FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Chen Yang,Dongyu Geng,Ying Sun,Aitong Li,Zengchao Zhou,Haiyue Hu,Yening Qiao,Yingrui Lu,Nanqing Xu,Lina Wang,Jianming Wang
Composite particles of oat protein isolate (OPI) and chitosan (CS) were fabricated under different pH and ratio to investigate their interactions, and then used as stabilizers to prepare emulsions for β-carotene delivery. The heat treatment of OPI yielded OPI′, and the binding of OPI′ to CS was enhanced due to the unfolding of its structure. With increasing OPI′:CS ratio and pH value, the particle size and turbidity initially increased and then decreased, accompanied by a shift in the dominant interaction from electrostatic to hydrophobic forces. The strongest hydrophobic interaction was observed at OPI′:CS = 5:1 and pH 7. The emulsion prepared under these conditions exhibited the smallest droplet size (1.55 μm), excellent storage stability, and a high bioaccessibility of β-carotene (36.78%) during in vitro digestion. Furthermore, the OPI′/CS emulsion markedly enhanced the retention of β-carotene under various storage temperatures and UV irradiation, demonstrating great potential for delivering lipophilic bioactive compounds.
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International Journal of Applied Glass Science
·
2026
·Vol. 17
·期 3
·e70037
·
IF 2
Wei Han,Wengui Ru,Rugeng Liu,Xiyang Liu,Linghao Hou,Weiqun Shi,Hui He,Mei Li
137 Cs has become one of the key challenges in the dry reprocessing of spent fuel due to its poor separability and high radioactivity. The synthesis of Cs 2 SnCl 6 for the removal of CsCl from waste salts and the preparation of Cs 2 SnCl 6 -glass composites was investigated in this study. The optimal conditions for the hydrothermal synthesis of Cs 2 SnCl 6 are a reaction at 150°C for 6 h, and XRD results indicate that the product is a pure cubic phase. CsCl is removed from LiCl-KCl-CsCl waste salts by the synthesis of Cs 2 SnCl 6 . This method enables efficient and selective separation of Cs + from waste salts with a Cs + content of 2.5–10 wt.%, achieving a removal efficiency of over 96%. The glass composites have a maximum embedding rate of 30 wt.%. Cs + and Cl − are uniformly distributed in the glass matrix, and the glass matrix exhibits good compatibility with Cs 2 SnCl 6 . The PCT test showed that the normalized leaching rates of Cs + and Cl − on the 28th day were as low as 1.6×10 − 4 and 3.4×10 − 4 g·m − 2 ·d − 1 , respectively, demonstrating that the Cs 2 SnCl 6 -glass composite exhibits excellent leaching resistance.
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MACROMOLECULAR RESEARCH
·
2018
·Vol. 26
·期 10
·892-899
·
IF 1.767
Huang Mengjia,Li Jie,Chen Jia,Zhou Mi,He Jianguo
The wound healing for tympanic membrane (TM) perforations is one of the most common clinic treatment. New designs of biomaterials, and lately tissue-engineered composites and grafts, have been applied for the management of TM perforation. In this work, a series of chitosan (CS)/polyvinyl alcohol (PVA) nanofibrous films have been fabricated as a kind of patch for repairing TM perforation. The scaffolds were crosslinked by glutaraldehyde solution to prevent them from being dissolved in the culture medium. The morphology of nanofibers from different precursors has been observed by using scanning electron microscopy (SEM). And the crosslinked films have been characterized by SEM and Fourier transform infrared spectroscopy for confirming its morphology and chemical structure. We found the films with crosslinking showed stronger tensile strength and modulus compared to the uncrosslinked one. And the mechanical properties could be tuned by the crosslinking time. In addition, after crosslinked, the films showed good thermostability and water-resistance, characterized by thermo gravimetric analyzer and contact angle meter. The cell viability studies with human umbilical vein endothelial cells, fibroblasts and mesenchymal stem cells demonstrated that the nanofibrous scaffolds formed by electrospinning process had no side effects for cell proliferation. However, a better way of crosslinking CS/PVA films needs to be further studied.
研究领域:
生物材料学
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组织工程学
·
耳科学
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ACS Omega
·
2023
·
IF 4.1
Hui Sun,Bingbing Wang,Youxiu Xie,Fengchun Li,Tao Xu,Bin Yu
The biodegradable activity antibacterial materials have been widely applied on food preservation because they not only protect foods from pathogenic attacks but also relieve environmental pollution. Biodegradable melt-blown nonwovens (MB) have several advantages over the other materials in terms of a simpler and more environmentally friendly fabrication process, higher specific surface area, and lower cost. Herein, polylactic acid (PLA) MB is first modified by polydopamine (PDA) to activate the surface. Then, chitosan (CS) and cinnamon essential oil (CEO) are used to decorate the surface of the modified PLA MB via a simple one-pot method to prepare CEO/CS@PLA MB with different CEO contents. Compared with PLA MB, CEO/CS@PLA MB had a rougher surface and larger average fiber diameter, while the average pore diameter and air permeability reduced. The input of CEO led to a decrease in the tensile strength of CEO/CS@PLA MB and an obvious increase in the elongation at break. The combination of CS and CEO shows excellent synergistic antibacterial effect. The antibacterial efficiencies of CEO/CS@PLA MB against Escherichia coli and Staphylococcus aureus enhance with the increase of the CEO content. When the weight ratio of CS to CEO is 1:2, the antibacterial efficiencies of CEO2/CS@PLA MB against E. coli and S. aureus are 99.98 and 99.99%, respectively. When being applied to the preservation of fresh strawberry, CEO2/CS@PLA MB can effectively inhibit the microbial growth in strawberry and reduce decay, which extends the shelf time of strawberry.
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PubMed
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COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 5
·481-490
·
IF 2.4
Liu Kedong,Chen Yun,Yang Zhaoqi,Jin Jian
In recent years, natural polyelectrolyte complex chitosan/poly-γ-glutamic acid (CS/γ-PGA) has emerged as a promising nanocarrier delivery system for drug delivery due to its non-toxic and easily degradable properties. However, tightly bound CS/γ-PGA complexes often lead to lower encapsulation efficiency of peptide drugs without coordination of metal ions. In this investigation, we find that procyanidin (PC), as a cross-linking agent, is able to combine with CS and insulin through hydrogen bonding, which significantly improve encapsulation efficiency of insulin up to 90% in CS/γ-PGA/PC complex nanoparticles (CNPs). The results of this study demonstrate that CNPs release insulin in a pH-dependent approach and greatly reduce its enzymatic degradation in vitro. The transepithelial permeability of the CNPs is 8.1-fold higher than that of native insulin via both endocytosis and paracellular passways. Further pharmacokinetic studies reveal an oral pharmacological availability of 9.81 ± 1.32% in type I diabetic rats after intragastric administration of freeze-dried CNPs which loaded in enteric-coated capsules. In consequence, CNPs not only improve oral bioavailability of insulin but also are a promising delivery platform for insulin or other peptide/protein drugs. Graphical Abstract
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Bioengineered
·
2022
·
IF 6.832
Wei-Hao Wu,Xiao-Mei Ma,Jian-Qing Huang,Qin Lai,Fu-Neng Jiang,Cui-Yun Zou,Long-Tian Chen,Lian Yu
This study investigated whether CRISPR/Cas9 (D10A) nickase-mediated gene editing can correct the aberrant Hb Constant Spring mutation (Hb CS or HBA2: c.427 T > C) in fibroblasts. Vectors for repairing the α-globin-encoding gene, HBA2:c.427 T > C mutation, includingthe CRISPR/Cas9(D10A)-sg plasmid and donor with homology arms, were constructed and used to perform gene editing in patient-derived fibroblasts. We subsequently analyzed the genetic correction, the gene editing efficiency and off-target effect. Sequencing analysis and the BamHI assay showed that HB CS mutant cells were repaired with Hb CS point mutations, the editing efficiency was 4.18%~9.34% and no off-target effects were detected. The results indicate that the HB CS mutant gene is effectively repaired by the CRISPR/Cas9 (D10A)system, which may enable truly personalized therapy for precise repair of α-thalassemia.
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PubMed
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Solar RRL
·
2021
·Vol. 5
·期 5
·2100036
·
IF 8.582
Jun-Yan Li,Hong-Yan Chen,Yong Jiang,Dai-Bin Kuang
To make full use of solar energy and achieve effective separation of photogenerated carriers, semiconductor heterojunction engineering is becoming increasingly significant nowadays. Herein, Cs x WO 3 /CsPbBr 3 heterojunctions via cosharing the Cs atom are synthesized by a facile acid solution method, which involves the in situ growth of CsPbBr 3 nanoparticles on the surface of Cs x WO 3 nanorods. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) tests confirm that a high-quality interface with strong interaction between Cs x WO 3 and CsPbBr 3 is constructed successfully. Thus, a direct Z-scheme charge transfer pathway is built in such close-contact heterojunctions, which can not only effectively prevent the recombination of photogenerated carriers, but also preserve the carriers with higher redox abilities, as confirmed by electron spin resonance (ESR) as well as Kelvin probe force microscopy (KPFM). As a proof of concept, the photocatalytic hydrogen production performance of Cs x WO 3 /CsPbBr 3 is evaluated in ethyl acetate, and a 17-fold enhancement in hydrogen production rate as compared with pristine Cs x WO 3 is obtained, verifying the effective charge separation in such heterojunctions. Herein, a new idea for in situ synthesis of high-quality perovskite-based heterojunctions is provided, which will broaden their optoelectrical applications.
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ENERGY & FUELS
·
2020
·
IF 3.421
Huaikui Yuan,Zejun Zhang,Yuanzhu Mi,Fan Ye,Wangfu Liu,Jiazhe Kuan,Xia Jiang,Yue Luo
Relatively low cost, environmental friendly, and high-efficiency silicon dioxide/carbon sphere composite demulsifiers (SiO2@CS) were prepared via an in situ hydrothermal–calcination route. They were characterized by Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction. The demulsifiers with different ratios of SiO2 and CS were systematically investigated. The effect of the temperature, standing time, and dosage of SiO2@CS on the demulsification performance was determined by the bottle test. The efficiency reached the highest value of 89.52% when the dosage, temperature, and standing time were 300 mg/L, 70 °C, and 150 min, respectively. Also, the pH value and salinity were inspected. It was encouraging to find that the demulsifier had good acid, alkali, and salt tolerance. Investigations of the wettability, dynamic interfacial tension, and self-assembly of the interfacial film and microexaminations were carried out to probe the possible mechanism. SiO2@CS exhibited good adsorption, flocculation, and coalescence abilities in the demulsification process. The current work is beneficial for the further understanding of the demulsification process and also provides a promising demulsifier to deal with the water-in-crude oil emulsion.
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RSC Advances
·
2019
·Vol. 9
·期 52
·30125-30133
·
IF 3.049
Lili Xu,Hongbo Suo,Renmin Liu,Houmei Liu,Hongdeng Qiu
In this study, a novel magnetic composite (Fe3O4@CS/GO/Ag) modified with chitosan (CS), graphene oxide (GO) and Ag nanoparticles (Ag NPs) was successfully prepared as an efficient adsorbent for detection of rhodamine B (RB) combined with a fluorescence technique. The properties of the magnetic composite were confirmed by field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, and vibrating sample magnetometry. The components of Fe3O4@CS/GO/Ag endowed it with excellent extraction performance and convenient operation. The main parameters affecting extraction and desorption efficiency were all investigated systematically. Under the optimized experimental conditions, the proposed method showed linear ranges (0.2–6.0 μg L−1) with R2 = 0.9992. The limits of detection (LODs) and quantification (LOQs) were 0.05 and 0.2 μg L−1 (n = 3), respectively. Fe3O4@CS/GO/Ag exhibited outstanding extraction efficiency for RB, compared with CS-coated Fe3O4 nanoparticles (Fe3O4@CS) and GO-modified Fe3O4@CS (Fe3O4@CS/GO). The applicability of the proposed method was investigated by analyzing four real samples (waste water, soft drink, shampoo, and red pencil) and the spiked recoveries ranged between 94% and 97% with RSD ranging from 3% to 6%, which showed that the proposed method had satisfactory practicability and operability.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Wanqing Li,Yuhang Li,Hongquan Fu,Guangxing Yang,Qiao Zhang,Shengzhou Chen,Feng Peng
A novel phosphorus-doped Co 9 S 8 and carbon nanosphere composite (Co 9 S 8 /P@CS) was successfully prepared by adding a certain amount of sodium hypophosphite during the thermal treatment process of preparing Co 9 S 8 . The results of XRD and XPS confirmed the incorporation of phosphorus into the lattice of Co 9 S 8 . Electrochemical tests demonstrated that Co 9 S 8 /P@CS performs a high electrocatalytic activity for oxygen evolution reaction (OER). Under the current density of 10 mA cm −2 , Co 9 S 8 /P@CS-1:2 as the best catalyst has the lowest overpotential of 233 mV and Tafel slope of 48 mV dec –1 , which is far superior to the current noble-metal catalyst IrO 2 (414 mV, 96 mV dec –1 ). A rechargeable Zn-air battery was assembled with Co 9 S 8 /P@CS-1:2 as the air-electrode catalyst. Its maximum power density reached 142.50 mW cm −2 at 0.56 V and the current density was 255.47 mA cm −2 , significantly higher than those of the battery made by Pt/C-IrO 2 catalysts. Especially, after 350 h (1050 cycles) of charge and discharge, the performance of this assembled battery did not show a significant decrease, predicting a broad application prospect. In-situ Fourier transform infrared spectroscopy (FTIR) and density functional theory (DFT) calculations were used to analyze the active sites of catalyst and catalytic mechanism, revealing the relationships between structure and the catalytic performance for OER.
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PHYTOCHEMISTRY
·
2025
·
IF 3.4
Xing-Yan Feng,Sui-Qun Yang,Xiao-Ming Li,Xin Li,Bin-Gui Wang,Ling-Hong Meng
Chemical investigation of the cold-seep-sourced fungus Talaromyces trachyspermus CS-106 resulted in the isolation of six previously undescribed phenolic glucopyranosides, talarosides A – F ( 1 – 6 ), two previously undescribed phenolic cysteine derivatives, talacysteines A and B ( 7 and 8 ), and five known congeners 9 – 13 . The results from in vitro bioassay indicated that compounds 3 , 6 , and 9 displayed potent activities against several tested phytopathogenic fungal strains. Specially, the chloroquinone derivative, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (compound 9 ), exhibited a broad spectrum of fungicidal activity against Alternaria brassicae , Colletotrichum gloeosporioides , Fusarium graminearum , and F. oxysporum , with MIC values ranging from 0.5 to 4 μg/mL. In vivo testing on tomato fruits showed that 9 displayed considerable curative efficacy against F. oxysporum . Both scanning electron microscopy and cryo-SEM analysis indicated that 9 possessed a strong ability to destroy the surface morphology of mycelia and seriously interfere with the growth of the fungal pathogen. Compound 9 also exhibited pronounced succinate dehydrogenase (SDH) inhibitory activity from the in vitro SDH inhibitory assay. Molecular docking simulations were performed to explore the intermolecular interaction of 9 with SDH enzyme from F. oxysporum . These findings presented a promising lead compound such as compound 9 for the discovery of SDH inhibitor as antifungal agents.
研究领域:
天然产物化学
·
微生物生物技术
·
抗真菌药物发现
·
海洋真菌代谢物
·
生物有机化学
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Journal of Macromolecular Science Part B-Physics
·
2025
·
IF 1.4
Jianxun Yao,Jifan Zhan,Hanwu Liu,Tingting Yan
Auricular reconstruction remains a significant challenge in tissue engineering due to the auricle’s complex anatomy and functional requirements. To address the limitations of autologous cartilage grafts, we developed a composite scaffold consisting of porous ultra-high molecular weight polyethylene (UHMWPE) integrated with a polyvinyl alcohol/chitosan (PVA/CS) double-network hydrogel reinforced with 2 wt% nano-hydroxyapatite (HA). The scaffold was fabricated via powder sintering and physical crosslinking and exhibited high porosity (>41%), a tensile strength of 2.80 MPa, and enhanced water retention. The addition of HA improved both the mechanical strength and antibacterial properties of the composite. The hydrogel component demonstrated stable swelling behavior, hemolysis rates below 5%, and good cytocompatibility. These findings demonstrate that the UHMWPE/PVA-CS/HA composite scaffold, combining the rigidity of a sintered porous framework with the flexibility and bioactivity of a reinforced hydrogel, offers a novel and promising platform for patient-specific auricular reconstruction with balanced mechanical, biological, and antibacterial properties.
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