DIABETES RESEARCH AND CLINICAL PRACTICE
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2025
·
IF 7.4
Mei He,Weiguang Luo,Shuwei Ning,Yuexin Yu,Bin Yang,Zhikun Guo
Objective Beta-hydroxybutyrate (BHB) has been demonstrated to enhance cardiac function in patients with diabetic cardiomyopathy (DCM), the underlying mechanism remains unclear. Methods A DCM rat model was established, BHB was administered via intraperitoneal injection. The therapeutic effects of BHB were assessed based on cardiac function, fasting glucose levels, myocardial fibrosis markers and myocardial macrophage polarization. To elucidate the mechanism of action, co-culture experiments were conducted using cardiac fibroblasts and peritoneal macrophages to evaluate collagen expression in fibroblasts and macrophage polarization under BHB treatment. Results BHB improved cardiac function in DCM rats, reduced fasting glucose levels, alleviated cardiac fibrosis and modulated macrophage polarization. After BHB treatment, the proportion of M1 macrophages decreased while that of M2 macrophages increased in the myocardium of DCM rats. Cardiac fibroblasts isolated from neonatal rats, when co-cultured with peritoneal macrophages under high-glucose conditions, exhibited altered macrophage polarization and collagen expression. High-glucose conditions promoted an increase in M1 macrophages and a decrease in M2 macrophages. BHB treatment reversed this trend by reducing M1 macrophages and promoting M2 macrophage polarization. Conclusions We show that BHB mitigates cardiac fibrosis in DCM rats by promoting M2 macrophage polarization. BHB may be a useful therapeutic approach for DCM treatment.
研究领域:
心脏病学
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内分泌学
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免疫学
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药理学
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DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2022
·Vol. 32
·期 2
·669-680
·
IF 2.525
Liu Ziping,Liu Shasha,Gao Decai,Li Yanan,Tian Ye,Bai Edith
In this work, a convenient and dual-signal readout optical sensing platform for the sensitively and selectively determination of beta-glucosidase (β-Glu) activity was reported using protein-inorganic hybrid nanoflowers [BSA-Cu 3 (PO 4 ) 2 ·3H 2 O] possessing peroxidase-mimicking activity. The nanoflowers (NFs) were facilely synthesized through a self-assembled synthesis strategy at room temperature. The as-prepared NFs could catalytically convert the colorless and non-fluorescent Amplex Red into colored and highly fluorescent resorufin in the presence of hydrogen peroxide via electron transfer process. β-Glu could hydrolyze cyanogenic glycoside, using amygdalin (Amy) as a model, into cyanide ions (CN − ), which can subsequently efficiently suppress the catalytic activity of NFs, accompanied with the fluorescence decrease and the color fading. The concentration of CN − was controlled by β-Glu-triggered enzymatic reaction of Amy. Thus, a sensing system was established for fluorescent and visual determination of β-Glu activity. Under the optimum conditions, the present fluorescent and visual bimodal sensing platform exhibited good sensitivity for β-Glu activity assay with a detection limit of 0.33 U·L −1 . The sensing platform was further applied to determinate β-Glu in real samples and satisfactory results were attained. Additionally, the optical sensing system can potentially be a promising candidate for β-Glu inhibitors screening.
研究领域:
生物化学
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分析化学
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纳米生物学
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DOI
PubMed
高影响因子
Cell Death & Disease
·
2019
·Vol. 10
·期 6
·1-14
·
IF 5.959
Guo Tian,Liu Tianyang,Sun Yun,Liu Xianna,Xiong Rongguo,Li He,Li Zhitao,Zhang Zhiguo,Tian Zhen,Tian Ye
In type 2 diabetes mellitus (T2DM), the overload of glucose and lipids can promote oxidative stress and inflammatory responses and contribute to the failure of beta cells. However, therapies that can modulate the function of beta cells and thus prevent their failure have not been well explored. In this study, beta cell injury model was established with palmitic acid (PA) to simulate the lipotoxicity (high-fat diet) found in T2DM. Sonodynamic therapy (SDT), a novel physicochemical treatment, was applied to treat injured beta cells. We found that SDT had specific effects on mitochondria and induced transient large amount of mitochondrial reactive oxygen species (ROS) production in beta cells. SDT also improved the morphology and function of abnormal mitochondria, inhibited inflammatory response and reduced beta cell dysfunction. The improvement of mitochondria was mediated by PINK1/Parkin-dependent mitophagy. Additionally, SDT rescued the transcription of PINK1 mRNA which was blocked by PA treatment, thus providing abundant PINK1 for mitophagy. Moreover, SDT also increased insulin secretion from beta cells. The protective effects of SDT were abrogated when mitophagy was inhibited by cyclosporin A (CsA). In summary, SDT potently inhibits lipotoxicity-induced beta cell failure via PINK1/Parkin-dependent mitophagy, providing theoretical guidance for T2DM treatment in aspects of islet protection.
研究领域:
内分泌学
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细胞生物学
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糖尿病研究
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DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2013
·
IF 4.675
Yingying Hu,Zhaoyin Wen,Xiangwei Wu,Yan Lu
Polarization problem caused by the incomplete wetting of sodium on β″-alumina has been considered as one of the most difficult issues in Na-beta batteries . Here, nickel nanowire network coatings have been designed and fabricated directly on the β″-alumina electrolyte surface to effectively alleviate this problem. The coating consists of interconnecting nickel nanowires with diameter of about ∼100 nm, forming a highly porous morphology. The structural parameters of the nickel network coatings can be tuned mainly by the amount of the poly(methyl-methacrylate) soft template in the precursors. The nickel nanowire network coatings are demonstrated to greatly improve the wettability of the β″-alumina ceramics by molten sodium. Moreover, the nickel coating displays low sheet resistance of ca. 1 Ω sq −1 . The results of Na/β″-alumina/Na symmetric cells at 350 °C reveal that the polarization and the interfacial resistance of the cell is alleviated intensively by the nickel coating, mainly due to the greatly improved wetting performance of the β″-alumina ceramics. This modification design and the soft-template-assisted synthetic method could be readily extended to any other substrate surfaces with arbitrary shape.
研究领域:
材料科学
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能源存储技术
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Weijian Lu,Jianwen Zhang,Shiqi Zhang,Chen Ji,Ying Wu,Huiyong Chen,Yanxiong Fang,Jinxiang Dong,Baoyu Liu
The development of zeolite catalysts for linear alkylbenzene production is of crucial importance in achieving green chemical processes for the detergent industry. In the present research, the fabricated beta zeolite catalysts exhibited extraordinary activity (73%) and selectivity of 2-LAB (85%) in the alkylation of benzene with 1-dodecene, which benefited from the open micropore-to-mesopore networks, exposed acid sites, and shape-selectivity of special topology of beta zeolites. The computer calculations revealed that both benzene and 1-dodecene can enter into the 12-MR channels of beta zeolites, in which 1-dodecene was adsorbed on the surface of 12-MR channels in the form of chemical adsorption, and the fixed 1-dodecene was attached to benzene combined with the matched pore size of 12-MR channels of beta zeolites to effectively produce the desired 2-LAB. Moreover, the mesopore beta zeolites also presented superior stability compared with traditional micropore beta zeolite in the alkylation between benzene and 1-dodecene due to enhanced diffusion. Our work definitely paved a way to develop mesopore beta zeolites as a new type of highly efficient heterogeneous catalysts for industrial production of 2-LAB.
研究领域:
化学工程
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催化
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材料科学
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产品关联
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 3
·1119
·
IF 4.6
Xingran Kou,Xinping Zhang,Ying Cheng,Miao Yu,Qingran Meng,Qinfei Ke
Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO2), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO2reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.Keywords:spray drying;microcapsules;mannitol;crystallisation;caking
研究领域:
药学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Lujie Liu,Lu Liu,Kaidi Zhang,Mingyang Qin,Huimin Luan,Zhaochi Feng,Jiexun Chen,Liang Wang,Feng-Shou Xiao
Selective transformation of olefins is an important route to produce cyclic monoether glycol products, but the current catalysts still suffer from insufficient activity, selectivity, and durability. Herein, we reported that molybdenum oxide on siliceous beta zeolite was highly efficient for the selective conversion of cyclohexene with a trans-2-methoxycyclohexanol yield as high as 95% in the presence of methanol and tert-butyl hydroperoxide as an oxidant. This reaction included the epoxidation of cyclohexene and subsequent solvolysis. Mechanistic studies revealed that the siliceous beta zeolite benefited the formation of abundant monomeric MoOx species, which was efficient for both the epoxidation of cyclohexene and subsequent solvolysis. Furthermore, this catalyst was also active for the conversion of other olefins, achieving the corresponding β-alkoxyalcohols.
研究领域:
催化
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化学工程
·
有机化学
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产品关联
DOI
高影响因子
FUEL
·
2023
·
IF 7.4
Huan Wang,Xueyin Zhang,Zhipeng Su,Tiehong Chen
Oxidative dehydrogenation of propane in the presence of carbon dioxide (CO 2 ) effectively promotes the utilization of alkanes and CO 2 to produce high value-added olefins and carbon monoxide products. In this work, bimetallic PtCo nanoparticles with diameter of 1–2.5 nm loaded on dealuminated nano-Beta zeolite were successfully prepared for propane oxidative dehydrogenation with CO 2 . The silanol groups formed after dealuminization of nano-Beta zeolite acted as the anchoring sites to enhance the dispersion of PtCo nanoparticles , and the introduction of Co further promoted the uniform distribution of Pt, resulting in smaller bimetallic PtCo nanoparticles. By optimizing the Pt/Co ratio, the conversion of propane and CO 2 at 550 °C was as high as 51.8 % and 30.6 %, respectively. The dealuminized Beta supported PtCo nanoparticles exhibited high stability during the reaction, and there was no obvious aggregation of PtCo nanoparticles after 6 h on stream. In this study, the highly efficient catalyst prepared by impregnation method using modified commercial zeolite as the carrier is suitable for large-scale production and shows great practical prospect in the application of propane oxidative dehydrogenation with CO 2 .
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DOI
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2025
·
IF 3.1
Zhou Mengmeng,Jiang Zehua,Zhang Maosen,Feng Sa,Ma Boyuan,Kan Shunli,Fu Xuanhao,Zhu Rusen
This study aimed to investigate the potential pharmacological effects of icariin (ICA) in the treatment of spinal cord injury (SCI). Network pharmacology was used to focus on the potential targets and biological processes of ICA in SCI. Molecular docking was used to verify the ability of ICA to bind to its core targets. Finally, valuate the efficacy and potential mechanisms of ICA in treating spinal cord injury through in vitro and in vivo experiments. A total of 37 targets were screened out, and core genes were screened out from the protein‒protein interaction network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these targets are enriched mainly in response to hypoxia, regulation of the cellular response to stress, and the TGF-beta signaling pathway. Molecular docking analysis showed that ICA has good docking ability with core targets. In animal experiments, Basso, Beattie and Bresnahan scores, catwalk gait analysis, hematoxylin and eosin staining, and RT-qPCR showed that ICA can inhibit spinal cord inflammation and effectively improve the behavioral and histological recovery after SCI rats. Western blot and immunofluorescence showed that ICA can reduce astrocyte activation and downregulate the TGF-beta signaling pathway after SCI. In addition, ICA can promote axonal nerve elongation and promotes angiogenesis after spinal cord injury in rats. In vitro experiments revealed that ICA can inhibit TGFβ1-induced activation of the TGF-beta signaling pathway and astrocyte activation. ICA treats SCI through multiple targets and pathways. ICA plays a major role in protecting nerves, promoting angiogenesis, and inhibiting reactive astrocyte activation in the treatment of SCI.
研究领域:
神经科学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 13
·期 6
·120316
·
IF 7.2
Jiahe Sun,Wenyue Hou,Ziyi Ma,Guojun Yin,Hongying Lü,Zhiguo Zhu
Creating highly active Mo-incorporated zeolites for catalytic applications remains a significant challenge in materials synthesis. Traditional hydrothermal methods often struggle to balance rapid crystallization with effective Mo incorporation and control over the resulting material's porosity. This work introduces a novel synthetic strategy based on rapid structural reconstruction to produce high-performance Mo-Beta zeolites. Full crystallinity is achieved in just 3 h at 140 °C, a significant improvement over the conventional approaches. The resulting Mo-Beta materials feature a hierarchical micro- and mesoporous architecture and a tunable Si/Mo ratio (53–202), allowing for optimized catalytic performance. These zeolites demonstrate exceptional activity in the oxidative desulfurization of dibenzothiophene, accomplishing a remarkable mass-specific activity (1.50 h –1 ) and turnover frequency (20.8 h –1 ) under the optimized reaction conditions (10 mL model oil; DBT concentration of 500 μg mL –1 ; H 2 O 2 /DBT = 3; 45 mg catalyst; 60 °C). These metrics significantly exceed those reported for many other heteroatom-containing zeolite catalysts. Moreover, the synthesized Mo-Beta catalyst exhibits excellent stability at the reaction time of 1 h. However, slight activity loss is observed at a short reaction time of 0.25 h after five reaction runs and the catalytic activity can be regenerated by calcination. This rapid structural reconstruction method offers a promising new route for the efficient synthesis of advanced Mo-zeolites and highlights their potential for sustainable catalytic applications.
研究领域:
材料化学
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催化
·
无机合成
·
环境化学
·
石油化学加工
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Jingyi Yang,Wenli Shi,Xiangyang Liu,Yafei Zhang,Yang Lu,Xia Gao
This study developed a paper-based colorimetric aptasensor for the detection of β-lactoglobulin (β-LG) in foods, using copper‑cobalt metal-organic framework (CuCo-MOF) as the core catalyst. The sensor achieved a detection limit as low as 0.102 mg/L. and a wide linear range (0.39–1250 mg/L). It offered a simple detection procedure with less than 20 min detection time, making it more suitable for on-site food safety screening. Validation with commercial ELISA confirmed its suitability for analyzing real-food samples, such as milk and infant formula. The developed paper-based RGB colorimetric aptasensor emerges as a user-friendly and economical assay for high-throughput, visual, and accurate determination of β-LG in foods.
研究领域:
食品科学与技术
·
分析化学
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生物传感器
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纳米材料
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食品安全监测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 129
·期 4
·1952-1958
·
IF 1.395
Wei-Sheng Guan,Jun-Ru Lei,Xu Wang,Ya Zhou,Chen-Chen Lu,Shao-Fang Sun
Magnetic nanoparticles were attached to yeast by co-precipitation reaction of FeCl 3 ·6H 2 O and FeCl 2 ·4H 2 O. Then, based on magnetite yeast composites (M@Y), the magnetic molecularly imprinted polymers (MMIPs) were synthesized for the selective recognition of beta-cypermethrin (PP 321 ). MMIPs were characterized by scanning electron microscopy, X-ray diffraction, vibrating sample magnetometer, Fourier transform infrared analysis, thermogravimetric analysis, and elemental analysis. MMIPs exhibited uniform morphology and magnetic property (Ms = 17.87 emu/g) and thermal stability. Batch mode adsorption studies were carried out to investigate the specific adsorption equilibrium, kinetics, and selective recognition. The Langmuir isotherm model was fitted to the equilibrium data slightly better than the Freundlich model, and the adsorption capacity of MMIPs was 39.64 mg/g at 298 K. The kinetic properties of MMIPs were well described by the pseudo-second-order equation. Hydrogen bonds between methacrylic acid and PP 321 were mainly responsible for the adsorption mechanism. The MMIPs prepared were applied to the separation of PP 321 from experimental samples successfully. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）