxiang Lv,Yueyue Wang,Kexing Han,Chenghua Zhu,Lixu Xie
Bacterial infections cause high morbidity and mortality worldwide, and the emergence of drug-resistant bacteria further complicates the treatment of infections. Therefore, it is necessary to continuously develop new treatment methods. Polymyxin B (PMB), as the last line of defense, can combat most aerobic Gram-negative bacilli including common drug-resistant bacteria in clinical practice. However, the suboptimal lung tissue concentration of PMB and dose-dependent nephrotoxicity and neurotoxicity limit its clinical application. The nanodrug delivery system offers several key advantages, including high drug loading capacity, excellent biocompatibility, controlled release mechanisms, and targeted delivery. These features enhance the bioavailability of drugs while simultaneously reducing their toxicity and minimizing side effects. In this study, we designed a targeted nanodrug delivery system (PMB@HMnO2@NM) consisting of hollow mesoporous manganese dioxide (HMnO2) coated with neutrophil membrane (NM). In a mouse model of acute pneumonia induced by multidrug-resistant Pseudomonas aeruginosa, treatment with PMB@HMnO2@NM demonstrated the ability to target bacterial aggregation and specifically deliver the drug to the infected lung tissue. This targeted approach resulted in improved survival rates and reduced inflammatory damage without causing adverse effects. The findings of this study suggest the potential for developing a new class of multifunctional nanodrugs, providing new therapeutic strategies for multidrug-resistant (MDR) bacterial infections. Furthermore, these results provide a solid foundation for the design of biomimetic nanosized antibacterial drugs.
研究领域:
医学
·
纳米生物学
·
感染性疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2023
·Vol. 13
·期 7
·1078
·
IF 3.9
Ze Hong,Jingying Ouyang,Jiaxin Li,Han Zheng,Ying Liu
Multi-heterojunctions are more promising than single heterojunctions in photocatalysis due to the availability of more interfaces between each component. However, photocatalytic activity is highly dependent on the contact mode of individual components. In this work, we assembled gold nanoparticles/oxygen-deficient (anatase/B-phase) TiO2multi-heterojunction microspheres using spray pyrolysis and focused on their contact mode-governed photocatalytic activity. The results reveal that using oxygen-deficient (anatase/B-phase) TiO2microspheres as building blocks could significantly enhance the absorption of visible light and the photocatalytic activity of a gold–TiO2system toward the photocatalytic carbon monoxide oxidation. Furthermore, loading gold nanoparticles onto B-phase TiO2could facilitate a more prominent enhancement of activity than that of pure B-phase TiO2, benefiting from the two-electron reduction of oxygen at the interface of TiO2/Au. Meanwhile, the high crystallinity of B-phase TiO2microspheres allows for a gold loading amount of 1 wt% in the gold/(anatase/B-phase) TiO2system, which is 1.67 times more active than pure B-phase TiO2microspheres, in the photocatalytic oxidation of carbon monoxide to generate carbon dioxide.Keywords:photocatalytic carbon monoxide oxidation;B-phase TiO2;oxygen-deficient;microspheres
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 9
·697
·
IF 3.504
Jun Yang,Taiping Xie,Chenglun Liu,Longjun Xu
Dy-doped BiOCl powder photocatalyst was synthesized A one–step coprecipitation method. The incorporation of Dy3+replaced partial Bi3+in BiOCl crystal lattice system. For Rhodamine B (RhB) under visible light irradiation, 2% Dy doped BiOCl possessed highly efficient photocatalytic activity and photodegradation efficiency. The photodegradation ratio of RhB could reach 97.3% after only 30 min of photocatalytic reaction; this was more than relative investigations have reported in the last two years. The main reason was that the 4f electron shell of Dy in the BiOCl crystal lattice system can generate a special electronic shell structure that facilitated the transfer of electron from valance band to conduction band and separation of the photoinduced charge carrier. Apart from material preparation, this research is expected to provide important references for RhB photodegradation in practical applications.Keywords:Dy3+;BiOCl;photocatalyst;RhB photodegradation;doping modification
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）