CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Yan Huang,Maowen Chen,Yiding Shen,Xinkun Shen,Menghuan Li,Yanan Li,Yuan Liu,Kaiyong Cai,Zhong Luo,Yan Hu
Osteoporosis is a common bone disease characterized by the systemic disruption of hone homeostasis, where the imbalance between bone resorption and formation causes deterioration of bone structure and bone mass loss. Targeted restoration of bone hemostasis has thus become a promising strategy for osteoporosis treatment. For this purpose, we report a bone-targeted nanoformulation based on CaCO 3 nanomaterials, which could be activated in the acidic osteoporotic microenvironment and cooperatively regulate the activity of osteoclasts and osteoblasts to reverse bone deterioration. Herein, a clinical antiosteoporosis drug β-estradiol (E2) is first biomineralized using CaCO 3 to form physiologically stable nanocores. Meanwhile, azido groups are introduced onto MC3T3-E1 cells through incubation with AC 4 ManNAz. The azido-tagged MC3T3-E1 cell membranes are extracted for the camouflaging of the CaCO 3 @E2 nanocores to enhance their in vivo stability and availability, while also enabling the surface modification of bone-targeting dibenzocyclooctyne-tagged alendronate moieties via copper-free click reaction. After the selective deposition into acidic osteoporotic bone tissues, the CaCO 3 @E2 cores would be spontaneously degraded to release E2 and Ca 2+ ions, which would systematically inhibit the activity of osteoclasts while promoting osteoblast-mediated new bone formation, eventually ameliorating the osteoporosis symptoms. This study offers an effective approach for osteoporosis treatment in the clinics.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-15
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IF 10.2
Su Runping,Gu Jingjing,Sun Juanjuan,Zang Jie,Zhao Yuge,Zhang Tingting,Chen Yingna,Chong Gaowei,Yin Weimin,Zheng Xiao,Liu Bingbing,Huang Li,Ruan Shuangrong,Dong Haiqing,Li Yan,Li Yongyong
Antigen self-assembly nanovaccines advance the minimalist design of therapeutic cancer vaccines, but the issue of inefficient cross-presentation has not yet been fully addressed. Herein, we report a unique approach by combining the concepts of “antigen multi-copy display” and “calcium carbonate (CaCO 3 ) biomineralization” to increase cross-presentation. Based on this strategy, we successfully construct sub-100 nm biomineralized antigen nanosponges (BANSs) with high CaCO 3 loading (38.13 wt%) and antigen density (61.87%). BANSs can be effectively uptaken by immature antigen-presenting cells (APCs) in the lymph node upon subcutaneous injection. Achieving efficient spatiotemporal coordination of antigen cross-presentation and immune effects, BANSs induce the production of CD4 + T helper cells and cytotoxic T lymphocytes, resulting in effective tumor growth inhibition. BANSs combined with anti-PD-1 antibodies synergistically enhance anti-tumor immunity and reverse the tumor immunosuppressive microenvironment. Overall, this CaCO 3 powder-mediated biomineralization of antigen nanosponges offer a robust and safe strategy for cancer immunotherapy.
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2023
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IF 12.6
Huanhuan Li,Wenhui Geng,Zhixiong Qi,Waqas Ahmad,Suleiman A. Haruna,Quansheng Chen
In this work, a stimuli-responsive SERS biosensor was fabricated for tetracycline (TTC) by “signal-on” strategy using (EDTA)-driven polyethyleneimine grafted calcium carbonate ( [email protected] 3 ) microcapsule and chitosan-Fe magnetic microbeads ( [email protected] ). Initially, aptamer conjugated magnetic-bead [email protected] @Apt with superparamagnetism and excellent biocompatibility was employed as capture probe, which facilitated the rapid and easy magnetic separation. Subsequently, the PEI cross-linked layer and aptamer network layer were constructed onto the outer layer of CaCO 3 @4-ATP microcapsule to form sensing probes ( [email protected] 3 @ [email protected] ) via the layer-by-layer assembly method. In the presence of TTC, a sandwich SERS-assay was exploited by aptamer recognition induced target-bridged strategy. When the solution of EDTA was added, the core layer of CaCO 3 would be dissolved quickly, destroying the microcapsule to release 4-ATP. The released 4-ATP could be quantitatively monitored by dripping the supernatant onto the [email protected] SERS platform, resulting in a strong Raman “signal-on”. Under the optimal conditions, a good linear relationship was established with a correlation coefficient ( R 2 ) of 0.9938 and a LOD of 0.03 ng/mL. Additionally, the application capacity of the biosensor to detect TTC was also affirmed in food matrixes, and the results were consistent with the standard ELISA method ( P > 0.05). Hence, this SERS biosensor affords extensive application prospects for TTC detection with multiple merits such as high sensitivity, environment friendliness, and high stability.
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ELECTROCHIMICA ACTA
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2022
·
IF 7.336
Xiaobo Ma,Lijun Gao,Qiyu Zhang,Weibo Hua,Yating Zhang,Xinyang Li,Juan Yang,Shujiang Ding,Chao Hu
The traditional Haber-Bosch N 2 fixation process suffers from rigorous reaction conditions and massive CO 2 emission. By contrast, N 2 electroreduction by water to the direct production of NH 3 can be conducted at room temperature and atmospheric pressure, and thus has been attracting increasingly attention. Herein, we develop a nano-CaCO 3 template route for the synthesis of Fe, N co-doped porous carbon materials from zeolitic imidazolate framework-8 (ZIF-8). The Fe atoms are atomically dispersed in the skeleton of carbon and bonded with four nitrogen atoms . Interestingly, the morphology and pore structure of these carbons have notable effects on their performance for the electrocatalytic reduction of N 2 . With an optimized morphology and pore structure tuned by the addition of nano-CaCO 3 template, the ZIF-8 derived Fe, N co-doped carbon catalyst shows a Faradaic efficiency of 13.14% and a NH 3 yield as high as 13.01 µg h −1 mg cat −1 (−0.2 vs . reversible hydrogen electrode) for N 2 reduction reaction in 0.1 M KOH aqueous electrolyte . Morphology engineering strategy may open a new path to designing and synthesizing high-performance carbon-based catalysts for the electroreduction of N 2 to NH 3 .
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APPLIED SURFACE SCIENCE
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2022
·
IF 7.392
Yingyue Hu,Xinyao Hu,Lu Xue,Baolong Cui,Yi Du
The modulation of crystal surface is one of the important means of photocatalyst modification. BiOBr photocatalyst with exposed (1 1 0) facets was synthesized at room temperature and pressure using CaCO 3 as a directing agent in this experiment. The addition of CaCO 3 not only promoted the exposed facets of BiOBr from (1 0 2) to (1 1 0), but also improved its ability of photocatalytic degradation of pollutants, meanwhile, changed the specific surface area of BiOBr, provided more active sites, and enhanced the adsorption capacity of BiOBr. At the same time, the effects of different alkaline earth metals on the performance of BiOBr photocatalytic materials were compared, it was determined that the degradation rate of RhB of BiOBr photocatalyst reached 97% within 60 min when adding 500 wt% CaCO 3 , and the main active group in the degradation experiment was h + . In conclusion, BiOBr with different main exposed facets was prepared in this paper, and a new idea was provided for alkaline earth metals in the field of photocatalysis.
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TRIBOLOGY LETTERS
·
2022
·Vol. 70
·期 3
·1-14
·
IF 3.327
Wu Can,Xie Yijia,Zhao Huijun,Yang Haining,Li Xinglin,Ni Jing
The influences of Hexagonal boron nitride (hBN) and Calcium carbonate (CaCO 3 ) nanoparticles on tribological and bearing vibration properties of polyurea grease (PG) were investigated. The microstructure, friction coefficient, wear morphology, and bearing vibration test of five components of greases were conducted. The results showed that the addition of 1 wt% hBN, playing the role of isolation protection and nano-abrasive, could improve the wear and vibration reduction performance of PG. However, the addition of CaCO 3 nanoparticles at the same time, playing the role of deposition and recovery, could further improve the tribological and vibration reduction performance of PG, which was attributed to the synergistic effect of CaCO 3 and hBN particles. The findings revealed that PG with the addition of 1 wt% hBN + 5 wt% CaCO 3 nanoparticles had the greatest tribological and vibration suppression performance, which is due to the synergistic effect of hBN and CaCO 3 nanoparticles. Additionally, the wettability tests showed that the addition of hBN and CaCO 3 nanoparticles could significantly increase the flow of base oil on the PG soap fibers, resulting in the most effective bearing vibration suppression.
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JOURNAL OF SOLID STATE CHEMISTRY
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2021
·
IF 3.498
Falong Wang,Yaqiang Dong,Liang Chang,Yan Pan,Qiang Chi,Mengji Gong,Jiawei Li,Aina He,Xinmin Wang
In this paper, a novel type of nano-CaCO 3 /epoxy nanocomposites insulating layer for the FeSiCr/carbonyl-iron soft magnetic composites (SMCs) has been successfully developed. The novel inorganic/resin nanocomposites can greatly reduce the core loss of the SMCs while maintain other excellent magnetic properties . By optimizing the content of insulating layer, the FeSiCr/carbonyl-iron SMCs exhibits the lowest core loss of 466.5 mW/cm 3 at a maximum magnetic induction of 50 mT and frequency of 100 kHz, which is greatly reduced by 24.2%, compared with the sample only coated by epoxy resin . Meanwhile, the effective permeability and quality factor remains high. In addition, the production process of the novel nano-CaCO 3 /epoxy nanocomposites insulating layer exhibits the advantages of simplicity, convenience and low cost compared with other ceramic coatings (Al 2 O 3 , MgO , SiO 2 , etc.) and surface nitride coatings, which is more suitable for the industrialization of molded inductors, and therefore has a variety of industrial application prospects.
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ENERGY
·
2020
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IF 6.082
Azhar Abbas Khosa,J. Yan,C.Y. Zhao
CaCO 3 /CaO based thermochemical energy storage system has a promising potential for the concentrated solar power plants. However, the low reactivity and sintering of CaCO 3 /CaO restricts the energy storage/release performance of this system. In this work, we report ZnO as a new doping material for the CaCO 3 /CaO TCES system. We tested different loadings of ZnO and determined an optimal loading for the best performance. The reaction kinetics of both the doped as well as the undoped system in the decarbonation step is presented in detail. Furthermore, the energy storage capacity and the cyclic stability over first 100 cycles is reported. It is found that the ZnO-doped CaCO 3 can absorb 1478.8 J/g energy at the optimal loading. The cyclic conversion of the ZnO-doped system stabilizes after 20 cycles, which is an improvement from the undoped system that shows a slow but steady decline even after 100 cycles. ZnO seems to be a viable doping material, which considering its low cost and availability can lead to an improved thermochemical energy storage system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Kegui Zhang,Wenzhong Yang,Feng Ge,Bin Xu,Yun Chen,Xiaoshuang Yin,Ying Liu,Huanzhen Zuo
A composite coating containing konjac glucomannan (KGM) and CaCO 3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The effect of Ca(OH) 2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements. Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM). The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure. The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO 3 . The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal. After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Depeng Liu,Bo Yu,Guohua Jiang,Weijiang Yu,Yang Zhang,Bin Xu
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from insulin-loaded CaCO 3 microparticles (INS-CaCO 3 MPs) and poly(vinyl pyrrolidone) (PVP) as matrix were fabricated with two-step centrifuging and molding process to immobilize insulin in the MNs. The as-prepared INS-CaCO 3 /PVP MNs exhibited remarkable mechanical strength and slower solubility properties when compared with pure PVP MNs. In vitro skin insertion capability was determined by staining with FITC-labeled insulin which was revealed after insertion, gradually diffusing from the puncture sites to deeper tissues. In vivo pharmacodynamic studies were then conducted to estimate the feasibility of the administration of insulin-loaded dissolving MNs on diabetic rats for glucose regulation. The relative pharmacological availability ( RPA ) and relative bioavailability ( RBA ) of insulin from MNs were 98.2 and 96.6%. Thus, this study suggests that the use of INS-CaCO 3 /PVP MNs achieved both high efficiency and constant release of insulin in comparison with the traditional subcutaneous injection approach and presented a promising device to delivery insulin for diabetic therapy.
研究领域:
药剂学
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糖尿病治疗
·
生物材料科学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Bao-Qi Feng,Han-Qing Chen,Chao Ping,Xiang Huang,Wen-Long Liu,Bao-Xia Dong,Yun-Lei Teng
The development of inert additive-doped CaO-based CO 2 adsorbents is a promising method to obtain efficient CO 2 adsorbents, while multiple programs are frequently involved, the organic solvent is often used, and CO 2 is sometimes released in the process of preparation. In this study, we first report that inert additive-doped CaO-based adsorbents can be synthesized in one pot by the mechanochemical hydrogenation reduction of CaCO 3 producing methane and avoiding CO 2 emission. The prepared CaO@C and CaO@MgO@C composites are high-performance CO 2 adsorbents with high CO 2 adsorption capacity and superior cycling stability. The results show that the CO 2 capture capacities of the CaO@C and CaO@MgO@C composites are 19.14 and 14.53 wt% higher than that of the BM-CaO (37.07 wt%), respectively, at 650 °C carbonation for 2 h. Notably, the activity losses of the CaO@C and CaO@MgO@C composites after 30 cycles are about 47.93 and 29.33%, which are much lower than that of the BM-CaO (60.39%). The performance of the CaO@C and CaO@MgO@C adsorbents is comparable to that of adsorbents synthesized by the conventional methods, but this work provides novel, simple, solution-free, and sustainable strategies to synthesize effective CaO-based CO 2 adsorbents in one pot.
研究领域:
材料科学
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环境化学
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能源工程
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无机化学
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碳捕集与封存
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绿色化学
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功能材料
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2020
·
IF 2.734
Jiahong Dou,Fang Zhao,Wenting Fan,Zhonghang Chen,Xuhong Guo
An ideal anticancer drug release system is designed to release drugs over a prolonged period while minimizing the initial burst to significantly reduce the side effects and the number of medications. In this study, CaCO 3 particles (average diameter 800-1600 nm with PDI < 0.2) aiming at such controlled release system were successfully prepared via Flash Nano Precipitation technique. Hydroxypropyl methylcellulose and sodium dodecyl sulfate were both employed as additives for CaCO 3 crystallization to promote the formation of vaterite and convex-disc-shaped CaCO 3 , and at the same time as stabilizers for CaCO 3 particles to control particle growth and avoid particle agglomeration . By using the as-prepared vaterites, a satisfying drug loading capacity (~0.1 mg drug/mg particle) was realized, and prolonged drug release was achieved with a low initial release (< 10% within 1 day at pH = 6.0) and approximately zero-order release kinetics before 36 h ( R 2 > 0.97) or after 36 h ( R 2 > 0.99). Besides, by changing the particle size, different drug release kinetics could be achieved while the high drug loading capacity and low initial release were both maintained. The vaterite particles prepared in this work could be a potential candidate drug carrier for extended drug release with minimized initial burst and a constant drug releasing rate.
研究领域:
药物递送
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材料科学
·
生物医学工程
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