JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
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2019
·Vol. 95
·期 3
·665-674
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IF 2.659
Yating Liu,Ming Li,Qingyan Zhang,Picai Qin,Xiandong Wang,Guannan He,Ling Li
BACKGROUND The photocatalytic activity of a pristine semiconductor is unsatisfactory due to the rapid recombination of photogenerated electrons and holes. Constructing composite photocatalysts has proven to be an effective method to suppress electron–hole recombination. The composites composed of two materials usually are synthesized through a two-step process. However, in this work, a simple one-step solvothermal method employing an homogeneous reaction system was adopted to synthesize a tungsten trioxide (WO 3 )-copper sulfide (CuS) nanosheet heterojunction with enhanced photocatalytic properties. RESULTS The formation of the WO 3 -CuS heterojunction was confirmed by X-ray diffraction, transmission electron microscopy, energy-dispersive X-ray and X-ray photoelectron spectroscopy analysis. The composites showed improved visible light harvesting ability, and enhanced photoelectric and photocatalytic properties compared with pure WO 3 . The optimized composite displayed a photocurrent almost five-fold greater than the sum of the photocurrents of WO 3 and CuS, and had superior performance for methylene blue (MB) degradation and hexavalent chromium [Cr(VI)] reduction. The MB degradation and Cr(VI) reduction efficiencies were both improved when they co-existed in the photocatalytic system. Interferential ions Cl − and NO 3 − were much less effective in the degradation of MB than in the reduction of Cr(VI). CONCLUSIONS Improved photocatalytic activity was achieved after coupling CuS with WO 3 , due to the enhanced visible light absorption and efficient electron–hole separation. Photogenerated holes were found to be the dominant reactive species in the MB photodegradation process. A synergistic effect existed between MB degradation and Cr(VI) reduction. Interferential ions Cl − and NO 3 − had much greater effect on Cr(VI) reduction than MB degradation. © 2019 Society of Chemical Industry
研究领域:
材料科学
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环境科学
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DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Xueling Long,Siyi Li,Yuxiang Ma,Yuting Cao,Shaoping Sun
Transdermal delivery is considered as a promising convenient and painless approach for the delivery of insulin. In this study, an amphiphilic peptide derivative of oleic acid modified octaarginine (R8-OA) and a photothermal nanomaterial of hyaluronic acid modified CuS (CuS-HA) were successfully synthesized. Using both materials as carriers, CuS-HA enveloped R8-OA@insulin nanocomplexes (HERNCs) were prepared. In vitro studies demonstrated that R8-OA could chemically enhance the penetration of insulin through the stratum corneum. In vivo laser activation studies suggested that CuS-HA in HERNCs could ablate the stratum corneum, thus facilitating the insulin penetration through physical enhancement. The hypoglycemic effect study revealed that blood glucose level in diabetic mice decreased to 42.3% within 4 h, and the value was maintained at 75.1% after 24 h. These results underscored the potential of the enveloped nanocomplexes for enhanced transdermal delivery of insulin.
研究领域:
纳米医学
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药物递送
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透皮治疗
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糖尿病治疗
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生物材料
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DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2023
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IF 22.1
Ao Zhang,Zhongqing Jiang,Shaoda Zhang,Penghua Lan,Naihua Miao,Weiheng Chen,Ning Huang,Xiaoning Tian,Yangjie Liu,Zhongyu Cai
We report the development of non-noble transition metal sulfide catalysts Mn-CuS-x for high-efficiency and selective H 2 O 2 production. In this study, we synthesized Mn-CuS-x with coral-shaped hierarchical porous structure through one-pot hydrothermal reaction. The Mn-CuS-x possesses large specific surface area with plenty of crystalline defects via heteroatom doping of Mn. The Mn-CuS-x kinetically favored 2e − pathway over 4e − pathway, resulting in high selectivity (>92%) to H 2 O 2 production and high H 2 O 2 concentration (∼24.5 mM at 0.6 V vs. RHE) within 3 h for the optimized Mn-CuS-2 catalysts (synthesized with a molar ratio of 1:3:8 (MnCl 2 ·4 H 2 O: CuCl 2 ·2 H 2 O: C 2 H 5 NS)). The Mn-CuS-2 showed excellent stability, indicating that the Mn-CuS electrocatalysts can simultaneously achieve both high stability and enhanced H 2 O 2 production. Our first-principles calculations further confirmed that the heteroatom Mn doping to CuS thermodynamically makes the 2e – -ORR pathway more favorable. This study provides a green, low-cost, and efficient route to produce H 2 O 2 , which is very promising for generating chemicals and liquid fuels.
研究领域:
材料科学
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电催化
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能源化学
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DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2023
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IF 6.1
Jian Liu,Baoheng Yin,Shuang Li,Lian Mi,Guanghao Yin,Feng Li,Lingmei Zhong,Na Bai,Xue Li
Reactive oxygen species (ROS)-based photodynamic therapy (PDT) and heat-based photothermal therapy (PTT) have garnered significant attention for their non-resistant and minimally invasive characteristics in the treatment of bacterial infections. However, the excessive generation of ROS during treatment can lead to persistent levels of oxidative stress, causing irreversible damage to surrounding tissues. In this study, we successfully synthesized a multifunctional nanocomposite consisting of hollow interior and porous surface nanostructured copper sulfide (Nano CuS) loaded with Rutin, a compound known for its ROS scavenging properties. This nanocomposite effectively eliminates bacteria through PDT and PTT in the initial stage, while simultaneously releasing Rutin to clear ROS at the site of inflammation. This dual therapeutic approach provides antimicrobial and anti-inflammatory effects, making it a promising strategy for combating bacterial infections. Overall, our synthesized nanomaterial demonstrates excellent efficacy in antibacterial and anti-inflammatory applications, offering new insights for future developments in infection treatments.
研究领域:
纳米技术
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生物医学工程
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药学
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微生物学
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DOI
高影响因子
NANOTECHNOLOGY
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2022
·Vol. 34
·期 1
·015713
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IF 3.953
Zheyuan Liu,Lingfang Qiu,Ke Wen,Banpeng Cao,Ping Li,Yi Tang,Xiangshu Chen,Hidetoshi Kita,Shuwang Duo
Photocatalysts with heterojunction structure have been widely used for organic degradation. In this study, CuS/g-C3N4 heterojunction was formed by in situ self-assembly via a simply hydrothermal method. A series of characterizations were applied to analyzing the morphology, structure, optical properties and photo-induced electron transfer of the samples. The effect of CuS mass ratio in the CuS/g-C3N4 composite on methyl blue (10 mg l−1) degradation under visible-light illumination was discussed. When CuS mass ratio was 60%, CuS/g-C3N4 behaved the highest photocatalytic efficiency which is 17 times higher than that of pure g-C3N4, and the optimal heterojunction exhibited promising photocatalytic stability as well. The synthesized CuS/g-C3N4 with intimate contact and promising photocatalytic performance provides important implications on analogous researches on g-C3N4-based heterojunctions for photocatalytic applications.
研究领域:
材料科学
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环境科学
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光催化技术
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
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2023
·Vol. 190
·期 4
·1-9
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IF 5.7
Tu Xinman,Deng Lamei,Ren Boyuan,Xu Zihan,Zhang Li
A conventional colorimetric method based on CuS-catalyzed H 2 O 2 is improved by a dual-modification strategy and employed for thioglycolic acid (TGA) determination. The doping of Co(II) can enhance ion exchange efficiency. Meanwhile, the modification of g-C 3 N 4 can increase specific surface area and decrease unspecific aggregation. The constructed g-C 3 N 4 /Co-CuS nanocomposite exhibited a favorable catalytic feature. A Michaelis constant (K m ) value of 0.02 mM has been achieved, which is 1/160 of those of CuS and horseradish peroxidase (HRP). The g-C 3 N 4 /Co-CuS displays a rapid color response in 3 min and resulted in a stable measurable signal within 10 min. In the determination procedure, the sulfhydryl contained in TGA is capable of preventing TMB oxidation via competing the · OH produced by catalysis and caused a color distinction that is related to the TGA amount. The distinctions of absorbance (λ max = 652 nm) of different concentrations of TGA are recorded. Linearity is obtained in the ranges of 2.5 – 20 µM and 20 – 160 µM, and the LOD is 0.14 µM. In the real sample assays of perm agent and Qianhu lake water, the recoveries were 96.70 – 106.84% and 100.21 – 101.90%, respectively. This demonstrates that the proposed dual-modification strategy for CuS contributes to highly efficient and convenient determination of TGA in daily cosmetics and water analysis. Graphical Abstract
研究领域:
分析化学
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材料科学
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环境科学
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化妆品科学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Chenyang Guo,Haoran Chen,Jiaofeng Ye,Jingmin Ran,Libang Feng,Yanhua Liu,Jianbin Zhang,Dianming Li
The simultaneous integration of high strength, toughness, and self-healing capacity in a single material has presented significant challenges. Additionally, most self-healing systems require external stimuli like artificial light or heat to activate the repair process. This study addressed these issues by incorporating TiO 2 /CuS heterojunction nanocrystals into a dynamic oxime-urethane-based polyurethane with metal-coordination interactions. The heterojunction broadened the material's light absorption to entire-spectrum sunlight, enabling the synthesized polyurethane to achieve efficient solar-driven self-healing. The resulting polyurethane exhibited a high healing efficiency of 98.6 % under sunlight, along with outstanding mechanical properties including a tensile strength of 28.43 MPa, elongation at break of 1755 %, toughness of 261.7 MJ/m 3 , and fracture energy of 246.64 kJ/m 2 . Meanwhile, the TiO 2 /CuS heterojunction also endowed the material with strong antibacterial properties, demonstrating a 99 % antibacterial rate. This work resolved the inherent conflict between mechanical performance and self-healing efficiency through the synergistic design of heterojunction nanocrystals and dynamic bonds. It provided a new strategy for developing high-strength, tough materials with effective sunlight-responsive self-healing capabilities. The resulting material holds great potential for applications in smart coatings, flexible electronics, wearable devices.
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Yanlei Liu,Mengbo Shan,Lange Du,Weihao Sun,Dapeng Wu,Qing Bi,Hongju Wang,Yufang Liu
A scalable strategy with commercial feasibility was developed to in situ generate TiO 2 nanowires/amorphous CuS@TiO 2 nanolayer (TiO 2 /CuS@TiO 2 ) composites on the surface of titanium mesh through a sequent hydrothermal method, successive ionic layer adsorption and reaction (SILAR), and atomic layer deposition (ALD) techniques. The TiO 2 /CuS@TiO 2 composites could respectively harness the incident light with different spectra at the photothermal center (CuS, visible and near-infrared light) and photocatalytic center (TiO 2 , UV and visible light), which leads to the effective utilization of the solar energy. Benefiting from the CuS photothermal-induced local heating effect of CuS, the adjacent micro-zone temperature could be elevated and the activation energy barrier could be reduced by 10.5 kJ mol −1 , which promotes the activation of surface lattice oxygen and dissolved oxygen in the photocatalytic process. Meanwhile, the ALD generated TiO 2 nanolayer could both serve as reactive centers but also protecting armor for the CuS, which prohibited the peeling and oxidation of the thermal centers, leading to a high stability of the photocatalyst, which exhibits no obvious fading after 20-cycle reuse. A flow reactor was conceived and made by 3D print and the Ti-mesh based photocatalyst was integrated, which demonstrates high photocatlytic performances, manifesting its great potential for large-scale water treatment.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
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2018
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IF 4.37
Bin Li,Zhongyin Jiang,Diya Xie,Yiqing Wang,Xingzhen Lao
Background Photothermal therapy (PTT) has received extensive attention owing to its non-invasive nature and highly therapeutic outcomes. PTT agents and near-infrared (NIR) laser are essential elements in PTT. However, most PTT agents are composed of heavy metals, characterized by serious cytotoxicity and side effects, and NIR irradiation often damages normal tissue owing to the high dose, thus limiting the clinical application of PTT. Purpose In this regard, exploring new perspectives enabling more PTT agents to be enriched into the tumor and NIR laser irradiation decay in PTT is vital. Methods In this study, cetuximab (Ab), an anti-angiogenic antibody which targets the EGFR, was modified on CuS NPs (CuS-Ab NPs) to improve the aggregation of CuS NPs in the tumor. Results The cellular uptake data and the biodistribution results showed comparable accumulation of CuS-Ab NPs in tumor, thus decreasing the cytotoxicity and side effects in normal tissues. More importantly, the modification of Ab in CuS-Ab NPs impressively inhibited the formation and progression of tumor vessels, as demonstrated by immunohistochemistry staining. The introduction of anti-vessel treatment requires CuS-Ab NPs to provide weak PTT, which means that a small amount of laser energy is required, inevitably causing negligible damage to normal tissue. Conclusion Therefore, our tailor-made CuS-Ab NPs have promising potential in clinical applications.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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药学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
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2022
·Vol. 12
·期 14
·2359
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IF 5.719
Hao Fu,Weiwei Liu,Junqing Li,Wenguang Wu,Qian Zhao,Haoming Bao,Le Zhou,Shuyi Zhu,Jinglin Kong,Hongwen Zhang,Weiping Cai
Surface-enhanced Raman scattering (SERS) provides an unprecedented opportunity for fingerprinting identification and trace-level detection in chemistry, biomedicine, materials, and so on. Although great efforts have been devoted to fabricating sensitive plasmonic nanomaterials, it is still challenging to batch-produce a SERS substrate with high sensitivity, good reproducibility, and perfect recyclability. Here, we describe a facile fabrication of three-dimensional (3D) hierarchical Au/CuS nanocomposites, in which high-density Au nanotips enable highly SERS-active sensing, and the well-defined microflower (MF) geometry produces perfect signal reproducibility (RSD < 5%) for large laser spot excitations (>50 μm2), which is particularly suitable for practical on-site detection with a handheld Raman spectrometer. In addition, a self-cleaning ability of this Au/CuS Schottky junction photocatalyst under sunlight irradiation allows complete removal of the adsorbed analytes, realizing perfect regeneration of the SERS substrates over many cycles. The mass-production, ultra-sensitive, high-reproducibility, and fast-recyclability features of hierarchical Au/CuS MFs greatly facilitate cost-effective and field SERS detection of trace analytes in practice.Keywords:Au/CuS hybrids;high-density nanotips;SERS;signal reproducible;substrate recyclable
研究领域:
化学
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材料科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Xiangwei Yuan,Yao Jin,Li Xu,Lian Ou,Junchun Guo,Qian Wang,Xiaoli Xiong
Efficient and sensitive detection of hydroquinone (HQ) in aquatic environments is paramount for environmental and human health protection. In this study, the CuS nanoparticles are successfully anchored on N-doped carbon nanofibers (CuS/N-CNFs) by electrospinning and sulfuration strategies. The resultant CuS/N-CNFs nanozyme catalyst exhibits abundant sulfur vacancies and mesoporous carbon structures, resulting in excellent electrocatalytic activity for the oxidation of HQ. Furthermore, the catalyst demonstrates significant peroxisase-like activity, which can catalyze colorless 3,3′, 5,5′ −tetramethylbenzidine (TMB) to blue oxTMB in the presence of H 2 O 2 . The mechanism investigations reveal that •OH radical serves as the main active species in this process. Based on these unique properties, a novel electrochemical and colorimetric dual-mode sensor is constructed for HQ detection with linear ranges of 1–614 μM and 1–57 μM, respectively, and the limit of detections (LODs) of 0.293 and 0.621 μM (S/N = 3). Moreover, the established HQ sensor platform is expected to be potential candidate for practical applications due to its satisfactory sensitivity and selectivity in real water samples.
研究领域:
环境科学
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电化学传感
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纳米材料
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Zhen Jin,Yunkai Wang,Miaomiao Han,Li Wang,Fei Lin,Qianfang Jia,Wu Ren,Jiawei Xu,Wenhao Yang,Guo-an Zhao,Xuming Sun,Changqin Jing
Tumor microenvironment (TME)-responsive size-changeable and biodegradable nanoplatforms for multimodal therapy possess huge advantages in anti-tumor therapy. Hence, we developed a hyaluronic acid (HA) modified CuS/MnO 2 nanosheets (HCMNs) as a multifunctional nanoplatform for synergistic chemodynamic therapy (CDT)/photothermal therapy (PTT)/photodynamic therapy (PDT). The prepared HCMNs exhibited significant NIR light absorption and photothermal conversion efficiency because of the densely deposited ultra-small sized CuS nanoparticles on the surface of MnO 2 nanosheet. They could precisely target the tumor cells and rapidly decomposed into small sized nanostructures in the TME, and then efficiently promote intracellular ROS generation through a series of cascade reactions. Moreover, the local temperature elevation induced by photothermal effect also promote the PDT based on CuS nanoparticles and the Fenton-like reaction of Mn 2+ , thereby enhancing the therapeutic efficiency. Furthermore, the T 1 -weighted magnetic resonance (MR) imaging was significantly enhanced by the abundant Mn 2+ ions from the decomposition process of HCMNs. In addition, the CDT/PTT/PDT synergistic therapy using a single NIR light source exhibited considerable anti-tumor effect via in vitro cell test. Therefore, the developed HCMNs will provide great potential for MR imaging and multimodal synergistic cancer therapy.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）